Browsing by Author "L.B. Prasad"

Now showing 1 - 5 of 5

A piperidinium-carbodithioate salt: Synthesis, crystal structure, spectral, cation-interaction and electrochemical studies
(Elsevier B.V., 2019) Paras Nath; M.K. Bharty; L.B. Prasad; R.J. Butcher; J.P. Jasinski
An ionic compound 4-methyl-piperidinium 4-methyl-piperidinecarbodithioate (MPMP) C6H14N+·C7H12NS2 ¯ has been synthesized from the one pot reaction of 4-methylpiperidine and carbon disulfide. The compound is well characterized on the basis of elemental analysis, IR, NMR, UV–visible and single crystal X-ray diffraction data. The compound introduces the concept of hydrogen bonding interactions in two ionic species and its effect on crystal packing. The asymmetric unit of the compound consists of 4-methyl-piperidinium cation and 4-methyl-piperidinecarbodithioate anion. Inter and intramolecular N[sbnd]H⋯S contacts link piperidinium cation and carbodithioate anion and stabilize the crystal packing in solid state. The compound crystallizes in monoclinic system with space group P 21/c. The interaction of the compound with different metal ion solutions is studied and it shows interesting red shifts with Co2+, Cu+, Cu2+ and Ni2+ ions which suggests that MPMP may be a useful probe for sensing of these ions. Cyclic voltammetric analysis of the compound exhibits quasi-reversible redox behaviour. © 2019 Elsevier B.V.
Cd(II) Dithiocarbamate Complexes: Synthesis, Spectral Studies, Thermogravimetric Analysis and Semiconducting Behaviour
(Asian Publication Corporation, 2023) V.K. Maurya; L.B. Prasad; A. Singh; K. Shiv; S. Kumar; M.K. Bharty
Five new homoleptic Cd(II) dithiocarbamate complexes (1-5) have been synthesized and characterized by IR, NMR, UV-visible spectroscopic and thermogravimetric analysis. Single-crystal X-ray diffraction study of complex 1 revealed a triclinic system with space group P-1 and possesses a centrosymmetric dimeric structure. In this complex, both C-H···S and C-H···π intermolecular interactions are playing a crucial role in the stabilization of the dithiocarbamate complex. Complexes (1-5) show weak conductivity at ambient temperature (rt = 10-9-10-10 S·cm-1) because of the absence of M···S/S···S intermolecular stacking. Plot of log versus T-1 in the 303-363 K range indicates their semiconducting behaviour. However, their electrical conductivities gradually increase with increasing temperature and ideally decrease with decreasing temperature range showing their semiconducting nature. TGA showed thermal decomposition of complexes into CdS as the final product with grain size of 1-10 nm. © 2023 Chemical Publishing Co.. All rights reserved.
In vitro and In silico anticancer activities of Mn(ii), Co(ii), and Ni(ii) complexes: synthesis, characterization, crystal structures, and DFT studies
(Royal Society of Chemistry, 2022) M.K. Gond; Shivendra Kumar Pandey; R. Singh; Manoj K. Bharty; Partha Pratim Manna; V.K. Singh; B. Maiti; L.B. Prasad; R.J. Butcher
The development of a potent metallodrug to prevent the progression of cancer is needed urgently. Here, three new complexes [Mn(pfth)2(o-phen)] (1), [Co(pfth)2(en)] (2) and [Ni(pfth)2(en)] (3) based on a 4-phenyl-(2-furoyl)-thiosemicarbazide (Hpfth) ligand containing 1,10 phenanthroline (o-phen)/ethylenediamine (en) as secondary ligands have been synthesized. The synthesized complexes have been characterized by various analytical, spectroscopic (IR, UV-vis., NMR), and single-crystal X-ray diffraction techniques. The results obtained by quantum chemical calculations (DFT and TD-DFT) agree with the experimentally observed values. The tumoricidal potential of Mn, Co, and Ni salts, ligand Hpfth, and their coordinate complexes was evaluated against K562, MCF-7, and DL cancer cell lines. Both short-term (XTT and MTT assays) and long-term (clonogenic assay) treatment of the tumor cells studied through colorimetric, clonogenic, and fluorescence-based assays by the complexes demonstrated true anti-tumor effects against these cancer cells. The results suggest the significant antitumor potential of the metal-ligand complexes against the tumor cells in a dose-dependent manner with