Browsing by Author "Kate E. LeGrand"

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Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018
(Nature Research, 2021) Damaris Kinyoki; Aaron E. Osgood-Zimmerman; Natalia V. Bhattacharjee; Lauren E. Schaeffer; Alice Lazzar-Atwood; Dan Lu; Samuel B. Ewald; Katie M. Donkers; Ian D. Letourneau; Michael Collison; Megan F. Schipp; Amanuel Abajobir; Sima Abbasi; Nooshin Abbasi; Mitra Abbasifard; Mohsen Abbasi-Kangevari; Hedayat Abbastabar; Foad Abd-Allah; Ahmed Abdelalim; Sherief M. Abd-Elsalam; Amir Abdoli; Ibrahim Abdollahpour; Aidin Abedi; Hassan Abolhassani; Biju Abraham; Lucas Guimarães Abreu; Michael R. M. Abrigo; Ahmed Abualhasan; Eman Abu-Gharbieh; Abdelrahman I. Abushouk; Manfred Mario Kokou Accrombessi; Maryam Adabi; Oladimeji M. Adebayo; Adeyinka Emmanuel Adegbosin; Victor Adekanmbi; Olatunji O. Adetokunboh; Daniel Adedayo Adeyinka; Davoud Adham; Shailesh M. Advani; Pradyumna Agasthi; Mohammad Aghaali; Sohail Ahmad; Tauseef Ahmad; Keivan Ahmadi; Sepideh Ahmadi; Muktar Beshir Ahmed; Miloud Taki Eddine Aichour; Budi Aji; Oluwaseun Oladapo Akinyemi; Addis Aklilu; Chisom Joyqueenet Akunna; Ziyad Al-Aly; Turki M. Alanzi; Jacqueline Elizabeth Alcalde-Rabanal; Biresaw Wassihun Alemu; Ayinalem Alemu; Robert Kaba Alhassan; Sheikh Mohammad Alif; Vahid Alipour; Hesam Alizade; Syed Mohamed Aljunid; Amir Almasi-Hashiani; Hesham M. Al-Mekhlafi; Rajaa M. Al-Raddadi; Nelson Alvis-Guzman; Saeed Amini; Fatemeh Amiri; Dickson A. Amugsi; Nahla Hamed Anber; Robert Ancuceanu; Tudorel Andrei; Masresha Tessema Anegago; Mina Anjomshoa; Fereshteh Ansari; Alireza Ansari-Moghaddam; Zelalem Alamrew Anteneh; Ernoiz Antriyandarti; Davood Anvari; Razique Anwer; Muhammad Aqeel; Jalal Arabloo; Morteza Arab-Zozani; Olatunde Aremu; Habtamu Abera Areri; Al Artaman; Afsaneh Arzani; Malke Asaad; Mehran Asadi-Aliabadi; Ali A. Asadi-Pooya; Mulusew A. Asemahagn; Mohammad Asghari Jafarabadi; Mengistu M. Ashebir; Zerihun Ataro; Seyyede Masoume Athari; Seyyed Shamsadin Athari; Maha Moh’d Wahbi Atout; Marcel Ausloos; Nefsu Awoke; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Yared Asmare Aynalem; Muluken Altaye Ayza; Abbas Azadmehr; Darshan B; Tesleem Kayode Babalola; Alaa Badawi; Ashish D. Badiye; Mohammad Amin Bahrami; Mohan Bairwa; Shankar M. Bakkannavar; Palash Chandra Banik; Adhanom Gebreegziabher Baraki; Miguel A. Barboza; Huda Basaleem; Sanjay Basu; Mohsen Bayati; Bayisa Abdissa Baye; Gholamreza Bazmandegan; Neeraj Bedi; Tariku Tesfaye Tesfaye Bekuma; Michelle L. Bell; Isabela M. Bensenor; Kidanemaryam Berhe; Abadi Kidanemariam Berhe; Kidanemariam Alem Berhie; Dinesh Bhandari; Nikha Bhardwaj; Pankaj Bhardwaj; Krittika Bhattacharyya; Suraj Bhattarai; Zulfiqar A. Bhutta; Ali Bijani; Boris Bikbov; Antonio Biondi; Minyichil Birhanu; Raaj Kishore Biswas; Moses John Bockarie; Somayeh Bohlouli; Mahdi Bohluli; Archith Boloor; Shiva Borzouei; Nicola Luigi Bragazzi; Dejana Braithwaite; Andre R. Brunoni; Sharath Burugina Nagaraja; Zahid A. Butt; Florentino Luciano Caetano dos Santos; Luis Alberto Cámera; Josip Car; Rosario Cárdenas; Felix Carvalho; Joao Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Franz Castro; Muge Cevik; Wagaye Fentahun Chanie; Jaykaran Charan; Souranshu Chatterjee; Vijay Kumar Chattu; Sarika Chaturvedi; Simiao Chen; Ken Lee Chin; Mohiuddin Ahsanul Kabir Chowdhury; Aubrey J. Cook; Vera Marisa Costa; Elizabeth A. Cromwell; Berihun Assefa Dachew; Henok Dagne; Baye Dagnew; Tukur Dahiru; Saad M. A. Dahlawi; Haijiang Dai; Hancheng Dai; Lalit Dandona; Rakhi Dandona; Parnaz Daneshpajouhnejad; Farah Daoud; Jai K. Das; Rajat Das Gupta; Aditya Prasad Dash; Claudio Alberto Dávila-Cervantes; Kairat Davletov; Farah Deeba; Jan-Walter De Neve; Edgar Denova-Gutiérrez; Kebede Deribe; Assefa Desalew; Getenet Ayalew Dessie; Sagnik Dey; Meghnath Dhimal; Govinda Prasad Dhungana; Mostafa Dianatinasab; Daniel Diaz; Isaac Oluwafemi Dipeolu; Shirin Djalalinia; Hoa Thi Do; Fariba Dorostkar; Leila Doshmangir; Bereket Duko; Andre Rodrigues Duraes; Lucas Earl; Hisham Atan Edinur; Ferry Efendi; Rajesh Elayedath; Teshome Bekele Elema; Hala Rashad Elhabashy; Shaimaa I. El-Jaafary; Iman El Sayed; Maysaa El Sayed Zaki; Aisha Elsharkawy; Yasser Mohamed El-Sherbiny; Maha El Tantawi; Daniel Adane Endalew; Babak Eshrati; Khalil Eskandari; Sharareh Eskandarieh; Ibtihal Fadhil; Emerito Jose A. Faraon; Mohammad Fareed; Pawan Sirwan Faris; Medhat Farwati; Farshad Farzadfar; Abidemi Omolara Fasanmi; Nazir Fattahi; Nelsensius Klau Fauk; Valery L. Feigin; Berhanu Elfu Feleke; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Nataliya A. Foigt; Artem Alekseevich Fomenkov; Masoud Foroutan; Joel Msafiri Francis; Richard Charles Franklin; Marisa Freitas; Takeshi Fukumoto; Mohamed M. Gad; Abhay Motiramji Gaidhane; Reta Tsegaye Gayesa; Biniyam Sahiledengle Geberemariyam; Birhan Gebresillassie Gebregiorgis; Hadush Gebremariam; Tesfay B. B. Gebremariam; Leake Gebremeskel; Gebreamlak Gebremedhn Gebremeskel; Assefa Ayalew Gebreslassie; Yilma Chisha Dea Geramo; Hailay Abrha Gesesew; Bradford D. Gessner; Lemma Getacher; Keyghobad Ghadiri; Fatemeh Ghaffarifar; Mansour Ghafourifard; Mahsa Ghajarzadeh; Farhad Ghamari; Ahmad Ghashghaee; Nermin Ghith; Syed Amir Gilani; Tiffany K. Gill; Myron Anthony Godinho; Philimon N. Gona; Ayman Grada; Mohammed Ibrahim Mohialdeen Gubari; Nachiket Gudi; Davide Guido; Rashid Abdi Guled; Yuming Guo; Rachita Gupta; Rajeev Gupta; Arvin Haj-Mirzaian; Randah R. Hamadeh; Demelash Woldeyohannes Handiso; Asif Hanif; Arief Hargono; Ahmed I. Hasaballah; Md Mehedi Hasan; Syed Shahzad Hasan; Maryam Hashemian; Abdiwahab Hashi; Shoaib Hassan; Amr Hassan; Soheil Hassanipour; Hadi Hassankhani; Khezar Hayat; Mohamed I. Hegazy; Reza Heidari-Soureshjani; Nathaniel J. Henry; Claudiu Herteliu; Fatemeh Heydarpour; Sousan Heydarpour; Hagos Degefa de Hidru; Chi Linh Hoang; Ramesh Holla; Julia Hon; Sung Hwi Hong; Praveen Hoogar; Seyyed Nasrollah Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Peter J. Hotez; Mowafa Househ; Tanvir M. Huda; Dawit Hoyiso Huluko Huluko; Syed Ather Hussain; Bing-Fang Hwang; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Leeberk Raja Inbaraj; Usman Iqbal; M. Mofizul Islam; Sheikh Mohammed Shariful Islam; Chinwe Juliana Iwu; Chidozie C. D. Iwu; Farhad Jadidi-Niaragh; Mohammad Ali Jahani; Vardhmaan Jain; Mihajlo Jakovljevic; Amir Jalali; Farzad Jalilian; Manthan Dilipkumar Janodia; Tahereh Javaheri; Ravi Prakash Jha; Oommen John; Kimberly B. Johnson; Jost B. Jonas; Jitendra Jonnagaddala; Nitin Joseph; Ankur Joshi; Farahnaz Joukar; Jacek Jerzy Jozwiak; Ali Kabir; Zubair Kabir; Tanvir Kahlon; Leila R. Kalankesh; Rohollah Kalhor; Ashwin Kamath; Zahra Kamiab; Tanuj Kanchan; Umesh Kapil; Neeti Kapoor; Behzad Karami Matin; Salah Eddin Karimi; Ayele Semachew Kasa; Gebremicheal Gebreslassie Kasahun; Zemenu Yohannes Kassa; Gebrehiwot G. Kassa; Getinet Kassahun; Gbenga A. Kayode; Ali Kazemi Karyani; Tibebeselassie S. Keflie; Peter Njenga Keiyoro; Bayew Kelkay; Maryam Keramati; Daniel Bekele Ketema; Nauman Khalid; Mohammad Khammarnia; Md Nuruzzaman Khan; Maseer Khan; Junaid Khan; Khaled Khatab; Amir M. Khater; Mona M. Khater; Abdullah T. Khoja; Jagdish Khubchandani; Neda Kianipour; Young-Eun Kim; Yun Jin Kim; Ruth W. Kimokoti; Sezer Kisa; Adnan Kisa; Tufa Kolola; Ali Koolivand; Soewarta Kosen; Parvaiz A. Koul; Ai Koyanagi; Kewal Krishan; Vijay Krishnamoorthy; Barthelemy Kuate Defo; Nuworza Kugbey; Vaman Kulkarni; G. Anil Kumar; Nithin Kumar; Pushpendra Kumar; Manasi Kumar; Om P. Kurmi; Dian Kusuma; Ben Lacey; Deepesh P. Lad; Dharmesh Kumar Lal; Faris Hasan Lami; Iván Landires; Anders O. Larsson; Savita Lasrado; Matthew B. Laurens; Carlo La Vecchia; Avula Laxmaiah; Paul H. Lee; Shaun Wen Huey Lee; Kate E. LeGrand; Sonia Lewycka; Bingyu Li; Shanshan Li; Xuefeng Liu; Jaifred Christian F. Lopez; Daiane Borges Machado; Shilpashree Madhava Kunjathur; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; D.R. Mahadeshwara Prasad; Phetole Walter Mahasha; Mina Maheri; Narayan B. Mahotra; Azeem Majeed; Venkatesh Maled; Shokofeh Maleki; Reza Malekzadeh; Deborah Carvalho Malta; Abdullah A. Mamun; Fariborz Mansour-Ghanaei; Borhan Mansouri; Mohammad Ali Mansournia; Md Dilshad Dilshad Manzar; Carlos Alberto Marrugo Arnedo; Francisco Rogerlândio Martins-Melo; Anthony Masaka; Pallab K. Maulik; Benjamin K. Mayala; Medhin Mehari; Man Mohan Mehndiratta; Entezar Mehrabi Nasab; Fereshteh Mehri; Kala M. Mehta; Wahengbam Bigyananda Meitei; Teferi Mekonnen; Gebrekiros Gebremichael Meles; Mulugeta Melku; Walter Mendoza; Ritesh G. Menezes; Meresa Berwo Mengesha; Endalkachew Worku Mengesha; Tuomo J. Meretoja; Abera M. Mersha; Workua Mekonnen Metekiya; Tomasz Miazgowski; Irmina Maria Michalek; G.K. Mini; Shabir Ahmad Mir; Andreea Mirica; Erkin M. Mirrakhimov; Hamed Mirzaei; Maryam Mirzaei; Mehdi Mirzaei-Alavijeh; Sanjeev Misra; Babak Moazen; Masoud Moghadaszadeh; Yousef Mohammad; Dara K. Mohammad; Naser Mohammad Gholi Mezerji; Seyyede Momeneh Mohammadi; Abdollah Mohammadian-Hafshejani; Reza Mohammadpourhodki; Hayat Maeruf Mohammed; Salahuddin Mohammed; Ammas Siraj Mohammed; Shafiu Mohammed; Jemal Abdu Mohammed; Mohammad A. Mohseni Bandpei; Ali H. Mokdad; Alex Molassiotis; Lorenzo Monasta; Masoud Moradi; Maziar Moradi-Lakeh; Rahmatollah Moradzadeh; Paula Moraga; Abbas Mosapour; Simin Mouodi; Seyyed Meysam Mousavi; Amin Mousavi Khaneghah; Getaneh Baye B. Mulu; Mehnaz Munir; Moses K. Muriithi; G.V.S. Murthy; Ghulam Mustafa; Ashraf F. Nabhan; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Shankar Prasad Nagaraju; Mohsen Naghavi; Gurudatta Naik; Mukhammad David Naimzada; Vinay Nangia; Jobert Richie Nansseu; Atta Abbas Naqvi; Bruno Ramos Nascimento; Smitha Nayak; Vinod C. Nayak; Javad Nazari; Rawlance Ndejjo; Ionut Negoi; Ruxandra Irina Negoi; Henok Biresaw Netsere; Georges Nguefack-Tsague; Josephine W. Ngunjiri; Cuong Tat Nguyen; Diep Ngoc Nguyen; Huong Lan Thi Nguyen; Yeshambel T. Nigatu; Rajan Nikbakhsh; Amin Reza Nikpoor; Chukwudi A. Nnaji; Vuong Minh Nong; Jean Jacques Noubiap; Virginia Nunez-Samudio; Vincent Ebuka Nwatah; Tafadzwa Nyanhanda; Bogdan Oancea; Felix Akpojene Ogbo; Onome Bright Oghenetega; In-Hwan Oh; Daniel Micheal Okello; Morteza Oladnabi; Andrew T. Olagunju; Jacob Olusegun Olusanya; Bolajoko Olubukunola Olusanya; Ahmed Omar Bali; Muktar Omer Omer; Abidemi E. Emmanuel Omonisi; Obinna E. Onwujekwe; Alberto Ortiz; Eduardo Ortiz-Panozo; Nikita Otstavnov; Stanislav S. Otstavnov; Mayowa O. Owolabi; P.A. Mahesh; Jagadish Rao Padubidri; Abhijit P. Pakhare; Keyvan Pakshir; Adrian Pana; Songhomitra Panda-Jonas; Anamika Pandey; Seithikurippu R. Pandi-Perumal; Helena Ullyartha Pangaribuan; Deepak Kumar Pasupula; Sangram Kishor Patel; Urvish K. Patel; Ashish Pathak; George C. Patton; Hamidreza Pazoki Toroudi; Jeevan Pereira; Julia Moreira Pescarini; Hai Quang Pham; Brandon V. Pickering; Saeed Pirouzpanah; Meghdad Pirsaheb; Khem Narayan Pokhrel; Maarten J. Postma; Faheem Hyder Pottoo; Hadis Pourchamani; Hadi Pourjafar; Hossein Poustchi; Sergio I. Prada; Dimas Ria Angga Pribadi; Zahiruddin Quazi Syed; Navid Rabiee; Ata Rafiee; Fakher Rahim; Mohammad Hifz Ur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Rajesh Kumar Rai; Aashish Rajesh; Pradhum Ram; Kiana Ramezanzadeh; Chhabi Lal Ranabhat; Sowmya J. Rao; Satish Rao; Prateek Rastogi; Priya Rathi; Lal Rawal; Wasiq Faraz Rawasia; Reza Rawassizadeh; Lemma Demissie Regassa; Robert C. Reiner; Bhageerathy Reshmi; Nima Rezaei; Omid Rezahosseini; Aziz Rezapour; Seyed Mohammad Riahi; Daniela Ribeiro; Ana Isabel Ribeiro; Jennifer Rickard; Hirbo Shore Roba; Leonardo Roever; Luca Ronfani; Morteza Rostamian; Susan Fred Rumisha; Godfrey M. Rwegerera; Siamak Sabour; Ehsan Sadeghi; Sahar Saeedi Moghaddam; Rajesh Sagar; Amirhossein Sahebkar; Mohammad Ali Sahraian; S. Mohammad Sajadi; Nasir Salam; Marwa Rashad Salem; Hossein Samadi Kafil; Itamar S. Santos; Milena M. Santric-Milicevic; Sivan Yegnanarayana Iyer Saraswathy; Nizal Sarrafzadegan; Benn Sartorius; Arash Sarveazad; Brijesh Sathian; Thirunavukkarasu Sathish; Deepak Saxena; Alyssa N. Sbarra; David C. Schwebel; Anbissa Muleta Senbeta; Debarka Sengupta; Subramanian Senthilkumaran; Sadaf G. Sepanlou; Allen Seylani; Feng Sha; Omid Shafaat; Saeed Shahabi; Mohammad Shahbaz; Izza Shahid; Masood Ali Shaikh; Mohammed Feyisso Shaka; Ali S. Shalash; Mahdi Shamali; Mehran Shams-Beyranvand; MohammadBagher Shamsi; Morteza Shamsizadeh; Mohammed Shannawaz; Kiomars Sharafi; Amrollah Sharifi; Aziz Sheikh; Abbas Sheikhtaheri; Ranjitha S. Shetty; B. Suresh Kumar Shetty; Adithi Shetty; Wondimeneh Shibabaw Shiferaw; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Reza Shirkoohi; Velizar Shivarov; Soraya Siabani; Sudeep K. Siddappa Malleshappa; Tariq Jamal Siddiqi; Negussie Boti Sidemo; Balbir Bagicha Singh; Surya Singh; Yitagesu Sintayehu; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Mohammad Reza Sobhiyeh; Amin Soheili; Shahin Soltani; Muluken Bekele Sorrie; Emma Elizabeth Spurlock; Chandrashekhar T. Sreeramareddy; Agus Sudaryanto; Mu’awiyyah Babale Sufiyan; Iyad Sultan; Rafael Tabarés-Seisdedos; Takahiro Tabuchi; Biruk Wogayehu Taddele; Eyayou Girma Tadesse; Amir Taherkhani; Zemenu Tamir; Animut Tagele Tamiru; Md Ismail Tareque; Abdelghani Tbakhi; Hirut Teame; Yonas Getaye Tefera; Arash Tehrani-Banihashemi; Yohannes Tekalegn; Merhawi Gebremedhin Tekle; Berhane Fseha Teklehaimanot; Mohamad-Hani Temsah; Getayeneh Antehunegn Tesema; Kavumpurathu Raman Thankappan; Nihal Thomas; Takele Tiki; Asres Bedaso Tilahune; Mariya Vladimirovna Titova; Marcos Roberto Tovani-Palone; Khanh Bao Tran; Bach Xuan Tran; Rajnish Tripathi; Jaya Prasad Tripathy; Phuong N. Truong; Riaz Uddin; Anayat Ullah; Chukwuma David Umeokonkwo; Chigozie Jesse Uneke; Bhaskaran Unnikrishnan; Era Upadhyay; Muhammad Shariq Usman; Marco Vacante; Alireza Vakilian; Sahel Valadan Tahbaz; Pascual R. Valdez; Yasser Vasseghian; Madhur Verma; Francesco S. Violante; Bay Vo; Yohannes Dibaba Wado; Yasir Waheed; Yafeng Wang; Yuan-Pang Wang; Kinley Wangdi; Girmay Teklay Weldesamuel; Andrea Werdecker; Taweewat Wiangkham; Nuwan Darshana Wickramasinghe; Charles Shey Wiysonge; Tewodros Eshete Wonde; Ai-Min Wu; Chenkai Wu; Yang Xie; Ali Yadollahpour; Seyed Hossein Yahyazadeh Jabbari; Tomohide Yamada; Mingyou Yang; Sanni Yaya; Vahid Yazdi-Feyzabadi; Tomas Y. Yeheyis; Alex Yeshaneh; Yigizie Yeshaw; Yordanos Gizachew Yeshitila; Mekdes Tigistu Yilma; Paul Yip; Melissa F. Young; Zabihollah Yousefi; Taraneh Yousefinezhadi; Hebat-Allah Salah A. Yousof; Abdilahi Yousuf Yousuf; Chuanhua Yu; Yong Yu; Shamsa Zafar; Syed Saoud Zaidi; Zoubida Zaidi; Josefina Zakzuk; Sojib Bin Zaman; Mohammad Zamani; Maryam Zamanian; Alireza Zandifar; Alireza Zangeneh; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Dejene Tesfaye Zewdie; Kaleab Alemayehu Zewdie; Yunquan Zhang; Cong Zhu; Arash Ziapour; Nicholas J. Kassebaum; Simon I. Hay
Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Additionally, we provide subnational disparity analyses to provide a comprehensive overview of anemia prevalence inequalities within these countries and predict progress toward the World Health Organization’s Global Nutrition Target (WHO GNT) to reduce anemia by half by 2030. Our results demonstrate widespread moderate improvements in overall anemia prevalence but identify only three LMICs with a high probability of achieving the WHO GNT by 2030 at a national scale, and no LMIC is expected to achieve the target in all their subnational administrative units. Our maps show where large within-country disparities occur, as well as areas likely to fall short of the WHO GNT, offering precision public health tools so that adequate resource allocation and subsequent interventions can be targeted to the most vulnerable populations. © 2021, The Author(s).
