Browsing by Author "K.R.C. Reddy"

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Acute and sub-chronic toxicity study of Brahmi ghrita in rodents
(BRNSS Publication Hub, 2014) Yadav Kapil Deo; K.R.C. Reddy; Vikas Kumar
Context: Brahmi Ghrita (BG) contains Brahmi (Bacopa monneri), Vacha (Acorus calamus), Kushtha (Saussurea lappa), Shankhapushpi (Convolvulus pluricaulis) and Puran Ghrita, mentioned for treatment of various diseases. Aim: To assess acute and sub-chronic toxicity of Brahmi Ghrita in mice and rats, respectively. Materials and Methods: In acute toxicity study, Swiss strain albino mice were administered orally Brahmi Ghrita doses of 1, 2.5 and 5 g/kg and observed for behavioural changes and mortality, if any. In sub chronic toxicity study, Charles Foster albino rats were administered two doses of Brahmi Ghrita i.e., 400 and 800 mg/kg, p.o. for 30 consecutive days. During 30 days of treatment, rats were observed for any changes in body weight and daily food and water intake. After 30 days, rats were sacrificed for haematological, biochemical and histopathology study. Result: There was no mortality or abnormal behaviour, observed in acute toxicity study in mice at all the three dose levels. In sub-chronic toxicity study, Brahmi Ghrita did not produce any significant changes in body weight and daily food and water intake of rats when compared to control group rats. Further, haematological and biochemical parameters were also found normal. Histopathological study revealed normal architecture of kidney and liver of Brahmi ghrita treated rats. Conclusion: Brahmi Ghrita is safe in rodent and mice.
Analytical substantiation of an antidiabetic ayurvedic formulation Eladi Churna through fourier transmission infrared
(BRNSS Publication Hub, 2017) Komal Bansal; K.R.C. Reddy
Aim: This study aims to evaluate possible functional group and phytoconstituents present in all the ingredients of Eladi Churna as well as in final dosage form (Eladi Churna). Materials and Methods: For infrared (IR) spectroscopy, all the samples were mixed with KBr in moisture free environment in a ratio of 1: 100, then, pellets were prepared and processed for scanning. Results and Discussions: Different absorbance peaks in Fourier transmission IR (FTIR) spectrum indicates the presence of phytoconstituents such as phenols, polyphenols, tannins, carbohydrates, and glycosides. Conclusion: By the usage of FTIR different bonding interactions and presence of phytoconstituents has been evaluated in separate ingredients as well as in final formulation. FTIR, if used in a proper manner, can act as a boon in the analytical validation of herbal medicines which are a complex mixture of phytoconstituents.
Anti-hyperglycaemic study of Eladi churna in streptozotocin (STZ) induced diabetic rats
(National Institute of Science Communication and Information Resources (NISCAIR), 2019) Komal Bansal; K.R.C. Reddy; Anshuman Trigunayat
Diabetes mellitus is the seventh leading cause of death worldwide, with a frequent occurrence of Type II diabetes as compared to Type I. The aim of this present study was to evaluate the anti-hyperglycaemic effect of a classical herbomineral preparation Eladi Churna in STZ induced Type II diabetic rats. Thirty adult charles foster albino rats were allocated in to five groups with six animals in each group: Group I (Control Group), Group II (Diabetic control group without any medication), group III (Standard drug Glibenclamide at 1mg/kg of body weight), group IV (Eladi Churna at 300 mg/kg of body weight), group V (Eladi Churna at 600 mg/kg of body weight). Diabetes was induced by intraperitoneal injection of STZ at dose level of 35mg/kg. The whole study was conducted for 28 days. The animals were examined for blood glucose levels on 0, 7, 14, 21, 28 days respectively and other biochemical parameters such as serum cholestrol, HDL, LDL, Triglycerides, SGOT, SGPT were evaluated on day 0 and 28, respectively. The results showed that a gradual reduction in blood glucose level was assessed on administration of Eladi Churna at two different dose levels. But it was more significant at dose level of 600 mg/kg as p<0.05 with a mean±SD value of 107.34±2.67 on day 28 as compared to mean±SD value of 494.40±43.99 on day 3 (after induction of diabetes mellitus). And the results were almost analogous to potent antidiabetic drug glibenclamide with a mean±SD value of 95.44±7.44 on day 28. And the drug was also responsible for maintenance of alterations in other biochemical parameters, associated with diabetes mellitus, thus depicting its potent anti hyperglycaemic and hypolipidaemic actions. © 2019, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
