Browsing by Author "Kumari Nirja"

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Plastic toxin Bisphenol-A depresses the contractile activity of rat ileum and colon in vitro
(Association of Physiologists and Pharmacologists of India, 2018) Kumari Nirja; Parul Sharma; Anil Kumar Tiwari; M.B. Mandal
Bisphenol A (BPA), a plastic toxin, is required in the production of various plastic items including water bottles, baby feeding bottles and other food and beverage containers. Since, the primary source of human exposure to BPA is the leachate from food and beverage containers, gastro intestinal tissues are particularly susceptible to BPA-induced changes. Therefore, the present study was undertaken to explore the possible effects of BPA on contractility in adult rat ileum and colon. In an organ bath preparation, isometric contractions were recorded from segments of dissected out colon and ileum, with the help of force transducer and digitized data acquisition system. The results indicated that BPA (1-100 μM) significantly (p<0.05) depresses contractile tension and frequency of ileum and colon in a dose dependent manner. Further, the exploration of possible mechanisms for BPA-induced decline in contractile responses revealed that the decrease in contractility was independent of estrogen receptors, nitric oxide and cholinergic system. © 2018, Association of Physiologists and Pharmacologists of India. All rights reserved.