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
(Elsevier B.V., 2020) Cristiana Abbafati; Kaja M. Abbas; Mohammad Abbasi; Mitra Abbasifard; Mohsen Abbasi-Kangevari; Hedayat Abbastabar; Foad Abd-Allah; Ahmed Abdelalim; Mohammad Abdollahi; Ibrahim Abdollahpour; Aidin Abedi; Parisa Abedi; Kedir Hussein Abegaz; Hassan Abolhassani; Akine Eshete Abosetugn; Victor Aboyans; Elissa M. Abrams; Lucas Guimarães Abreu; Michael R.M. Abrigo; Abdulaziz Khalid Abu Haimed; Ahmed Abualhasan; Eman Abu-Gharbieh; Laith Jamal Abu-Raddad; Abdelrahman I. Abushouk; Alyssa Acebedo; Ilana N. Ackerman; Maryam Adabi; Tim Adair; Abdu A. Adamu; Oladimeji M. Adebayo; Isaac Akinkunmi Adedeji; Victor Adekanmbi; Jaimie D. Adelson; Abiodun Moshood Adeoye; Olatunji O. Adetokunboh; Davoud Adham; Shailesh M. Advani; Mohsen Afarideh; Mahdi Afshari; Ashkan Afshin; Emilie E. Agardh; Gina Agarwal; Pradyumna Agasthi; Kareha M. Agesa; Mohammad Aghaali; Seyed Mohammad Kazem Aghamir; Anurag Agrawal; Tauseef Ahmad; Alireza Ahmadi; Keivan Ahmadi; Mehdi Ahmadi; Hamid Ahmadieh; Ehsan Ahmadpour; Muktar Beshir Ahmed; Budi Aji; Temesgen Yihunie Akalu; Rufus Olusola Akinyemi; Tomi Akinyemiju; Blessing Akombi; Chisom Joyqueenet Akunna; Fares Alahdab; Ziyad Al-Aly; Khurshid Alam; Noore Alam; Samiah Alam; Tahiya Alam; Fahad Mashhour Alanezi; Turki M. Alanzi; Samuel B. Albertson; Jacqueline Elizabeth Alcalde-Rabanal; Niguse Meles Alema; Biresaw Wassihun Alemu; Yihun Mulugeta Alemu; Khalid F. Alhabib; Robert Kaba Alhassan; Muhammad Ali; Saqib Ali; Gianfranco Alicandro; Mehran Alijanzadeh; Cyrus Alinia; Vahid Alipour; Hesam Alizade; Syed Mohamed Aljunid; François Alla; Peter Allebeck; Majid Abdulrahman Hamad Almadi; Ali Almasi; Amir Almasi-Hashiani; Nihad A. Almasri; Hesham M. Al-Mekhlafi; Abdulaziz M. Almulhim; Jordi Alonso; Rajaa M. Al-Raddadi; Khalid A. Altirkawi; Arwa Khalid Alumran; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Azmeraw T. Amare; Bekalu Amare; Saeed Amini; Mostafa Amini-Rarani; Arya Aminorroaya; Fatemeh Amiri; Arianna Maever L. Amit; Dickson A. Amugsi; Gianna Gayle Herrera Amul; Etsay Woldu Anbesu; Robert Ancuceanu; Deanna Anderlini; Jason A. Anderson; Catalina Liliana Andrei; Tudorel Andrei; Sofia Androudi; Colin Angus; Mina Anjomshoa; Fereshteh Ansari; Iman Ansari; Alireza Ansari-Moghaddam; Ippazio Cosimo Antonazzo; Carl Abelardo T. Antonio; Catherine M. Antony; Ernoiz Antriyandarti; Davood Anvari; Razique Anwer; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Aleksandr Y. Aravkin; Aseb Arba Kinfe Arba; Olatunde Aremu; Filippo Ariani; Timur Aripov; Bahram Armoon; Johan Ärnlöv; Oluwaseyi Olalekan Arowosegbe; Krishna K. Aryal; Afsaneh Arzani; Malke Asaad; Mehran Asadi-Aliabadi; Ali A. Asadi-Pooya; Samaneh Asgari; Babak Asghari; Mohammad Asghari Jafarabadi; Charlie Ashbaugh; Michael Assmus; Zahra Atafar; Seyyed Shamsadin Athari; Desta Debalkie Atnafu; Maha Moh'd Wahbi Atout; Sachin R. Atre; Madhu Sudhan Atteraya; Floriane Ausloos; Marcel Ausloos; Leticia Avila-Burgos; Euripide Frinel Gbenato Arthur Avokpaho; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Getie Lake Aynalem; Yared Asmare Aynalem; Muluken Altaye Ayza; Samad Azari; Ghasem Azarian; Zelalem Nigussie Azene; Gulrez Azhar; Peter S. Azzopardi; B.B. Darshan; Ebrahim Babaee; Alaa Badawi; Ashish D. Badiye; Mojtaba Bagherzadeh; Eleni Bagli; Mohammad Amin Bahrami; Atif Amin Baig; Mohan Bairwa; Mohammad Hossein Bakhshaei; Ahad Bakhtiari; Shankar M. Bakkannavar; Arun Balachandran; Senthilkumar Balakrishnan; Shivanthi Balalla; Shelly Balassyano; Alberto Baldasseroni; Kylie Ball; Shoshana H. Ballew; Daniela Balzi; Maciej Banach; Srikanta K. Banerjee; Palash Chandra Banik; Marlena S. Bannick; Agegnehu Bante Bante; Simachew Animen Bante; Adhanom Gebreegziabher Baraki; Miguel A. Barboza; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Lope H. Barrero; Celine M. Barthelemy; Lingkan Barua; Akbar Barzegar; Huda Basaleem; Quique Bassat; Sanjay Basu; Bernhard T. Baune; Mohsen Bayati; Bayisa Abdissa Baye; Gholamreza Bazmandegan; Jacob S. Becker; Neeraj Bedi; Ettore Beghi; Masoud Behzadifar; Yannick Béjot; Tariku Tesfaye Tesfaye Bekuma; Michelle L. Bell; Aminu K. Bello; Rose G. Bender; Derrick A. Bennett; Fiona B. Bennitt; Isabela M. Bensenor; Catherine P. Benziger; Kidanemaryam Berhe; Adam E. Berman; Eduardo Bernabe; Robert S. Bernstein; Gregory J. Bertolacci; Akshaya Srikanth Bhagavathula; Reshmi Bhageerathy; Neeraj Bhala; Dinesh Bhandari; Pankaj Bhardwaj; Anusha Ganapati Bhat; Krittika Bhattacharyya; Suraj Bhattarai; Zulfiqar A. Bhutta; Sadia Bibi; Molly H. Biehl; Ali Bijani; Boris Bikbov; Ver Bilano; Muhammad Shahdaat Bin Sayeed; Antonio Biondi; Binyam Minuye Birihane; Donal Bisanzio; Catherine Bisignano; Raaj Kishore Biswas; Helen Bitew; Tone Bjørge; Moses John Bockarie; Somayeh Bohlouli; Mehdi Bohluli; Hunduma Amensisa Bojia; Srinivasa Rao Bolla; Archith Boloor; Alexandra S. Boon-Dooley; Guilherme Borges; Antonio Maria Borzì; Shiva Borzouei; Dipan Bose; Cristina Bosetti; Soufiane Boufous; Rupert Bourne; Oliver J. Brady; Dejana Braithwaite; Michael Brauer; Carol Brayne; Nicholas J.K. Breitborde; Susanne Breitner; Hermann Brenner; Alexey V. Breusov; Paul Svitil Briant; Andrew M. Briggs; Andrey Nikolaevich Briko; Nikolay Ivanovich Briko; Gabrielle B. Britton; Traolach Brugha; Dana Bryazka; Rachelle Buchbinder; Blair R. Bumgarner; Katrin Burkart; Richard Thomas Burnett; Sharath Burugina Nagaraja; Reinhard Busse; Zahid A. Butt; Florentino Luciano Caetano dos Santos; Leah E. Cahill; Lucero Cahuana-Hurtado; Tianji Cai; Charlton S.K.H. Callender; Luis Alberto Cámera; Ismael R. Campos-Nonato; Julio Cesar Campuzano Rincon; Jackie Cao; Josip Car; Rosario Cárdenas; Giulia Carreras; Juan J. Carrero; Felix Carvalho; Joao Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Giulio Castelpietra; Chris D. Castle; Emma Castro; Franz Castro; Ferrán Catalá-López; Kate Causey; Christopher R. Cederroth; Kelly M. Cercy; Ester Cerin; Julian Chalek; Joht Singh Chandan; Alex R. Chang; Angela Y. Chang; Jung-Chen Chang; Kai-Lan Chang; Jaykaran Charan; Fiona J. Charlson; Vijay Kumar Chattu; Sarika Chaturvedi; Nicolas Cherbuin; Odgerel Chimed-Ochir; Ken Lee Chin; Jesus Lorenzo Chirinos-Caceres; Daniel Youngwhan Cho; Jee-Young Jasmine Choi; Hanne Christensen; Dinh-Toi Chu; Michael T. Chung; Sheng-Chia Chung; Flavia M. Cicuttini; Liliana G. Ciobanu; Massimo Cirillo; Beniamino Cislaghi; Thomas Khaled Dwayne Classen; Aaron J. Cohen; Emma L. Collins; Haley Comfort; Kelly Compton; Sara Conti; Owen R. Cooper; Barbara Corso; Paolo Angelo Cortesi; Vera Marisa Costa; Ewerton Cousin; Richard G. Cowden; Benjamin C. Cowie; Elizabeth A. Cromwell; Andrew J. Croneberger; Di H. Cross; Marita Cross; Christopher Stephen Crowe; Jessica A. Cruz; Steven Cummins; Matthew Cunningham; Saad M.A. Dahlawi; Haijiang Dai; Hancheng Dai; Albertino Antonio Moura Damasceno; Giovanni Damiani; Emanuele D'Amico; Lalit Dandona; Rakhi Dandona; Parnaz Daneshpajouhnejad; William James Dangel; Anna-Karin Danielsson; Jiregna Darega Gela; Paul I. Dargan; Aso Mohammad Darwesh; Ahmad Daryani; Jai K. Das; Rajat Das Gupta; José das Neves; Aditya Prasad Dash; Gail Davey; Claudio Alberto Dávila-Cervantes; Adrian C. Davis; Dragos Virgil Davitoiu; Kairat Davletov; Diego De Leo; Jan-Walter De Neve; Frances E. Dean; Nicole K. DeCleene; Amanda Deen; Louisa Degenhardt; Marissa DeLang; Robert Paul Dellavalle; Feleke Mekonnen Demeke; Gebre Teklemariam Demoz; Desalegn Getnet Demsie; Edgar Denova-Gutiérrez; Nebiyu Dereje Dereje; Kebede Deribe; Nikolaos Dervenis; Rupak Desai; Assefa Desalew; Getenet Ayalew Dessie; Keshab Deuba; Samath Dhamminda Dharmaratne; Govinda Prasad Dhungana; Mostafa Dianatinasab; Diana Dias da Silva; Daniel Diaz; Zahra Sadat Dibaji Forooshani; Martin Dichgans; Alireza Didarloo; Zachary V. Dingels; Ilse N. Dippenaar; M. Ashworth Dirac; Shirin Djalalinia; Hoa Thi Do; Klara Dokova; David Teye Doku; Christiane Dolecek; Andrew J. Dolgert; Fariba Dorostkar; Chirag P. Doshi; Pratik P. Doshi; Leila Doshmangir; Abdel Douiri; Matthew C. Doxey; Kerrie E. Doyle; Tim Robert Driscoll; Eleonora Dubljanin; Susanna J. Dunachie; Bruce B. Duncan; Andre Rodrigues Duraes; Arielle Wilder Eagan; Hedyeh Ebrahimi; Mohammad Ebrahimi Kalan; David Edvardsson; Andem Effiong; Joshua R. Ehrlich; Nevine El Nahas; Iman El Sayed; Maysaa El Sayed Zaki; Maha El Tantawi; Iffat Elbarazi; Islam Y. Elgendy; Hala Rashad Elhabashy; Shaimaa I. El-Jaafary; Aisha Elsharkawy; Iqbal R.F. Elyazar; Mohammad Hassan Emamian; Sophia Emmons-Bell; Holly E. Erskine; Babak Eshrati; Khalil Eskandari; Sharareh Eskandarieh; Saman Esmaeilnejad; Firooz Esmaeilzadeh; Alireza Esteghamati; Sadaf Esteghamati; Kara Estep; Arash Etemadi; Atkilt Esaiyas Etisso; Oluchi Ezekannagha; Jessica Fanzo; Tamer Farag; Mohammad Farahmand; Anwar Faraj; Emerito Jose A. Faraon; Mohammad Fareed; Roghiyeh Faridnia; Carla Sofia e Sá Farinha; Andrea Farioli; Pawan Sirwan Faris; Andre Faro; Mithila Faruque; Farshad Farzadfar; Nazir Fattahi; Ali Akbar Fazaeli; Mehdi Fazlzadeh; Valery L. Feigin; Rachel Feldman; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Giannina Ferrara; Pietro Ferrara; Alize J. Ferrari; Manuela L. Ferreira; Garumma Tolu Feyissa; Irina Filip; Florian Fischer; James L. Fisher; Ryan Fitzgerald; Carsten Flohr; Luisa Sorio Flor; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Artem Alekseevich Fomenkov; Lisa M. Force; Carla Fornari; Masoud Foroutan; Jack T. Fox; Joel Msafiri Francis; Tahvi D. Frank; Richard Charles Franklin; Marisa Freitas; Weijia Fu; Takeshi Fukumoto; Kai Fukutaki; John E. Fuller; Nancy Fullman; João M. Furtado; Mohamed M. Gad; Abhay Motiramji Gaidhane; Emmanuela Gakidou; Natalie C. Galles; Silvano Gallus; Amiran Gamkrelidze; Alberto L. Garcia-Basteiro; William M. Gardner; Biniyam Sahiledengle Geberemariyam; Abiyu Mekonnen Gebrehiwot; Ketema Bizuwork Gebremedhin; Gebreamlak Gebremedhn Gebremeskel; Leake G. Gebremeskel; Begashaw Melaku Gebresillassie; Assefa Ayalew Ayalew Ayalew Gebreslassie; Yilma Chisha Dea Geramo; Abraham Geremew; Anna Gershberg Hayoon; Hailay Abrha Gesesew; Peter W. Gething; Kebede Embaye Gezae; Maryam Ghadimi; Keyghobad Ghadiri; Fatemeh Ghaffarifar; Mansour Ghafourifard; Alireza Ghajar; Farhad Ghamari; Ahmad Ghashghaee; Hesam Ghiasvand; Nermin Ghith; Asadollah Gholamian; Rakesh Ghosh; Simona Giampaoli; Syed Amir Gilani; Paramjit Singh Gill; Tiffany K. Gill; Richard F. Gillum; Ibrahim Abdelmageed Ginawi; Themba G. Ginindza; Mojgan Gitimoghaddam; Giorgia Giussani; Mustefa Glagn; Ekaterina Vladimirovna Glushkova; Elena V. Gnedovskaya; Myron Anthony Godinho; Salime Goharinezhad; Mahaveer Golechha; Srinivas Goli; Ricardo Santiago Gomez; Philimon N. Gona; Sameer Vali Gopalani; Emily Goren; Giuseppe Gorini; Taren M. Gorman; Harrison Chase Gottlich; Houman Goudarzi; Amir Hossein Goudarzian; Alessandra C. Goulart; Bárbara Niegia Garcia Goulart; Ayman Grada; Felix Greaves; Michal Grivna; Giuseppe Grosso; Mohammed Ibrahim Mohialdeen Gubari; Nachiket Gudi; Harish Chander Gugnani; Andre Luiz Sena Guimaraes; Rafael Alves Guimarães; Rashid Abdi Guled; Teklemariam Gultie; Gaorui Guo; Yuming Guo; Rahul Gupta; Rajeev Gupta; Subodh Sharan Gupta; Tarun Gupta; Juanita A. Haagsma; Vladimir Hachinski; Beatrix Haddock; Nima Hafezi-Nejad; Abdul Hafiz; Hailey Hagins; Lydia M. Haile; Teklehaimanot Gereziher Haile; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Brian J. Hall; Iman Halvaei; Randah R. Hamadeh; Kanaan Hamagharib Abdullah; Sajid Hameed; Samer Hamidi; Erin B. Hamilton; Melanie S. Hammer; Chieh Han; Hannah Han; Demelash Woldeyohannes Handiso; Asif Hanif; Graeme J. Hankey; Hamidreza Haririan; Josep Maria Haro; James D. Harvey; Ahmed I. Hasaballah; Md Mehedi Hasan; Edris Hasanpoor; Amir Hasanzadeh; Maryam Hashemian; Abdiwahab Hashi; Amr Hassan; Shoaib Hassan; Soheil Hassanipour; Hadi Hassankhani; Rasmus J. Havmoeller; Roderick J. Hay; Simon I. Hay; Khezar Hayat; Behzad Heibati; Behnam Heidari; Golnaz Heidari; Reza Heidari-Soureshjani; Delia Hendrie; Kiana Henny; Andualem Henok; Hannah J. Henrikson; Nathaniel J. Henry; Molly E. Herbert; Claudiu Herteliu; Fatemeh Heydarpour; Thomas R. Hird; Hung Chak Ho; Hans W. Hoek; Michael K. Hole; Ramesh Holla; Bruce Hollingsworth; Praveen Hoogar; Kathleen Pillsbury Hopf; Nobuyuki Horita; H. Dean Hosgood; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mowafa Househ; Damian G. Hoy; Mohamed Hsairi; Thomas Hsiao; Vivian Chia-Rong Hsieh; Guoqing Hu; Kejia Hu; Tanvir M. Huda; Fernando N. Hugo; Ayesha Humayun; Rabia Hussain; Chantal K. Huynh; Bing-Fang Hwang; Vincent C. Iannucci; Ivo Iavicoli; Charles Ugochukwu Ibeneme; Segun Emmanuel Ibitoye; Nayu Ikeda; Kevin S. Ikuta; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Mohammad Hasan Imani-Nasab; Leeberk Raja Inbaraj; Helen Ippolito; Usman Iqbal; Seyed Sina Naghibi Irvani; Caleb Mackay Salpeter Irvine; M. Mofizul Islam; Md. Mohaimenul Islam; Sheikh Mohammed Shariful Islam; Farhad Islami; Hiroyasu Iso; Rebecca Q. Ivers; Chidozie C.D. Iwu; Chinwe Juliana Iwu; Ihoghosa Osamuyi Iyamu; Jalil Jaafari; Kathryn H. Jacobsen; Farhad Jadidi-Niaragh; Hussain Jafari; Morteza Jafarinia; Deepa Jahagirdar; Mohammad Ali Jahani; Nader Jahanmehr; Mihajlo Jakovljevic; Amir Jalali; Farzad Jalilian; Spencer L. James; Hosna Janjani; Manthan Dilipkumar Janodia; Tahereh Javaheri; Javad Javidnia; Achala Upendra Jayatilleke; Panniyammakal Jeemon; Ensiyeh Jenabi; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Peng Jia; Lars Johansson; Oommen John; Yetunde O. John-Akinola; Catherine Owens Johnson; Sarah Charlotte Johnson; Jost B. Jonas; Tamas Joo; Ankur Joshi; Farahnaz Joukar; Jacek Jerzy Jozwiak; Mikk Jürisson; Ali Kabir; Zubair Kabir; Hamed Kalani; Rizwan Kalani; Leila R. Kalankesh; Rohollah Kalhor; Aruna M. Kamath; Zahra Kamiab; Tanuj Kanchan; Neeti Kapoor; Behzad Karami Matin; Marina Karanikolos; André Karch; Mohd Anisul Karim; Salah Eddin Karimi; Seyed Asaad Karimi; Seyed M. Karimi; Ayele Semachew Kasa; Getachew Mullu Kassa; Nicholas J. Kassebaum; Srinivasa Vittal Katikireddi; Norito Kawakami; Gbenga A. Kayode; Ali Kazemi Karyani; Suzanne H. Keddie; Peter Njenga Keiyoro; Cathleen Keller; Laura Kemmer; Parkes J. Kendrick; Maia Kereselidze; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Nauman Khalid; Mohammad Khammarnia; Ejaz Ahmad Khan; Gulfaraz Khan; Maseer Khan; Young-Ho Khang; Khaled Khatab; Amir M. Khater; Mona M. Khater; Mahalaqua Nazli Khatib; Maryam Khayamzadeh; Salman Khazaei; Habibolah Khazaie; Mohammad Taghi Khodayari; Abdullah T. Khoja; Jagdish Khubchandani; Roba Khundkar; Neda Kianipour; Christian Kieling; Cho-Il Kim; Daniel Kim; Young-Eun Kim; Yun Jin Kim; Ruth W. Kimokoti; Yohannes Kinfu; Adnan Kisa; Sezer Kisa; Katarzyna Kissimova-Skarbek; Niranjan Kissoon; Mika Kivimäki; Cameron J. Kneib; Luke D. Knibbs; Megan Knight; Ann Kristin Skrindo Knudsen; Jonathan M. Kocarnik; Sonali Kochhar; David S.Q. Koh; Stefan Kohler; Tufa Kolola; Hamidreza Komaki; Jacek A. Kopec; Anna V. Korotkova; Vladimir Andreevich Korshunov; Soewarta Kosen; Anirudh Kotlo; Parvaiz A. Koul; Ai Koyanagi; Moritz U.G. Kraemer; Michael A. Kravchenko; Kewal Krishan; Kris J. Krohn; Hans Kromhout; K.S. Shaji; Barthelemy Kuate Defo; Burcu Bicer Kucuk; Nuworza Kugbey; Vaman Kulkarni; G. Anil Kumar; Manasi Kumar; Nithin Kumar; Pushpendra Kumar; Vivek Kumar; Girikumar Kumaresh; Om P. Kurmi; Dian Kusuma; Hmwe Hmwe Kyu; Carlo La Vecchia; Ben Lacey; Dharmesh Kumar Lal; Ratilal Lalloo; Tea Lallukka; Jennifer O. Lam; Faris Hasan Lami; Qing Lan; Iván Landires; Justin J. Lang; Sinéad M. Langan; Van Charles Lansingh; Sonia Lansky; Heidi Jane Larson; Samantha Leigh Larson; Anders O. Larsson; Savita Lasrado; Zohra S. Lassi; Kathryn Mei-Ming Lau; Paolo Lauriola; Pablo M. Lavados; Jeffrey V. Lazarus; Lisiane F. Leal; Janet L. Leasher; Jorge R. Ledesma; Paul H. Lee; Shaun Wen Huey Lee; Andrew T. Leever; Kate E. LeGrand; James Leigh; Matilde Leonardi; Haley Lescinsky; Janni Leung; Miriam Levi; Sarah Lewington; Bingyu Li; Shanshan Li; Lee-Ling Lim; Christine Lin; Ro-Ting Lin; Christine Linehan; Shai Linn; Stefan Listl; Hung-Chun Liu; Shiwei Liu; Simin Liu; Xuefeng Liu; Yang Liu; Zichen Liu; Justin Lo; Rakesh Lodha; Giancarlo Logroscino; Katharine J. Looker; Alan D. Lopez; Jaifred Christian F. Lopez; Platon D. Lopukhov; Stefan Lorkowski; Paulo A. 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Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and development investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study