Anti-hyperglycemic and anti-hyperlipidemic effect of poly-herbal formulation in streptozotocin-nicotinamide induced diabetic rats
(Medknow Publications, 2015) Anoop Gupta; Vikas Kumar; K.R.C. Reddy
Introduction: Diabetes mellitus is one of the important metabolic diseases, and the percentage of affected population is increasing day by day. The search for better medicament is the need of hour. Aim: Poly-herbal formulation (PF) containing fourteen plant materials is studied for anti-hyperglycemic and anti hyperlipidemic effect. Material and methods: A total of 36 rats were taken for the study. The rats of either sex randomly divided into five groups, among these five groups, four groups contained 6 animals in each, whereas one group, i.e., normal control groups contain 12 animals. Group one (control) animals were treated with carboxy methyl cellulose, whereas group two animals were treated with streptozotocin (STZ) to induce diabetes. Group three animals were treated with 300 mg dose test drug and group four treated with 600 mg of the test drug. Whereas group five was treated with a known anti-diabetic drug, i.e., glibenclamide 10 mg. Result: It is found that the testing drug PF is a novel medicine having significant anti hyperglycemic effect and anti hyperlipidemic effect. No significant change was found in HDL level. Conclusion: PF is having good antidiabetic effect against STZ-nicotinamide induced model of diabetic rats.
Clinical evaluation of Talapotaka Churna – A polyherbal Ayurvedic formulation in type 2 Diabetes mellitus
(National Institute of Science Communication and Information Resources (NISCAIR), 2018) Guruprasad C. Nille; K.R.C. Reddy; J.S. Tripathi
To evaluate and compare the antidiabetic effect of Talapotaka Churna in Type II Diabetes mellitus patients were registered from S. S. Hospital, Banaras Hindu University, Varanasi. Patients were randomly divided in four groups for treatment of four different medicine groups: [Group A- Talapotaka Churna (4 g TID) with Takra (Buttermilk) before meal; Group B- Talapotaka Churna (4 g TID) with warm water before meal; Group C- Talapotaka Churna (4 g TID) with ongoing allopathic treatment with water before meal. Group D- Glimepride treated (1 mg BD) before meal]. The treatment was given for a period of two months. Fasting blood sugar, postprandial blood sugar, HbA1c, SGOT, SGPT, Sr. Creatinine and lipid profile level were estimated biochemically. The results were promising and reveal that Talapotaka Churna can be a safe, acceptable and effective alternative or adjuvant to the conventional oral hypoglycemic agents. Holistic principles of Ayurveda when used as supplementary for modern drugs in diabetes show their effects on all bodily symptoms and helps to minimize them in which modern drug fails. So, it is the need of time to support the modern medications with Ayurvedic therapy. © 2018, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
Comparative antidiabetic investigation of Talapotaka Churna and Avartaki Churna in STZ-induced diabetic rats
(BRNSS Publication Hub, 2016) Guruprasad C. Nille; Shardendu Mishra; Anshuman Trigunayat; K.R.C. Reddy
Aim: To compare the antidiabetic effect of Talapotaka Churna and Avartaki Churna in experimental animals. Materials and Methods: Talapotaka Churna (Avartaki [Cassia auriculata L.], Amalaki [Emblica officinalis G.], Haridra [Curcuma longa L.], and Daruharidra [Berberis aristata]) and Avartaki Churna (C. auriculata L.) were prepared by the standard procedure of Churna Kalpana. Diabetes was induced by streptozotocin (35 mg/kg) solution (intra-peritoneal). After assessment of hyperglycemia as an approximate induction of diabetes, a group of animals (TP300 and AV300) were treated with a dose of 300 mg/kg of Talapotaka Churna and Avartaki Churna each. For treatment comparison, Group III animals were treated with a standard antidiabetic drug, glibenclamide 1 mg/kg. Blood sugar and lipid profile level were estimated biochemically. Results: Talapotaka Churna and Avartaki Churna both reduced fasting blood glucose significantly on various doses in STZ-induced diabetic rats. Talapotaka Churna and Avartaki Churna also showed a reduction in the levels of total cholesterol, triglycerides, low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol but it increases the levels of high-density lipoprotein-cholesterol in diabetic rats. Conclusion: Talapotaka Churna and Avartaki Churna have significant antidiabetic and antihyperlipidemic activities in Type 2DM rats, which seem to scientifically validate its traditional uses and might be promising drugs in the therapy of diabetes mellitus and its hyperlipidemic complications.
