Browsing by Author "Kapil Deo Yadav"

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Anti-obesity mechanism of curcuma longa L. - An over view
(National Institute of Science Communication and Information Resources (NISCAIR), 2016) Kapil Deo Yadav; Anand K. Chaudhury
Chronic low grade inflammation is one important reason for the development of obesity and the inflammation is initiated by excess nutrient from metabolic cell and is characterized by increasing TNFα, interlukins, cytokinines, etc. Besides this, genetic, social, behavioural and environmental factors alone or interaction with each other influences diet, physical activity by affecting complex hypothalamic neuro-circuitry. These increase leptin level, inflammatory mediators and reactive oxygen species (ROS), which positively correlate with obesity. Curcuma longa L., commonly known as Haridra have been used for treatment of obesity and diabetes since ancient time in Ayurveda, the Indian traditional system of medicine. From current research, it has been observed that C. longa inhibit secretion of leptin, pro-inflammatory mediators and over production of ROS, whereas it increases secretion of insulin, adiponectin in plasma. Increased serum adiponectin insulin and decreased production of ROS negatively correlate with obesity. In addition to these, C. longa inhibit early growth response (Egr-1) gene, which is related to development of obesity. It is clear that by affecting leptin, adiponectin, inflammatory mediators, ROS, regulating nutritional environment and Egr-1 gene, lipogenic gene and ob gene, C. longa may be affirmative for management of obesity. © 2016, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
Classical and contemporary methods for conversion of toxic unstable mercury to safe and stable mercury
(National Institute of Science Communication and Information Resources (NISCAIR), 2016) Kapil Deo Yadav; Anand K. Chaudhary
Different nations of world are trying to eradicate use of mercury from the world because of its harmful effect on ecosystem that ultimately affect on human and wildlife, but there is problem of disposal because of its liquid nature. For this purpose various processing technologies were developed to convert it in to compound formulations which are stable at normal temperature and pressures as well as non-toxic in nature. In this sequence different technologies were developed by ancient and contemporary researchers for physical and chemical stabilization of mercury. Physical stabilization is done by amalgamation process that converts mercury in to solid form and less toxic in comparison to liquid mercury. This physical stabilization methodology is closely resembles Parad Bandh which is quoted in classical literature of Rasa Shastra. In chemical stabilization, mercury is converted in to non toxic compound mainly by chemical reaction with sulphur by Mayasa and DELA technology and resulting in formation of black and red colour mercury sulphide. These technologies are quite comparable to pharmaceutical technology of Parpati and Kupi pakwa developed by ancient researchers of Ayurveda. And these preparations are indicated for the treatment of gastrointestinal disorders and disorders starting from acute disorders to chronic nature. In this way we can say that contemporary science can develop stabilization technology of mercury only for mercury disposal while Ayurvedic researchers developed expertise to convert these disposed mercury for the benefit of humanity since 12th century. © 2016, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
Cosmeceutical assets of ancient and contemporary ayurvedic astuteness
(Medknow Publications, 2015) Kapil Deo Yadav; Anand Kumar Chaudhary
Cosmeceuticals are topical pharmaceutical hybrids intended to enhance the beauty that provides additional healthrelated function. Skin acts as a natural barrier between internal and external environments thus play an important role in vital biological functions such as protection against mechanical/chemical damages, microorganisms, and ultraviolet damage. All most all manuscripts of ayurvedic literature are full of cosmeceutical product, but these are spread throughout manuscripts along with their rationality. In the current scenario, different companies are manufacturing ayurvedic cosmeceutical product by taking some of the ingredients of different cosmeceutical formulation mentioned in ayurvedic texts. The basic approach of these two different groups of the formulation is different from each other, but their ultimate goal is to enhance the personal appearance of a person. It is observed that classical ayurvedic cosmeceutical formulation may act through improvement of the general condition of the person as well as the direct impact of skin and hair, whereas contemporary cosmeceuticals product enhances beauty mainly by the direct impact of skin and hair than general condition of the person.
