Browsing by Author "J.S. Tripathi"

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Anti-platelet aggregating activity of a polyherbal compound-shirishadi - In vitro study
(Oriental Scientific Publishing Company, 2017) Kajaria Divya; J.S. Tripathi; S.K. Tiwari
The present study aims to search a drug that acts on platelet aggregation to validate the fact that preventing platelet aggregation is helpful in successful management of bronchial asthma in addition with the effect on previously proved mechanism. With this aim it was planned to search the effect of a polyherbal drug - Shirishadi on platelet aggregation. It is worthy here to mention that this drug (Shirishadi) is chosen on the basis of clinical evidence suggesting its potent anti-asthmatic effect. Anti-platelet property of Shirishadi polyherbal compound was evaluated using thrombin induced platelet aggregation isolated from human blood (collected from healthy volunteers) by differential centrifugation. Under in vitro conditions, 15 min pre-incubation with the Shirishadi polyherbal compound (200μg/ml) significantly (p< 0.001) inhibit thrombin- induced platelet aggregation. These findings suggest that Shirishadi, a polyherbal formulation possesses potent anti-platelet aggregation activity in the experimental models of in vitro platelet aggregation. Copyright © 2017 Oriental Scientific Publishing Company.all rights reserved.
Biologics (biological agents): A new approach in the treatment of psoriasis
(Innovare Academics Sciences Pvt. Ltd, 2016) Singh Satyapal; J.S. Tripathi; N.P. Rai
Psoriasis is a chronic inflammatory and multifactorial systemic disorder with predominant manifestation over the skin and/or joints resulting from interactions between genetic pre-disposition and triggering environmental factors. Due to its systemic nature, patients exhibit a broad spectrum of symptoms that vary in severity. Although many patients, particularly those with the limited form of the disease, may be treated with topical therapy, those with extensive (moderate to severe) psoriasis eventually require phototherapy, systemic, or biologic therapy to adequately suppress the systemic, immunopathogenic process. Biological agents (biologics or biologicals) are a set of different engineered proteins. These are immunosuppressive agents, designed to selectively interfere with the immune mechanisms that induce psoriasis. Their use is restricted to the treatment of moderate to severe psoriasis, which has failed to respond to systemic therapies (and/or phototherapy) or where such treatments are contra-indicated or not tolerated. Biologics are becoming increasingly useful for the treatment of many skin diseases including psoriasis, particularly as alternatives for patients who have failed to tolerate or respond to conventional systemic therapies or where non-biologic systemic agents are unsuitable due to the presence of comorbidities. Biological therapies provide a targeted approach to treatment through interaction with specific components of the underlying immune and inflammatory disease processes. © 2016, Innovare Academics Sciences Pvt. Ltd. All rights reserved.
Clinical evaluation of Talapotaka Churna – A polyherbal Ayurvedic formulation in type 2 Diabetes mellitus
(National Institute of Science Communication and Information Resources (NISCAIR), 2018) Guruprasad C. Nille; K.R.C. Reddy; J.S. Tripathi