Different modes of water pollution
(Kalpana Corporation, 2008) K.R.C. Reddy; P. Singh
Water is one of the most important natural resources in which, when the toxic substances enter, get dissolved or lie suspended or get deposited to make the water polluted. This results in the deterioration of the quality of water due to which the aquatic ecosystem, health of human beings and animals are adversely affected. Water pollution is a large set of adverse effects upon water bodies, such as lakes, rivers, oceans and groundwater caused by human activities. Water pollution is a major problem all over the world and it has been suggested that it is the leading worldwide cause of deaths and diseases and accounts for the deaths of more than 14,000 people daily. © 2008 - Kalpana Corporation.
Echo of Lodhradi Kashaya in lipid profile of type 2 diabetes mellitus patients
(Innovare Academics Sciences Pvt. Ltd, 2017) Varun Kumar Singh; K.R.C. Reddy
Objective: Lipid profile is matter to concern in fast changing lifestyle, and especially in diabetic mellitus (DM) patients. In arena of DM, obesity and high lipid contour is a causative problem and lead to generate the related problems too. Hence, tracking of lipid profile in DM patients is necessary as part of treatment approach. Hence, the present study was conducted to track the effect of Lodhradi Kashaya spray dried (LKSD) powder on lipid profile in Type 2 DM patients. Methods: Total 31 patients were taken following the guideline mention in Central Council for Research in Ayurveda and Siddha protocol for DM research. They were divided into two groups, Groups A and B and given LKSD (4 and 2 g TDS (three times a day), respectively, dissolved in water) for 3 months. They are investigated for their blood serum creatinine and lipid profile (cholesterol, low-density lipoprotein [LDL], high-density lipoprotein [HDL], very LDL [VLDL], and triglyceride). The patients response has also been noted regarding palatability acceptance and ease of administration. Result: LKSD was found significantly effective in total cholesterol (p=0.001 and 0.073), triglyceride (p=0.002 and 0.003), HDL (p˂0.001 and 0.026), LDL (p=0.563 and p˂0.001), and VLDL (p=0.024 and 0.003). Patients had reported that formulation is easy to take in spite of its astringency in taste. Conclusion: Lodhradi Kashaya has capability to control and take care of disturbance in lipid profile in DM patients and thus enhance their living confidence. © 2017 The Authors.
