Browsing by Author "Lalit Prashant Meena"

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Assessing the Effectiveness of Double-fortified Salt in Improving Iron Biomarkers and Hemoglobin Concentration among Adolescent Girls in the Chandauli District, Uttar Pradesh, India
(Wolters Kluwer Medknow Publications, 2025) Ravi Shankar; Bhavna Sharma; Priyanshu Rastogi; Afreen Sultana; Hari Shankar; Manushi Srivastava; S. Dasaratha Kumar; Lalit Prashant Meena; Shantanu Sharma
Background: Double fortified salt (DFS) is an innovative new fortified food product that provides humans with small but critical amounts of iodine and iron through their diet. Objectives: The present study involved assessing the effectiveness of DFS in improving the status of iron biomarkers and hemoglobin (Hb) concentration among adolescent girls in Chandauli district, Uttar Pradesh. Materials and Methods: A double-blind, randomized controlled trial was conducted in 26 villages of the Chandauli district among 602 adolescent girls (15–19 years). Venous blood samples were collected from anemic adolescent girls, followed by a baseline survey. One group received DFS along with nutrition education, whereas the other group received iodized salt and nutrition education. An end line survey was conducted to compare the outcomes. The Wilcoxon signed–rank test was employed to evaluate the differences in median values of biochemical parameters, and a regression test was used to assess the association of DFS with the change in serum iron levels from baseline to end line. Results: The Hb levels among girls increased by 1.7 g% from baseline to end line (P < 0.001), and serum iron levels rose by 8.4 µg/dL (P < 0.001). After adjusting for covariates and confounders, the DFS was positively associated with a greater increase in serum iron levels compared to iodized salt (P < 0.05). Conclusion: The present study identified an easy and economical solution to mitigate iron deficiency without causing side effects such as toxicity or stomach upset as with iron tablets. DFS is shown to be an effective public health strategy for enhancing the nutritional status and overall health among adolescent girls. © 2025 Indian Journal of Public Health.
Diagnostic Dilemma in Peripartum Management of von Willebrand Disease: a Case Report
(Springer, 2021) Megha Garg; Uma Pandey; Lalit Prashant Meena
[No abstract available]
Estimation of cardiovascular risk severity in chronic periodontitis patients; [Kronik periodontitli hastalarda kardiyovasküler riskin ciddiyetinin tahmini]
(Gulhane Military Medical Academy, 2015) Mousumi Kundu; Lalit Prashant Meena; Kamlakar Tripathi; Richik Tripathi; Sarita Parihar; Amit Nandan; Dhar Dwivedi
AIM: Chronic periodontal lesion releases pro-inflammatory cytokines which might be accountable for cardiovascular disease. This study was undertaken to access cardiovascular risk by chronic periodontitis. METHOD: The study group comprised of 100 patients with chronic periodontitis (CPD) and 50 healthy control without chronic periodontitis. Periodontal index of each tooth was calculated using Russel’s score. Carotid Intima Media thickness (CIMT) was assessed with a 7.5-MHz linear-array transducer and Ankle-Brachial Pressure Indices (ABPI) were measured with a continuous-wave Doppler machine, ultrasonic gel, and a sphygmomanometer. Full blood counts were performed and levels of serum lipid were determined by autoanalyzer whereas high sensitive C-reactive protein (hsCRP) were measured by ELISA in patients and control. RESULTS: Mean left Carotid Intima Media thickness (CIMT) and mean right CIMT was significantly higher in patients as compared to control (p<0.001). Ankle brachial pressure index (ABPI) was not statistically significant between the two groups. Blood lipid profile was augmented in patient group as compare to control and hsCRP is also following the same pattern. CONCLUSION: Chronic periodontitis (CPD) is associated with increased risk of cardiovascular disease as evidenced by increased hsCRP and radiological parameters. Successful periodontal therapy could decrease serum inflammatory parameters. © 2015, TAF Preventive Medicine Bulletin. ALL RIGHTS RESERVED.
