Browsing by Author "K.D. Yadav"

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A novel herbomineral formulation Sahaj vati as shelf life enhancer of nutraceuticals based on aflatoxin inhibitory and antioxidant activity
(OMICS International, 2017) K.D. Yadav; A.K. Dwivedy; A.K. Chaudhary; N.K. Dubey
The present investigation deals with chemical standardization and aflatoxin inhibitory and antioxidant activity of a herbomineral formulation, sahaj vati prepared in two batches (batch I and II) by mixing shilajeet (thick exudates of the mountain during summer season), guggul (Commiphora mukul (stocks) hook.), haridra (Curcuma longa L) and chitrak (Plumbago zeylanica L) with levigation of Agnimantha kwatha (Premna mucronata L). Batch I was prepared by mixing shilajeet, guggul, haridra and chitrak in equal proportion (25% each by weight) while batch II comprised shilajeet (44.7%), guggul (44.7%), haridra (4.8%) and chitrak (5.8%) by weight. Sahaj vati II showed highest (96%) inhibition of aflatoxin production at concentration of 10 000 µg/ml. Suddha guggul exhibited strong antioxidant activity showing lowest IC50 at concentration of 20.56 µg/ml. Based on these findings, the newly formulated herbomineral formulation could be recommended for value addition of nutraceuticals by enhancing their shelf life against lipid per oxidation and aflatoxin contamination. © 2017, OMICS International. All rights reserved.
Anti-oxidant potential of herbal formulation (Sahaj vati) modulating leptin, insulin activity
(National Institute of Science Communication and Information Resources, 2021) K.D. Yadav; A. Singh; A.K. Chaudhary
Obesity increased at alarming rate is considered as a serious health risk and the World Health Organization wishes to halt the rise of obesity. Therefore, search for the treatment and dietary mediations is fundamental to lessen or potentially forestall the corpulence. Sahaj Vati was prepared using Shilajeet, Curcuma longa, Plumbago zeylanica, Commiphora mukul and might be helpful to reduce obesity. Twenty four albino rats were randomized into four equal groups and were selected as control, positive control, as standard (orlistat) and Sahaj Vati treated group, respectively. Monosodium glutamate (MSG) was administered at a dose of 10 mg/kg body weight for 10 days and Sahaj Vati & orlistat was regulated orally at portion of 200 and 10 mg/kg body weight individually for four week. After four week, the body weight of animals, serum leptin, insulin, total oxidant, total antioxidant and oxidative stress index were estimated. It was observed that body weight was significantly increased by MSG whereas body weight was significantly decreased by orlistat and Sahaj Vati. Sahaj Vati significantly increased insulin concentration, total anti-oxidant status and decreased total oxidant status & oxidative stress and significantly decreased leptin concentration. Thus, Sahaj Vati decreases body weight by modulating leptin & insulin concentration as well as total oxidant status, total anti-oxidant status & oxidative stress. © 2021, National Institute of Science Communication and Information Resources. All rights reserved.
Bioavailability enhancement of partially water soluble solid medicament in traditional system of medicine
(Indian Pharmaceutical Association, 2017) K.D. Yadav; A.K. Chaudhary; A.K. Verma
Liquid state medicaments like Kwatha (decoction), sneha kalpa (oleaginous preparation), asavarista (biomedical fermentation) are supposed to have higher bioavailability due to higher absorption whereas solid state medicaments such as herbal churna (powder), bhasma and herbomineral formulations has theoretical low bioavailability, this may be due to poor water solubility. It has been claimed that bhasma is very effective at low dose. A question about how Bhasma and other preparations be effective in very low doses despite lower water solubility needs to be answered. In a bid to find the answer ancient and contemporary literature was scrutinized with respect to pharmaceutical aspects. It was found that particle reduction technology improved solubility, and bioavailability and particle size reduction technologies such as bhavan, and bhasmikaran. Were practiced in Ayurveda, which might correspond to liquid assisted grinding and tribochemistry. Particle size below 1 mm causes disruption of solute-solute interaction and increases bioavailability. Tribochemistry may produce nanoparticles either mechanically or by thermally-induced chemistry at the asperity tips due to flash temperatures and one affects the other. The reaction of solid state components during liquid-assisted grinding also is an important method responsible for the conversion of inert precursors, such as metal oxides, into hybrid inorganic-organic materials. Thus particle reduction technology enhances the bioavailability of poor water soluble components, apart from that use, liquid media in process supposed to assist the particle reduction technology and potentiation. Thus, with the help of suitable particle size reduction technology and synergistic action bioavailability of poorly water soluble components could be enhanced. © This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms
Characterization of Sahaj Vati using infrared and UV/Vis spectroscopy
(Indian Pharmaceutical Association, 2018) K.D. Yadav; A.K. Chaudhary
Sahaj Vati, an Ayurvedic herbo-mineral formulation comprising of Suddha Shilajeet, Suddha Guggul, Haridra and Chitrak, has been used for treatment of obesity. Two types of Sahaj Vati was prepared namely I and II, Sahaj Vati I was prepared by bhavana of Agnimanth kwatha to the powder of Suddha Shilajeet, Suddha Guggul, Haridra and Chitrak whereas Sahaj Vati II was prepared by dissolving the Suddha Shilajeet, Suddha Guggul in Haridra and Chitrak kwatha followed by bhavana of Agnimanth kwatha. The characterization of Suddha Shilajeet, Suddha Guggul, Haridra, Chitrak and both Sahaj Vati was carried out using infrared spectroscopy and UV/Vis-infrared study. It was observed that IR absorption peaks of both Sahaj Vati did not absolutely match with its ingredients and some peaks of ingredients were totally absent in both Sahaj Vati. It was also observed that peaks of Sahaj Vati I and II differ significantly from each other. UV/Vis spectra of both Sahaj Vati showed absorption in region of 200-700 and 200-500 nm, respectively. Thus both Sahaj Vatis have different IR and UV/Vis spectra. © 2018 Indian Pharmaceutical Association. All rights reserved.
Quality control measure of jeeva rasa avaleha: A male sexual stimulant
(National Institute of Science Communication and Information Resources, 2021) V. Kumar; K.D. Yadav; T.D. Singh; A.K. Chaudhary
In spite of numerous Vajeekarana formulations being available in the market, the prevalence erectile dysfunction is increasing irrespective of race or economic status. The aim of the present study was to measure the quality control parameters of Jeeva Rasa Avaleha used as male sexual stimulant. It was prepared by using seven drugs, namely Shuddha Hingula, Shuddha Shilajatu, with powders of roots of five herbs viz., Aakarakarabha, Ashwagandha, Shweta Mushali, Shatavari and tuber of Vidarikanda. Qualitative and quantitative analyses of JRA such as reducing sugar, non-reducing sugar, fat content, water soluble extractive, pH, thin layer chromatography (TLC) and energy dispersive x-ray spectroscopy (EDX) were performed. It was observed that 9.8% moisture content and 15.12% water-soluble extractive were in JRA, respectively. EDX and AAS study showed that formulation had heavy metals within permissible limit except mercury which is an ingredient of JRA. Both qualitative and quantitative analysis of JRA indicates safety of formulation and therefore it may be prescribed for the treatment of erectile dysfunction. © 2021, National Institute of Science Communication and Information Resources. All rights reserved.