Dose finding study of sahaj vati (Comprised of Shilajeet, Haridra, Guggul and Chitrak) in validated animal model of obesity
(National Institute of Science Communication and Information Resources (NISCAIR), 2018) Kapil Deo Yadav; Amit Singh; Anand K. Chaudhary
Efficacy of Sahaj Vati containing Shilajeet, Guggul, Haridra and Chitrak has been evaluated at dose of 100, 200 and 400 mg/kg body weight after screening the appropriate diet induced obesity model (monosodium glutamate and cafeteria diet induced). It has been observed that both monosodium glutamate and cafeteria diet increases body weight but cafeteria diet also causes dyslipidemia. At the dose of 400 mg/kg, body weight of animal was significantly decreased with increased total cholesterol, low-density lipoprotein and triglycerides and insignificant decrease of body weight occurs at dose of 100 mg/kg along with increased triglycerides. At the dose of 200 mg/kg body weight was significantly decreased along with the significant increase of high-density lipoprotein and insignificant decrease in very low-density lipoprotein, low-density lipoprotein, and triglycerides. On the basis of present finding we conclude that monosodium glutamate is more suitable for induction of obesity whereas cafeteria diet for obesity associated with dyslipidemia and Sahaj Vati at the dose of 200 mg/kg body weight is more appropriate for reduction of body weight. © 2018, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
Encouraging effect of Brahmi Ghrita in amnesia
(BRNSS Publication Hub, 2013) Kapil Deo Yadav; K.R.C. Reddy; Vikas Kumar
Context: Brahmi Ghrita (BG) contains Brahmi (Bacopa monneri), Vacha (Acorus calamus), Kushtha (Saussurea lappa), Shankhapushpi (Convolvulus pluricaulis) and Puran Ghrita, prepared as per sneha paka process. Aim: The aim of this study was to assess the learning and memory activity of BG in Amnesic rats. Materials and Methods: The Learning and memory activity of BG (400 and 800 mg/kg, per oral) was evaluated in scopolamine (1 mg/kg, sub cutaneous) challenged rats, using elevated maze plus, passive avoidance test and active avoidance test. Results: BG treated scopolamine challenged rat demonstrated a significant decrease in transfer latency in modified elevated plus maze test and increase in step through latency in passive avoidance test compared to control rats in a dose dependent manner. BG treated rats took significant less number of total trials, shock trial and total time for jumping into safe compartment. Conclusion: BG antagonises the action of scopolamine.
Fingerprinting of Sahaj Vati, additive for natural lovastatin production
(National Institute of Science Communication and Information Resources, 2022) Kapil Deo Yadav; Abhishek Kumar Dwivedy; Vinod Kumar Yadav; Nawal Kishor Dubey; Anand Kumar Chaudhary
The lovastatin has been used in hypercholesterolemia and heart diseases for therapeutic as well as preventative purposes and it is naturally obtained from filamentous fungi such as Aspergillus through biotechnological approach. The additives in fungal media which enhances the fungal growth should also increase the production of lovastatin. Finger printing of Sahaj Vati, a herbo-mineral formulation comprising mixture of Plumbago zeylanica, Curcuma longa, Shilajeet, Commiphora mukul and Clerodendrum phlomidis powder to be added in medium for fungal growth. The fungal growth activity of both batches of Sahaj Vati was tested for fungal isolate of A. flavus by contact measure through hyphal development restraint test utilizing Potato dextrose agar (PDA) and SMKY medium followed by chromatographic and different techniques for standardization. Sahaj Vati has lower antifungal index & increased the fungal biomass and separation of compound was higher in mobile phase Benzene: Ethyl acetate: Pyridine: 5:4.9:0.1 & Hexane: Chloroform: Pyridine: 2.7:1. Sahaj Vati increased the growth and biomass of A. flauvs which may be used for natural production of lovastatin. © 2022, National Institute of Science Communication and Information Resources. All rights reserved.
Is mercury really toxic? The way forward for its judicious medicinal applications based on the therapeutic doctrines of Ayurveda
(Indian Academy of Sciences, 2018) Kapil Deo Yadav; Anand K. Chaudhary
Mercury-based formulations have been extensively used in Indian and Chinese systems of medicine with high therapeutic index. However, at present mercury is considered as a global pollutant having potent neurotoxic effects. Also, it has been proposed to ban the export, import and manufacture of a range of products containing mercury from 2021. This situation compels one to ponder how mercury-based formulations were safe during ancient times, but are now considered to be toxic. Naturally mercury occurs in three forms, viz. elemental (Hg), inorganic (HgS, HgCl2) and organic (MeHg). Organic mercury is completely absorbed by gastrointestinal tract, and elemental mercury is 75-80% absorbed by the lungs only in vapour state, while 10% of inorganic mercury is absorbed by the gastrointestinal tract. Additionally, organic mercury crosses the blood brain barrier and placenta, producing neurotoxic symptoms and foetal toxicity. In Ayurvedic science, mercury is converted only into inorganic form with special stabilization technology and this stabilized mercury is converted to mercuric polysulphides under gastrointestinal conditions, whereas elemental mercury is converted to organic form by specific bacteria. Thus mercury available in the atmosphere is converted into organic form that is highly toxic, while using Ayurvedic methods it is converted to inorganic form having potent therapeutic activity. Judicious and injudicious application of mercury has advantageous and disadvantageous effect respectively. © 2018, Indian Academy of Sciences.