(Elsevier Inc., 2020) Gregory A. Roth; George A. Mensah; Catherine O. Johnson; Giovanni Addolorato; Enrico Ammirati; Larry M. Baddour; Noel C. Barengo; Andrea Beaton; Emelia J. Benjamin; Catherine P. Benziger; Aime Bonny; Michael Brauer; Marianne Brodmann; Thomas J. Cahill; Jonathan R. Carapetis; Alberico L. Catapano; Sumeet Chugh; Leslie T. Cooper; Josef Coresh; Michael H. Criqui; Nicole K. DeCleene; Kim A. Eagle; Sophia Emmons-Bell; Valery L. Feigin; Joaquim Fernández-Sola; F. Gerry R. Fowkes; Emmanuela Gakidou; Scott M. Grundy; Feng J. He; George Howard; Frank Hu; Lesley Inker; Ganesan Karthikeyan; Nicholas J. Kassebaum; Walter J. Koroshetz; Carl Lavie; Donald Lloyd-Jones; Hong S. Lu; Antonio Mirijello; Awoke T. Misganaw; Ali H. Mokdad; Andrew E. Moran; Paul Muntner; Jagat Narula; Bruce Neal; Mpiko Ntsekhe; Gláucia M.M. Oliveira; Catherine M. Otto; Mayowa O. Owolabi; Michael Pratt; Sanjay Rajagopalan; Marissa B. Reitsma; Antonio Luiz P. Ribeiro; Nancy A. Rigotti; Anthony Rodgers; Craig A. Sable; Saate S. Shakil; Karen Sliwa; Benjamin A. Stark; Johan Sundström; Patrick Timpel; Imad I. Tleyjeh; Marco Valgimigli; Theo Vos; Paul K. Whelton; Magdi Yacoub; Liesl J. Zuhlke; Mohsen Abbasi-Kangevari; Alireza Abdi; Aidin Abedi; Victor Aboyans; Woldu A. Abrha; Eman Abu-Gharbieh; Abdelrahman I. Abushouk; Dilaram Acharya; Tim Adair; Oladimeji M. Adebayo; Zanfina Ademi; Shailesh M. Advani; Khashayar Afshari; Ashkan Afshin; Gina Agarwal; Pradyumna Agasthi; Sohail Ahmad; Sepideh Ahmadi; Muktar B. Ahmed; Budi Aji; Yonas Akalu; Wuraola Akande-Sholabi; Addis Aklilu; Chisom J. Akunna; Fares Alahdab; Ayman Al-Eyadhy; Khalid F. Alhabib; Sheikh M. Alif; Vahid Alipour; Syed M. Aljunid; François Alla; Amir Almasi-Hashiani; Sami Almustanyir; Rajaa M. Al-Raddadi; Adeladza K. Amegah; Saeed Amini; Arya Aminorroaya; Hubert Amu; Dickson A. Amugsi; Robert Ancuceanu; Deanna Anderlini; Tudorel Andrei; Catalina Liliana Andrei; Alireza Ansari-Moghaddam; Zelalem A. Anteneh; Ippazio Cosimo Antonazzo; Benny Antony; Razique Anwer; Lambert T. Appiah; Jalal Arabloo; Johan Ärnlöv; Kurnia D. Artanti; Zerihun Ataro; Marcel Ausloos; Leticia Avila-Burgos; Asma T. Awan; Mamaru A. Awoke; Henok T. Ayele; Muluken A. Ayza; Samad Azari; B.B. Darshan; Nafiseh Baheiraei; Atif A. Baig; Ahad Bakhtiari; Maciej Banach; Palash C. Banik; Emerson A. Baptista; Miguel A. Barboza; Lingkan Barua; Sanjay Basu; Neeraj Bedi; Yannick Béjot; Derrick A. Bennett; Isabela M. Bensenor; Adam E. Berman; Yihienew M. Bezabih; Akshaya S. Bhagavathula; Sonu Bhaskar; Krittika Bhattacharyya; Ali Bijani; Boris Bikbov; Mulugeta M. Birhanu; Archith Boloor; Luisa C. Brant; Hermann Brenner; Nikolay I. Briko; Zahid A. Butt; Florentino Luciano Caetano dos Santos; Leah E. Cahill; Lucero Cahuana-Hurtado; Luis A. Cámera; Ismael R. Campos-Nonato; Carlos Cantu-Brito; Josip Car; Juan J. Carrero; Felix Carvalho; Carlos A. 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Yilgwan; Naohiro Yonemoto; Chuanhua Yu; Hasan Yusefzadeh; Geevar Zachariah; Sojib Bin Zaman; Muhammed S. Zaman; Maryam Zamanian; Ramin Zand; Alireza Zandifar; Afshin Zarghi; Mikhail S. Zastrozhin; Anasthasia Zastrozhina; Zhi-Jiang Zhang; Yunquan Zhang; Wangjian Zhang; Chenwen Zhong; Zhiyong Zou; Yves Miel H. Zuniga; Christopher J.L. Murray; Valentin Fuster
Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases. © 2020 The Authors
Global Burden of Cardiovascular Diseases and Risks, 1990-2022
(Elsevier Inc., 2023) George A. Mensah; Valentin Fuster; Christopher J.L. Murray; Gregory A. Roth; George A. Mensah; Yohannes Habtegiorgis Abate; Mohammadreza Abbasian; Foad Abd-Allah; Ashkan Abdollahi; Mohammad Abdollahi; Deldar Morad Abdulah; Auwal Abdullahi; Ayele Mamo Abebe; Aidin Abedi; Armita Abedi; Olugbenga Olusola Abiodun; Hiwa Abubaker Ali; Eman Abu-Gharbieh; Niveen M.E. Abu-Rmeileh; Salahdein Aburuz; Abdelrahman I. Abushouk; Ahmed Abu-Zaid; Tigist Demssew Adane; Nicola J. Adderley; Oladimeji M. Adebayo; Bashir Aden; Temitayo Esther Adeyeoluwa; Olorunsola Israel Adeyomoye; Qorinah Estiningtyas Sakilah Adnani; Fatemeh Afrashteh; Shadi Afyouni; Saira Afzal; Pradyumna Agasthi; Antonella Agodi; Constanza Elizabeth Aguilera Arriagada; Williams Agyemang-Duah; Bright Opoku Ahinkorah; Aqeel Ahmad; Danish Ahmad; Firdos Ahmad; Muayyad M. 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Geleijnse; Urge Gerema; Alireza Ghajar; Seyyed-Hadi Ghamari; Mohammad Reza Ghasemi; Ghazal Ghasempour Dabaghi; Afsaneh Ghasemzadeh; Ramy Mohamed Ghazy; Maryam Gholamalizadeh; Arun Digambarrao Ghuge; Paramjit Singh Gill; Tiffany K. Gill; Richard F. Gillum; Elena V. Gnedovskaya; Ali Golchin; Pouya Goleij; Giuseppe Gorini; Alessandra C. Goulart; Anmol Goyal; Kashish Goyal; Shi-Yang Guan; Giovanni Guarducci; Mesay Dechasa Gudeta; Avirup Guha; Stefano Guicciardi; David Gulisashvili; Damitha Asanga Gunawardane; Cui Guo; Anish Kumar Gupta; Bhawna Gupta; Indarchand Ratanlal Gupta; Kartik Gupta; Mohak Gupta; Rajat Das Gupta; Rajeev Gupta; Renu Gupta; Sapna Gupta; Veer Bala Gupta; Vijai Kumar Gupta; Vivek Kumar Gupta; Lami Gurmessa; Reyna Alma Gutiérrez; Farrokh Habibzadeh; Mostafa Hadei; Helia Sadat Haeri Boroojeni; Aram Halimi; Sebastian Haller; Rabih Halwani; Randah R. Hamadeh; Nadia M. Hamdy; Samer Hamidi; Chieh Han; Qiuxia Han; Graeme J. Hankey; Md. Abdul Hannan; Arief Hargono; Josep Maria Haro; Faizul Hasan; Ikramul Hasan; Hamidreza Hasani; Maryam Hashemian; Md Saquib Hasnain; Amr Hassan; Ikrama Hassan; Johannes Haubold; Rasmus J. Havmoeller; Simon I. Hay; Khezar Hayat; Youssef Hbid; Omar E. Hegazi; Tadele Yohannes Hegena; Mohammad Heidari; Bartosz Helfer; Brenda Yuliana Herrera-Serna; Claudiu Herteliu; Hamed Hesami; Kamran Hessami; Keyvan Heydari; Kamal Hezam; Yuta Hiraike; Nguyen Quoc Hoan; Ramesh Holla; Md Mahbub Hossain; Md. Belal Hossain; Hassan Hosseinzadeh; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mohamed Hsairi; Junjie Huang; Michael Hultström; Hong-Han Huynh; Bing-Fang Hwang; Khalid S. Ibrahim; Oluwatope Olaniyi Idowu; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Mustapha Immurana; Leeberk Raja Inbaraj; Muhammad Iqhrammullah; Sheikh Mohammed Shariful Islam; Faisal Ismail; Nahlah Elkudssiah Ismail; Gaetano Isola; Masao Iwagami; J. Linda Merin; Jalil Jaafari; Louis Jacob; Abdollah Jafarzadeh; Khushleen Jaggi; Haitham Jahrami; Akhil Jain; Nityanand Jain; Ammar Abdulrahman Jairoun; Mihajlo Jakovljevic; Roland Dominic G. Jamora; Nilofer Javadi; Sathish Kumar Jayapal; Shubha Jayaram; Rime Jebai; Rebuma Sorsa Jeben; Sun Ha Jee; Anil K. Jha; Ravi Prakash Jha; Vivekanand Jha; Heng Jiang; Yinzi Jin; Yash B. Jobanputra; Catherine Owens Johnson; Mohammad Jokar; Tamas Joo; Abel Joseph; Nitin Joseph; Charity Ehimwenma Joshua; Jacek Jerzy Jozwiak; Mikk Jürisson; Ali Kabir; Zubair Kabir; Vidya Kadashetti; Farima Kahe; Rizwan Kalani; Laleh R. Kalankesh; Farnaz Kalantar; Yogeshwar Kalkonde; Sanjay Kalra; Ashwin Kamath; Sagarika Kamath; Arun Kamireddy; Tanuj Kanchan; Himal Kandel; Arun R. Kanmanthareddy; Kehinde Kazeem Kanmodi; Sushil Kumar Kansal; Daniel John Kapner; Sitanshu Sekhar Kar; Paschalis Karakasis; Prabin Karki; Faizan Zaffar Kashoo; Hengameh Kasraei; Eskeziaw Abebe Kassahun; Nicholas J. Kassebaum; Patrick D.M.C. Katoto; Neda Kaydi; Foad Kazemi; Sina Kazemian; Sara Kazeminia; Jessica A. Kerr; Emmanuelle Kesse-Guyot; Mohammad Keykhaei; Mohamad Mehdi Khadembashiri; Mohammad Amin Khadembashiri; Morteza Abdullatif Khafaie; Himanshu Khajuria; Amirmohammad Khalaji; Nauman Khalid; Alireza Khalilian; Rovshan Khalilov; Asaduzzaman Khan; Ejaz Ahmad Khan; Junaid Khan; M. Nuruzzaman Khan; Maseer Khan; Mohammad Jobair Khan; Muhammad Shahzeb Khan; Yusra H. Khan; Mahammed Ziauddin Khan Suheb; Shaghayegh Khanmohammadi; Khaled Khatab; Sorour Khateri; Hamid Reza Khayat Kashani; Khalid A. Kheirallah; Feriha Fatima Khidri; Saeid Kian; Zemene Demelash Kifle; Ruth W. Kimokoti; Adnan Kisa; Sezer Kisa; Ali-Asghar Kolahi; Farzad Kompani; Gerbrand Koren; Ashwin Laxmikant Kotnis; Parvaiz A. Koul; Ai Koyanagi; Kewal Krishan; Hare Krishna; Vijay Krishnamoorthy; Yuvaraj Krishnamoorthy; Md Abdul Kuddus; Mohammed Kuddus; Mukhtar Kulimbet; Vishnutheertha Kulkarni; Akshay Kumar; Ashish Kumar; Naveen Kumar; Nithin Kumar; Rahul Kumar; Netsanet Bogale Kumsa; Kunle Rotimi Kunle; Dian Kusuma; Ilias Kyriopoulos; Carlo La Vecchia; Ben Lacey; Muhammad Awwal Ladan; Lucie Laflamme; Chandrakant Lahariya; Arista Lahiri; Daphne Teck Ching Lai; Tea Lallukka; Qing Lan; Iván Landires; Francesco Lanfranchi; Bagher Larijani; Anders O. Larsson; Savita Lasrado; Kamaluddin Latief; Kaveh Latifinaibin; Jerrald Lau; Paolo Lauriola; Khuong Le; Long Khanh Dao Le; Nhi Huu Hanh Le; Thao Thi Thu Le; Trang Diep Thanh Le; Trang Thi Bich Le; Caterina Ledda; Munjae Lee; Paul H. Lee; Seung Won Lee; Wei-Chen Lee; Yo Han Lee; Kate E. LeGrand; Mall Leinsalu; Matilde Leonardi; Temesgen L. Lerango; An Li; Ming-Chieh Li; Wei Li; Xiaopan Li; Yichong Li; Lee-Ling Lim; Stephen S. Lim; Ro-Ting Lin; Megan Lindstrom; Shai Linn; Gang Liu; Simin Liu; Xiaofeng Liu; Xuefeng Liu; Katherine M. Livingstone; Erand Llanaj; Platon D. Lopukhov; Arianna Maever Loreche; László Lorenzovici; Stefan Lorkowski; Paulo A. Lotufo; Giancarlo Lucchetti; Alessandra Lugo; Zheng Feei Ma; Farzan Madadizadeh; Ralph Maddison; Javier A. Magaña Gómez; Julien Magne; D.R. Mahadeshwara Prasad; Mehrdad Mahalleh; Mansour Adam Mahmoud; Elham Mahmoudi; Behnaz Mahmoudvand; Omar Mohamed Makram; Elaheh Malakan Rad; Reza Malekzadeh; Kashish Malhotra; Iram Malik; Muhammad Sajeel Ahmed Malik; Tauqeer Hussain Mallhi; Deborah Carvalho Malta; Aseer Manilal; Yosef Manla; Yasaman Mansoori; Borhan Mansouri; Pejman Mansouri; Mohammad Ali Mansournia; Hamid Reza Marateb; Mirko Marino; Daniela Martini; Santi Martini; Sharmeen Maryam; Roy Rillera Marzo; Alireza Masoudi; Sahar Masoudi; Clara N. Matei; Yasith Mathangasinghe; Elezebeth Mathews; Manu Raj Mathur; Jishanth Mattumpuram; Richard James Maude; Andrea Maugeri; Mahsa Mayeli; Mohsen Mazidi; John J. McGrath; Steven M. McPhail; Enkeleint A. Mechili; John Robert Carabeo Medina; Jitendra Kumar Meena; Kamran Mehrabani-Zeinabad; Max Alberto Mendez Mendez-Lopez; Walter Mendoza; Ritesh G. Menezes; Belayneh Mengist; Sultan Ayoub Meo; Haftu Asmerom Meresa; Atte Meretoja; Tuomo J. Meretoja; Tomislav Mestrovic; Kukulege Chamila Dinushi Mettananda; Sachith Mettananda; Laurette Mhlanga; Tianyue Mi; Junmei Miao Jonasson; Tomasz Miazgowski; Irmina Maria Michalek; Ted R. Miller; Le Huu Nhat Minh; Neema W. Minja; Pouya Mir Mohammad Sadeghi; Niloofar Mirdamadi; Andreea Mirica; Erkin M. Mirrakhimov; Moonis Mirza; Mohammad Mirza-Aghazadeh-Attari; Prasanna Mithra; Zahra Moghimi; Jama Mohamed; Mouhand F.H. Mohamed; Nouh Saad Mohamed; Soheil Mohammadi; Hussen Mohammed; Mustapha Mohammed; Salahuddin Mohammed; Shafiu Mohammed; Nagabhishek Moka; Ali H. Mokdad; Hossein Molavi Vardanjani; Sara Momtazmanesh; Lorenzo Monasta; Fateme Montazeri; AmirAli Moodi Ghalibaf; Yousef Moradi; Paula Moraga; Lidia Morawska; Negar Morovatdar; Shane Douglas Morrison; Jakub Morze; Ebrahim Mostafavi; Amirmahdi Mostofinejad; Vincent Mougin; Parsa Mousavi; Seyed Ehsan Mousavi; Dariush Mozaffarian; Ahmed Msherghi; Lorenzo Muccioli; Ulrich Otto Mueller; Sumoni Mukherjee; Kavita Munjal; Efrén Murillo-Zamora; Ghulam Mustafa; Sathish Muthu; Julius C. Mwita; Woojae Myung; Ahamarshan Jayaraman Nagarajan; Shankar Prasad Nagaraju; Ganesh R. Naik; Gurudatta Naik; Tapas Sadasivan Nair; Mohammad Sadeq Najafi; Noureddin Nakhostin Ansari; Vinay Nangia; Sreenivas Narasimha Swamy; Shumaila Nargus; Bruno Ramos Nascimento; Gustavo G. Nascimento; Hadis Nasoori; Zuhair S. Natto; Javaid Nauman; Muhammad Naveed; Biswa Prakash Nayak; Vinod C. Nayak; Hadush Negash; Ionut Negoi; Ruxandra Irina Negoi; Reza Nejad Shahrokh Abadi; Seyed Aria Nejadghaderi; Chakib Nejjari; Mohammad Hadi Nematollahi; Samata Nepal; Nawi Ng; Dang H. Nguyen; Phat Tuan Nguyen; Van Thanh Nguyen; Robina Khan Niazi; Shawn S. Nijjar; Muhammad A. Nizam; Efaq Ali Noman; Shuhei Nomura; Mamoona Noreen; Bo Norrving; Jean Jacques Noubiap; Chisom Adaobi Nri-Ezedi; Mpiko Ntsekhe; Dieta Nurrika; Chimezie Igwegbe Nzoputam; Ogochukwu Janet Nzoputam; Kehinde O. Obamiro; Martin James O'Donnell; Onome Bright Oghenetega; Ayodipupo Sikiru Oguntade; James Odhiambo Oguta; Sylvester Reuben Okeke; Akinkunmi Paul Okekunle; Lawrence Okidi; Osaretin Christabel Okonji; Patrick Godwin Okwute; Andrew T. Olagunju; Muideen Tunbosun Olaiya; Matifan Dereje Olana; Matthew Idowu Olatubi; Gláucia Maria Moraes Oliveira; Abdulhakeem Abayomi Olorukooba; Isaac Iyinoluwa Olufadewa; Yinka Doris Oluwafemi; Gideon Olamilekan Oluwatunase; Goran Latif Omer; Mohammad Mehdi Ommati; Kanyin Liane Ong; Sokking Ong; Kenneth Ikenna Onyedibe; Michal Ordak; Doris V. Ortega-Altamirano; Alberto Ortiz; Esteban Ortiz-Prado; Wael M.S. Osman; Uchechukwu Levi Osuagwu; Adrian Otoiu; Stanislav S. Otstavnov; Mayowa O. Owolabi; P.A. Mahesh Padukudru; Alicia Padron-Monedero; Jagadish Rao Padubidri; Mahsa Pahlavikhah Varnosfaderani; Tamás Palicz; Raffaele Palladino; Feng Pan; Hai-Feng Pan; Seithikurippu R. Pandi-Perumal; Paraskevi Papadopoulou; Seoyeon Park; Roberto Passera; Jay Patel; Shankargouda Patil; Dimitrios Patoulias; Venkata Suresh Patthipati; Shrikant Pawar; Amy E. Peden; Paolo Pedersini; Minjin Peng; Veincent Christian Filipino Pepito; Emmanuel K. Peprah; Marcos Pereira; Maria Odete Pereira; Mario F.P. Peres; Arokiasamy Perianayagam; Norberto Perico; Fanny Emily Petermann-Rocha; Hoang Tran Pham; Anil K. Philip; David M. Pigott; Thomas Pilgrim; Michael A. Piradov; Evgenii Plotnikov; Dimitri Poddighe; Roman V. Polibin; Ramesh Poluru; Ghazaleh Pourali; Akram Pourshams; Pranil Man Singh Pradhan; Manya Prasad; Elton Junio Sady Prates; Bharathi M. Purohit; Jagadeesh Puvvula; Ibrahim Qattea; Gangzhen Qian; Maryam Faiz Qureshi; Mehrdad Rabiee Rad; Amir Radfar; Seyedeh Niloufar Rafiei Alavi; Ibrar Rafique; Alberto Raggi; Fakher Rahim; Md Jillur Rahim; Mehran Rahimi; Mosiur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Bita Rahmani; Shayan Rahmani; Vahid Rahmanian; Pramila Rai; Sathish Rajaa; Ali Rajabpour-Sanati; Prashant Rajput; Pradhum Ram; Prasanna Ram; Sudha Ramalingam; Shakthi Kumaran Ramasamy; Sheena Ramazanu; Pushkal Sinduvadi Ramesh; Juwel Rana; Kritika Rana; Chhabi Lal Ranabhat; Nemanja Rancic; Amey Rane; Shubham Ranjan; Annemarei Ranta; Indu Ramachandra Rao; Mithun Rao; Sowmya J. Rao; Sina Rashedi; Vahid Rashedi; Ahmed Mustafa Rashid; Azad Rasul; Zubair Ahmed Ratan; Giridhara Rathnaiah Babu; Nakul Ravikumar; Salman Rawaf; Iman Razeghian-Jahromi; Christian Razo; Murali Mohan Rama Krishna Reddy; Elrashdy Moustafa Mohamed Redwan; Giuseppe Remuzzi; Luis Felipe Reyes; Nazila Rezaei; Mohsen Rezaeian; Antonio Luiz P. Ribeiro; Daniela Ribeiro; Reza Rikhtegar; Leonardo Roever; Debby Syahru Romadlon; Luca Ronfani; Himanshu Sehar Sekhar Rout; Nitai Roy; Priyanka Roy; Andrzej Rynkiewicz; Aly M.A. Saad; Zahra Saadatian; Siamak Sabour; Simona Sacco; Rajesh Sachdeva; Basema Saddik; Erfan Sadeghi; Umar Saeed; Fahimeh Safaeinejad; Fatemeh Saheb Sharif-Askari; Narjes Saheb Sharif-Askari; Amirhossein Sahebkar; Soumya Swaroop Sahoo; Seyed Aidin Sajedi; Mirza Rizwan Sajid; Joseph W. Sakshaug; Nasir Salam; Afeez Abolarinwa Salami; Mohamed A. Saleh; Sana Salehi; Marwa Rashad Salem; Mohammed Z.Y. Salem; Sara Samadzadeh; Saad Samargandy; Vijaya Paul Samuel; Abdallah M. Samy; Juan Sanabria; Rama Krishna Sanjeev; Milena M. Santric-Milicevic; Muhammad Arif Nadeem Saqib; Made Ary Sarasmita; Aswini Saravanan; Yaser Sarikhani; Tanmay Sarkar; Rodrigo Sarmiento-Suárez; Gargi Sachin Sarode; Sachin C. Sarode; Thirunavukkarasu Sathish; Anudeep Sathyanarayan; Monika Sawhney; Mehdi Sayyah; Benedikt Michael Schaarschmidt
[No abstract available]
Global injury morbidity and mortality from 1990 to 2017: Results from the global burden of disease study 2017