Effect of Chanaka Yoga as a dietary supplement in the management of Type II diabetes mellitus patients
(BRNSS Publication Hub, 2016) Anjali Singh; K.R.C. Reddy
Aim: The aim of this study was to evaluate and compare the antidiabetic effect of Chanaka Yoga in Type II diabetes mellitus (DM) patients. Materials and Methods: Fifty-six patients of Type II DM were registered from the Outpatient Department of Rasa Shastra, Sir Sunderlal Hospital, Banaras Hindu University, Varanasi. Patients were randomly divided into two groups for treatment of two different medicine groups (Group A - Chanaka Yoga [10 g 1 time a day]; Group B-Glimepiride treated [1 mg]). The treatment was given for 3 months. Fasting blood sugar, post prandial sugar, hemoglobin A1c, serum glutamic oxaloacetic transaminase, serum glutamic-pyruvic transaminase, serum creatinine, and lipid profile level were estimated biochemically. Result: The results were promising and revealed that Chanaka Yoga can be a safe, acceptable, and effective alternative to the conventional oral hypoglycemic. Conclusion: Holistic principles of Ayurveda when used as supplementary for modern drugs in diabetes show its effects on all body symptoms and help minimize them in which modern drug fails. Hence, it is the need of time to support the modern medications with Ayurvedic therapy. © 2016 BRNSS Publication Hub. All rights reserved.
Encouraging effect of Brahmi Ghrita in amnesia
(BRNSS Publication Hub, 2013) Kapil Deo Yadav; K.R.C. Reddy; Vikas Kumar
Context: Brahmi Ghrita (BG) contains Brahmi (Bacopa monneri), Vacha (Acorus calamus), Kushtha (Saussurea lappa), Shankhapushpi (Convolvulus pluricaulis) and Puran Ghrita, prepared as per sneha paka process. Aim: The aim of this study was to assess the learning and memory activity of BG in Amnesic rats. Materials and Methods: The Learning and memory activity of BG (400 and 800 mg/kg, per oral) was evaluated in scopolamine (1 mg/kg, sub cutaneous) challenged rats, using elevated maze plus, passive avoidance test and active avoidance test. Results: BG treated scopolamine challenged rat demonstrated a significant decrease in transfer latency in modified elevated plus maze test and increase in step through latency in passive avoidance test compared to control rats in a dose dependent manner. BG treated rats took significant less number of total trials, shock trial and total time for jumping into safe compartment. Conclusion: BG antagonises the action of scopolamine.
Histological changes in ovaries of mice exposed to Butea monosperma: Preliminary study; [cambios histológicos en ovarios de ratón expuestos a Butea monosperma: Estudio preliminar]
(Universidad de la Frontera, 2010) Neelam Gupta; Gajendra Singh; S.M. Singh; K.R.C. Reddy
In Ayurvedic practice Butea onosperma (Palash) is in clinical use for hundreds of years as a ontraceptive. Seeds of Butea monosperma are also used as an anthelmitic (Ansani et al., 1979) and antimicrobial (Avirutnant & Pongpan, 1983). Butea monosperma (Fabaceae family) locally known as Palash (Dhak) if given for 3 consecutive days acts as an antifertility agent for which it has been is traditionally used since time immemorial. The objective of the present study was to search the effect of Butea monosperma seeds on the ovary of mice. Observations in the present study were massive degeneration of ova in almost all the follicles, irrespective of the stage of their development. The ova from treated animals showed different stages of necrotic process. Moreover, the arrangement of follicular cells was also disturbed. The Palash seeds in the form of powder when administered orally with distilled water, according to the body weight i.e.2g/Kg, of female mice, for three consecutive days showed notable changes in ovaries. The animals were sacrificed on day next to the last day of treatment and ovaries were extirpated. varies studied histologically after Haematoxylin & Eosin staining showed most of the follicle in immature state with ndefined nucleus and nucleoli in the ovum. Others showed degenerative changes in the ovum. Follicles had lost their normal shape and arrangement and organization of granulosa cells. It was conspicuous to find that almost all follicles including graafian follicles of treated ovaries were undergoing degenerative changes simultaneously. The rate of apoptosis in the granulosa cells when studied was found increased in treated cases as compared with control. The study suggests that the disintegration of ova in the ovaries is a specific effect of Butea monosperma seed administration.