higher growth inhibition, apoptosis, and inhibition in colony formation in comparison to either metal salts or free ligands. Complexes 1 and 3 induce more growth inhibition as compared to complex 2 against all cancer cell lines. Complex 3 demonstrated impressive tumoricidal properties in a clonogenic assay in comparison to complexes 1 and 2. These studies establish the role of metal centers in antiproliferative activities and reveal that Ni(ii) exhibits more potent anti-tumoricidal activity. Molecular docking studies of Hpfth and complexes 1-3 were also performed against three target proteins 6NE5: Myeloid Cell Leukemia-1 (Mcl-1), 6E91: Carbonic anhydrase IX (CA IX), and 6H0W: Lysine Demethylase 4D and the results displayed favorable binding interactions. © 2022 The Royal Society of Chemistry
Low temperature hydrothermal synthesis and characterization of iron oxide powders of diverse morphologies from spent pickle liquor
(Elsevier, 2015) Manish K. Sinha; Sushanta K. Sahu; Pratima Meshram; L.B. Prasad; Banshi D. Pandey
Iron oxide nanoparticles (goethite and hematite) of various shapes have been synthesized through a simple hydrothermal reaction from the stripped solution of Fe(III) obtained after extraction and separation of Zn and Fe from spent pickle liquor. The influence of pH and synthesis time on the structure and morphology of the as-prepared α-Fe2O3 are investigated. It was possible to control the particle size and shape by adjusting the pH (2-12) of the starting solutions and time of synthesis (1-6h). Under the appropriate conditions, rod-like α-FeOOH (goethite) and hexagonal α-Fe2O3 (hematite) materials of the uniform nano-crystalline structure were selectively synthesized in large quantities. The morphology and structure of the final products were investigated in detail by X-ray powder diffraction pattern (XRD), transmission electron microscopy (TEM), Raman spectroscopy and vibrational sample magnetometer (VSM). The probable mechanism of formation of uniform α-FeOOH and α-Fe2O3 nano-particles is discussed on the basis of the experimental results and characterization studies. The evaluation of the magnetic property has established the weak ferromagnetism characteristics of both goethite and hematite at room temperature. © 2015 Elsevier B.V.
Synthesis, characterizations, crystal structure and anticancer activity of Mn(II), Co(II) and Ni(II) complexes of N′-cyclohexyl-2-thiophene-carbonyl hydrazine carbothioamide
(Elsevier Ltd, 2023) Shubham Jaiswal; Lokesh Yadav; Shivendra Kumar Pandey; Suryansh Chandra; M.K. Bharty; L.B. Prasad; A. Acharya
The current century has witnessed continuous and exponential increase in the number of patients suffering from different types of sarcomas. To cure these sarcomas, there are continuous efforts to develop more efficient and less cytotoxic anti-cancerous and antitumor drugs. A thiosemicarbazide derived N-cyclohexyl-2-thiophene-carbonyl hydrazine carbothioamide (Htach) and its metal complexes [Mn(tach)2(o-phen)] (1), [Co(tach)2(o-phen)] (2), [Ni(tach)2(o-phen)] (3) were synthesized and reported here. In these complexes, o-phen was used as secondary ligand for coordinatively saturation of metal ions. The synthesized ligand and complexes are well characterized with different elemental analysis FT-IR, and UV–visible and HR-MS spectroscopy. Further, Complex 1 was characterized by single XRD and crystallized in monoclinic system with space group P 21/n. The anti-proliferative potential of ligand and its complexes were evaluated against Dalton's lymphoma (DL) cancer cell lines through MTT, AO/EtBr and DAPI based assays. The effect of these metal complexes on normal cell lines (splenocyte) has been also investigated. Our investigation reveals that metal–ligand complexes have significant strong anticancer activity against tumor cells in a dose-dependent mode, whereas minimal effect on normal cell lines. For ligand and complexes 1–3, the IC50 values were found as 20, 10, 20 and 5 µM, respectively. These results suggest that among Mn, Co and Ni complexes, nickel complex will be more effective for the functionalization of anticancer agents. © 2023 Elsevier Ltd