To evaluate and compare the antidiabetic effect of Talapotaka Churna in Type II Diabetes mellitus patients were registered from S. S. Hospital, Banaras Hindu University, Varanasi. Patients were randomly divided in four groups for treatment of four different medicine groups: [Group A- Talapotaka Churna (4 g TID) with Takra (Buttermilk) before meal; Group B- Talapotaka Churna (4 g TID) with warm water before meal; Group C- Talapotaka Churna (4 g TID) with ongoing allopathic treatment with water before meal. Group D- Glimepride treated (1 mg BD) before meal]. The treatment was given for a period of two months. Fasting blood sugar, postprandial blood sugar, HbA1c, SGOT, SGPT, Sr. Creatinine and lipid profile level were estimated biochemically. The results were promising and reveal that Talapotaka Churna can be a safe, acceptable and effective alternative or adjuvant to the conventional oral hypoglycemic agents. Holistic principles of Ayurveda when used as supplementary for modern drugs in diabetes show their effects on all bodily symptoms and helps to minimize them in which modern drug fails. So, it is the need of time to support the modern medications with Ayurvedic therapy. © 2018, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
Comparative clinical evaluation of an ayurvedic regimen in the management of senile dementia
(International Journal of Research in Ayurveda and Pharmacy, 2013) Ansari Obed Ahmed; J.S. Tripathi; I.S. Gambhir
An enhanced life expectancy in developed countries has been accompanied by an increased number of people suffering from age-associated dementia. Senile dementia is a syndrome due to disease of the brain, usually of a chronic or progressive nature, in which there is disturbance of multiple higher cortical functions, without any impairment in consciousness. Prevalence rates for senile dementia increase essentially with advancing age. The prevalence rate rises to 54.8% in individuals above 95 years of age. So far, efforts to find a cure for Alzheimer Disease (AD) have been disappointing, and the drugs currently available to treat the disease address only its symptoms and with limited effectiveness. Present study was design to see the efficacy of Saraswata ghrita along with Shirobasti on Senile dementia. A total number of 34 patient of Senile dementia were recruited by using ICD- 10 criteria of Dementia and MMSE scores and randomly divided in to two groups. Alzheimer's disease assessment scale (cognitive subscale) has been used to evaluate the clinical condition of the patients of Senile dementia. After completion of treatment Saraswata ghrita along with Shirobasti shows statistically significant results on clinical and neuro-cognitive parameters.
Evaluation of antimicrobial activity and bronchodialator effect of a polyherbal drug-Shrishadi
(Asian Pacific Tropical Biomedicine Press, 2012) Divya Kumari Kajaria; Mayank Gangwar; Dharmendra Kumar; Amit Kumar Sharma; Ragini Tilak; Gopal Nath; Yamini Bhusan Tripathi; J.S. Tripathi; S.K. Tiwari
Objective: To investigate antimicrobial and bronchodialator effect of hydroalcholic extract of polyherbal drug Shirishadi containing Shirisha (Albezzia lebbeck), Nagarmotha (Cyprus rotandus) & Kantakari (Solanum xanthocarpum). Methods: Antimicrobial activity was evaluated by disc diffusion method and MIC, MBC, MFC were calculated by micro dilution method. Hydroalcholic extract of this preparation was investigated for its phytochemical analysis, phenol and flavonoid were determined by spectrophotometric method and in vivo bronchodilator effect was analysed by convulsion time. Results: The phytochemical tests revealed presence of alkaloids, anthraquinones, carbohydrates, flavonoids, saponins and tannins. The antimicrobial result showed the MIC of 6.25 mg/mL against Staphylococcus aureus and 12.5 mg/mL for Escherichia coli and 12.5 mg/mL against remaining bacteria tested, with strong antifungal activity. The maximum inhibition zone is found against Pseudomonas aeruginosa with MIC 16 mg/mL. Drug showed significant bronchodilator effect with 27.86% & 36.13% increase in preconvulsion time of guinea pigs pretreated with 100 & 200 mg/kg body weight of extract. Conclusions: The study reveals that the extracts possess antibacterial activity and antifungal activity in a dose dependent manner. This antimicrobial property may be due to presence of several saponins, further studies are highly needed for the drug development. © 2012 Asian Pacific Tropical Biomedical Magazine.