Hypoglycemic effect of Lodhradi Kashaya Ghanavati in streptozotocin-induced hyperglycemia in rats
(Medknow Publications, 2015) Rakesh B. Bramhankar; K.R.C. Reddy; Anshuman Trigunayat
Objective: To evaluate the hypoglycemic effect of Lodhradi Kashaya Ghanavati (LKGV) in experimental animals, LKGV was prepared, containing Lodhra (Symplocose racemosa), Haritaki (Terminalia chebula), Musta (Cyperus rotundus), and Katphal (Myrica esculanta). Materials and Methods: LKGV was prepared by the standard procedure of Kashaya Ghanavati. Hyperglycemia was induced to create an equivalent to the diabetic state by giving streptozotocin (STZ) solution (intra-peritoneal [i.p.]) 65 mg/kg, 15 min after initial administration of 120 mg/kg nicotinamide i.p. After assessment of hyperglycemia as an approximate induction of diabetes, group of animals (III, IV, and V) were treated with dose titrations using 50, 150, and 275 mg/kg of LKGV. For treatment comparison, Group VI animals were treated with a standard hypoglycemic drug, glibenclamide 10 mg/kg. Blood sugar, the level was assessed by glucometer on the 7th, 14th, 21st, and 28th day. Results: LKGV extract produced a significantly reduction of fasting blood glucose with various doses in STZ-induced diabetic rats. In a 4-week study, LKGV produced a significant reduction in blood glucose compared to glibenclamide. Conclusion: LKGV and glibenclamide significantly reduced blood sugar level. The results were more significant with successive days in this in vivo comparative study.
Hypoglycemic effect of Talapotaka Churna in streptozotocin-induced hyperglycemia in rats
(Medknow Publications, 2016) Guruprasad C. Nille; Shardendu Mishra; Anshuman Trigunayat; K.R.C. Reddy
Objective: To evaluate the antihyperglycemic effect of Talapotaka Churna in experimental animals, Talapotaka Churna was prepared, containing Avartaki (Cassia auriculata), Amalaki (Emblica officinalis), Haridra (Curcuma longa), and Daruharidra (Berberis aristata). Materials and Methods: Talapotaka Churna was prepared by the standard procedure of Churna Kalpana. Hyperglycemia was induced to create an equivalent to the diabetic state by giving streptozotocin (STZ) solution (intraperitoneal) 35 mg/kg. After assessment of hyperglycemia as an approximate induction of diabetes, group of animals (IV and V) were treated with doses 300 and 600 mg/kg of Talapotaka Churna. For treatment comparison, Group III animals were treated with a standard hypoglycemic drug, glibenclamide 10 mg/kg. Blood sugar, the level was estimated by glucometer on the 7th, 14th, 21st, and 28th day. Results: Talapotaka Churna produced a significantly lowering of fasting blood glucose with various doses in STZ-induced diabetic rats. In a 4-week study, Talapotaka Churna produced a significant reduction in blood glucose compared to glibenclamide. Conclusion: Talapotaka Churna and glibenclamide significantly lowered blood glucose level. The results were found more significant with respect to treatment days in this in vivo comparative study.
In-vivo potential of Musa paradisiaca Linn. (Stmn.) in streptozotocin-induced diabetic rats
(Medknow Publications, 2016) Mishra Ashish; K.R.C. Reddy; D.N.S. Gautam; S.K. Maurya; Seth Ankit
Objective: Musa paradisiaca belonging to family Musaceae is a well-known herb having many pharmacological properties including antidiabetic activity. In ancient text, Basavaraju was reported the stamen of this plant as antidiabetic agent in a dietary recipe. The main aim of this study was to explore the in-vivo antidiabetic property of its stamen. Materials and Methods: Aqueous extract of M. paradisiaca stamen (AqMP, 100, 200, and 400 mg/kg, p.o.) was evaluated for hypoglycemic effect in normoglycemic rats and consequences on oral glucose tolerance test (OGTT) by measuring the tail blood glucose concentrations. Further, blood glucose level was measured after 7th, 14th, and 21th days in streptozotocin-nicotinamide (STZ 65 mg/kg, i.p. and NDA 110 mg/kg, i.p.) induced-diabetic rats treated with AqMP and reference drug glibenclamide (5 mg/kg, b.w. p.o.). Results: The result with normoglycemic rats shows that the AqMP (400 mg/kg, p.o.) did not have any hypoglycemic effect, and it effectively control the blood glucose level in OGTT within 30-60 min after glucose (2 g/kg) administration without causing any hypoglycemic effect. Moreover, the drug (400 mg/kg, p.o.) was also found to be effective in controlling the blood sugar level in STZ-NDA induce diabetic rat as compare to glibenclamide. Conclusion: The study shows that the drug exhibit significant in-vivo antidiabetic potential as well as support its traditional use in diabetes.