(BMJ Publishing Group, 2020) Spencer L. James; Chris D. Castle; Zachary V. Dingels; Jack T. Fox; Erin B. Hamilton; Zichen Liu; Nicholas L.S. Roberts; Dillon O. Sylte; Nathaniel J. Henry; Kate E. LeGrand; Ahmed Abdelalim; Amir Abdoli; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Aidin Abedi; Akine Eshete Abosetugn; Abdelrahman I. Abushouk; Oladimeji M. Adebayo; Marcela Agudelo-Botero; Tauseef Ahmad; Rushdia Ahmed; Muktar Beshir Ahmed; Miloud Taki Eddine Aichour; Fares Alahdab; Genet Melak Alamene; Fahad Mashhour Alanezi; Animut Alebel; Niguse Meles Alema; Suliman A. Alghnam; Samar Al-Hajj; Beriwan Abdulqadir Ali; Saqib Ali; Mahtab Alikhani; Cyrus Alinia; Vahid Alipour; Syed Mohamed Aljunid; Amir Almasi-Hashiani; Nihad A. Almasri; Khalid Altirkawi; Yasser Sami Abdeldayem Amer; Saeed Amini; Arianna Maever Loreche Amit; Catalina Liliana Andrei; Alireza Ansari-Moghaddam; Carl Abelardo T. Antonio; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Zohreh Arefi; Olatunde Aremu; Filippo Ariani; Amit Arora; Malke Asaad; Babak Asghari; Nefsu Awoke; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Samad Azari; Ghasem Azarian; Alaa Badawi; Ashish D. Badiye; Eleni Bagli; Atif Amin Baig; Mohan Bairwa; Ahad Bakhtiari; Arun Balachandran; Maciej Banach; Srikanta K. Banerjee; Palash Chandra Banik; Amrit Banstola; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Lope H. Barrero; Akbar Barzegar; Mohsen Bayati; Bayisa Abdissa Baye; Neeraj Bedi; Masoud Behzadifar; Tariku Tesfaye Bekuma; Habte Belete; Corina Benjet; Derrick A. Bennett; Isabela M. Bensenor; Kidanemaryam Berhe; Pankaj Bhardwaj; Anusha Ganapati Bhat; Krittika Bhattacharyya; Sadia Bibi; Ali Bijani; Muhammad Shahdaat Bin Sayeed; Guilherme Borges; Antonio Maria Borzì; Soufiane Boufous; Alexandra Brazinova; Nikolay Ivanovich Briko; Shyam S. Budhathoki; Josip Car; Rosario Cárdenas; Félix Carvalho; João Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Giulio Castelpietra; Ferrán Catalá-López; Ester Cerin; Joht S. Chandan; Wagaye Fentahun Chanie; Soosanna Kumary Chattu; Vijay Kumar Chattu; Irini Chatziralli; Neha Chaudhary; Daniel Youngwhan Cho; Mohiuddin Ahsanul Kabir Chowdhury; Dinh-Toi Chu; Samantha M. Colquhoun; Maria-Magdalena Constantin; Vera M. Costa; Giovanni Damiani; Ahmad Daryani; Claudio Alberto Dávila-Cervantes; Feleke Mekonnen Demeke; Asmamaw Bizuneh Demis; Gebre Teklemariam Demoz; Desalegn Getnet Demsie; Afshin Derakhshani; Kebede Deribe; Rupak Desai; Mostafa Dianati Nasab; Diana Dias da Silva; Zahra Sadat Dibaji Forooshani; Kerrie E. Doyle; Tim Robert Driscoll; Eleonora Dubljanin; Bereket Duko Adema; Arielle Wilder Eagan; Aziz Eftekhari; Elham Ehsani-Chimeh; Maysaa El Sayed Zaki; Demelash Abewa Elemineh; Shaimaa I. El-Jaafary; Ziad El-Khatib; Christian Lycke Ellingsen; Mohammad Hassan Emamian; Daniel Adane Endalew; Sharareh Eskandarieh; Pawan Sirwan Faris; Andre Faro; Farshad Farzadfar; Yousef Fatahi; Wubalem Fekadu; Tomas Y. Ferede; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Garumma Tolu Feyissa; Irina Filip; Florian Fischer; Morenike Oluwatoyin Folayan; Masoud Foroutan; Joel Msafiri Francis; Richard Charles Franklin; Takeshi Fukumoto; Biniyam Sahiledengle Geberemariyam; Abadi Kahsu Gebre; Ketema Bizuwork Gebremedhin; Gebreamlak Gebremedhn Gebremeskel; Berhe Gebremichael; Getnet Azeze Gedefaw; Birhanu Geta; Mansour Ghafourifard; Farhad Ghamari; Ahmad Ghashghaee; Asadollah Gholamian; Tiffany K. Gill; Alessandra C. Goulart; Ayman Grada; Michal Grivna; Mohammed Ibrahim Mohialdeen Gubari; Rafael Alves Guimarães; Yuming Guo; Gaurav Gupta; Juanita A. Haagsma; Nima Hafezi-Nejad; Hassan Haghparast Bidgoli; Brian James Hall; Randah R. Hamadeh; Samer Hamidi; Josep Maria Haro; Md Mehedi Hasan; Amir Hasanzadeh; Soheil Hassanipour; Hadi Hassankhani; Hamid Yimam Hassen; Rasmus Havmoeller; Khezar Hayat; Delia Hendrie; Fatemeh Heydarpour; Martha Híjar; Hung Chak Ho; Chi Linh Hoang; Michael K. Hole; Ramesh Holla; Naznin Hossain; Mehdi Hosseinzadeh; Sorin Hostiuc; Guoqing Hu; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena Ilic; Milena D. Ilic; Leeberk Raja Inbaraj; Endang Indriasih; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; M. Mofizul Islam; Rebecca Q. Ivers; Kathryn H. Jacobsen; Mohammad Ali Jahani; Nader Jahanmehr; Mihajlo Jakovljevic; Farzad Jalilian; Sudha Jayaraman; Achala Upendra Jayatilleke; Ravi Prakash Jha; Yetunde O. John-Akinola; Jost B. Jonas; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; Suresh Banayya Jungari; Mikk Jürisson; Ali Kabir; Rajendra Kadel; Amaha Kahsay; Leila R. Kalankesh; Rohollah Kalhor; Teshome Abegaz Kamil; Tanuj Kanchan; Neeti Kapoor; Manoochehr Karami; Amir Kasaeian; Hagazi Gebremedhin Kassaye; Taras Kavetskyy; Hafte Kahsay Kebede; Peter Njenga Keiyoro; Abraham Getachew Kelbore; Bayew Kelkay; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Nauman Khalid; Ibrahim A. Khalil; Rovshan Khalilov; Mohammad Khammarnia; Ejaz Ahmad Khan; Maseer Khan; Tripti Khanna; Habibolah Khazaie; Fatemeh Khosravi Shadmani; Roba Khundkar; Daniel N. Kiirithio; Young-Eun Kim; Daniel Kim; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Hamidreza Komaki; Shivakumar K.M. Kondlahalli; Vladimir Andreevich Korshunov; Ai Koyanagi; Moritz U.G. Kraemer; Kewal Krishan; Burcu Kucuk Bicer; Nuworza Kugbey; Vivek Kumar; Nithin Kumar; G. Anil Kumar; Manasi Kumar; Girikumar Kumaresh; Om P. Kurmi; Oluwatosin Kuti; Carlo La Vecchia; Faris Hasan Lami; Prabhat Lamichhane; Justin J. Lang; Van C. Lansingh; Dennis Odai Laryea; Savita Lasrado; Arman Latifi; Paolo Lauriola; Janet L. Leasher; Shaun Wen Huey Lee; Tsegaye Lolaso Lenjebo; Miriam Levi; Shanshan Li; Shai Linn; Xuefeng Liu; Alan D. Lopez; Paulo A. Lotufo; Raimundas Lunevicius; Ronan A. Lyons; Mohammed Madadin; Muhammed Magdy Abd El Razek; Narayan Bahadur Mahotra; Marek Majdan; Azeem Majeed; Jeadran N. Malagon-Rojas; Venkatesh Maled; Reza Malekzadeh; Deborah Carvalho Malta; Navid Manafi; Amir Manafi; Ana-Laura Manda; Narayana Manjunatha; Fariborz Mansour-Ghanaei; Borhan Mansouri; Mohammad Ali Mansournia; Joemer C. Maravilla; Lyn M. March; Amanda J. Mason-Jones; Seyedeh Zahra Masoumi; Benjamin Ballard Massenburg; Pallab K. Maulik; Gebrekiros Gebremichael Meles; Addisu Melese; Zeleke Aschalew Melketsedik; Peter T.N. Memiah; Walter Mendoza; Ritesh G. Menezes; Meresa Berwo Mengesha; Melkamu Merid Mengesha; Tuomo J. Meretoja; Atte Meretoja; Hayimro Edemealem Merie; Tomislav Mestrovic; Bartosz Miazgowski; Tomasz Miazgowski; Ted R. Miller; G.K. Mini; Andreea Mirica; Erkin M. Mirrakhimov; Mehdi Mirzaei-Alavijeh; Prasanna Mithra; Babak Moazen; Masoud Moghadaszadeh; Efat Mohamadi; Yousef Mohammad; Karzan Abdulmuhsin Mohammad; Aso Mohammad Darwesh; Naser Mohammad Gholi Mezerji; Abdollah Mohammadian-Hafshejani; Milad Mohammadoo-Khorasani; Reza Mohammadpourhodki; Shafiu Mohammed; Jemal Abdu Mohammed; Farnam Mohebi; Mariam Molokhia; Lorenzo Monasta; Yoshan Moodley; Mahmood Moosazadeh; Masoud Moradi; Ghobad Moradi; Maziar Moradi-Lakeh; Farhad Moradpour; Lidia Morawska; Ilais Moreno Velásquez; Naho Morisaki; Shane Douglas Morrison; Tilahun Belete Mossie; Atalay Goshu Muluneh; Srinivas Murthy; Kamarul Imran Musa; Ghulam Mustafa; Ashraf F. Nabhan; Ahamarshan Jayaraman Nagarajan; Gurudatta Naik; Mukhammad David Naimzada; Farid Najafi; Vinay Nangia; Bruno Ramos Nascimento; Morteza Naserbakht; Vinod Nayak; Duduzile Edith Ndwandwe; Ionut Negoi; Josephine W. Ngunjiri; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Rajan Nikbakhsh; Dina Nur Anggraini Ningrum; Chukwudi A. Nnaji; Peter S. Nyasulu; Felix Akpojene Ogbo; Onome Bright Oghenetega; In-Hwan Oh; Emmanuel Wandera Okunga; Andrew T. Olagunju; Tinuke O. Olagunju; Ahmed Omar Bali; Obinna E. Onwujekwe; Kwaku Oppong Asante; Heather M. Orpana; Erika Ota; Nikita Otstavnov; Stanislav S. Otstavnov; P.A. Mahesh; Jagadish Rao Padubidri; Smita Pakhale; Keyvan Pakshir; Songhomitra Panda-Jonas; Eun-Kee Park; Sangram Kishor Patel; Ashish Pathak; Sanghamitra Pati; George C. Patton; Kebreab Paulos; Amy E. Peden; Veincent Christian Filipino Pepito; Jeevan Pereira; Hai Quang Pham; Michael R. Phillips; Marina Pinheiro; Roman V. Polibin; Suzanne Polinder; Hossein Poustchi; Swayam Prakash; Dimas Ria Angga Pribadi; Parul Puri; Zahiruddin Quazi Syed; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Anwar Rafay; Ata Rafiee; Alireza Rafiei; Fakher Rahim; Siavash Rahimi; Vafa Rahimi-Movaghar; Muhammad Aziz Rahman; Ali Rajabpour-Sanati; Fatemeh Rajati; Ivo Rakovac; Kavitha Ranganathan; Sowmya J. Rao; Vahid Rashedi; Prateek Rastogi; Priya Rathi; Salman Rawaf; Lal Rawal; Reza Rawassizadeh; Vishnu Renjith; Andre M.N. Renzaho; Serge Resnikoff; Aziz Rezapour; Ana Isabel Ribeiro; Jennifer Rickard; Carlos Miguel Rios González; Luca Ronfani; Gholamreza Roshandel; Anas M. Saad; Yogesh Damodar Sabde; Siamak Sabour; Basema Saddik; Saeed Safari; Roya Safari-Faramani; Hamid Safarpour; Mahdi Safdarian; S. Mohammad Sajadi; Payman Salamati; Farkhonde Salehi; Saleh Salehi Zahabi; Marwa R. Rashad Salem; Hosni Salem; Omar Salman; Inbal Salz; Abdallah M. Samy; Juan Sanabria; Lidia Sanchez Riera; Milena M. Santric Milicevic; Abdur Razzaque Sarker; Arash Sarveazad; Brijesh Sathian; Monika Sawhney; Susan M. Sawyer; Sonia Saxena; Mehdi Sayyah; David C. Schwebel; Soraya Seedat; Subramanian Senthilkumaran; Sadaf G. Sepanlou; Seyedmojtaba Seyedmousavi; Feng Sha; Faramarz Shaahmadi; Saeed Shahabi; Masood Ali Shaikh; Mehran Shams-Beyranvand; Morteza Shamsizadeh; Mahdi Sharif-Alhoseini; Hamid Sharifi; Aziz Sheikh; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Soraya Siabani; Inga Dora Sigfusdottir; Pankaj Kumar Singh; Jasvinder A. Singh; Dhirendra Narain Sinha; Catalin-Gabriel Smarandache; Emma U.R. Smith; Amin Soheili; Bija Soleymani; Ali Reza Soltanian; Joan B. Soriano; Muluken Bekele Sorrie; Ireneous N. Soyiri; Dan J. Stein; Mark A. Stokes; Babale Sufiyan Mu'awiyyah; Hafiz Ansar Rasul Suleria; Bryan L. Sykes; Rafael Tabarés-Seisdedos; Karen M. Tabb; Biruk Wogayehu Taddele; Degena Bahrey Tadesse; Animut Tagele Tamiru; Ingan Ukur Tarigan; Yonatal Mesfin Tefera; Arash Tehrani-Banihashemi; Merhawi Gebremedhin Tekle; Gebretsadkan Hintsa Tekulu; Ayenew Kassie Tesema; Berhe Etsay Tesfay; Rekha Thapar; Asres Bedaso Tilahune; Kenean Getaneh Tlaye; Hamid Reza Tohidinik; Roman Topor-Madry; Bach Xuan Tran; Khanh Bao Tran; Jaya Prasad Tripathy; Alexander C. Tsai; Lorainne Tudor Car; Saif Ullah; Irfan Ullah; Maida Umar; Bhaskaran Unnikrishnan; Era Upadhyay; Olalekan A. Uthman; Pascual R. Valdez; Tommi Juhani Vasankari; Narayanaswamy Venketasubramanian; Francesco S. Violante; Vasily Vlassov; Yasir Waheed; Girmay Teklay Weldesamuel; Andrea Werdecker; Taweewat Wiangkham; Haileab Fekadu Wolde; Dawit Habte Woldeyes; Dawit Zewdu Wondafrash; Temesgen Gebeyehu Wondmeneh; Adam Belay Wondmieneh; Ai-Min Wu; Rajaram Yadav; Ali Yadollahpour; Yuichiro Yano; Sanni Yaya; Vahid Yazdi-Feyzabadi; Paul Yip; Engida Yisma; Naohiro Yonemoto; Seok-Jun Yoon; Yoosik Youm; Mustafa Z. Younis; Zabihollah Yousefi; Yong Yu; Chuanhua Yu; Hasan Yusefzadeh; Telma Zahirian Moghadam; Zoubida Zaidi; Sojib Bin Zaman; Mohammad Zamani; Maryam Zamanian; Hamed Zandian; Ahmad Zarei; Fatemeh Zare; Zhi-Jiang Zhang; Yunquan Zhang; Sanjay Zodpey; Lalit Dandona; Rakhi Dandona; Louisa Degenhardt; Samath Dhamminda Dharmaratne; Simon I. Hay; Ali H. Mokdad; Robert C. Reiner; Benn Sartorius; Theo Vos
Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs). Findings In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505). Interpretation Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Global, regional, and national age-specific progress towards the 2020 milestones of the WHO End TB Strategy: a systematic analysis for the Global Burden of Disease Study 2021
(Elsevier Ltd, 2024) Jorge R. Ledesma; Jianing Ma; Meixin Zhang; Ann V. L. Basting; Huong Thi Chu; Avina Vongpradith; Amanda Novotney; Kate E. LeGrand; Yvonne Yiru Xu; Xiaochen Dai; Sneha Ingle Nicholson; Lauryn K. Stafford; Austin Carter; Jennifer M. Ross; Hedayat Abbastabar; Meriem Abdoun; Deldar Morad Abdulah; Richard Gyan Aboagye; Hassan Abolhassani; Woldu Aberhe Abrha; Hiwa Abubaker Ali; Eman Abu-Gharbieh; Salahdein Aburuz; Isaac Yeboah Addo; Abiola Victor Adepoju; Kishor Adhikari; Qorinah Estiningtyas Sakilah Adnani; Saryia Adra; Abel Afework; Shahin Aghamiri; Williams Agyemang-Duah; Bright Opoku Ahinkorah; Danish Ahmad; Sajjad Ahmad; Amir Mahmoud Ahmadzade; Haroon Ahmed; Mohammed Ahmed; Ayman Ahmed; Karolina Akinosoglou; Tareq Mohammed Ali Al-Ahdal; Nazmul Alam; Mohammed Albashtawy; Mohammad T. AlBataineh; Adel Ali Saeed Al-Gheethi; Abid Ali; Endale Alemayehu Ali; Liaqat Ali; Zahid Ali; Syed Shujait Shujait Ali; Kasim Allel; Awais Altaf; Jaffar A. Al-Tawfiq; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Reza Amani; Ganiyu Adeniyi Amusa; Jimoh Amzat; Jason R. Andrews; Abhishek Anil; Razique Anwer; Aleksandr Y. Aravkin; Damelash Areda; Anton A. Artamonov; Raphael Taiwo Aruleba; Mulusew A. Asemahagn; Sachin R. Atre; Avinash Aujayeb; Davood Azadi; Sina Azadnajafabad; Ahmed Y. Azzam; Muhammad Badar; Ashish D. Badiye; Sara Bagherieh; Saeed Bahadorikhalili; Atif Amin Baig; Maciej Banach; Biswajit Banik; Mainak Bardhan; Hiba Jawdat Barqawi; Zarrin Basharat; Pritish Baskaran; Saurav Basu; Maryam Beiranvand; Melaku Ashagrie Belete; Makda Abate Belew; Uzma Iqbal Belgaumi; Apostolos Beloukas; Paulo J. G. Bettencourt; Akshaya Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Ashish Bhargava; Vivek Bhat; Jasvinder Singh Bhatti; Gurjit Kaur Bhatti; Boris Bikbov; Veera R. Bitra; Vesna Bjegovic-Mikanovic; Danilo Buonsenso; Katrin Burkart; Yasser Bustanji; Zahid A. Butt; Paulo Camargos; Yu Cao; Sinclair Carr; Felix Carvalho; Luca Cegolon; Muthia Cenderadewi; Muge Cevik; Yaacoub Chahine; Vijay Kumar Chattu; Patrick R. Ching; Hitesh Chopra; Eunice Chung; Mareli M. Claassens; Kaleb Coberly; Natália Cruz-Martins; Bashir Dabo; Sriharsha Dadana; Omid Dadras; Isaac Darban; Jiregna Darega Gela; Aso Mohammad Darwesh; Mahmood Dashti; Berecha Hundessa Demessa; Biniyam Demisse; Solomon Demissie; Awoke Masrie Asrat Derese; Kebede Deribe; Hardik Dineshbhai Desai; Vinoth Gnana Chellaiyan Devanbu; Arkadeep Dhali; Kuldeep Dhama; Sameer Dhingra; Thao Huynh Phuong Do; Deepa Dongarwar; Haneil Larson Dsouza; John Dube; Arkadiusz Marian Dziedzic; Abdelaziz Ed-Dra; Ferry Efendi; Diyan Ermawan Effendi; Aziz Eftekharimehrabad; Nopryan Ekadinata; Temitope Cyrus Ekundayo; Muhammed Elhadi; Legesse Tesfaye Elilo; Theophilus I. Emeto; Luchuo Engelbert Bain; Adeniyi Francis Fagbamigbe; Ayesha Fahim; Alireza Feizkhah; Getahun Fetensa; Florian Fischer; Abduzhappar Gaipov; Aravind P. Gandhi; Rupesh K. Gautam; Miglas W. Gebregergis; Mesfin Gebrehiwot; Kahsu Gebrekirstos Gebrekidan; Kazem Ghaffari; Fariba Ghassemi; Ramy Mohamed Ghazy; Amador Goodridge; Anmol Goyal; Shi-Yang Guan; Mesay Dechasa Gudeta; Rashid Abdi Guled; Novianti Br Gultom; Veer Bala Gupta; Vivek Kumar Gupta; Sapna Gupta; Hailey Hagins; Semira Goitom Hailu; Wase Benti Hailu; Samer Hamidi; Asif Hanif; Harapan Harapan; Rumina Syeda Hasan; Shoaib Hassan; Johannes Haubold; Kamal Hezam; Sung Hwi Hong; Nobuyuki Horita; Md Belal Hossain; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Hong-Han Huynh; Segun Emmanuel Ibitoye; Kevin S. Ikuta; Irena M. Ilic; Milena D. Ilic; Md Rabiul Islam; Nahlah Elkudssiah Ismail; Faisal Ismail; Abdollah Jafarzadeh; Mihajlo Jakovljevic; Mahsa Jalili; Manthan Dilipkumar Janodia; Nabi Jomehzadeh; Jost B. Jonas; Nitin Joseph; Charity Ehimwenma Joshua; Zubair Kabir; Bhushan Dattatray Kamble; Tanuj Kanchan; Himal Kandel; Kehinde Kazeem Kanmodi; Rami S. Kantar; Ibraheem M. Karaye; Arman Karimi Behnagh; Gebrehiwot G. Kassa; Rimple Jeet Kaur; Navjot Kaur; Himanshu Khajuria; Faham Khamesipour; Yusra H. Khan; M. Nuruzzaman Khan; Mahammed Ziauddin Khan Suheb; Khaled Khatab; Fatemeh Khatami; Min Seo Kim; Soewarta Kosen; Parvaiz A. Koul; Sindhura Lakshmi Koulmane Laxminarayana; Kewal Krishan; Burcu Kucuk Bicer; Md Abdul Kuddus; Mukhtar Kulimbet; Nithin Kumar; Dharmesh Kumar Lal; Iván Landires; Kamaluddin Latief; Trang Diep Thanh Le; Thao Thi Thu Le; Caterina Ledda; Munjae Lee; Seung Won Lee; Temesgen L. Lerango; Stephen S. Lim; Chaojie Liu; Xuefeng Liu; Platon D. Lopukhov; Hong Luo; Hengliang Lv; Preetam Bhalchandra Mahajan; Amir Ali Mahboobipour; Azeem Majeed; Elaheh Malakan Rad; Kashish Malhotra; Muhammad Sajeel Ahmed Malik; Lesibana Anthony Malinga; Tauqeer Hussain Mallhi; Aseer Manilal; Bernardo Alfonso Martinez-Guerra; Francisco Rogerlândio Martins-Melo; Roy Rillera Marzo; Hossein Masoumi-Asl; Vasundhara Mathur; Richard James Maude; Ravi Mehrotra; Ziad A. Memish; Walter Mendoza; Ritesh G. Menezes; Muayad Aghali Merza; Tomislav Mestrovic; Laurette Mhlanga; Sanjeev Misra; Arup Kumar Misra; Prasanna Mithra; Babak Moazen; Hussen Mohammed; Ali H. Mokdad; Lorenzo Monasta; Catrin E. Moore; Parsa Mousavi; Francesk Mulita; Fungai Musaigwa; Raman Muthusamy; Ahamarshan Jayaraman Nagarajan; Pirouz Naghavi; Ganesh R. Naik; Gurudatta Naik; Sanjeev Nair; Tapas Sadasivan Nair; Zuhair S. Natto; Biswa Prakash Nayak; Hadush Negash; Dang H. Nguyen; Van Thanh Nguyen; Robina Khan Niazi; Chukwudi A. Nnaji; Lawrence Achilles Nnyanzi; Efaq Ali Noman; Shuhei Nomura; Bogdan Oancea; Kehinde O. Obamiro; Ismail A. Odetokun; Daniel Bogale Odo Odo; Oluwakemi Ololade Odukoya; In-Hwan Oh; Chukwuma O. Okereke; Osaretin Christabel Okonji; Eyal Oren; Edgar Ortiz-Brizuela; Uchechukwu Levi Osuagwu; Amel Ouyahia; P.A. Mahesh Padukudru; Pragyan Paramita Parija; Romil R. Parikh; Seoyeon Park; Ashwaghosha Parthasarathi; Shankargouda Patil; Shrikant Pawar; Minjin Peng; Veincent Christian Filipino Pepito; Prince Peprah; João Perdigão; Norberto Perico; Hoang Tran Pham; Maarten J. Postma; Attur Ravindra Attur Prabhu; Manya Prasad; Akila Prashant; Elton Junio Sady Prates; Fakher Rahim; Mosiur Rahman; Muhammad Aziz Rahman; Masoud Rahmati; Sathish Rajaa; Shakthi Kumaran Ramasamy; Indu Ramachandra Rao; Sowmya J. Rao; Deepthi Rapaka; Ahmed Mustafa Rashid; Zubair Ahmed Ratan; Nakul Ravikumar; Salman Rawaf; Murali Mohan Rama Krishna Reddy; Elrashdy Moustafa Mohamed Redwan; Giuseppe Remuzzi; Luis Felipe Reyes; Nazila Rezaei; Mohsen Rezaeian; Omid Rezahosseini; Mónica Rodrigues; Priyanka Roy; Guilherme de Andrade Ruela; Siamak Sabour; Basema Saddik; Umar Saeed; Sher Zaman Safi; Narjes Saheb Sharif-Askari; Fatemeh Saheb Sharif-Askari; Amirhossein Sahebkar; Biniyam Sahiledengle; Soumya Swaroop Sahoo; Nasir Salam; Afeez Abolarinwa Salami; Samreen Saleem; Mohamed A. Saleh; Hossein Samadi Kafil; Sara Samadzadeh; Yoseph Leonardo Samodra; Rama Krishna Sanjeev; Aswini Saravanan; Susan M. Sawyer; Siddharthan Selvaraj; Sabyasachi Senapati; Subramanian Senthilkumaran; Pritik A. Shah; Samiah Shahid; Masood Ali Shaikh; Sunder Sham; Mohammad Ali Shamshirgaran; Mohd Shanawaz; Medha Sharath; Samendra P. Sherchan; Ranjitha S. Shetty; Hesamaddin Shirzad-Aski; Aminu Shittu; Emmanuel Edwar Siddig; João Pedro Silva; Surjit Singh; Paramdeep Singh; Harpreet Singh; Jasvinder A. Singh; Md Shahjahan Siraj; Siswanto Siswanto; Ranjan Solanki; Yonatan Solomon; Joan B. Soriano; Chandrashekhar T. Sreeramareddy; Vijay Kumar Srivastava; Paschalis Steiropoulos; Chandan Kumar Swain; Takahiro Tabuchi; Mircea Tampa; Jacques J. L. Lukenze Tamuzi; Nathan Y. Tat; Razieh Tavakoli Oliaee; Gebrehiwot Teklay; Edosa Geta Tesfaye; Belay Tessema; Pugazhenthan Thangaraju; Rekha Thapar; Chern Choong Chern Thum; Jansje Henny Vera Ticoalu; Imad M. Tleyjeh; Ruoyan Tobe-Gai; Temesgen Mohammed Toma; Khai Hoan Tram; Aniefiok John Udoakang; Tungki Pratama Umar; Chukwuma David Umeokonkwo; Seyed Mohammad Vahabi; Asokan Govindaraj Vaithinathan; Job F. M. van Boven; Shoban Babu Varthya; Ziyue Wang; Muktar S. A. Warsame; Ronny Westerman; Tewodros Eshete Wonde; Sajad Yaghoubi; Siyan Yi; Vahit Yigit; Dong Keon Yon; Naohiro Yonemoto; Chuanhua Yu; Fathiah Zakham; Moein Zangiabadian; Francis Zeukeng; Haijun Zhang; Yang Zhao; Peng Zheng; Magdalena Zielinska; Joshua A. Salomon; Robert C. Reiner; Mohsen Naghavi; Theo Vos; Simon I. Hay; Christopher J. L. Murray; Hmwe Hmwe Kyu
