Browsing by Author "Krishna Kumar Gupta"

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Anti-proliferative effect of oyster mushroom, pleurotus from florida (Misnomer) p. florida (agaricomycetes) against hela and siha cervical cancer cells: Mushroom-boon for cancer therapies
(Indian Association of Biomedical Scientists, 2019) Ravi Kant Pathak; Deepika Singh; Krishna Kumar Gupta; Shweta Maurya
Introduction and Aim: Worldwide, people are suffering from the increased risk of cancer due to change in lifestyle, feeding habit and quality of food. To overcome this global problem, Mushroom act as a magic wand. The recent investigations reveal that cancer prevalence is inversely proportional to the intake of mushroom; this is because of its proteins, vitamins, carbohydrate and antioxidants contents. Materials and Methods: Among various species of mushrooms, Pleurotus mushrooms are considered as nutraceuticals i.e. it has nutritional and medicinal values. However, mushroom products and extracts possess immunomodulating and direct cytotoxic effect on cancer cells. Results: The results from the present study shows the potential cytotoxic effect of Pleurotus from Florida against cervical cancer (SIHA) cell line through apoptosis. When SIHA cells were incubated with varying concentration of methanolic extract of Pleurotus from Florida for time (48 hrs). The MTT assay revealed the cytotoxic activity of MME of Pleurotus from Florida in a dose dependent manner. The cell cycle analysis of the SIHA cells revealed that MME of Pleurotus from Florida have anti-cancerous activity. Conclusion: The study could be concluded as the Pleurotus from Florida extract can be useful in the treatment of cervical cancers. The chemical compounds present in the P. from Florida might be useful in the development of drug for the treatment of cancer patients. © 2019, Indian Association of Biomedical Scientists. All rights reserved.
Root coverage with bridge flap
(2013) Pushpendra Kumar Verma; Ruchi Srivastava; T.P. Chaturvedi; Krishna Kumar Gupta
Gingival recession in anterior teeth is a common concern due to esthetic reasons or root sensitivity. Gingival recession, especially in multiple anterior teeth, is of huge concern due to esthetic reasons. Various mucogingival surgeries are available for root coverage. This case report presents a new bridge flap technique, which allows the dentist not only to cover the previously denuded root surfaces but also to increase the zone of attached gingiva at a single step. In this case, a coronally advanced flap along with vestibular deepening technique was used as root coverage procedure for the treatment of multiple recession-type defect. Here, vestibular deepening technique is used to increase the width of the attached gingiva. The predictability of this procedure results in an esthetically healthy periodontium, along with gain in keratinized tissue and good patient's acceptance.