Browsing by Author "Kavita"

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Ayurveda-Based Traditional Indian Knowledge of Uterine Fibroids
(Association of Ayurvedic Physicians of India, 2025) Shikha Singh; Kavita; Neha Garg
Owing to altered lifestyles and metabolic syndromes, a variety of gynecological problems, including uterine fibroids, are common in modern days. Uterine fibroids (UFs) are one of the most prominent solid benign tumors of females, affecting the quality of life. Uterine myomas or fibroids are an overgrowth of the myometrium tissue. Hormonal therapy, hysterectomy, myomectomy, and uterine artery embolization are some of the current therapies for uterine fibroids. Patients’ unwillingness to long-term hormonal medication, the anxiety of surgery, and the need for future pregnancy require them to search for an alternative system of medicine. In this review, we looked into the ancient Ayurvedic texts for Ayurvedic descriptions of uterine fibroids, their etiology, pathology, and treatment options. In Traditional Indian Knowledge, i.e., Ayurvedic texts, there is no direct description of uterine fibroids. Ayurvedic texts describe overgrowth or tumors under Apachi, Galgand, Granthi, and Arbuda. Based on the symptoms, Apachi, Galgand, and Granthi are not considered UF. The pathogenesis of shat-kriyakala (six stages of disease development), clinical features, classification, prognosis, and treatment of Arbuda are closely related to UF and considered as Mansaj Garbhashaya-gat yapya Arbuda. This review analyzes literature from Brihattrayi and Laghutrayi, traditional Indian medicine knowledge, and correlates with UF to enhance our comprehension of the clinical findings related to the UF. The findings can open new avenues for the treatment of UFs as described in Ayurveda. © 2025, Association of Ayurvedic Physicians of India. All rights reserved.
Contemporary approaches in the management of uterine leiomyomas
(Elsevier Ireland Ltd, 2023) Shikha Singh; Praveen Kumar; Kavita; Saurabh Singh Rathore; Yashasvi Singh; Neha Garg
Background: Leiomyomas (fibroids), the most common benign solid tumours in females, originate from the myometrium and are associated with poor quality of life for patients. The current management of uterine leiomyomas mainly includes surgical interventions such as hysterectomy and myomectomy, either by laparoscopy or laparotomy, which have several complications and are not ideal for preserving fertility. Therefore, there is a need to develop or repurpose medical treatments that do not require surgical intervention. Objective: Many drugs are used to treat the symptoms associated with uterine fibroids. The main objective of this systematic review is to give an up-to-date account of potential pharmacological agents (non-surgical methods) for the management of uterine leiomyomas. Search strategy: PubMed was searched for scientific and clinical literature using the keyword ‘uterine fibroids’ along with the drug names described in each section. For example, ‘uterine fibroids’ and ‘ulipristal acetate’ were the keywords used to search for literature on ulipristal acetate (UPA). Results: Various preclinical and clinical studies have shown that some drugs and herbal formulations exhibit activity in the management of uterine leiomyomas. Recent studies found that drugs such as UPA, elagolix, EC313, asoprisnol, nutritional supplements and herbal preparations were helpful in treating the symptoms associated with uterine leiomyomas. Conclusion: Many drugs show efficacy in patients with symptomatic uterine fibroids. UPA is one of the most studied and prescribed medicines for uterine fibroids; however, its usage has been restricted due to a few recent incidences of hepatic toxicity. Herbal drugs and natural supplements have also shown promising effects on uterine fibroids. The synergistic effects of nutritional and herbal supplements have been reported in certain cases, and should be studied in detail. Further research is warranted to identify the mode of action of the drugs, and to determine the precise conditions that would explain the causes of toxicity in some patients. © 2023 Elsevier B.V.
Immunomodulatory potential of himalayan plant: Withania somnifera
(Bentham Science Publishers, 2023) Kavita; Naina Rajak; Praveen Kumar; Shikha Singh; Neha Garg
Withania somnifera, a herb used in Ayurveda since ancient times, is commonly found in the Himalayan belt. Withania somnifera is reported to be useful in fever, arthritis, asthma, bronchitis, tuberculosis, syphilis, and cancers. Its leaves are found to be effective against swelling, chest pain, sores, and ulcers. Withania possesses antioxidant, immunomodulatory, anti-inflammatory, anti-stress, anti-bacterial, antimicrobial, anti-fungal, anti-tumor, adaptogenic, and memory-enhancing properties. Among the bioactive compounds present in Withania, Withaferin A is the most important and well-explored compound having anti-cancer activity among several other activities. Many studies have reported the anti-inflammatory action of Withania somnifera and isolated Withaferin A. In this chapter, we have summarized the antiinflammatory activities exhibited by this multifaceted medicinal plant. © 2023 Bentham Science Publishers. All rights reserved.
Pharmacological, therapeutic, and immunomodulatory role of Tinospora cordifolia
(Bentham Science Publishers, 2023) Naina Rajak; Kavita; Praveen Kumar; Shikha Singh; Neha Garg
Tinospora cordifolia (TC, Giloy, Guduchi, or Amrita) is a valuable medicinal herb in the Indian System of Medicine (ISM), Chinese, and other traditional systems of medicine. TC contains a broad array of therapeutic phytoconstituents like alkaloids, glycosides, steroids, terpenoids, aliphatic compounds, diterpene lactones, phenolics, and flavonoids. TC is hailed for its therapeutic use with anti-inflammatory, anti-cancer, anti-diabetic, cardiac disease, anti-arthritis, and anti-microbial properties. TC induces immunomodulatory effects through the induction of macrophage activation, pro-inflammatory and anti-inflammatory cytokines, lymphocyte proliferation, and also secretion of interleukins. The present chapter highlights the biological properties, therapeutic use, and immunomodulatory pathways of Tinospora cordifolia. © 2023 Bentham Science Publishers. All rights reserved.