Browsing by Author "Komal Bansal"

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Analytical substantiation of an antidiabetic ayurvedic formulation Eladi Churna through fourier transmission infrared
(BRNSS Publication Hub, 2017) Komal Bansal; K.R.C. Reddy
Aim: This study aims to evaluate possible functional group and phytoconstituents present in all the ingredients of Eladi Churna as well as in final dosage form (Eladi Churna). Materials and Methods: For infrared (IR) spectroscopy, all the samples were mixed with KBr in moisture free environment in a ratio of 1: 100, then, pellets were prepared and processed for scanning. Results and Discussions: Different absorbance peaks in Fourier transmission IR (FTIR) spectrum indicates the presence of phytoconstituents such as phenols, polyphenols, tannins, carbohydrates, and glycosides. Conclusion: By the usage of FTIR different bonding interactions and presence of phytoconstituents has been evaluated in separate ingredients as well as in final formulation. FTIR, if used in a proper manner, can act as a boon in the analytical validation of herbal medicines which are a complex mixture of phytoconstituents.
Anti-hyperglycaemic study of Eladi churna in streptozotocin (STZ) induced diabetic rats
(National Institute of Science Communication and Information Resources (NISCAIR), 2019) Komal Bansal; K.R.C. Reddy; Anshuman Trigunayat
Diabetes mellitus is the seventh leading cause of death worldwide, with a frequent occurrence of Type II diabetes as compared to Type I. The aim of this present study was to evaluate the anti-hyperglycaemic effect of a classical herbomineral preparation Eladi Churna in STZ induced Type II diabetic rats. Thirty adult charles foster albino rats were allocated in to five groups with six animals in each group: Group I (Control Group), Group II (Diabetic control group without any medication), group III (Standard drug Glibenclamide at 1mg/kg of body weight), group IV (Eladi Churna at 300 mg/kg of body weight), group V (Eladi Churna at 600 mg/kg of body weight). Diabetes was induced by intraperitoneal injection of STZ at dose level of 35mg/kg. The whole study was conducted for 28 days. The animals were examined for blood glucose levels on 0, 7, 14, 21, 28 days respectively and other biochemical parameters such as serum cholestrol, HDL, LDL, Triglycerides, SGOT, SGPT were evaluated on day 0 and 28, respectively. The results showed that a gradual reduction in blood glucose level was assessed on administration of Eladi Churna at two different dose levels. But it was more significant at dose level of 600 mg/kg as p<0.05 with a mean±SD value of 107.34±2.67 on day 28 as compared to mean±SD value of 494.40±43.99 on day 3 (after induction of diabetes mellitus). And the results were almost analogous to potent antidiabetic drug glibenclamide with a mean±SD value of 95.44±7.44 on day 28. And the drug was also responsible for maintenance of alterations in other biochemical parameters, associated with diabetes mellitus, thus depicting its potent anti hyperglycaemic and hypolipidaemic actions. © 2019, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
Remedial merits of Piper longum Linn with astonishing antidiabetic potential
(BRNSS Publication Hub, 2017) Komal Bansal; Chandra Shekhar; K.R.C. Reddy
Over the past three decades, the number of people with diabetes mellitus (DM) has doubled globally, making it one of the most important public health challenges to all nations. This has been stimulating the development of novel and potentially more effective therapeutic approaches to treat the disease. Even after the availability of a massive amount of hypoglycemic drugs in conventional system, herbals are gaining much attention because of its spectacular therapeutic potential and also help to sustain the healthy condition of the body. In this review article, a highly valuable drug Pippali (Piper longum) has been evaluated on the basis of its pharmacognostical, pharmacological, and therapeutical background. The plant possesses significant antidiabetic activity. The systemic dysfunction associated with DM can also be cured by Pippali. Plant through exhibiting synergistic action gives a valuable response in hepatic, digestive, cardiac, and respiratory disorders. The purpose of this review is to enlighten all the remedial aspects of P. longum with a special focus on its antidiabetic potential. © 2014 International Journal of Green Pharmacy.