Nocardia farcinica as a causative agent of lung abscess
(Wolters Kluwer Medknow Publications, 2015) Manoj Meena; Ramakant Dixit; Harish Sabarigirivasan; Govind Narayan Srivastava; Lalit Prashant Meena
[No abstract available]
Prevalence of transfusion transmissible infection in blood donors at tertiary care centre of eastern Uttar Pradesh
(J. K. Welfare and Pharmascope Foundation, 2020) Sandip Kumar; Neeraj Dhameja; Satendra Kumar; Sunil Rao; Lalit Prashant Meena; Satyendra Kumar Singh; Neelam Singh
Microbiological safety is very important aspect of blood transfusion services (BTS). Viral infectious agents possess a great risk of transfusion transmitted disease. On the one hand, blood or component transfusion is a lifesav-ing modality but on the other hand it can cause great mortality or morbid-ity in recipient if not used judiciously. The main aim of the study is to evaluate the prevalence of HIV, HBV, HCV, Syphilis and Malaria amongst all types of donors donated at blood bank of Sir Sunderlal Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi during the year 2017. This was a retrospective study. The blood donors included in this study include all donors coming directly to blood bank and blood donation camps orga-nized by blood bank. Total donation during that period was 22255 units. A detailed questionnaire was given to the donors for registration. A total of 226 units (1.01%) were seropositive. The sero-prevalence of HIV, HBV, HCV, and Syphilis were 0.9% (21), 0.79% (177), 0.09% (22), 0.02% (6) respectively. No cases of malaria were detected. TTI can be reduced by motivating maximum voluntary blood donation, reducing replacement donation, public information and donor education awareness programme, stringent donor screening criteria and vigilance of error. © 2020 International Journal of Research in Pharmaceutical Sciences. All rights reserved.
Primary/local hepatic tuberculosis without dissemination
(BMJ Publishing Group, 2015) Manoj Meena; Ramakant Dixit; Lalit Prashant Meena; Jai Kumar Samaria
We present a rare case of primary hepatic tuberculosis in a 50-year-old man who presented with pain at the right hypochondrium. The diagnosis was established by fineneedle aspiration cytology (FNAC) of the primary hepatic lesions in both lobes of the liver, which was further supported by histopathological examination and tissue PCR for Mycobacterium tuberculosis in the FNAC specimens. Copyright © 2015 BMJ Publishing Group.
Role of B‑type natriuretic peptide level in predicting future cardiac events in patients presenting with dyspnea (a hospital‑based study)
(Wolters Kluwer, 2019) Saswata Saha; Lalit Prashant Meena; Jaya Chakravarty; Madhukar Rai
Introduction: Acute dyspnea is one of the most common reasons for admission to emergency rooms. Differentiation of heart failure (HF) from other causes of shortness of breath is often difficult but compulsory. Natriuretic peptides are present in higher concentration in patients with HF and have a potential diagnostic role. The decline in B type natriuretic peptide (BNP) levels subsequent to the treatment of acute HF could predict the future risk of HF and/or cardiac event. Materials and Methods: This was an in‑hospital longitudinal study conducted on adult patients presenting with acute dyspnea to the Department of General Medicine in our institution from January 1, 2016, to December 31, 2016. Eligible patients were followed up over a period of the next 6 months from their day of the first visit. Patients presenting with acute dyspnea were selected. Patients were evaluated using predetermined pro forma including history, physical examination, blood investigations, electrocardiography, chest X‑ray, BNP analysis, and two‑dimensional echo. BNP levels of the patients with BNP >500 pg/ml at the time of admission were again measured at the time of discharge, and these patients were followed up for 6 months for any endpoint. Results: This study of 100 participants gives insight about common etiologies among the patients presenting with acute dyspnea in which HF is a competing diagnosis. In the study, a BNP cutoff of 413 pg/ml determines cardiogenic dyspnea. Out of 60 patients with BNP >500 pg/ml at admission, 22 patients had at least 1 endpoint by the end of 6 months. Cutoff for determination of an endpoint for BNP at admission and BNP at discharge was 1298 and 367.5 pg/ml, respectively. Conclusion: The study showed that BNP at admission and BNP at discharge determines prognosis in patients presenting with dyspnea. The study shows BNP as a better predictor of prognosis than ejection fraction or past history of any cardiac event. © 2019 Heart India | Published by Wolters Kluwer - Medknow.