Interpretation of Chanaka Yoga by Fourier transform infrared spectroscopy
(Medknow Publications, 2016) Anjali Singh; K.R.C. Reddy
Aim: To evaluate possible interaction in Chanaka Yoga, which is used in Prameha Prakaran. Materials and Methods: For IR scanning, the samples were mixed with KBr in proportion to 1:100 ratio and compressed to form pellet using hydraulic compression machine. All the samples were analyzed for variation in the functional group and bonding pattern since the final sample is the mixture of all the six ingredients. Results and Discussion: The peaks found in FTIR spectra of Chanaka Yoga shows the presence of hydrogen-bonded alcohol and phenols, hydrogen-bonded acid, aldehydes and ketones, aromatic hydrocarbons, ketones, esters and aldehydes, alcohol and ether, alkenes and alkenes. Conclusion: Peaks of Chanaka Yoga were found similar in pattern, and the absorbance corresponding to the allotted chemical constituents was similar with the ingredients analyzed separately. This study shows a pathway for the chemical basis of similarity in a pattern in inference when ayurvedic formulation has a multi-ingredient concept.
Menstrual cycle as protective factor and increasing risk factor of diabetes mellitus in male persons proved according to the ancient ayurvedic literature
(Medknow Publications, 2016) K.R.C. Reddy; Guruprasad Nille; Varun Kumar Singh; Anjali Singh; Rakesh Bramhankar; Bhaswati Bhattacharya
Introduction: The current demographic definitions for diabetes mellitus have not cited gender nor accounted for the possibility that healthy menstrual cycles may be a protective factor for the development of Type 2/noninsulin-dependent diabetes mellitus. The ancient physician Vallabhacharya posits that the monthly cycle of menstruation rids the blood of toxins that may build up and cause disease and presents this as a reason for less prevalence of Prameha (Madhumeha/diabetes) in women. Aim: The study conducted as a meta-analysis of five clinical studies to observe whether a significant difference in diabetes occurrence exists in menstruating females and similarly-aged males, as well as non-menstruating older females versus 50+ aged males. Materials and Methods: A meta-analysis was conducted with data from a series of clinical studies conducted at the Outpatient Department of SS Hospital, IMS, BHU. The studies were done in conjunction with MD (Ayurveda) and PhD (Ayurveda) studies in the Department of Rasa Shastra, Faculty of Ayurveda, at BHU, Varanasi. Using different Ayurvedic dosage forms, in five different clinical studies, collected data included gender and age group as well as blood sugar levels. Results: The results of each of five studies revealed that the numbers of male patients are more in number. The numbers of females in the study of menstrual age were less than those who had stopped menstruating. Conclusion: The results support the Ayurvedic logic that the menstrual period is an effective physiologic occurrence for regular cleaning of the blood and proposed the male gender as a possible risk factor for diabetes.
Necessity of implication of GMP in Ayurvedic Pharmacies to prevent water pollution
(Kalpana Corporation, 2008) K.R.C. Reddy
Ayurveda the ancient Indian Medical Science practiced since vedic period. In ayurvedic drugs contains not only plant, or the material derived from the herbs, besides them metals, minerals, and animal products are also used in a number of formulations, indicated for various ailments. In the process of manufacturing of ayurvedic drugs various processes, involve, like shodhana (purification), marana (incineration), swedana (fomentation), mardana (trituration), jarana (roasting) and many other unique procedures, employed for raw material (herbs, metals, minerals, animal origin) as per described in different ayurvedic texts. All these procedure involving the use of water, and there is large amount of water excreted by ayurvedic pharmacies, so there is a need of proper disposal of water to prevent hazardous untoward effect in human being, agriculture. © 2008 - Kalpana Corporation.