Background: Global evaluations of the progress towards the WHO End TB Strategy 2020 interim milestones on mortality (35% reduction) and incidence (20% reduction) have not been age specific. We aimed to assess global, regional, and national-level burdens of and trends in tuberculosis and its risk factors across five separate age groups, from 1990 to 2021, and to report on age-specific progress between 2015 and 2020. Methods: We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021) analytical framework to compute age-specific tuberculosis mortality and incidence estimates for 204 countries and territories (1990–2021 inclusive). We quantified tuberculosis mortality among individuals without HIV co-infection using 22 603 site-years of vital registration data, 1718 site-years of verbal autopsy data, 825 site-years of sample-based vital registration data, 680 site-years of mortality surveillance data, and 9 site-years of minimally invasive tissue sample (MITS) diagnoses data as inputs into the Cause of Death Ensemble modelling platform. Age-specific HIV and tuberculosis deaths were established with a population attributable fraction approach. We analysed all available population-based data sources, including prevalence surveys, annual case notifications, tuberculin surveys, and tuberculosis mortality, in DisMod-MR 2.1 to produce internally consistent age-specific estimates of tuberculosis incidence, prevalence, and mortality. We also estimated age-specific tuberculosis mortality without HIV co-infection that is attributable to the independent and combined effects of three risk factors (smoking, alcohol use, and diabetes). As a secondary analysis, we examined the potential impact of the COVID-19 pandemic on tuberculosis mortality without HIV co-infection by comparing expected tuberculosis deaths, modelled with trends in tuberculosis deaths from 2015 to 2019 in vital registration data, with observed tuberculosis deaths in 2020 and 2021 for countries with available cause-specific mortality data. Findings: We estimated 9·40 million (95% uncertainty interval [UI] 8·36 to 10·5) tuberculosis incident cases and 1·35 million (1·23 to 1·52) deaths due to tuberculosis in 2021. At the global level, the all-age tuberculosis incidence rate declined by 6·26% (5·27 to 7·25) between 2015 and 2020 (the WHO End TB strategy evaluation period). 15 of 204 countries achieved a 20% decrease in all-age tuberculosis incidence between 2015 and 2020, eight of which were in western sub-Saharan Africa. When stratified by age, global tuberculosis incidence rates decreased by 16·5% (14·8 to 18·4) in children younger than 5 years, 16·2% (14·2 to 17·9) in those aged 5–14 years, 6·29% (5·05 to 7·70) in those aged 15–49 years, 5·72% (4·02 to 7·39) in those aged 50–69 years, and 8·48% (6·74 to 10·4) in those aged 70 years and older, from 2015 to 2020. Global tuberculosis deaths decreased by 11·9% (5·77 to 17·0) from 2015 to 2020. 17 countries attained a 35% reduction in deaths due to tuberculosis between 2015 and 2020, most of which were in eastern Europe (six countries) and central Europe (four countries). There was variable progress by age: a 35·3% (26·7 to 41·7) decrease in tuberculosis deaths in children younger than 5 years, a 29·5% (25·5 to 34·1) decrease in those aged 5–14 years, a 15·2% (10·0 to 20·2) decrease in those aged 15–49 years, a 7·97% (0·472 to 14·1) decrease in those aged 50–69 years, and a 3·29% (–5·56 to 9·07) decrease in those aged 70 years and older. Removing the combined effects of the three attributable risk factors would have reduced the number of all-age tuberculosis deaths from 1·39 million (1·28 to 1·54) to 1·00 million (0·703 to 1·23) in 2020, representing a 36·5% (21·5 to 54·8) reduction in tuberculosis deaths compared to those observed in 2015. 41 countries were included in our analysis of the impact of the COVID-19 pandemic on tuberculosis deaths without HIV co-infection in 2020, and 20 countries were included in the analysis for 2021. In 2020, 50 900 (95% CI 49 700 to 52 400) deaths were expected across all ages, compared to an observed 45 500 deaths, corresponding to 5340 (4070 to 6920) fewer deaths; in 2021, 39 600 (38 300 to 41 100) deaths were expected across all ages compared to an observed 39 000 deaths, corresponding to 657 (–713 to 2180) fewer deaths. Interpretation: Despite accelerated progress in reducing the global burden of tuberculosis in the past decade, the world did not attain the first interim milestones of the WHO End TB Strategy in 2020. The pace of decline has been unequal with respect to age, with older adults (ie, those aged >50 years) having the slowest progress. As countries refine their national tuberculosis programmes and recalibrate for achieving the 2035 targets, they could consider learning from the strategies of countries that achieved the 2020 milestones, as well as consider targeted interventions to improve outcomes in older age groups. Funding: Bill & Melinda Gates Foundation. © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the Global Burden of Diseases Study 2019
(Elsevier Ltd, 2021) Deepa Jahagirdar; Magdalene K. Walters; Amanda Novotney; Edmond D. Brewer; Tahvi D. Frank; Austin Carter; Molly H. Biehl; Hedayat Abbastabar; E.S. Abhilash; Eman Abu-Gharbieh; Laith Jamal Abu-Raddad; Victor Adekanmbi; Daniel Adedayo Adeyinka; Qorinah Estiningtyas Sakilah Adnani; Saira Afzal; Soodabeh Aghababaei; Bright Opoku Ahinkorah; Sajjad Ahmad; Keivan Ahmadi; Sepideh Ahmadi; Ehsan Ahmadpour; Muktar Beshir Ahmed; Tarik Ahmed Rashid; Yusra Ahmed Salih; Addis Aklilu; Tayyaba Akram; Chisom Joyqueenet Akunna; Hanadi Al Hamad; Fares Alahdab; Fahad Mashhour Alanezi; Ekaterina A. Aleksandrova; Kefyalew Addis Alene; Liaqat Ali; Vahid Alipour; Sami Almustanyir; Nelson Alvis-Guzman; Edward Kwabena Ameyaw; Hubert Amu; Catalina Liliana Andrei; Tudorel Andrei; Davood Anvari; Jalal Arabloo; Olatunde Aremu; Judie Arulappan; Desta Debalkie Atnafu; Beatriz Paulina Ayala Quintanilla; Muluken Altaye Ayza; Samad Azari; B.B. Darshan; Maciej Banach; Till Winfried Bärnighausen; Fabio Barra; Amadou Barrow; Sanjay Basu; Shahrzad Bazargan-Hejazi; Habtamu Gebrehana Belay; Tezera Moshago Berheto; Woldesellassie Mequanint Bezabhe; Yihienew Mequanint Bezabih; Akshaya Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Krittika Bhattacharyya; Sadia Bibi; Ali Bijani; Catherine Bisignano; Obasanjo Afolabi Bolarinwa; Archith Boloor; Azizbek A. Boltaev; Nikolay Ivanovich Briko; Danilo Buonsenso; Katrin Burkart; Zahid A. Butt; Chao Cao; Jaykaran Charan; Souranshu Chatterjee; Soosanna Kumary Chattu; Vijay Kumar Chattu; Sonali Gajanan Choudhari; Dinh-Toi Chu; Rosa A.S. Couto; Richard G. Cowden; Berihun Assefa Dachew; Omid Dadras; Amare Belachew Dagnew; Saad M.A. Dahlawi; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; José das Neves; Louisa Degenhardt; Feleke Mekonnen Demeke; Abebaw Alemayehu Desta; Keshab Deuba; Deepak Dhamnetiya; Govinda Prasad Dhungana; Mostafa Dianatinasab; Daniel Diaz; Shirin Djalalinia; Linh Phuong Doan; Fariba Dorostkar; Hisham Atan Edinur; Andem Effiong; Sahar Eftekharzadeh; Maysaa El Sayed Zaki; Rajesh Elayedath; Muhammed Elhadi; Shaimaa I. El-Jaafary; Ziad El-Khatib; Aisha Elsharkawy; Aklilu Endalamaw; Aman Yesuf Endries; Sharareh Eskandarieh; Ifeanyi Jude Ezeonwumelu; Sayeh Ezzikouri; Mohammad Farahmand; Emerito Jose A. Faraon; Abidemi Omolara Fasanmi; Simone Ferrero; Lorenzo Ferro Desideri; Irina Filip; Florian Fischer; Morenike Oluwatoyin Folayan; Masoud Foroutan; Takeshi Fukumoto; Mohamed M. Gad; Muktar A. Gadanya; Abhay Motiramji Gaidhane; Tushar Garg; Reta Tsegaye Gayesa; Eyob Alemayehu Gebreyohannes; Hailay Abrha Gesesew; Abera Getachew Obsa; Keyghobad Ghadiri; Ahmad Ghashghaee; Syed Amir Gilani; Themba G. Ginindza; Ionela-Roxana Glăvan; Ekaterina Vladimirovna Glushkova; Mahaveer Golechha; Harish Chander Gugnani; Bhawna Gupta; Sapna Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Samer Hamidi; Senad Handanagic; Shafiul Haque; Harapan Harapan; Arief Hargono; Ahmed I. Hasaballah; Abdiwahab Hashi; Shoaib Hassan; Soheil Hassanipour; Khezar Hayat; Ileana Heredia-Pi; Kamal Hezam; Ramesh Holla; Praveen Hoogar; Mohammad Enamul Hoque; Mostafa Hosseini; Mehdi Hosseinzadeh; Mohamed Hsairi; Rabia Hussain; Segun Emmanuel Ibitoye; Bulat Idrisov; Kevin S. Ikuta; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Seyed Sina Naghibi Irvani; M. Mofizul Islam; Nahlah Elkudssiah Ismail; Ramaiah Itumalla; Ihoghosa Osamuyi Iyamu; Roxana Jabbarinejad; Vardhmaan Jain; Ranil Jayawardena; Ravi Prakash Jha; Nitin Joseph; Ali Kabir; Zubair Kabir; Rohollah Kalhor; Feroze Kaliyadan; Ashwin Kamath; Tanuj Kanchan; Himal Kandel; Getinet Kassahun; Patrick D.M.C. Katoto; Gbenga A. Kayode; Ermiyas Mulu Kebede; Hafte Kahsay Kebede; Himanshu Khajuria; Nauman Khalid; Ejaz Ahmad Khan; Gulfaraz Khan; Khaled Khatab; Min Seo Kim; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Sonali Kochhar; Vladimir Andreevich Korshunov; Parvaiz A. Koul; Sindhura Lakshmi Koulmane Laxminarayana; Ai Koyanagi; Kewal Krishan; Barthelemy Kuate Defo; G. Anil Kumar; Manasi Kumar; Nithin Kumar; Alexander Kwarteng; Dharmesh Kumar Lal; Iván Landires; Savita Lasrado; Zohra S. Lassi; Jeffrey V. Lazarus; Jane Jean-Hee Lee; Yeong Yeh Lee; Kate E. LeGrand; Christine Lin; Xuefeng Liu; Emilie R. Maddison; Hassan Magdy Abd El Razek; Phetole Walter Mahasha; Azeem Majeed; Alaa Makki; Ahmad Azam Malik; Wondimu Ayele Manamo; Mohammad Ali Mansournia; Francisco Rogerlândio Martins-Melo; Seyedeh Zahra Masoumi; Ziad A. Memish; Ritesh G. Menezes; Endalkachew Worku Mengesha; Hayimro Edemealem Merie; Amanual Getnet Mersha; Tomislav Mestrovic; Peter Meylakhs; Nour Mheidly; Ted R. Miller; Andreea Mirica; Babak Moazen; Yousef Mohammad; Mokhtar Mohammadi; Arif Mohammed; Salahuddin Mohammed; Shafiu Mohammed; Modhurima Moitra; Ali H. Mokdad; Mariam Molokhia; Mohammad Ali Moni; Ghobad Moradi; Yousef Moradi; Christine Mpundu-Kaambwa; Sumaira Mubarik; Sandra B. Munro; Lillian Mwanri; Jean B. Nachega; Ahamarshan Jayaraman Nagarajan; Aparna Ichalangod Narayana; Muhammad Naveed; Biswa Prakash Nayak; Sabina O. Nduaguba; Sandhya Neupane Kandel; Georges Nguefack-Tsague; Trang Huyen Nguyen; Molly R. Nixon; Chukwudi A. Nnaji; Jean Jacques Noubiap; Virginia Nuñez-Samudio; Thomas Elliot Nyirenda; Onome Bright Oghenetega; Andrew T. Olagunju; Babayemi Oluwaseun Olakunde; Oluwatomi Funbi Owopetu; P.A. Mahesh; Jagadish Rao Padubidri; Smita Pakhale; Tarang Parekh; Fatemeh Pashazadeh Kan; Shrikant Pawar; Veincent Christian Filipino Pepito; Emmanuel K. Peprah; Marina Pinheiro; Khem Narayan Pokhrel; Roman V. Polibin; Richard Charles G. Pollok; Maarten J. Postma; Zahiruddin Quazi Syed; Amir Radfar; Raghu Anekal Radhakrishnan; Fakher Rahim; Vafa Rahimi-Movaghar; Shadi Rahimzadeh; Mosiur Rahman; Amir Masoud Rahmani; Pradhum Ram; Chhabi Lal Ranabhat; Priyanga Ranasinghe; Chythra R. Rao; Sowmya J. Rao; Priya Rathi; David Laith Rawaf; Salman Rawaf; Lemma Demissie Regassa; Inayat ur Rehman; Andre M.N. Renzaho; Nima Rezaei; Omid Rezahosseini; Mohammad Sadegh Rezai; Aziz Rezapour; Rezaul Karim Ripon; Voilet Rodrigues; Denis O. Roshchin; Godfrey M. Rwegerera; Umar Saeed; Sahar Saeedi Moghaddam; Rajesh Sagar; K.M. Saif-Ur-Rahman; Marwa Rashad Salem; Mehrnoosh Samaei; Abdallah M. Samy; Milena M. Santric-Milicevic; Satish Saroshe; Brijesh Sathian; Maheswar Satpathy; Monika Sawhney; Aletta Elisabeth Schutte; Allen Seylani; Masood Ali Shaikh; Mohammed Feyisso Shaka; Hina Shamshad; Morteza Shamsizadeh; Mohammed Shannawaz; Adithi Shetty; Jae Il Shin; K.M. Shivakumar; Jasvinder A. Singh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Ranjani Somayaji; Sergey Soshnikov; Emma Elizabeth Spurlock; Dan J. Stein; Mu'awiyyah Babale Sufiyan; Hooman Tadbiri; Birkneh Tilahun Tadesse; Eyayou Girma Tadesse; Animut Tagele Tamiru; Elvis Enowbeyang Tarkang; Nuno Taveira; Yohannes Tekalegn; Fisaha Haile Tesfay; Gizachew Assefa Tessema; Rekha Thapar; Marcos Roberto Tovani-Palone; Eugenio Traini; Bach Xuan Tran; Alexander C. Tsai; Biruk Shalmeno Tusa; Saif Ullah; Chukwuma David Umeokonkwo; Bhaskaran Unnikrishnan; Sahel Valadan Tahbaz; Jorge Hugo Villafañe; Sergey Konstantinovitch Vladimirov; Bay Vo; Avina Vongpradith; Giang Thu Vu; Yasir Waheed; Richard G. Wamai; Guan Wang; Yanzhong Wang; Paul Ward; Ronny Westerman; Andrea Sylvia Winkler; Lalit Yadav; Seyed Hossein Yahyazadeh Jabbari; Taklo Simeneh Yazie; Siyan Yi; Vahit Yiğit; Birhanu Wubale Yirdaw; Naohiro Yonemoto; Chuanhua Yu; Ismaeel Yunusa; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Zhi-Jiang Zhang; Alimuddin Zumla; Joshua A. Salomon; Jeffrey W. Eaton; Mohsen Naghavi; Laura Dwyer-Lindgren; Haidong Wang; Stephen S. Lim; Simon I. Hay; Christopher J.L. Murray; Hmwe H. Kyu
Background: The sustainable development goals (SDGs) aim to end HIV/AIDS as a public health threat by 2030. Understanding the current state of the HIV epidemic and its change over time is essential to this effort. This study assesses the current sex-specific HIV burden in 204 countries and territories and measures progress in the control of the epidemic. Methods: To estimate age-specific and sex-specific trends in 48 of 204 countries, we extended the Estimation and Projection Package Age-Sex Model to also implement the spectrum paediatric model. We used this model in cases where age and sex specific HIV-seroprevalence surveys and antenatal care-clinic sentinel surveillance data were available. For the remaining 156 of 204 locations, we developed a cohort-incidence bias adjustment to derive incidence as a function of cause-of-death data from vital registration systems. The incidence was input to a custom Spectrum model. To assess progress, we measured the percentage change in incident cases and deaths between 2010 and 2019 (threshold >75% decline), the ratio of incident cases to number of people living with HIV (incidence-to-prevalence ratio threshold <0·03), and the ratio of incident cases to deaths (incidence-to-mortality ratio threshold <1·0). Findings: In 2019, there were 36·8 million (95% uncertainty interval [UI] 35·1–38·9) people living with HIV worldwide. There were 0·84 males (95% UI 0·78–0·91) per female living with HIV in 2019, 0·99 male infections (0·91–1·10) for every female infection, and 1·02 male deaths (0·95–1·10) per female death. Global progress in incident cases and deaths between 2010 and 2019 was driven by sub-Saharan Africa (with a 28·52% decrease in incident cases, 95% UI 19·58–35·43, and a 39·66% decrease in deaths, 36·49–42·36). Elsewhere, the incidence remained stable or increased, whereas deaths generally decreased. In 2019, the global incidence-to-prevalence ratio was 0·05 (95% UI 0·05–0·06) and the global incidence-to-mortality ratio was 1·94 (1·76–2·12). No regions met suggested thresholds for progress. Interpretation: Sub-Saharan Africa had both the highest HIV burden and the greatest progress between 1990 and 2019. The number of incident cases and deaths in males and females approached parity in 2019, although there remained more females with HIV than males with HIV. Globally, the HIV epidemic is far from the UNAIDS benchmarks on progress metrics. Funding: The Bill & Melinda Gates Foundation, the National Institute of Mental Health of the US National Institutes of Health (NIH), and the National Institute on Aging of the NIH. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Mapping development and health effects of cooking with solid fuels in low-income and middle-income countries, 2000–18: a geospatial modelling study
