Browsing by Author "Kumari Swati Sharma"

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Intramolecular Cyclization of -COY (Y = OH, NHPh) to Photoredox Functionalized Benzylic C(sp3)-H Bond. Attractive Approach to Construct γ, δ-lactones and lactams Scaffolds
(John Wiley and Sons Inc, 2024) Kumari Swati Sharma; Sandip Kumar Tiwari; Ganesh Pandey
Synthesis of γ and δ-lactones and lactams are reported in high yield by the cyclization of −COY (Y=OH, NHPh) to the photo redox functionalized benzylic C(sp3)−H bond. © 2024 Wiley-VCH GmbH.
Regioselective C(sp2)-H imidation of arenes by redox neutral visible-light photocatalysis
(Royal Society of Chemistry, 2022) Manoj Kumar Ghosh; Kumari Swati Sharma; Ganesh Pandey
We report herein a redox neutral visible light-induced regioselective C(sp2)-H imidation of electron-rich arenes and heteroarenes using conceptually designed redox-active 1 as a source of the N-centered imidyl radical. Structurally diverse aromatic imides were obtained in moderate to good yields. This methodology has been successfully employed for the late stage imidation of complex molecules and has also been applied towards the formal total synthesis of the marine natural products carpatamides A, B and D. It has further been shown that the generated imides can easily be converted to the corresponding anilines in situ directly. © 2023 The Royal Society of Chemistry.
Visible-Light-Induced Secondary Benzylic C(sp3)-H Functionalization for Nucleophilic Substitution: An Intermolecular C-X (C-N, C-C, and C-Br) Bond Forming Reaction
(American Chemical Society, 2025) Kumari Swati Sharma; Nagender Thadem; Ganesh Pandey
Exploring new synthetic methods that harness visible light represents a breakthrough in organic synthesis. Amides, amines, nitriles, and halides are essential functional groups and serve as key building blocks in the synthesis of complex molecules in organic and medicinal chemistry. This study introduces a novel intermolecular benzylic C-X (C-N, C-C, and C-Br) bond formation via photoredox benzylic C(sp3)-H bonds. This methodology enables the synthesis of secondary amides, nitriles, and halides through reacting secondary benzylic substrates with readily accessible reagents including BocNH2, benzamide, acetamide, TMSCN, and TBAB. This approach displays the potential of being sustainable and efficient to afford amidation, cyanation, and halogenation products in good yields. © 2025 American Chemical Society.