Need of conservation and cultivation of ayurvedic medicinal plants for meeting health needs and for reducing air pollution
(Kalpana Corporation, 2007) K.R.C. Reddy; Sridurga
[No abstract available]
Pharmaceutical - Nutraceutical aspect of Chanaka Yoga: A herbal formulation for DM II
(BRNSS Publication Hub, 2016) Anjali Singh; K.R.C. Reddy
Introduction: In the last few decades, there has been exponential growth in the field of herbal remedies. Pharmacopoeial preparations such as avleha (semisolid), swarasa (expressed juice), kalka (mass), him (cold infusion) and phanta (hot infusion), kwatha (decoction), and churna (powder) form the backbone of Ayurvedic formulations. Newer guidelines for standardization, manufacture, and quality control, and scientifically rigorous research will be necessary for traditional treatments. This traditional knowledge can serve as a powerful search engine that will greatly facilitate drug discovery. Aim: The aim of this study is to standardize Chanaka Yoga in Kwath churna form. The powder form makes this traditional drug more stable for long-term storage and hence, easier to preserve. Materials and Methods: Chanaka Yoga Kwath churna is an Ayurvedic formulation containing Chanaka (Cicer aritinum) as one of its chief ingredients. The basic preparation of this drug is a Kwath churna. We checked the microbial load and nutrient values (using International Standard IS and Association of Official Analytical Chemists methods). Results: The powdered form of Chanaka Yoga Kwath churna yielded a weight loss of approximately 2.5% of the total weight of ingredients. The quantity of total fiber of Churna was found higher. Conclusion: Chanaka Yoga Kwath churna may be a good therapeutic and dietary medicine for Diabetic patients, which may be easily prepared at home.
Pharmaceutical processing and standardization of modified dosage form of Lodhradi Kashaya as spray dried powder
(Medknow Publications, 2015) Varun Kumar Singh; K.R.C. Reddy
Introduction: Lodhradi Kashaya is a classical formulation mentioned in Vaidya Chintamani under Kaphaj Prameha and in Basavarajiyam under Prameha Prakarana. The therapeutic efficacy of the Lodhradi Kashaya was described as Madhumehajeet, i.e., win over diabetes mellitus. Lodhradi Kashaya was selected for research study, and formulation was modified as instant dissolving powder because classical kwath (decoction) had shorter shelf life, and it is difficult to prepare fresh kwath each time while administration. Aim: Pharmaceutical preparation and standardization of Lodhradi Kashaya spray dried powder. Materials and Methods: Lodhradi Kashaya spray dried powder was prepared by complete aqueous extraction of ingredients followed by drying with spray drier. Physicochemical testing, and standardization of finished formulation was done by following standard protocol. Results: Finished spray dried Kashaya powder was evaluated for different standardization parameter which showed limit of detection (5.86%), pH of 1% w/v solution (3.55) and 5% w/v solution (3.42), total ash value (10.68%), acid insoluble ash (0.47%), extractive value in water (84.95%), and methanol and ethyl acetate (51.21% and 0.86%, respectively). Spray dried powder was fine (pass through 80# mesh) in nature. Lodhradi Kashaya spray dried extract requires time span to get soluble as 15 s (30°C), 11 s (40°C), and 8 s (60°C) on gentle stirring. It was also evaluated for heavy metal, and microbial load that was found are within limit. Conclusion: Lodhradi Kashaya decoction powder dosage form is very convenient to prepare Kashaya dosage form while administration whenever and whereever it is required in busy life schedule. This study and approach will be helpful to revitalize the Kashaya dosage form as it has better exposure and probably better efficacy in the human body.