Browsing by Author "K. Narasimha Murthy"

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Bayesian competing risk analysis: An application to nasopharyngeal carcinoma patients data
(John Wiley and Sons Inc, 2021) Rakesh Kumar Saroj; K. Narasimha Murthy; Mukesh Kumar; Atanu Bhattacharjee; Kamalesh Kumar Patel
Background: The Cox proportional hazard (CPH) model is normally used to study the death event data. The presence of competing risk (CR) is often encountered in health data, hence it becomes difficult to manage time to event data in clinical study. Bayesian approach is considered to manage the CR events in clinical data. Objectives: The objective of study is to find the predictors associated with overall survival of nasopharyngeal carcinoma (NPC) patients. Further, our purpose is to use a Bayesian model that can analyze time to event data in the presence of CR. Methods: Total 245 patients with NPC were taken (https://www.ncbi.nlm.nih.gov/geo/). The sociodemographic and clinical variables were considered for analysis purposes. R software and openBUGS were used to overcome the computational problems of CPH and Bayesian models. The Markov chain Monte Carlo (MCMC) method was used to compute the regression coefficients of Bayesian model. Results: The study shows that among NPC patients, the covariates chemotherapy, smoking, N-stage, and tumor site are associated with the higher risk for the deaths occurring in the cancer patients. The posterior mean estimates of proposed Bayesian model for significant factors have been obtained. The posterior mean and standard deviation estimates help to improve the survival of patients in the presence of CR. Conclusions: It is very difficult to use the CR model with Bayesian approach in health research for nonstatistical researcher due to lack of information. This paper is dedicated to the application of Bayesian approach for CR analysis on NPC data. © 2020 The Authors. Computational and Systems Oncology published by Wiley Periodicals LLC.
The role of psychological factors in aetiopathogenesis and management of obesity related diseases
(2011) J.S. Tripathi; P.S. Byadgi; K. Narasimha Murthy
The obesity is a challenging problem in to-days world which if left un tackled leads to a variety of associated illnesses like Hypertension, Diabetes mellitus, Cardiovascular disorders, Cerebro vascular accidents etc. The common etiological factors which are implicated include sedentary life style, genetic fa ctors, dietary factors and endocrine factors, but the psychological factors are often overlooked which are the most important factor perpetuating binge eating behavour. The emotional instability, depression, stress, sexual abuse etc, often result in compulsive over eating leading to obesity. Thus the comprehensive management of obesity and the associated illnesses should include the proper tackling of these psychological components apart from other common thera pies. The present article critically analyses the role of these factors in the causation of obesity and its different management strategies which includes sattvavajaya as an Ayurvedic technique.