Management of COVID-19: Ayurvedic perspective
(National Institute of Science Communication and Information Resources, 2020) Y.B. Tripathi; N. Joshi; S.K. Dubey; P.S. Byadgi; S. Bhat; R. Prasad; B.K. Dwivedi; K.K. Pandey; J.S. Tripathi; C.S. Pandey; K.H.H.V.S.S.N. Murthy; S. Suman; A.K. Pandey; V. Srivastava; V. Jaisawal; K.N. Dwivedi
Ayurveda, a branch of AYUSH system of health care in India is considered as alternative/complementary of medicine (CAM) in WHO. Here, its products are covered under “drug and cosmetics” act but in abroad they are supplements or functional foods. The aim of Ayurveda is to maintain the wellness of a healthy person and to treat a patient. For treatment, Ayurveda adopts 3 approaches i.e., (1) Daivavyapasharya chikitsa) (ypareht enivid 2 ( Yuktivyapashraya chikitsa (Rational therapy) 3 Satvavajaya chikitsa (Psychotherapy) and focuses to enhance the Vyadhikshmatwa (capacity to fight against spread of pathogenesis by strengthening all 7 dhatus (rasa, rakta, meda, mansa, asthi, majja and shukra). The disease COVID-19 falls under “Bhootvidya (GrahaVidya)", which is one of the 8 branches of “Astanga Ayurveda”. It is an “Agantuja” disease, where the disease symptoms appear in 1st stage followed by its spread in the body. Thus, progress of disease (Samprapti) has been considered under concept of shatkriyakala (6 stages of disease development), which has been given high importance for deciding the stage of disease progress and its treatment protocol. Here, we have described the introduction to Astang Ayurveda, concept of disease pathogenesis and holistic approach of treatment in respect to management of COVID-19. It specifically covers symptom based stage of disease progress and its targeted treatment guideline by including all 3 approaches of treatment, described above. Here, the current line of diagnosis, treatment and research related to COVID-19 management has been included, which are reported by basic scientists and physicians of allopathic system. These are indexed in Pubmed and web of science and also described in classical text books of Ayurveda. The same has been reviewed and summarized here, with an objective of possible correlation between the 2 languages of science of health care. © 2020, National Institute of Science Communication and Information Resources. All rights reserved.
The analgesic and anti-inflammatory activities of the hydroalcholic extract of "Shirishadi compound" in animal model
(2011) Divya Kajaria; J.S. Tripathi; S.K. Tiwari; B.L. Pandey
The main objective of the present investigation is to evaluate the anti-inflammatory & analgesic activity of ethanolic extract of Shirishadi polyherbal compound on rats. Shirishadi compound consist of three herbal drugs namely- Shirisha (Albizzia lebbeck), Nagarmotha (Cyprus rotandus) & Kantakari (Solanum xanthocarpum).In Ayurveda (ancient Indian system of medicine) all these herbs alone or in combination with other herbs are commonly used in the managmant of bronchial asthma. In the carrageenan-induced rat paw edema test for acute inflammation, the extract of Shirishadi compound in doses of 50mg, 200 mg and 500 mg/kg body weight showed 77% and 79% and 81% inhibition of edema, respectively, at the end of 4h which is comparable to that of standard ( endomethacin) i.e. 92%. In the acetic acid induced writhing test the extract of Shirishadi compound ( 200 and 500 mg/kg body weight) showed a significant (p<0.001) reduction in the number of writhes with 65.6% and 70.9% of inhibition, respectively. In radiant heat tail-flick test the crude extract produced 58.1% (p<0.001) and 61.1% (p<0.001) elongation of tail flicking time 30 minutes after oral doses of 200 and 500 mg/kg body weight respectively . After 60 minutes the extract showed 56.3% (p<0.001) and 59% (p<0.001) elongation of tail flicking time. Experimental results showed that Shirishadi compound has persuasive anti-inflammmatory property along with significant analgesic activity.
The role of psychological factors in aetiopathogenesis and management of obesity related diseases
(2011) J.S. Tripathi; P.S. Byadgi; K. Narasimha Murthy
The obesity is a challenging problem in to-days world which if left un tackled leads to a variety of associated illnesses like Hypertension, Diabetes mellitus, Cardiovascular disorders, Cerebro vascular accidents etc. The common etiological factors which are implicated include sedentary life style, genetic fa ctors, dietary factors and endocrine factors, but the psychological factors are often overlooked which are the most important factor perpetuating binge eating behavour. The emotional instability, depression, stress, sexual abuse etc, often result in compulsive over eating leading to obesity. Thus the comprehensive management of obesity and the associated illnesses should include the proper tackling of these psychological components apart from other common thera pies. The present article critically analyses the role of these factors in the causation of obesity and its different management strategies which includes sattvavajaya as an Ayurvedic technique.