Study to evaluate the role of serum LDH in the diagnosis of Megaloblastic anemia by treatment response at a tertiary care center in the northeastern part of India
(J. K. Welfare and Pharmascope Foundation, 2019) Saurabh Chopra; Lalit Prashant Meena; Jaya Chakravarty; Madhukar Rai
Megaloblastic anemia and Myelodysplastic syndrome are generally considered mutually exclusive diagnosis and at times becomes difficult to diagnose on the first encounter even after performing bone marrow examination. Aim of this study is to evaluate the role of LDH in the diagnosis of Megaloblastic anemia by treatment response at a tertiary care center in the northeastern part of India. Patients with age more than 12 years, Hemoglobin of patients less than 10 gm/dl, MCV ≥ 100 fl, Reticulocyte count <2.5 were included in the study. Based on serum LDH level patients were divided into two groups. Group A with serum LDH level≥1200 U/L and Group B with serum LDH level of less than 1200 U/L. All these patients of serum LDH≥1200 U/L were given a treatment trial of injectable Vitamin B12 containing 1000 >g of Vitamin B12 for 14 days. The response to treatment was monitored by an increment in reticulocyte count at day 5 and day 14. Bone marrow aspiration was done in all patients who had serum LDH less than 1200 mg/dl. Seventy-nine consecutive patients, who presented with anemia (Hb<10 g/dl) and macrocytosis (MCV > 100 fl) were included in the study. Median LDH values were higher in the patients who responded (vitamin B12 deficient megaloblastic anemia) as compared to non-responders. 93.5% of patients with megaloblastic anemia had Vitamin B12 deficiency, and in comparison, the folic acid deficiency was present among just 6.5 percent patients. Serum Vitamin B 12 and Folic acid level should not be used as a sole criterion for the diagnosis of Megaloblastic anemia and other parameters such as MCV, LDH, and characteristic blood picture, should all be taken into consideration before planning an appropriate treatment strategy. © International Journal of Research in Pharmaceutical Sciences.
Treatment of chronic myeloid leukemia with generic imatinib in patients from northeastern part of india
(J. K. Welfare and Pharmascope Foundation, 2019) Siddharth Samrat; Lalit Prashant Meena; Jaya Chakravarty; Madhukar Rai
Imatinib is now used as the first-line drug to treat CML patient. However, the emergence of resistance to Imatinib in CML patient, the side effect of bone marrow suppression, fluid overload and gastritis are a major limitation of the use of Imatinib in the treatment of CML. This study was conducted to see the therapeutic response and side effect profile of generic Imatinib Mesylate in newly diagnosed CML patients. All cases of CML were given generic Imatinib and followed prospectively with a minimum follow-up of 6 months. They were followed at an interval of 2 weeks till complete hematologic response, thereafter at an interval of 6 to 8 weeks. Cytogenetic and molecular response at the end of one year also evaluated. Among 36 CML patients, 33 were in chronic phase 2 in accelerated phase and 1 in blast crisis while 35 were Philadel-phia+ve and 1 was ph–ve at initial presentation. Minimum duration to achieve CHR was 2 weeks with a mean of 5 weeks. At 3 month except one 35 patients achieved CHR (97%). Out of 36 patients, 27 were subjected for Philadelphia chromosome at one year which shown 23 patients (85.18%) achieved a major cytogenetic response. 8 (38%) patients achieved a major molecular response and one patient (4.76%) was having a complete molecular response at one year. 8 (22.22%) patients developed hematological toxicity to Imatinib with Pancytopenia most common. In conclusion, Generic Imatinib is having an excellent therapeutic response in CML patients although higher response rate may be due to smaller sample size and lesser duration of follow up. © International Journal of Research in Pharmaceutical Sciences.
Unmet Needs in Hemophilia: A Narrative Review
(Journal of Association of Physicians of India, 2025) Rabindra Kumar Jena; Tuphan Kanti Dolai; Jina Bhattacharyya; Kapil Garg; Sudha Sethy; Subhash C. Jha; Lalit Prashant Meena; Meera Varadarajan; Damodar Das; Nehal Patel; Anil I. Singh; Ramnath P. Nevrekar
This review assesses the current landscape of hemophilia management, focusing on identifying unmet clinical needs. Hemophilia, a rare genetic bleeding disorder, requires continuous and comprehensive care to improve patients’ life expectancy and quality of life (QoL). Despite advancements in treatment, challenges persist, including suboptimal bleed protection with current prophylactic options, the development of inhibitory alloantibodies, and the resulting joint damage leading to hemophilic arthropathy (HA). Additionally, the review highlights the significant physical and psychological burden on patients, impacting their education, employment, and overall QoL. Addressing these unmet needs through innovative therapies, improved access to care, and individualized treatment strategies is crucial for enhancing outcomes and reducing the overall burden of hemophilia, particularly in high-prevalence regions like India. © The Author(s). 2025.