Browsing by Author "Kamalesh Chakravarty"

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Blood and CSF biomarkers for post-stroke epilepsy: a systematic review
(BioMed Central Ltd, 2022) Priya Dev; Mareena Cyriac; Kamalesh Chakravarty; Abhishek Pathak
Post-stroke epilepsy is a common complication of ischemic stroke which adversely affects the prognosis of patients. Clinical and radiological parameters cannot adequately predict the risk. Therefore, the discovery of biomarkers is imperatively needed for predicting post-stroke epilepsy. We conducted a systematic review of diagnostic and prognostic biomarkers for post-stroke epilepsy through a comprehensive literature search in different databases. All articles that met our inclusion criteria were assessed for quality using the modified Quality Assessment of Diagnostic Accuracy Studies questionnaire. Eight eligible studies were included in this systematic review. Out of 22 assessed biomarkers, nine biomarkers showed significant association with post-stroke epilepsy. The T allele of CD40 (cluster of differentiation 40) −1C/T polymorphism, the CC genotype of TRPM6 (transient receptor potential cation channel subfamily M member 6) rs2274924, the allele polymorphism of MAD2 (mitochondrial aldehyde dehydrogenase 2), the mRNA level of interleukin-6 (IL-6), the plasma level of endostatin, and the mRNA expression of IL-1β show a positive correlation with post-stroke epilepsy; while S100 calcium-binding protein B, heat shock 70 kDa protein-8 and neuropeptide Y are inversely associated with post-stroke epilepsy. As a small number of patients were recruited, further studies are needed to confirm their potential use for predicting post-stroke epilepsy. © 2022, The Author(s).
Effect of persistent organic pollutants in patients with ischemic stroke and all stroke: A systematic review and meta-analysis
(Elsevier Ireland Ltd, 2023) Priya Dev; Kamalesh Chakravarty; Manoj Pandey; Rakesh Ranjan; Mareena Cyriac; Vijaya Nath Mishra; Abhishek Pathak
The role of environmental contaminants and their association with stroke is still being determined. Association has been shown with air pollution, noise, and water pollution; however, the results are inconsistent across studies. A systematic review and meta-analysis of the effect of persistent organic pollutants (POP) in ischemic stroke patients were conducted; a comprehensive literature search was carried out until 30th June 2021 from different databases. The quality of all the articles which met our inclusion criteria was assessed using Newcastle-Ottawa scaling; five eligible studies were included in our systematic review. The most studied POP in ischemic stroke was polychlorinated biphenyls (PCBs), and they have shown a trend for association with ischemic stroke. The study also revealed that living near a source of POPs contamination constitutes a risk of exposure and an increased risk of ischemic stroke. Although our study provides a strong positive association of POPs with ischemic stroke, more extensive studies must be conducted to prove the association. © 2023
Is Prevalence of Hypertension Increasing in First-Ever Stroke Patients?: A Hospital-Based Cross-Sectional Study
(S. Karger AG, 2019) Abhishek Pathak; Pradeep Kumar; Awadh Kishor Pandit; Kamalesh Chakravarty; Shubham Misra; Arun Kumar Yadav; Kameshwar Prasad
Background: Stroke is a devastating and disabling cerebrovascular disease with some amount of residual deficit leading to economic loss. Recent Indian studies have shown a stroke prevalence rate of 471.58/100,000 populations. Hypertension has been known to be the main risk factor for causing stroke. Purpose: To investigate the prevalence of hypertension in first-ever stroke patients and its comparison with the previous stroke registry. Methods: The study was a hospital-based cross-sectional study. Consecutive patients, who were admitted in the Neurology ward of All India Institute of Medical Sciences (AIIMS), New Delhi, India, were recruited for the study from the period July 2012 to January 2014. The stroke units consisted of a computerized record containing the details of all the admitted patients. Results: A total of 260 patients were recruited in which 194 (74.6%) were ischemic and 66 (25.4%) were hemorrhagic stroke patients. Hypertension was present in 169 (65%) patients. When compared with the previous stroke registry of 2,628 patients, hypertension was recorded in 1,503 (57.2%) patients. Conclusion: Our data show that there is an increase in the proportion of hypertension among first-ever stroke patients reported in AIIMS in the years 2012-2014 as compared to that reported in during the period 1998-2011. © 2018 S.Karger AG, Basel.