(Elsevier Ltd, 2022) Joseph Jon Frostad; QuynhAnh P. Nguyen; Mathew M. Baumann; Brigette F. Blacker; Laurie B. Marczak; Aniruddha Deshpande; Kirsten E. Wiens; Kate E. LeGrand; Kimberly B. Johnson; Mohsen Abbasi-Kangevari; Amir Abdoli; Hassan Abolhassani; Lucas Guimarães Abreu; Michael R. M. Abrigo; Niveen M.E. Abu-Rmeileh; Victor Adekanmbi; Anurag Agrawal; Muktar Beshir Ahmed; Ziyad Al-Aly; Fahad Mashhour Alanezi; Jacqueline Elizabeth Alcalde-Rabanal; Vahid Alipour; Khalid A. Altirkawi; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Adeladza Kofi Amegah; Saeed Amini; Fatemeh Amiri; Dickson A. Amugsi; Robert Ancuceanu; Catalina Liliana Andrei; Tudorel Andrei; Ernoiz Antriyandarti; Davood Anvari; Jalal Arabloo; Morteza Arab-Zozani; Seyyed Shamsadin Athari; Marcel Ausloos; Getinet Ayano; Yared Asmare Aynalem; Samad Azari; Ashish D. Badiye; Atif Amin Baig; Kalpana Balakrishnan; Maciej Banach; Sanjay Basu; Neeraj Bedi; Michelle L. Bell; Derrick A. Bennett; Krittika Bhattacharyya; Zulfiqar A. Bhutta; Sadia Bibi; Somayeh Bohlouli; Soufiane Boufous; Nicola Luigi Bragazzi; Dejana Braithwaite; Sharath Burugina Nagaraja; Zahid A. Butt; Florentino Luciano Caetano Dos Santos; Josip Car; Rosario Cárdenas; Felix Carvalho; Joao Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Ester Cerin; Soosanna Kumary Chattu; Vijay Kumar Chattu; Pankaj Chaturvedi; Sarika Chaturvedi; Simiao Chen; Dinh-Toi Chu; Sheng-Chia Chung; Saad M. A. Dahlawi; Giovanni Damiani; Lalit Dandona; Rakhi Dandona; Aso Mohammad Darwesh; Jai K. Das; Aditya Prasad Dash; Claudio Alberto Dávila-Cervantes; Diego De Leo; Jan-Walter De Neve; Getu Debalkie Demissie; Edgar Denova-Gutiérrez; Sagnik Dey; Samath Dhamminda Dharmaratne; Meghnath Dhimal; Govinda Prasad Dhungana; Daniel Diaz; Isaac Oluwafemi Dipeolu; Fariba Dorostkar; Leila Doshmangir; Andre Rodrigues Duraes; Hisham Atan Edinur; Ferry Efendi; Maha El Tantawi; Sharareh Eskandarieh; Ibtihal Fadhil; Nazir Fattahi; Nelsensius Klau Fauk; Seyed-Mohammad Fereshtehnejad; Morenike Oluwatoyin Folayan; Masoud Foroutan; Takeshi Fukumoto; Abhay Motiramji Gaidhane; Mansour Ghafourifard; Ahmad Ghashghaee; Syed Amir Gilani; Tiffany K. Gill; Alessandra C. Goulart; Bárbara Niegia Garcia Goulart; Ayman Grada; Mohammed Ibrahim Mohialdeen Gubari; Davide Guido; Yuming Guo; Rajat Das Gupta; Rajeev Gupta; Reyna Alma Gutiérrez; Nima Hafezi-Nejad; Randah R. Hamadeh; Ahmed I. Hasaballah; Soheil Hassanipour; Khezar Hayat; Behzad Heibati; Reza Heidari-Soureshjani; Nathaniel J. Henry; Claudiu Herteliu; Mehdi Hosseinzadeh; Mohamed Hsairi; Guoqing Hu; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Chidozie C. D. Iwu; Jalil Jaafari; Mihajlo Jakovljevic; Tahereh Javaheri; Ravi Prakash Jha; John S. Ji; Jost B. Jonas; Ali Kabir; Zubair Kabir; Rohollah Kalhor; Naser Kamyari; Tanuj Kanchan; Umesh Kapil; Neeti Kapoor; Gbenga A. Kayode; Peter Njenga Keiyoro; Yousef Saleh Khader; Nauman Khalid; Ejaz Ahmad Khan; Maseer Khan; Md Nuruzzaman Khan; Khaled Khatab; Mona M. Khater; Mahalaqua Nazli Khatib; Maryam Khayamzadeh; Jagdish Khubchandani; Gyu Ri Kim; Yun Jin Kim; Ruth W. Kimokoti; Adnan Kisa; Sezer Kisa; Luke D. Knibbs; Parvaiz A. Koul; Ai Koyanagi; Kewal Krishan; G. Anil Kumar; Manasi Kumar; Dian Kusuma; Carlo La Vecchia; Ben Lacey; Faris Hasan Lami; Qing Lan; Savita Lasrado; Paolo Lauriola; Paul H. Lee; Sonia Lewycka; Shanshan Li; Daiane Borges Machado; Phetole Walter Mahasha; Mina Maheri; Azeem Majeed; Afshin Maleki; Reza Malekzadeh; Deborah Carvalho Malta; Borhan Mansouri; Mohammad Ali Mansournia; Natalie Maria Martinez; Santi Martini; Francisco Rogerlândio Martins-Melo; Benjamin K. Mayala; Man Mohan Mehndiratta; Walter Mendoza; Ritesh G. Menezes; Endalkachew Worku Mengesha; Tuomo J. Meretoja; Tomislav Mestrovic; Irmina Maria Michalek; Erkin M. Mirrakhimov; Maryam Mirzaei; Roya Mirzaei; Babak Moazen; Yousef Mohammad; Abdollah Mohammadian-Hafshejani; Shafiu Mohammed; Ali H. Mokdad; Lorenzo Monasta; Maziar Moradi-Lakeh; Paula Moraga; Lidia Morawska; Abbas Mosapour; Simin Mouodi; Amin Mousavi Khaneghah; Satinath Mukhopadhyay; Sandra B. Munro; Christopher J. L. Murray; Ahamarshan Jayaraman Nagarajan; Mohsen Naghavi; Sanjeev Nair; Vinay Nangia; Bruno Ramos Nascimento; Javad Nazari; Ionut Negoi; Henok Biresaw Netsere; Josephine W. Ngunjiri; Huong Lan Thi Nguyen; Jean Jacques Noubiap; Bogdan Oancea; Felix Akpojene Ogbo; In-Hwan Oh; Andrew T. Olagunju; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Ahmed Omar Bali; Obinna E. Onwujekwe; Nikita Otstavnov; Stanislav S. Otstavnov; Mayowa O. Owolabi; P.A. Mahesh; Anamika Pandey; Eun-Cheol Park; Eun-Kee Park; Sangram Kishor Patel; Hai Quang Pham; Thomas Pilgrim; Meghdad Pirsaheb; Khem Narayan Pokhrel; Maarten J. Postma; Zahiruddin Quazi Syed; Navid Rabiee; Amir Radfar; Fakher Rahim; Mohammad Hifz Ur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Chhabi Lal Ranabhat; Sowmya J. Rao; Davide Rasella; Prateek Rastogi; Goura Kishor Rath; David Laith Rawaf; Salman Rawaf; Lal Rawal; Reza Rawassizadeh; Andre M. N. Renzaho; Bhageerathy Reshmi; Negar Rezaei; Nima Rezaei; Aziz Rezapour; Jennifer Rickard; Leonardo Roever; Luca Ronfani; Morteza Rostamian; Enrico Rubagotti; Godfrey M. Rwegerera; Basema Saddik; Ehsan Sadeghi; Sahar Saeedi Moghaddam; Rajesh Sagar; Amirhossein Sahebkar; Biniyam Sahiledengle; Marwa Rashad Salem; Abdallah M. Samy; Milena M. Santric-Milicevic; Sivan Yegnanarayana Iyer Saraswathy; Brijesh Sathian; Thirunavukkarasu Sathish; David C. Schwebel; Sadaf G. Sepanlou; Saeed Shahabi; Amira A. Shaheen; Izza Shahid; Masood Ali Shaikh; Ali S. Shalash; Mehran Shams-Beyranvand; Mohammed Shannawaz; Kiomars Sharafi; Aziz Sheikh; Sara Sheikhbahaei; Ranjitha S. Shetty; Wondimeneh Shibabaw Shiferaw; Mika Shigematsu; Jae Il Shin; K.M. Shivakumar; Soraya Siabani; Tariq Jamal Siddiqi; Balbir Bagicha Singh; Jasvinder A. Singh; Yitagesu Sintayehu; Muluken Bekele Sorrie; Ireneous N. Soyiri; Emma Elizabeth Spurlock; Chandrashekhar T. Sreeramareddy; Leo Stockfelt; Mu'awiyyah Babale Sufiyan; Rizwan Suliankatchi Abdulkader; Rafael Tabarés-Seisdedos; Takahiro Tabuchi; Amir Taherkhani; Mohamad-Hani Temsah; Kavumpurathu Raman Thankappan; Marcos Roberto Tovani-Palone; Eugenio Traini; Saif Ullah; Bhaskaran Unnikrishnan; Era Upadhyay; Sahel Valadan Tahbaz; Santosh Varughese; Francesco S. Violante; Bay Vo; Giang Thu Vu; Yasir Waheed; Yuan-Pang Wang; Catherine A. Welgan; Andrea Werdecker; Seyed Hossein Yahyazadeh Jabbari; Sanni Yaya; Vahid Yazdi-Feyzabadi; Mekdes Tigistu Yilma; Naohiro Yonemoto; Mustafa Z. Younis; Taraneh Yousefinezhadi; Chuanhua Yu; Yong Yu; Sojib Bin Zaman; Yunquan Zhang; Zhi-Jiang Zhang; Michael Brauer; Simon I. Hay; Robert C. Reiner
Background: More than 3 billion people do not have access to clean energy and primarily use solid fuels to cook. Use of solid fuels generates household air pollution, which was associated with more than 2 million deaths in 2019. Although local patterns in cooking vary systematically, subnational trends in use of solid fuels have yet to be comprehensively analysed. We estimated the prevalence of solid-fuel use with high spatial resolution to explore subnational inequalities, assess local progress, and assess the effects on health in low-income and middle-income countries (LMICs) without universal access to clean fuels. Methods: We did a geospatial modelling study to map the prevalence of solid-fuel use for cooking at a 5 km × 5 km resolution in 98 LMICs based on 2·1 million household observations of the primary cooking fuel used from 663 population-based household surveys over the years 2000 to 2018. We use observed temporal patterns to forecast household air pollution in 2030 and to assess the probability of attaining the Sustainable Development Goal (SDG) target indicator for clean cooking. We aligned our estimates of household air pollution to geospatial estimates of ambient air pollution to establish the risk transition occurring in LMICs. Finally, we quantified the effect of residual primary solid-fuel use for cooking on child health by doing a counterfactual risk assessment to estimate the proportion of deaths from lower respiratory tract infections in children younger than 5 years that could be associated with household air pollution. Findings: Although primary reliance on solid-fuel use for cooking has declined globally, it remains widespread. 593 million people live in districts where the prevalence of solid-fuel use for cooking exceeds 95%. 66% of people in LMICs live in districts that are not on track to meet the SDG target for universal access to clean energy by 2030. Household air pollution continues to be a major contributor to particulate exposure in LMICs, and rising ambient air pollution is undermining potential gains from reductions in the prevalence of solid-fuel use for cooking in many countries. We estimated that, in 2018, 205 000 (95% uncertainty interval 147 000–257 000) children younger than 5 years died from lower respiratory tract infections that could be attributed to household air pollution. Interpretation: Efforts to accelerate the adoption of clean cooking fuels need to be substantially increased and recalibrated to account for subnational inequalities, because there are substantial opportunities to improve air quality and avert child mortality associated with household air pollution. Funding: Bill & Melinda Gates Foundation. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17
(Elsevier Ltd, 2020) Aniruddha Deshpande; Molly K. Miller-Petrie; Paulina A. Lindstedt; Mathew M. Baumann; Kimberly B. Johnson; Brigette F. Blacker; Hedayat Abbastabar; Foad Abd-Allah; Ahmed Abdelalim; Ibrahim Abdollahpour; Kedir Hussein Abegaz; Ayenew Negesse Abejie; Lucas Guimarães Abreu; Michael R. M. Abrigo; Ahmed Abualhasan; Manfred Mario Kokou Accrombessi; Abdu A. Adamu; Oladimeji M. Adebayo; Isaac Akinkunmi Adedeji; Rufus Adesoji Adedoyin; Victor Adekanmbi; Olatunji O. Adetokunboh; Tara Ballav Adhikari; Mohsen Afarideh; Marcela Agudelo-Botero; Mehdi Ahmadi; Keivan Ahmadi; Anwar E. Ahmed; Muktar Beshir Ahmed; Temesgen Yihunie Akalu; Ali S. Akanda; Fares Alahdab; Ziyad Al-Aly; Noore Alam; Samiah Alam; Genet Melak Alamene; Turki M. Alanzi; James Albright; Ammar Albujeer; Jacqueline Elizabeth Alcalde-Rabanal; Animut Alebel; Zewdie Aderaw Alemu; Muhammad Ali; Mehran Alijanzadeh; Vahid Alipour; Syed Mohamed Aljunid; Ali Almasi; Amir Almasi-Hashiani; Hesham M. Al-Mekhlafi; Khalid A. Altirkawi; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Saeed Amini; Arianna Maever L. Amit; Gianna Gayle Herrera Amul; Catalina Liliana Andrei; Mina Anjomshoa; Ansariadi Ansariadi; Carl Abelardo T. Antonio; Benny Antony; Ernoiz Antriyandarti; Jalal Arabloo; Hany Mohamed Amin Aref; Olatunde Aremu; Bahram Armoon; Amit Arora; Krishna K. Aryal; Afsaneh Arzani; Mehran Asadi-Aliabadi; Daniel Asmelash; Hagos Tasew Atalay; Seyyed Shamsadin Athari; Seyyede Masoume Athari; Sachin R. Atre; Marcel Ausloos; Shally Awasthi; Nefsu Awoke; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Yared Asmare Aynalem; Samad Azari; Andrew S. Azman; Ebrahim Babaee; Alaa Badawi; Mojtaba Bagherzadeh; Shankar M. Bakkannavar; Senthilkumar Balakrishnan; Maciej Banach; Joseph Adel Mattar Banoub; Aleksandra Barac; Miguel A. Barboza; Till Winfried Bärnighausen; Sanjay Basu; Vo Dinh Bay; Mohsen Bayati; Neeraj Bedi; Mahya Beheshti; Meysam Behzadifar; Masoud Behzadifar; Diana Fernanda Bejarano Ramirez; Michelle L. Bell; Derrick A. Bennett; Habib Benzian; Dessalegn Ajema Berbada; Robert S. Bernstein; Anusha Ganapati Bhat; Krittika Bhattacharyya; Soumyadeep Bhaumik; Zulfiqar A. Bhutta; Ali Bijani; Boris Bikbov; Muhammad Shahdaat Bin Sayeed; Raaj Kishore Biswas; Somayeh Bohlouli; Soufiane Boufous; Oliver J. Brady; Andrey Nikolaevich Briko; Nikolay Ivanovich Briko; Gabrielle B. Britton; Alexandria Brown; Sharath Burugina Nagaraja; Zahid A. Butt; Luis Alberto Cámera; Ismael R. Campos-Nonato; Julio Cesar Campuzano Rincon; Jorge Cano; Josip Car; Rosario Cárdenas; Felix Carvalho; Carlos A. Castañeda-Orjuela; Franz Castro; Ester Cerin; Binaya Chalise; Vijay Kumar Chattu; Ken Lee Chin; Devasahayam J. Christopher; Dinh-Toi Chu; Natalie Maria Cormier; Vera Marisa Costa; Elizabeth A. Cromwell; Abel Fekadu Dadi; Tukur Dahiru; Saad M. A. Dahlawi; Rakhi Dandona; Lalit Dandona; Anh Kim Dang; Farah Daoud; Aso Mohammad Darwesh; Amira Hamed Darwish; Ahmad Daryani; Jai K. Das; Rajat Das Gupta; Aditya Prasad Dash; Claudio Alberto Dávila-Cervantes; Nicole Davis Weaver; Fernando Pio De La Hoz; Jan-Walter De Neve; Dereje Bayissa Demissie; Gebre Teklemariam Demoz; Edgar Denova-Gutiérrez; Kebede Deribe; Assefa Desalew; Samath Dhamminda Dharmaratne; Preeti Dhillon; Meghnath Dhimal; Govinda Prasad Dhungana; Daniel Diaz; Isaac Oluwafemi Dipeolu; Hoa Thi Do; Christiane Dolecek; Kerrie E. Doyle; Eleonora Dubljanin; Andre Rodrigues Duraes; Hisham Atan Edinur; Andem Effiong; Aziz Eftekhari; Nevine El Nahas; Maysaa El Sayed Zaki; Maha El Tantawi; Hala Rashad Elhabashy; Shaimaa I. El-Jaafary; Ziad El-Khatib; Hajer Elkout; Aisha Elsharkawy; Shymaa Enany; Daniel Adane Endalew; Babak Eshrati; Sharareh Eskandarieh; Arash Etemadi; Oluchi Ezekannagha; Emerito Jose A. Faraon; Mohammad Fareed; Andre Faro; Farshad Farzadfar; Alebachew Fasil; Mehdi Fazlzadeh; Valery L. Feigin; Wubalem Fekadu; Netsanet Fentahun; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Irina Filip; Florian Fischer; Carsten Flohr; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Masoud Foroutan; Richard Charles Franklin; Joseph Jon Frostad; Takeshi Fukumoto; Mohamed M. Gad; Gregory M. Garcia; Augustine Mwangi Gatotoh; Reta Tsegaye Gayesa; Ketema Bizuwork Gebremedhin; Yilma Chisha Dea Geramo; Hailay Abrha Gesesew; Kebede Embaye Gezae; Ahmad Ghashghaee; Farzaneh Ghazi Sherbaf; Tiffany K. Gill; Paramjit Singh Gill; Themba G. Ginindza; Alem Girmay; Zemichael Gizaw; Amador Goodridge; Sameer Vali Gopalani; Alessandra C. Goulart; Bárbara Niegia Garcia Goulart; Ayman Grada; Manfred S. Green; Mohammed Ibrahim Mohialdeen Gubari; Harish Chander Gugnani; Davide Guido; Rafael Alves Guimarães; Yuming Guo; Rahul Gupta; Rajeev Gupta; Giang Hai Ha; Juanita A. Haagsma; Nima Hafezi-Nejad; Dessalegn H. Haile; Michael Tamene Haile; Brian J. Hall; Samer Hamidi; Demelash Woldeyohannes Handiso; Hamidreza Haririan; Ninuk Hariyani; Ahmed I. Hasaballah; Md Mehedi Hasan; Amir Hasanzadeh; Hamid Yimam Hassen; Desta Haftu Hayelom; Mohamed I. Hegazy; Behzad Heibati; Behnam Heidari; Delia Hendrie; Andualem Henok; Claudiu Herteliu; Fatemeh Heydarpour; Hagos Degefa de Hidru; Thomas R. Hird; Chi Linh Hoang; Gillian I. Hollerich; Praveen Hoogar; Naznin Hossain; Mehdi Hosseinzadeh; Mowafa Househ; Guoqing Hu; Ayesha Humayun; Syed Ather Hussain; Mamusha Aman A. Hussen; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Milena D. Ilic; Mohammad Hasan Imani-Nasab; Usman Iqbal; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Rebecca Q. Ivers; Chinwe Juliana Iwu; Nader Jahanmehr; Mihajlo Jakovljevic; Amir Jalali; Achala Upendra Jayatilleke; Ensiyeh Jenabi; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Jost B. Jonas; Jacek Jerzy Jozwiak; Ali Kabir; Zubair Kabir; Tanuj Kanchan; André Karch; Surendra Karki; Amir Kasaeian; Gebremicheal Gebreslassie Kasahun; Habtamu Kebebe Kasaye; Getachew Mullu Kassa; Gebrehiwot G. Kassa; Gbenga A. Kayode; Mihiretu M. Kebede; Peter Njenga Keiyoro; Daniel Bekele Ketema; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Nauman Khalid; Rovshan Khalilov; Ejaz Ahmad Khan; Junaid Khan; Md Nuruzzaman Nuruzzaman Khan; Khaled Khatab; Mona M. Khater; Amir M. Khater; Maryam Khayamzadeh; Mohammad Khazaei; Mohammad Hossein Khosravi; Jagdish Khubchandani; Ali Kiadaliri; Yun Jin Kim; Ruth W. Kimokoti; Sezer Kisa; Adnan Kisa; Sonali Kochhar; Tufa Kolola; Hamidreza Komaki; Soewarta Kosen; Parvaiz A. Koul; Ai Koyanagi; Kewal Krishan; Barthelemy Kuate Defo; Nuworza Kugbey; Pushpendra Kumar; G. Anil Kumar; Manasi Kumar; Dian Kusuma; Carlo La Vecchia; Ben Lacey; Aparna Lal; Dharmesh Kumar Lal; Hilton Lam; Faris Hasan Lami; Van Charles Lansingh; Savita Lasrado; Georgy Lebedev; Paul H. Lee; Kate E. LeGrand; Mostafa Leili; Tsegaye Lolaso Lenjebo; Cheru Tesema Leshargie; Aubrey J. Levine; Sonia Lewycka; Shanshan Li; Shai Linn; Shiwei Liu; Jaifred Christian F. Lopez; Platon D. Lopukhov; Muhammed Magdy Abd El Razek; D.R. Mahadeshwara Prasad; Phetole Walter Mahasha; Narayan B. Mahotra; Azeem Majeed; Reza Malekzadeh; Deborah Carvalho Malta; Abdullah A. Mamun; Navid Manafi; Mohammad Ali Mansournia; Chabila Christopher Mapoma; Gabriel Martinez; Santi Martini; Francisco Rogerlândio Martins-Melo; Manu Raj Mathur; Benjamin K. Mayala; Mohsen Mazidi; Colm McAlinden; Birhanu Geta Meharie; Man Mohan Mehndiratta; Entezar Mehrabi Nasab; Kala M. Mehta; Teferi Mekonnen; Tefera Chane Mekonnen; Gebrekiros Gebremichael Meles; Hagazi Gebre Meles; Peter T. N. Memiah; Ziad A. Memish; Walter Mendoza; Ritesh G. Menezes; Seid Tiku Mereta; Tuomo J. Meretoja; Tomislav Mestrovic; Workua Mekonnen Metekiya; Bartosz Miazgowski; Ted R. Miller; G.K. Mini; Erkin M. Mirrakhimov; Babak Moazen; Bahram Mohajer; Yousef Mohammad; Dara K. Mohammad; Naser Mohammad Gholi Mezerji; Roghayeh Mohammadibakhsh; Shafiu Mohammed; Jemal Abdu Mohammed; Hassen Mohammed; Farnam Mohebi; Ali H. Mokdad; Yoshan Moodley; Ghobad Moradi; Masoud Moradi; Mohammad Moradi-Joo; Paula Moraga; Linda Morales; Abbas Mosapour; Jonathan F. Mosser; Simin Mouodi; Seyyed Meysam Mousavi; Miliva Mozaffor; Sandra B. Munro; Moses K. Muriithi; Christopher J. L. Murray; Kamarul Imran Musa; Ghulam Mustafa; Saravanan Muthupandian; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Mohsen Naghavi; Gurudatta Naik; Vinay Nangia; Bruno Ramos Nascimento; Javad Nazari; Duduzile Edith Ndwandwe; Ionut Negoi; Henok Biresaw Netsere; Josephine W. Ngunjiri; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Quynhanh P. Nguyen; Solomon Gedlu Nigatu; Dina Nur Anggraini Ningrum; Chukwudi A. Nnaji; Marzieh Nojomi; Ole F. Norheim; Jean Jacques Noubiap; Bogdan Oancea; Felix Akpojene Ogbo; In-Hwan Oh; Andrew T. Olagunju; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Obinna E. Onwujekwe; Doris V. Ortega-Altamirano; Osayomwanbo Osarenotor; Frank B. Osei; Mayowa O. Owolabi; P.A. Mahesh; Jagadish Rao Padubidri; Smita Pakhale; Adrian Pana; Eun-Kee Park; Sangram Kishor Patel; Ashish Pathak; Ajay Patle; Kebreab Paulos; Veincent Christian Filipino Pepito; Norberto Perico; Aslam Pervaiz; Julia Moreira Pescarini; Konrad Pesudovs; Hai Quang Pham; David M. Pigott; Thomas Pilgrim; Meghdad Pirsaheb; Mario Poljak; Ian Pollock; Maarten J. Postma; Farshad Pourmalek; Akram Pourshams; Sergio I. Prada; Liliana Preotescu; Hedley Quintana; Navid Rabiee; Mohammad Rabiee; Amir Radfar; Alireza Rafiei; Fakher Rahim; Siavash Rahimi; Vafa Rahimi-Movaghar; Mohammad Hifz Ur Rahman; Muhammad Aziz Rahman; Fatemeh Rajati; Chhabi Lal Ranabhat; Puja C. Rao; Davide Rasella; Goura Kishor Rath; Salman Rawaf; Lal Rawal; Wasiq Faraz Rawasia; Giuseppe Remuzzi; Vishnu Renjith; Andre M. N. Renzaho; Serge Resnikoff; Seyed Mohammad Riahi; Ana Isabel Ribeiro; Jennifer Rickard; Leonardo Roever; Luca Ronfani; Enrico Rubagotti; Salvatore Rubino; Anas M. Saad; Siamak