Browsing by Author "K.K. Gupta"

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A study on management of blood bank services at Sir Sunderlal hospital, BHU, Varanasi
(2011) Manoj Kumar; Madhumita Mukherjee; K.K. Gupta; Pallavi Pathak
Blood transfusion practices in a tertiary care hospital and teaching institute i.e SSL hospital, BHU, Varanasi were analysed through retrospective study of blood bank records for the year 2008-09. It was found that voluntary blood donation was 20.41% and 58.65% in the year 2008 and 2009 whereas replacement blood donations were 79.59% in the year 2008 and 41.35% in the year 2009. Male voluntary blood donors in the year 2008 and 2009 were 92.33% and 90.26% whereas male replacement donors in the year 2008 and 2009 were 91.09% and 89.55% respectively. Most common blood donor age group in the year 2008 -09 were from 21-35 years contributing 52.45% and 51.07% in respective years. Only 70.20% and 55.48% whole blood of the total blood units was utilized during this period and rest in the form of blood components. The prevalence of HIV seropositivity was nil. Hence it is inferred that more than 99% of the total blood collected in this blood bank is safe to use.
Acquired Bartter syndrome following gentamicin therapy
(Medknow Publications, 2016) J. Singh; M.L. Patel; K.K. Gupta; S.A. Pandey; A. Dinkar
Aminoglycoside nephrotoxicity may manifest as nonoliguric renal failure or tubular dysfunction, such as Fanconi-like syndrome, Bartter-like syndrome (BS), or distal renal tubular acidosis. We report a case who developed severe renal tubular dysfunction on the the 7 th day of gentamicin therapy, resulting in metabolic alkalosis, refractory hypokalemia, hypocalcemia, hypomagnesemia, and polyuria. The patient was diagnosed as a case of transient BS associated with gentamicin exposure. The patient recovered with conservative management. © 2016 Indian Journal of Nephrology | Published by Wolters Kluwer - Medknow.
Drosophila Watanabei, a new species of the montium subgroup of the melanogaster species group of the subgenus sophophora (Diptera: Drosophilidae)
(1992) J.P. Gupta; K.K. Gupta
Drosophila watanabei, sp. nov. is described and its relationship with other species within the montium subgroup is discussed. © 1992 Taylor & Francis Group, LLC.
The Ems Syndrome (8P11/12 Myeloproliferative Syndrome) or Human Stem Cell Leukemia/Lymphoma Syndrome-A Unique and Rare Case
(NLM (Medline), 2020) Prachi Mohapatra; K.K. Gupta; Nilesh Kumar; Lingaraj Nayak
[No abstract available]
The role of stem cells in osteoarthritis: An experimental study in rabbits
(British Editorial Society of Bone and Joint Surgery, 2014) A. Singh; S.C. Goel; K.K. Gupta; M. Kumar; G.R. Arun; H. Patil; V. Kumaraswamy; S. Jha
Introduction: Osteoarthritis (OA) is a progressively debilitating disease that affects mostly cartilage, with associated changes in the bone. The increasing incidence of OA and an ageing population, coupled with insufficient therapeutic choices, has led to focus on the potential of stem cells as a novel strategy for cartilage repair. Methods: In this study, we used scaffold-free mesenchymal stem cells (MSCs) obtained from bone marrow in an experimental animal model of OA by direct intra-articular injection. MSCs were isolated from 2.8 kg white New Zealand rabbits. There were ten in the study group and ten in the control group. OA was induced by unilateral transection of the anterior cruciate ligament of the knee joint. At 12 weeks post-operatively, a single dose of 1 million cells suspended in 1 ml of medium was delivered to the injured knee by direct intra-articular injection. The control group received 1 ml of medium without cells. The knees were examined at 16 and 20 weeks following surgery. Repair was investigated radiologically, grossly and histologically using haematoxylin and eosin, Safranin-O and toluidine blue staining. Results: Radiological assessment confirmed development of OA changes after 12 weeks. Rabbits receiving MSCs showed a lower degree of cartilage degeneration, osteophyte formation, and subchondral sclerosis than the control group at 20 weeks post-operatively. The quality of cartilage was significantly better in the cell-treated group compared with the control group after 20 weeks. Conclusions: Bone marrow-derived MSCs could be promising cell sources for the treatment of OA. Neither stem cell culture nor scaffolds are absolutely necessary for a favourable outcome. ©2014 The British Editorial Society of Bone & Joint Surgery.