Browsing by Author "J.K. Mishra"

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Comparative evaluation of two intranasal forms of Curcumin: Quantitation and impact on mouse model of asthma
(Elsevier B.V., 2023) Payal Singh; Ruchi Chawla; Ajai Kumar Pandey; J.K. Mishra; Rashmi Singh
Aim of the study: Present study aimed to investigate impact of two different intranasal forms of curcumin on mouse model of asthma and detection of its absorption after different time points of administration. Since the systemic bioavailability of curcumin is very low, therefore, intranasal route of administration has been explored here where systemic absorption of two intranasal forms of curcumin was evaluated. Materials and methods: To explore the possibilities of its absorption and role in amelioration of asthma, two intranasal forms of curcumin, nasal drop and aerosol were administered to control and asthmatic mice. Blood plasma and lungs were collected at different time points of curcumin administration. Separation was done by using isocratic reversed phase high performance liquid chromatography (HPLC). Airway inflammation and oxidative stress parameters like SOD, Catalase, ROS, lipid peroxidation, and total inflammatory cell recruitments were analyzed to study efficacy of two intranasal forms of curcumin. Results: Maximum absorption was noted at 3 hrs of different intranasal forms of curcumin, administration, i.e., nasal drop (1.93 ± 0.050 plasma, 2.87 ± 0.26 in lungs) and aerosol form of curcumin where better absorption was noted in aerosol form as compared to nasal drop (Lungs 3.08 ± 0.12 aerosol, 2.05 ± 0.020 nasal drop) at 1 h. Both, curcumin aerosol and nasal drops were effective in ameliorating oxidative stress (p < 0.05) associated with asthma in mice model. The present study may pave the way towards the development of intranasal curcumin as complementary medication because of its better absorption in plasma and lungs. © 2023 The Author(s)
Evaluating renal status in pulmonary tuberculosis: case of rural and urban patients in eastern UP
(1993) J.K. Mishra; D.C. Roy
Tuberculosis is one of the commonest health hazards in India, involving kidneys very frequently, the incidence level being next to pulmonary tuberculosis. This study is aimed at knowing the exact incidence and histological character of renal tuberculosis. This study also attempts to evaluate the progressive factors in different histopathological varieties. By trying different antitubercular regimens on these patients of renal turberculosis, we will be in the position to recommend a particular mode of therapy for the treatment of renal tuberculosis which may help to reduce the cost and period of treatment as well as to reduce the chances of transmission. -from Authors
Evaluating respiratory allergy in Varanasi and environs
(1990) D.C. Roy; J.K. Mishra
[No abstract available]
Health hazard and ecosystem in high altitude Himalaya, India
(1998) J.K. Mishra; R.P.B. Singh
The impact of ecosystem on health hazard in high altitude Himalaya is probably of the greatest stress for man. In contrast to others, it is permanent, invariable and irremediable. Despite such a stressful ecosystem millions of people live there under conditions of severe hypoxia and very low barometric pressure that create many physiopathological problems. The native population show a different and at the same time a more varied clinical picture. This can be considered as a true adaptation consisting mainly of increase in pulmonary vascular resistance, right ventricular hypertrophy, polycythaemia, reduction of cerebral and coronary output and low arterial pressure. Chronic bronchitis has been found as prevalent disease in males and females both, however at some villages this has been absent. Despite the other environmental hazards, the higher intensity of cigarette smoking was directly responsible for the high incidence of chronic bronchitis. In most populations both the mean blood pressure and the prevalence of hypertension increase with age. The incidence of obesity was lesser than the rest parts of India.
Serum malondialdehyde and lipid profile in bronchial asthma
(2002) H.D. Khanna; S.S. Dubey; R. Khanna; J.K. Mishra
The aim of present study was to evaluate serum levels of malondialdehyde (MDA) and lipoprotein transport cholesterol in bronchial asthma patients. The serum levels of total cholesterol and triacylglycerol were also determined in order to assess the lipid status of these patients. It was observed that serum contents of total cholesterol, low density lipoprotein cholesterol and MDA were significantly higher in both the group of patients (younger and elderly group) suffering from bronchial asthma. Moreover serum triacylglycerol, very low density lipoprotein cholesterol and high density lipoprotein cholesterol did not show any significant change as compared to control values. However the TC/HDL-C and LDL-C/HDL-C ratios were significantly higher in all these patients. Altered cholesterol ratios and serum MDA level in these patients have been related to increased risk of complications.