Browsing by Author "K.M. Singh"

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Controlled clinical trial of allylestrenol im the medical management of benign prostatic hyperplasia
(1997) N.P. Gupta; Monish Aron; K.M. Singh; R.B. Dwivedi
Drug therapy is a major treatment option in the medical management of benign prostatic hyperplasia (BPH). We designed a placebo controlled clinical trial, to study the efficacy and safety of Allylestrenol. From 3 centers, there were 90 cases and 90 controls. The following parameters were evaluated at 0, 3 and 6 months: symptom score (SS), prostate size (PS), maximum flow rate (MFR), post-void residual urine (PVR) and serum testosterone levels (T). The cases were started on tab.Allylestrenol 25 mg. and the controls on tab. B-complex twice a day. At 3 and 6 months, in the Allylestrenol group there was significant improvement in respect of symptom score, prostate size and maximum flow rate. There was no significant difference in the post-void residual urine. There was a significant decline in serum testosterone levels in the Allylestrenol group when compared to controls. The results are shown in the following table: SS PS MFR PVR T BASELINE CASES 13.50 32.47 11.85 74.12 20.80 CONTROLS 12.75 34.14 13.15 66.31 21.60 3 MONTHS CASES 9.04 28.75 14.12 60.65 CONTROLS 12.36 36.25 11.71 51.02 6 MONTHS CASES 6.89 25.01 15.08 49.14 17.15 CONTROLS 13.17 36.76 11.25 58.78 21.59 In the Allylestrenol group, transient nausea and vomiting was seen in 3 cases and 11 cases had a loss of libido that reversed on stopping the drug. We conclude that Allylestrenol is an effective drug for medical management of BPH.
Excited state normal vibrations and force field of ethynylbenzene
(1997) K.M. Singh; R.A. Singh; S.N. Thakur
Accurate vibrational frequencies of ethynylbenzene and three of its deuterated isomers in first excited state (1B2) have been used in the determination of intramolecular force constants and the assignments of vibrational frequencies have been discussed in the light of calculated potential energy distributions. The vibrational modes corresponding to normal frequencies ν30 and ν31 exhibit mode scrambling on ring deuteration. Evidence of Duschinsky mixing in going from ground to the excited state has been found in the vibrational modes ν6, ν13, ν31 and ν34 which are active in one photon absorption and also in ν30 which is active in two photon excitation spectrum.
Ground state normal vibrations and force field of ethynylbenzene
(1995) K.M. Singh; R.A. Singh; S.N. Thakur
An accurate intramolecular force field for ethynylbenzene and its three deuterated isomers is determined from experimentally observed vibrational frequencies. Vibrational assignments are discussed in the light of the calculated potential energy distribution. Mode ν15 of a2 symmetry is assigned at 655 and 657 cm-1 in C6D5CCH and C6D5CCD, respectively. The vibrational frequency of 162 cm-1 is given double assignment as ν24 and ν36. Harmonic mode scrambling is observed in ν27, ν29, ν30 and ν31 in going from the parent molecule to the one with ring deuteration. © 1995.