Sabour; Ehsan Sadeghi; Sahar Saeedi Moghaddam; Yahya Safari; Rajesh Sagar; Mohammad Ali Sahraian; S. Mohammad Sajadi; Mohammad Reza Salahshoor; Nasir Salam; Ahsan Saleem; Marwa Rashad Salem; Hosni Salem; Yahya Salimi; Hamideh Salimzadeh; Abdallah M. Samy; Juan Sanabria; Itamar S. Santos; Milena M. Santric-Milicevic; Bruno Piassi Sao Jose; Sivan Yegnanarayana Iyer Saraswathy; Nizal Sarrafzadegan; Benn Sartorius; Brijesh Sathian; Thirunavukkarasu Sathish; Maheswar Satpathy; Monika Sawhney; Mehdi Sayyah; Alyssa N. Sbarra; Lauren E. Schaeffer; David C. Schwebel; Anbissa Muleta Senbeta; Subramanian Senthilkumaran; Sadaf G. Sepanlou; Edson Serván-Mori; Azadeh Shafieesabet; Amira A. Shaheen; Izza Shahid; Masood Ali Shaikh; Ali S. Shalash; Mehran Shams-Beyranvand; Mohammadbagher Shamsi; Morteza Shamsizadeh; Mohammed Shannawaz; Kiomars Sharafi; Rajesh Sharma; Aziz Sheikh; B. Suresh Kumar Shetty; Wondimeneh Shibabaw Shiferaw; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Reza Shirkoohi; K.M. Shivakumar; Si Si; Soraya Siabani; Tariq Jamal Siddiqi; Diego Augusto Santos Silva; Balbir Bagicha Singh; Ambrish Singh; Virendra Singh; Narinder Pal Singh; Jasvinder A. Singh; Dhirendra Narain Sinha; Malede Mequanent Sisay; Eirini Skiadaresi; David L. Smith; Adauto Martins Soares Filho; Mohammad Reza Sobhiyeh; Anton Sokhan; Joan B. Soriano; Muluken Bekele Sorrie; Ireneous N. Soyiri; Emma Elizabeth Spurlock; Chandrashekhar T. Sreeramareddy; Agus Sudaryanto; Mu'awiyyah Babale Sufiyan; Hafiz Ansar Rasul Suleria; Bryan L. Sykes; Rafael Tabarés-Seisdedos; Takahiro Tabuchi; Degena Bahrey Tadesse; Ingan Ukur Tarigan; Bineyam Taye; Yonatal Mesfin Tefera; Arash Tehrani-Banihashemi; Shishay Wahdey Tekelemedhin; Merhawi Gebremedhin Tekle; Mohamad-Hani Temsah; Fisaha Haile Tesfay; Berhe Etsay Tesfay; Zemenu Tadesse Tessema; Kavumpurathu Raman Thankappan; Akhil Soman Thekkepurakkal; Nihal Thomas; Robert L. Thompson; Alan J. Thomson; Roman Topor-Madry; Marcos Roberto Tovani-Palone; Eugenio Traini; Bach Xuan Tran; Khanh Bao Tran; Irfan Ullah; Bhaskaran Unnikrishnan; Muhammad Shariq Usman; Olalekan A. Uthman; Benjamin S. Chudi Uzochukwu; Pascual R. Valdez; Santosh Varughese; Yousef Veisani; Francesco S. Violante; Sebastian Vollmer; Feleke Gebremeskel Whawariat; Yasir Waheed; Mitchell Taylor Wallin; Yuan-Pang Wang; Yafeng Wang; Kinley Wangdi; Daniel J. Weiss; Girmay Teklay Weldesamuel; Adhena Ayaliew Werkneh; Ronny Westerman; Taweewat Wiangkham; Kirsten E. Wiens; Tissa Wijeratne; Charles Shey Wiysonge; Haileab Fekadu Wolde; Dawit Zewdu Wondafrash; Tewodros Eshete Wonde; Getasew Taddesse Worku; Ali Yadollahpour; Seyed Hossein Yahyazadeh Jabbari; Tomohide Yamada; Mehdi Yaseri; Hiroshi Yatsuya; Alex Yeshaneh; Mekdes Tigistu Yilma; Paul Yip; Engida Yisma; Naohiro Yonemoto; Mustafa Z. Younis; Hebat-Allah Salah A. Yousof; Chuanhua Yu; Hasan Yusefzadeh; Siddhesh Zadey; Telma Zahirian Moghadam; Zoubida Zaidi; Sojib Bin Zaman; Mohammad Zamani; Hamed Zandian; Heather J. Zar; Taddese Alemu Zerfu; Yunquan Zhang; Arash Ziapour; Sanjay Zodpey; Yves Miel H. Zuniga; Simon I. Hay; Robert C. Reiner
Background: Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities. Methods: We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs. Findings: Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40·0% (95% uncertainty interval [UI] 39·4–40·7) to 50·3% (50·0–50·5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46·3% (95% UI 46·1–46·5) in 2017, compared with 28·7% (28·5–29·0) in 2000. Although some units improved access to the safest drinking water or sanitation facilities since 2000, a large absolute number of people continued to not have access in several units with high access to such facilities (>80%) in 2017. More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88·6% (95% UI 87·2–89·7) access overall. Many units were able to transition from the least safe facilities in 2000 to safe facilities by 2017; for units in which populations primarily practised open defecation in 2000, 686 (95% UI 664–711) of the 1830 (1797–1863) units transitioned to the use of improved sanitation. Geographical disparities in access to improved water across units decreased in 76·1% (95% UI 71·6–80·7) of countries from 2000 to 2017, and in 53·9% (50·6–59·6) of countries for access to improved sanitation, but remained evident subnationally in most countries in 2017. Interpretation: Our estimates, combined with geospatial trends in diarrhoeal burden, identify where efforts to increase access to safe drinking water and sanitation facilities are most needed. By highlighting areas with successful approaches or in need of targeted interventions, our estimates can enable precision public health to effectively progress towards universal access to safe water and sanitation. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17
(Elsevier Ltd, 2020) Kirsten E. Wiens; Paulina A. Lindstedt; Brigette F. Blacker; Kimberly B. Johnson; Mathew M. Baumann; Lauren E. Schaeffer; Hedayat Abbastabar; Foad Abd-Allah; Ahmed Abdelalim; Ibrahim Abdollahpour; Kedir Hussein Abegaz; Ayenew Negesse Abejie; Lucas Guimarães Abreu; Michael R.M. Abrigo; Ahmed Abualhasan; Manfred Mario Kokou Accrombessi; Dilaram Acharya; Maryam Adabi; Abdu A. Adamu; Oladimeji M. Adebayo; Rufus Adesoji Adedoyin; Victor Adekanmbi; Olatunji O. Adetokunboh; Beyene Meressa Adhena; Mohsen Afarideh; Sohail Ahmad; Keivan Ahmadi; Anwar E. Ahmed; Muktar Beshir Ahmed; Rushdia Ahmed; Temesgen Yihunie Akalu; Fares Alahdab; Ziyad Al-Aly; Noore Alam; Samiah Alam; Genet Melak Alamene; Turki M. Alanzi; Jacqueline Elizabeth Alcalde-Rabanal; Beriwan Abdulqadir Ali; Mehran Alijanzadeh; Vahid Alipour; Syed Mohamed Aljunid; Ali Almasi; Amir Almasi-Hashiani; Hesham M. Al-Mekhlafi; Khalid A. Altirkawi; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Saeed Amini; Arianna Maever L. Amit; Catalina Liliana Andrei; Mina Anjomshoa; Amir Anoushiravani; Fereshteh Ansari; Carl Abelardo T. Antonio; Benny Antony; Ernoiz Antriyandarti; Jalal Arabloo; Hany Mohamed Amin Aref; Olatunde Aremu; Bahram Armoon; Amit Arora; Krishna K. Aryal; Afsaneh Arzani; Mehran Asadi-Aliabadi; Hagos Tasew Atalay; Seyyed Shamsadin Athari; Seyyede Masoume Athari; Sachin R. Atre; Marcel Ausloos; Nefsu Awoke; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Yared Asmare Aynalem; Samad Azari; Peter S. Azzopardi; Ebrahim Babaee; Tesleem Kayode Babalola; Alaa Badawi; Mohan Bairwa; Shankar M. Bakkannavar; Senthilkumar Balakrishnan; Ayele Geleto Bali; Maciej Banach; Joseph Adel Mattar Banoub; Aleksandra Barac; Till Winfried Bärnighausen; Huda Basaleem; Sanjay Basu; Vo Dinh Bay; Mohsen Bayati; Estifanos Baye; Neeraj Bedi; Mahya Beheshti; Masoud Behzadifar; Meysam Behzadifar; Bayu Begashaw Bekele; Yaschilal Muche Belayneh; Michelle L. Bell; Derrick A. Bennett; Dessalegn Ajema Berbada; Robert S. Bernstein; Anusha Ganapati Bhat; Krittika Bhattacharyya; Suraj Bhattarai; Soumyadeep Bhaumik; Zulfiqar A. Bhutta; Ali Bijani; Boris Bikbov; Binyam Minuye Birihane; Raaj Kishore Biswas; Somayeh Bohlouli; Hunduma Amensisa Bojia; Soufiane Boufous; Oliver J. Brady; Nicola Luigi Bragazzi; Andrey Nikolaevich Briko; Nikolay Ivanovich Briko; Gabrielle B. Britton; Sharath Burugina Nagaraja; Reinhard Busse; Zahid A. Butt; Luis Alberto Cámera; Ismael R. Campos-Nonato; Jorge Cano; Josip Car; Rosario Cárdenas; Felix Carvalho; Carlos A. Castañeda-Orjuela; Franz Castro; Wagaye Fentahun Chanie; Pranab Chatterjee; Vijay Kumar Chattu; Tesfaye Yitna Chichiabellu; Ken Lee Chin; Devasahayam J. Christopher; Dinh-Toi Chu; Natalie Maria Cormier; Vera Marisa Costa; Carlos Culquichicon; Matiwos Soboka Daba; Giovanni Damiani; Lalit Dandona; Rakhi Dandona; Anh Kim Dang; Aso Mohammad Darwesh; Amira Hamed Darwish; Ahmad Daryani; Jai K. Das; Rajat Das Gupta; Aditya Prasad Dash; Gail Davey; Claudio Alberto Dávila-Cervantes; Adrian C. Davis; Dragos Virgil Davitoiu; Fernando Pio De la Hoz; Asmamaw Bizuneh Demis; Dereje Bayissa Demissie; Getu Debalkie Demissie; Gebre Teklemariam Demoz; Edgar Denova-Gutiérrez; Kebede Deribe; Assefa Desalew; Aniruddha Deshpande; Samath Dhamminda Dharmaratne; Preeti Dhillon; Meghnath Dhimal; Govinda Prasad Dhungana; Daniel Diaz; Isaac Oluwafemi Dipeolu; Shirin Djalalinia; Kerrie E. Doyle; Eleonora Dubljanin; Bereket Duko; Andre Rodrigues Duraes; Mohammad Ebrahimi Kalan; Hisham Atan Edinur; Andem Effiong; Aziz Eftekhari; Nevine El Nahas; Iman El Sayed; Maysaa El Sayed Zaki; Maha El Tantawi; Teshome Bekele Elema; Hala Rashad Elhabashy; Shaimaa I. El-Jaafary; Hajer Elkout; Aisha Elsharkawy; Iqbal R.F. Elyazar; Aklilu Endalamaw; Daniel Adane Endalew; Sharareh Eskandarieh; Alireza Esteghamati; Sadaf Esteghamati; Arash Etemadi; Oluchi Ezekannagha; Mohammad Fareed; Roghiyeh Faridnia; Farshad Farzadfar; Mehdi Fazlzadeh; Valery L. Feigin; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Irina Filip; Florian Fischer; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Masoud Foroutan; Richard Charles Franklin; Takeshi Fukumoto; Mohamed M. Gad; Reta Tsegaye Gayesa; Teshome Gebre; Ketema Bizuwork Gebremedhin; Gebreamlak Gebremedhn Gebremeskel; Hailay Abrha Gesesew; Kebede Embaye Gezae; Keyghobad Ghadiri; Ahmad Ghashghaee; Pramesh Raj Ghimire; Paramjit Singh Gill; Tiffany K. Gill; Themba G. Ginindza; Nelson G.M. Gomes; Sameer Vali Gopalani; Alessandra C. Goulart; Bárbara Niegia Garcia Goulart; Ayman Grada; Mohammed Ibrahim Mohialdeen Gubari; Harish Chander Gugnani; Davide Guido; Rafael Alves Guimarães; Yuming Guo; Rajeev Gupta; Nima Hafezi-Nejad; Dessalegn H. Haile; Gessessew Bugssa Hailu; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Randah R. Hamadeh; Samer Hamidi; Demelash Woldeyohannes Handiso; Hamidreza Haririan; Ninuk Hariyani; Ahmed I. Hasaballah; Md Mehedi Hasan; Edris Hasanpoor; Amir Hasanzadeh; Hadi Hassankhani; Hamid Yimam Hassen; Mohamed I. Hegazy; Behzad Heibati; Behnam Heidari; Delia Hendrie; Nathaniel J. Henry; Claudiu Herteliu; Fatemeh Heydarpour; Hagos Degefa De Hidru; Thomas R. Hird; Chi Linh Hoang; Enayatollah Homaie Rad; Praveen Hoogar; Mohammad Hoseini; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mowafa Househ; Mohamed Hsairi; Guoqing Hu; Mohammedaman Mama Hussen; Segun Emmanuel Ibitoye; Ehimario U. Igumbor; Olayinka Stephen Ilesanmi; Milena D. Ilic; Mohammad Hasan Imani-Nasab; Usman Iqbal; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Chinwe Juliana Iwu; Neda Izadi; Anelisa Jaca; Nader Jahanmehr; Mihajlo Jakovljevic; Amir Jalali; Achala Upendra Jayatilleke; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Jost B. Jonas; Jacek Jerzy Jozwiak; Ali Kabir; Zubair Kabir; Amaha Kahsay; Hamed Kalani; Tanuj Kanchan; Behzad Karami Matin; André Karch; Mohd Anisul Karim; Hamidreza Karimi-Sari Surendra Karki; Amir Kasaeian; Gebremicheal Gebreslassie Kasahun; Yawukal Chane Kasahun; Habtamu Kebebe Kasaye; Gebrehiwot G. Kassa; Getachew Mullu Kassa; Gbenga A. Kayode; Ali Kazemi Karyani; Mihiretu M. Kebede; Peter Njenga Keiyoro; Abraham Getachew Kelbore; Andre Pascal Kengne; Daniel Bekele Ketema; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Nauman Khalid; Rovshan Khalilov; Ejaz Ahmad Khan; Junaid Khan; Md Nuruzzaman Khan; Muhammad Shahzeb Khan; Khaled Khatab; Amir M. Khater; Mona M. Khater; Maryam Khayamzadeh; Mohammad Khazaei; Salman Khazaei; Mohammad Hossein Khosravi; Jagdish Khubchandani; Ali Kiadaliri; Yun Jin Kim; Ruth W. Kimokoti; Adnan Kisa; Sezer Kisa; Niranjan Kissoon; K.M. Shivakumar; Sonali Kochhar; Tufa Kolola; Hamidreza Komaki; Soewarta Kosen; Parvaiz A. Koul; Ai Koyanagi; Moritz U.G. Kraemer; Kewal Krishan; Nuworza Kugbey; G. Anil Kumar; Manasi Kumar; Pushpendra Kumar; Vivek Kumar; Dian Kusuma; Carlo La Vecchia; Ben Lacey; Sheetal D. Lad; Dharmesh Kumar Lal; Felix Lam; Faris Hasan Lami; Prabhat Lamichhane; Van Charles Lansingh; Savita Lasrado; Avula Laxmaiah; Paul H. Lee; Kate E. LeGrand; Mostafa Leili; Tsegaye Lolaso Lenjebo; Cheru Tesema Leshargie; Aubrey J. Levine; Shanshan Li; Shai Linn; Shiwei Liu; Simin Liu; Rakesh Lodha; Joshua Longbottom; Jaifred Christian F. Lopez; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; DR. Mahadeshwara Prasad; Phetole Walter Mahasha; Narayan B. Mahotra; Azeem Majeed; Reza Malekzadeh; Deborah Carvalho Malta; Abdullah A. Mamun; Navid Manafi; Ana Laura Manda; Narendar Dawani Dawanu Manohar; Mohammad Ali Mansournia; Chabila Christopher Mapoma; Joemer C. Maravilla; Gabriel Martinez; Santi Martini; Francisco Rogerlândio Martins-Melo; Anthony Masaka; Benjamin Ballard Massenburg; Manu Raj Mathur; Benjamin K. Mayala; Mohsen Mazidi; Colm McAlinden; Birhanu Geta Meharie; Man Mohan Mehndiratta; Kala M. Mehta; Tefera Chane Mekonnen; Gebrekiros Gebremichael Meles; Peter T.N. Memiah; Ziad A. Memish; Walter Mendoza; Ritesh G. Menezes; Seid Tiku Mereta; Tuomo J. Meretoja; Tomislav Mestrovic; Bartosz Miazgowski; Kebadnew Mulatu Mihretie; Ted R. Miller; G.K. Mini; Erkin M. Mirrakhimov; Babak Moazen; Bahram Mohajer; Amjad Mohamadi-Bolbanabad; Dara K. Mohammad; Karzan Abdulmuhsin Mohammad; Yousef Mohammad; Naser Mohammad Gholi Mezerji; Roghayeh Mohammadibakhsh; Noushin Mohammadifard; Jemal Abdu Mohammed; Shafiu Mohammed; Farnam Mohebi; Ali H. Mokdad; Mariam Molokhia; Lorenzo Monasta; Yoshan Moodley; Catrin E. Moore; Ghobad Moradi; Masoud Moradi; Mohammad Moradi-Joo; Maziar Moradi-Lakeh; Paula Moraga; Linda Morales; Ilais Moreno Velásquez; Abbas Mosapour; Simin Mouodi; Seyyed Meysam Mousavi; Miliva Mozaffor; Kindie Fentahun Muchie; Getahun Fentaw Mulaw; Sandra B. Munro; Moses K. Muriithi; Christoper J.L. Murray; G.V.S. Murthy; Kamarul Imran Musa; Ghulam Mustafa; Saravanan Muthupandian; Ashraf F. Nabhan; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Kovin S. Naidoo; Gurudatta Naik; Farid Najafi; Vinay Nangia; Jobert Richie Nansseu; Bruno Ramos Nascimento; Javad Nazari; Duduzile Edith Ndwandwe; Ionut Negoi; Henok Biresaw Netsere; Josephine W. Ngunjiri; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Trang Huyen Nguyen; Dabere Nigatu; Solomon Gedlu Nigatu; Dina Nur Anggraini Ningrum; Chukwudi A. Nnaji; Marzieh Nojomi; Vuong Minh Nong; Ole F. Norheim; Jean Jacques Noubiap; Soraya Nouraei Motlagh; Bogdan Oancea; Okechukwu Samuel Ogah; Felix Akpojene Ogbo; In-Hwan Oh; Andrew T. Olagunju; Tinuke O. Olagunju; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Obinna E. Onwujekwe; Eyal Oren; Doris V. Ortega-Altamirano; Osayomwanbo Osarenotor; Frank B. Osei; Mayowa O. Owolabi; Mahesh P A; Jagadish Rao Padubidri; Smita Pakhale; Sangram Kishor Patel; Angel J. Paternina-Caicedo; Ashish Pathak; George C. Patton; Deepak Paudel; Kebreab Paulos; Veincent Christian Filipino Pepito; Alexandre Pereira; Norberto Perico; Aslam Pervaiz; Julia Moreira Pescarini; Bakhtiar Piroozi; Meghdad Pirsaheb; Maarten J. Postma; Hadi Pourjafar; Farshad Pourmalek; Akram Pourshams; Hossein Poustchi; Sergio I. Prada; Narayan Prasad; Liliana Preotescu; Hedley Quintana; Navid Rabiee; Amir Radfar; Alireza Rafiei; Fakher Rahim; Afarin Rahimi-Movaghar; Vafa Rahimi-Movaghar; Mohammad Hifz Ur Rahman; Muhammad Aziz Rahman; Shafiur Rahman; Fatemeh Rajati; Saleem Muhammad Rana; Chhabi Lal Ranabhat; Davide Rasella; David Laith Rawaf; Salman Rawaf; Lal Rawal; Wasiq Faraz Rawasia; Vishnu Renjith; Andre M.N. Renzaho; Serge Resnikoff; Melese Abate Reta; Negar Rezaei; Mohammad Sadegh Rezai; Seyed Mohammad Riahi; Ana Isabel Ribeiro; Jennifer Rickard; Maria Rios-Blancas; Leonardo Roever; Luca Ronfani; Elias Merdassa Roro; Jennifer M. Ross; Enrico Rubagotti; Salvatore Rubino; Anas M. Saad; Yogesh Damodar Sabde; Siamak Sabour; Ehsan Sadeghi; Yahya Safari; Roya Safari-Faramani; Rajesh Sagar; Amirhossein Sahebkar; Mohammad Ali Sahraian; S. Mohammad Sajadi; Mohammad Reza Salahshoor; Nasir Salam; Payman Salamati; Hosni Salem; Marwa Rashad Salem; Yahya Salimi; Hamideh Salimzadeh; Abdallah M. Samy; Juan Sanabria; Milena M. Santric-Milicevic; Bruno Piassi Sao Jose; Sivan Yegnanarayana Iyer Saraswathy; Kaushik Sarkar; Abdur Razzaque Sarker; Nizal Sarrafzadegan; Benn Sartorius; Brijesh Sathian; Thirunavukkarasu Sathish; Monika Sawhney; Sonia Saxena; David C. Schwebel; Anbissa Muleta Senbeta; Subramanian Senthilkumaran; Sadaf G. Sepanlou; Edson Serván-Mori; Hosein Shabaninejad; Azadeh Shafieesabet; Masood Ali Shaikh; Ali S. Shalash; Seifadin Ahmed Shallo; Mehran Shams-Beyranvand; Mohammad Bagher Shamsi; Morteza Shamsizadeh; Mohammed Shannawaz; Kiomars Sharafi; Hamid Sharifi; Hatem Samir Shehata; Aziz Sheikh; B. Suresh Kumar Shetty; Kenji Shibuya; Wondimeneh Shibabaw Shiferaw; Desalegn Markos Shifti; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Reza Shirkoohi; Soraya Siabani; Tariq Jamal Siddiqi; Diego Augusto Santos Silva; Ambrish Singh; Jasvinder A. Singh; Narinder Pal Singh; Virendra Singh; Malede Mequanent Sisay; Eirini Skiadaresi; Mohammad Reza Sobhiyeh; Anton Sokhan; Shahin Soltani; Ranjani Somayaji; Moslem Soofi; Muluken Bekele Sorrie; Ireneous N. Soyiri; Chandrashekhar T. Sreeramareddy; Agus Sudaryanto; Mu’awiyyah Babale Sufiyan; Hafiz Ansar Rasul Suleria; Marufa Sultana; Bruno Fokas Sunguya; Bryan L. Sykes; Rafael Tabarés-Seisdedos; Takahiro Tabuchi; Degena Bahrey Tadesse; Ingan Ukur Tarigan; Aberash Abay Tasew; Yonatal Mesfin Tefera; Merhawi Gebremedhin Tekle; Mohamad-Hani Temsah; Berhe Etsay Tesfay; Fisaha Haile Tesfay; Belay Tessema; Zemenu Tadesse Tessema; Kavumpurathu Raman Thankappan; Nihal Thomas; Alemayehu Toma; Roman Topor-Madry; Marcos Roberto Tovani-Palone; Eugenio Traini; Bach Xuan Tran; Khanh Bao Tran; Irfan Ullah; Bhaskaran Unnikrishnan; Muhammad Shariq Usman; Benjamin S. Chudi Uzochukwu; Pascual R. Valdez; Santosh Varughese; Francesco S. Violante; Sebastian Vollmer; Feleke Gebremeskel Whawariat; Yasir Waheed; Mitchell Taylor Wallin; Yafeng Wang; Yuan-Pang Wang; Marcia Weaver; Bedilu Girma Weji; Girmay Teklay Weldesamuel; Catherine A. Welgan; Andrea Werdecker; Ronny Westerman; Taweewat Wiangkham; Charles Shey Wiysonge; Haileab Fekadu Wolde; Dawit Zewdu Wondafrash; Tewodros Eshete Wonde; Getasew Taddesse Worku; Ai-Min Wu; Gelin Xu; Ali Yadollahpour; Seyed Hossein Yahyazadeh Jabbari; Tomohide Yamada; Hiroshi Yatsuya; Alex Yeshaneh; Christopher Sabo Yilgwan; Mekdes Tigistu Yilma; Paul Yip; Engida Yisma; Naohiro Yonemoto; Seok-Jun Yoon; Mustafa Z. Younis; Mahmoud Yousefifard; Hebat-Allah Salah A. Yousof; Chuanhua Yu; Hasan Yusefzadeh; Siddhesh Zadey; Zoubida Zaidi; Sojib Bin Zaman; Mohammad Zamani; Hamed Zandian; Nejimu Biza Zepro; Taddese Alemu Zerfu; Yunquan Zhang; Xiu-Ju George Zhao; Arash Ziapour; Sanjay Zodpey; Yves Miel H. Zuniga; Simon I. Hay; Robert C. Reiner
Background: Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative forms of ORT; however, it is unclear whether RHF prevent child mortality. Previous studies have shown considerable variation between countries in ORS and RHF use, but subnational variation is unknown. This study aims to produce high-resolution geospatial estimates of relative and absolute coverage of ORS, RHF, and ORT (use of either ORS or RHF) in LMICs. Methods: We used a Bayesian geostatistical model including 15 spatial covariates and data from 385 household surveys across 94 LMICs to estimate annual proportions of children younger than 5 years of age with diarrhoea who received ORS or RHF (or both) on continuous continent-wide surfaces in 2000–17, and aggregated results to policy-relevant administrative units. Additionally, we analysed geographical inequality in coverage across administrative units and estimated the number of diarrhoeal deaths averted by increased coverage over the study period. Uncertainty in the mean coverage estimates was calculated by taking 250 draws from the posterior joint distribution of the model and creating uncertainty intervals (UIs) with the 2·5th and 97·5th percentiles of those 250 draws. Findings: While ORS use among children with diarrhoea increased in some countries from 2000 to 2017, coverage remained below 50% in the majority (62·6%; 12 417 of 19 823) of second administrative-level units and an estimated 6 519 000 children (95% UI 5 254 000–7 733 000) with diarrhoea were not treated with any form of ORT in 2017. Increases in ORS use corresponded with declines in RHF in many locations, resulting in relatively constant overall ORT coverage from 2000 to 2017. Although ORS was uniformly distributed subnationally in some countries, within-country geographical inequalities persisted in others; 11 countries had at least a 50% difference in one of their units compared with the country mean. Increases in ORS use over time were correlated with declines in RHF use and in diarrhoeal mortality in many locations, and an estimated 52 230 diarrhoeal deaths (36 910–68 860) were averted by scaling up of ORS coverage between 2000 and 2017. Finally, we identified key subnational areas in Colombia, Nigeria, and Sudan as examples of where diarrhoeal mortality remains higher than average, while ORS coverage remains lower than average. Interpretation: To our knowledge, this study is the first to produce and map subnational estimates of ORS, RHF, and ORT coverage and attributable child diarrhoeal deaths across LMICs from 2000 to 2017, allowing for tracking progress over time. Our novel results, combined with detailed subnational estimates of diarrhoeal morbidity and mortality, can support subnational needs assessments aimed at furthering policy makers' understanding of within-country disparities. Over 50 years after the discovery that led to this simple, cheap, and life-saving therapy, large gains in reducing mortality could still be made by reducing geographical inequalities in ORS coverage. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Subnational mapping of HIV incidence and mortality among individuals aged 15–49 years in sub-Saharan Africa, 2000–18: a modelling study
(Elsevier Ltd, 2021) Benn Sartorius; John D. VanderHeide; Mingyou Yang; Erik A. Goosmann; Julia Hon; Emily Haeuser; Michael A. Cork; Samantha Perkins; Deepa Jahagirdar; Lauren E. Schaeffer; Audrey L. Serfes; Kate E. LeGrand; Hedayat Abbastabar; Zeleke Hailemariam Abebo; Akine Eshete Abosetugn; Eman Abu-Gharbieh; Manfred Mario Kokou Accrombessi; Oladimeji M. Adebayo; Adeyinka Emmanuel Adegbosin; Victor Adekanmbi; Olatunji O. Adetokunboh; Daniel Adedayo Adeyinka; Bright Opoku Ahinkorah; Keivan Ahmadi; Muktar Beshir Ahmed; Yonas Akalu; Oluwaseun Oladapo Akinyemi; Rufus Olusola Akinyemi; Addis Aklilu; Chisom Joyqueenet Akunna; Fares Alahdab; Ziyad Al-Aly; Noore Alam; Alehegn Aderaw Alamneh; Turki M. Alanzi; Biresaw Wassihun Alemu; Robert Kaba Alhassan; Tilahun Ali; Vahid Alipour; Saeed Amini; Robert Ancuceanu; Fereshteh Ansari; Zelalem Alamrew Anteneh; Davood Anvari; Razique Anwer; Seth Christopher Yaw Appiah; Jalal Arabloo; Mulusew A. Asemahagn; Mohammad Asghari Jafarabadi; Wondwossen Niguse Asmare; Desta Debalkie Atnafu; Maha Moh'd Wahbi Atout; Alok Atreya; Marcel Ausloos; Atalel Fentahun Awedew; Beatriz Paulina Ayala Quintanilla; Martin Amogre Ayanore; Yared Asmare Aynalem; Muluken Altaye Ayza; Samad Azari; Zelalem Nigussie Azene; Zaheer-Ud-Din Babar; Atif Amin Baig; Senthilkumar Balakrishnan; Maciej Banach; Till Winfried Bärnighausen; Sanjay Basu; Mohsen Bayati; Neeraj Bedi; Tariku Tesfaye Bekuma; Woldesellassie M. Mequanint Bezabhe; Akshaya Srikanth Bhagavathula; Pankaj Bhardwaj; Krittika Bhattacharyya; Zulfiqar A. Bhutta; Sadia Bibi; Boris Bikbov; Tsegaye Adane Birhan; Zebenay Workneh Bitew; Moses John Bockarie; Archith Boloor; Oliver J. Brady; Nicola Luigi Bragazzi; Andrey Nikolaevich Briko; Nikolay Ivanovich Briko; Sharath Burugina Nagaraja; Zahid A. Butt; Rosario Cárdenas; Felix Carvalho; Jaykaran Charan; Souranshu Chatterjee; Soosanna Kumary Chattu; Vijay Kumar Chattu; Mohiuddin Ahsanul Kabir Chowdhury; Dinh-Toi Chu; Aubrey J. Cook; Natalie Maria Cormier; Richard G. Cowden; Carlos Culquichicon; Baye Dagnew; Saad M.A. Dahlawi; Giovanni Damiani; Parnaz Daneshpajouhnejad; Farah Daoud; Ahmad Daryani; José das Neves; Nicole Davis Weaver; Meseret Derbew Molla; Kebede Deribe; Abebaw Alemayehu Desta; Keshab Deuba; Samath Dhamminda Dharmaratne; Govinda Prasad Dhungana; Daniel Diaz; Shirin Djalalinia; Paul Narh Doku; Eleonora Dubljanin; Bereket Duko; Arielle Wilder Eagan; Lucas Earl; Jeffrey W. Eaton; Andem Effiong; Maysaa El Sayed Zaki; Maha El Tantawi; Rajesh Elayedath; Shaimaa I. El-Jaafary; Aisha Elsharkawy; Sharareh Eskandarieh; Oghenowede Eyawo; Sayeh Ezzikouri; Abidemi Omolara Fasanmi; Alebachew Fasil; Nelsensius Klau Fauk; Valery L. Feigin; Tomas Y. Ferede; Eduarda Fernandes; Florian Fischer; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Masoud Foroutan; Joel Msafiri Francis; Takeshi Fukumoto; Mohamed M. Gad; Biniyam Sahiledengle Geberemariyam; Birhan Gebresillassie Gebregiorgis; Berhe Gebremichael; Hailay Abrha Gesesew; Lemma Getacher; Keyghobad Ghadiri; Ahmad Ghashghaee; Syed Amir Gilani; Themba G. Ginindza; Mustefa Glagn; Mahaveer Golechha; Philimon N. Gona; Mohammed Ibrahim Mohialdeen Gubari; Harish Chander Gugnani; Davide Guido; Rashid Abdi Guled; Brian J. Hall; Samer Hamidi; Demelash Woldeyohannes Handiso; Arief Hargono; Abdiwahab Hashi; Soheil Hassanipour; Hadi Hassankhani; Khezar Hayat; Claudiu Herteliu; Hagos Degefa de Hidru; Ramesh Holla; H. Dean Hosgood; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mowafa Househ; Bing-Fang Hwang; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Seyed Sina Naghibi Irvani; Chidozie C.D. Iwu; Chinwe Juliana Iwu; Ihoghosa Osamuyi Iyamu; Vardhmaan Jain; Mihajlo Jakovljevic; Farzad Jalilian; Ravi Prakash Jha; Kimberly B. Johnson; Vasna Joshua; Farahnaz Joukar; Jacek Jerzy Jozwiak; Ali Kabir; Leila R. Kalankesh; Rohollah Kalhor; Ashwin Kamath; Naser Kamyari; Tanuj Kanchan; Behzad Karami Matin; André Karch; Salah Eddin Karimi; Ayele Semachew Kasa; Getinet Kassahun; Gbenga A. Kayode; Ali Kazemi Karyani; Peter Njenga Keiyoro; Bayew Kelkay; Nauman Khalid; Gulfaraz Khan; Junaid Khan; Md Nuruzzaman Khan; Khaled Khatab; Salman Khazaei; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Sonali Kochhar; Jacek A. Kopec; Soewarta Kosen; Sindhura Koulmane Laxminarayana; Ai Koyanagi; Kewal Krishan; Barthelemy Kuate Defo; Nuworza Kugbey; Vaman Kulkarni; Manasi Kumar; Nithin Kumar; Om P. Kurmi; Dian Kusuma; Desmond Kuupiel; Hmwe Hmwe Kyu; Carlo La Vecchia; Dharmesh Kumar Lal; Jennifer O. Lam; Iván Landires; Savita Lasrado; Jeffrey V. Lazarus; Alice Lazzar-Atwood; Paul H. Lee; Cheru Tesema Leshargie; Bingyu Li; Xuefeng Liu; Platon D. Lopukhov; Hawraz Ibrahim M. Amin; Deepak Madi; Phetole Walter Mahasha; Azeem Majeed; Afshin Maleki; Shokofeh Maleki; Abdullah A. Mamun; Navid Manafi; Mohammad Ali Mansournia; Francisco Rogerlândio Martins-Melo; Seyedeh Zahra Masoumi; Benjamin K. Mayala; Birhanu Geta Meharie; Hailemariam Abiy Alemu Meheretu; Hagazi Gebre Meles; Mulugeta Melku; Walter Mendoza; Endalkachew Worku Mengesha; Tuomo J. Meretoja; Abera M. Mersha; Tomislav Mestrovic; Ted R. Miller; Andreea Mirica; Mehdi Mirzaei-Alavijeh; Osama Mohamad; Yousef Mohammad; Abdollah Mohammadian-Hafshejani; Jemal Abdu Mohammed; Salahuddin Mohammed; Shafiu Mohammed; Ali H. Mokdad; Taklu Marama Mokonnon; Mariam Molokhia; Masoud Moradi; Yousef Moradi; Rahmatollah Moradzadeh; Paula Moraga; Jonathan F. Mosser; Sandra B. Munro; Ghulam Mustafa; Saravanan Muthupandian; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Mohsen Naghavi; Muhammad Naveed; Vinod C. Nayak; Javad Nazari; Rawlance Ndejjo; Samata Nepal; Henok Biresaw Netsere; Frida N. Ngalesoni; Georges Nguefack-Tsague; Josephine W. Ngunjiri; Yeshambel T. Nigatu; Samuel Negash Nigussie; Chukwudi A. Nnaji; Jean Jacques Noubiap; Virginia Nuñez-Samudio; Bogdan Oancea; Oluwakemi Ololade Odukoya; Felix Akpojene Ogbo; Olanrewaju Oladimeji; Andrew T. Olagunju; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Muktar Omer Omer; Abidemi E. Emmanuel Omonisi; Obinna E. Onwujekwe; Orish Ebere Orisakwe; Nikita Otstavnov; Mayowa O. Owolabi; P.A. Mahesh; Jagadish Rao Padubidri; Smita Pakhale; Adrian Pana; Seithikurippu R. Pandi-Perumal; Urvish K. Patel; Mona Pathak; George C. Patton; Shrikant Pawar; Emmanuel K. Peprah; Khem Narayan Pokhrel; Maarten J. Postma; Faheem Hyder Pottoo; Hadi Pourjafar; Dimas Ria Angga Pribadi; Zahiruddin Quazi Syed; Alireza Rafiei; Fakher Rahim; Mohammad Hifz Ur Rahman; Amir Masoud Rahmani; Pradhum Ram; Juwel Rana; Chhabi Lal Ranabhat; Satish Rao; Sowmya J. Rao; Priya Rathi; David Laith Rawaf; Salman Rawaf; Reza Rawassizadeh; Vishnu Renjith; Melese Abate Reta; Nima Rezaei; Aziz Rezapour; Ana Isabel Ribeiro; Jennifer M. Ross; Susan Fred Rumisha; Rajesh Sagar; Maitreyi Sahu; S. Mohammad Sajadi; Marwa Rashad Salem; Abdallah M. Samy; Brijesh Sathian; Aletta Elisabeth Schutte; Abdul-Aziz Seidu; Feng Sha; Omid Shafaat; Mohammad Shahbaz; Masood Ali Shaikh; Mohammed Feyisso Shaka; Aziz Sheikh; Kenji Shibuya; Jae Il Shin; K.M. Shivakumar; Negussie Boti Sidemo; Jasvinder A. Singh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Amin Soheili; Shahin Soltani; Oluwaseyi Dolapo Somefun; Muluken Bekele Sorrie; Emma Elizabeth Spurlock; Mu'awiyyah Babale Sufiyan; Biruk Wogayehu Taddele; Eyayou Girma Tadesse; Zemenu Tamir; Animut Tagele Tamiru; Frank C. Tanser; Nuno Taveira; Arash Tehrani-Banihashemi; Yohannes Tekalegn; Fisaha Haile Tesfay; Belay Tessema; Zemenu Tadesse Tessema; Bhaskar Thakur; Musliu Adetola Tolani; Roman Topor-Madry; Marco Torrado; Marcos Roberto Tovani-Palone; Eugenio Traini; Alexander C. Tsai; Gebiyaw Wudie Tsegaye; Irfan Ullah; Saif Ullah; Chukwuma David Umeokonkwo; Bhaskaran Unnikrishnan; Constantine Vardavas; Francesco S. Violante; Bay Vo; Yohannes Dibaba Wado; Yasir Waheed; Richard G. Wamai; Yanzhong Wang; Paul Ward; Andrea Werdecker; Nuwan Darshana Wickramasinghe; Tissa Wijeratne; Charles Shey Wiysonge; Temesgen Gebeyehu Wondmeneh; Tomohide Yamada; Sanni Yaya; Yigizie Yeshaw; Yordanos Gizachew Yeshitila; Mekdes Tigistu Yilma; Paul Yip; Naohiro Yonemoto; Tewodros Yosef; Hasan Yusefzadeh; Syed Saoud Zaidi; Leila Zaki; Maryam Zamanian; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Dejene Tesfaye Zewdie; Yunquan Zhang; Zhi-Jiang Zhang; Arash Ziapour; Simon I. Hay; Laura Dwyer-Lindgren
Background: High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods: In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to estimate HIV prevalence at the second administrative level in 44 countries in sub-Saharan Africa for 2000–18 and sought data on the number of individuals on antiretroviral therapy (ART) by second-level administrative unit. We then modified the Estimation and Projection Package (EPP) to use these HIV prevalence and treatment estimates to estimate HIV incidence and mortality by second-level administrative unit. Findings: The estimates suggest substantial variation in HIV incidence and mortality rates both between and within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater difference in estimated HIV incidence between the second-level administrative units with the lowest and highest estimated incidence levels. Across all 44 countries in 2018, HIV incidence ranged from 2·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and HIV mortality ranged from 0·8 (0·7–0·9) in Mauritania to 676·5 (513·6–888·0) deaths per 100 000 people in Lesotho. Variation in both incidence and mortality was substantially greater at the subnational level than at the national level and the highest estimated rates were accordingly higher. Among second-level administrative units, Guijá District, Gaza Province, Mozambique, had the highest estimated HIV incidence (4661·7 [2544·8–8120·3]) cases per 100 000 people in 2018 and Inhassunge District, Zambezia Province, Mozambique, had the highest estimated HIV mortality rate (1163·0 [679·0–1866·8]) deaths per 100 000 people. Further, the rate of reduction in HIV incidence and mortality from 2000 to 2018, as well as the ratio of new infections to the number of people living with HIV was highly variable. Although most second-level administrative units had declines in the number of new cases (3316 [81·1%] of 4087 units) and number of deaths (3325 [81·4%]), nearly all appeared well short of the targeted 75% reduction in new cases and deaths between 2010 and 2020. Interpretation: Our estimates suggest that most second-level administrative units in sub-Saharan Africa are falling short of the targeted 75% reduction in new cases and deaths by 2020, which is further compounded by substantial within-country variability. These estimates will help decision makers and programme implementers expand access to ART and better target health resources to higher burden subnational areas. Funding: Bill & Melinda Gates Foundation. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
The overlapping burden of the three leading causes of disability and death in sub-Saharan African children
(Nature Research, 2022) Robert C. Reiner; Catherine A. Welgan; Christopher E. Troeger; Mathew M. Baumann; Daniel J. Weiss; Aniruddha Deshpande; Brigette F. Blacker; Molly K. Miller-Petrie; Lucas Earl; Samir Bhatt; Hassan Abolhassani; Akine Eshete Abosetugn; Eman Abu-Gharbieh; Victor Adekanmbi; Olatunji O. Adetokunboh; Mohammad Aghaali; Budi Aji; Fares Alahdab; Ziyad Al-Aly; Robert Kaba Alhassan; Saqib Ali; Hesam Alizade; Syed Mohamed Aljunid; Amir Almasi-Hashiani; Hesham M. Al-Mekhlafi; Khalid A. Altirkawi; Nelson Alvis-Guzman; Azmeraw T. Amare; Saeed Amini; Dickson A. Amugsi; Robert Ancuceanu; Catalina Liliana Andrei; Fereshteh Ansari; Davood Anvari; Seth Christopher Yaw Appiah; Jalal Arabloo; Olatunde Aremu; Maha Moh’d Wahbi Atout; Marcel Ausloos; Floriane Ausloos; Martin Amogre Ayanore; Yared Asmare Aynalem; Zelalem Nigussie Azene; Alaa Badawi; Atif Amin Baig; Maciej Banach; Neeraj Bedi; Akshaya Srikanth Bhagavathula; Dinesh Bhandari; Nikha Bhardwaj; Pankaj Bhardwaj; Krittika Bhattacharyya; Zulfiqar A. Bhutta; Ali Bijani; Tesega Tesega Mengistu Birhanu; Zebenay Workneh Bitew; Archith Boloor; Oliver J. Brady; Zahid A. Butt; Josip Car; Felix Carvalho; Daniel C. Casey; Vijay Kumar Chattu; Mohiuddin Ahsanul Kabir Chowdhury; Dinh-Toi Chu; Camila H. Coelho; Aubrey J. Cook; Giovanni Damiani; Farah Daoud; Jiregna Darega Gela; Amira Hamed Darwish; Ahmad Daryani; Jai K. Das; Nicole Davis Weaver; Kebede Deribe; Assefa Desalew; Samath Dhamminda Dharmaratne; Mostafa Dianatinasab; Daniel Diaz; Shirin Djalalinia; Fariba Dorostkar; Eleonora Dubljanin; Bereket Duko; Laura Dwyer-Lindgren; Andem Effiong; Maysaa El Sayed Zaki; Maha El Tantawi; Shymaa Enany; Nazir Fattahi; Valery L. Feigin; Eduarda Fernandes; Pietro Ferrara; Florian Fischer; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Masoud Foroutan; Joseph Jon Frostad; Takeshi Fukumoto; Abhay Motiramji Gaidhane; Hailemikael Gebrekidan G. K. Gebrekrstos; Leake Gebremeskel; Assefa Ayalew Gebreslassie; Peter W. 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Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival. © 2022, The Author(s).