Browsing by Author "M. Rai"

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Additional Evidences of Cytogenetic Differentiation in Certain Linum Species with 2n=30 Chromosomes
(1982) M. Rai; K. Das
Meiotic studies in Linum usitatissimum L., Linum angustifolium Huds. and Linum africanum L. were carried out and 2n=30 chromosome number was confirmed. Among the 3 species, mean chiasmata per bivalent varied between 1.82 to 1.90 maximum being in Linum africanum. Secondary association of chromosomes were observed in Linum usitatissimum as well as in Linum angustifolium. However, the 2 species differed in number of bivalents associated. In Linum angustifolium as many as 8 bivalents were involved in association where as in Linum usitatissimum not more than 4 bivalents participated in such a association. In both the species, 11 II+2 IV configuration was most frequent. In all the species early separation of chromosomes in 1-3 bivalents was noted. In Linum angustifolium one of the secondarily associated bivalent invariable showed early separation. Despite secondary association and early separation, meiosis was normal in all the species. Pollen and ovule fertility was also normal. Cytological data in general revealed cryptic chromosomal differences among the 3 species. Linum angustifolium appeared closer to Linum usitatissimum than to Linum africanum. © 1982, Japan Mendel Society, International Society of Cytology. All rights reserved.
Antithrombin III activity in cerebrovascular accidents
(2003) V.P. Singh; M.K. Singh; V. Kumar; M.K. Sinha; R.C. Dwivedi; M. Rai; B. Dube
Cerebrovascular accidents are commonly due to occlusive or haemorrhagic lesions. The present prospective study was planned to find out role of antithrombin in possible etiopathological process, which might predispose an individual for stroke. Method: Biological activity of antithrombin III was done by the method as described by Innerfield et al (1976). Immunological estimation of an antithrombin III was done by single radial immunodiffusion by the technique of Mancini et al modified by Fahey and Mckelvey. Results: The biological and immunological activity of antithrombin III was measured in 98 patient of occlusive and 56 patients of haemorrhagic strokes. Significant depression in biological as well as immunological activity (p<0.001) was observed in occlusive stroke. In haemorrhagic stroke both, biological and immunological activity was increased. In follow up study, there was progressive normalization of both, biological as well as of immunological activity in both group. Conclusion: Decrease of antithrombin III in occlusive and increase in haemorrhagic stroke indicates that these changes have at least an additive role in the pathogenesis of stroke.
Chronic lymphocytic leukaemia terminating into plasma cell leukaemia
(2002) V.P. Singh; M. Rai; Jyoti Shukla; S. Sunder; Usha
Transformation of chronic lymphocytic lymphoma into plasma cell leukaemia is extremely rare. The diagnosis is made on if the circulating plasma cells in peripheral blood is in excess of 2000 cells/mm3.
Clinical profile and response to first-line ARV in HIV patients from eastern UP and Bihar: A retrospective study
(2013) Rohit Goel; M. Rai; J. Chakravarty; L.P. Meena; Narendra K. Tiwary; Shyam Sundar; Anju Bharti
Background and objectives: Spectrum of infections in Human Immunodeficiency Virus (HIV) infected patient from Eastern UP and Bihar has not been systemically evaluated. This study was conducted with the following objectives; a) explore the spectrum of clinical conditions associated with HIV disease, b)the difference between clinical and investigatory parameters in those patients who presented with infection from those who present without infection and c) to evaluate the effect of anti-retroviral (ARV) therapy. Methods: 1248 subjects who fulfilled the inclusion criteria were enrolled for the study from May 2007 to November 2008. Patients were evaluated for their baseline characteristics along with CD4 count and followed up for at least for 6 months after initiation of ARV (6-24 months). Result and interpretation: In this retrospective study, tuberculosis (58.96%) was the commonest infection followed by chronic diarrhoea (26.56%) and various skin infections. Males had significantly higher incidence (p value<.001) of infection as compared to females. There was a significant difference between the patients who presented with infection from those who presented without infection for their baseline weight (42.3 vs 45.42), haemoglobin (9.06 vs 9.91), mean CD4 count at baseline (107.38 vs 128.38/μL) and CD4 count after 6 month of therapy (298.09 vs 322.98 /μL). Mortality was also significantly high (p value<0.05) in those who presented with infection (19.95% vs 15.1%), although there was no difference between these two groups on their improvement in CD4 count from baseline after 6 months of therapy. Conclusion: Among the spectrum of infection in HIV patient from North East part of India, tuberculosis was commonest, followed by skin infections and chronic diarrhoea. Patients who presented with infection at the time of initial presentation had a low haemoglobin, body weight and CD4 count and had high initial mortality but if they survived they show similar response to ARV therapy as patients who presented without infection. © JAPI.
Comparative evaluation of parasitology and serological tests in the diagnosis of visceral leishmaniasis in India: A phase III diagnostic accuracy study
(2007) S. Sundar; R.K. Singh; S.K. Bimal; K. Gidwani; A. Mishra; R. Maurya; S.K. Singh; K.D. Manandhar; M. Boelaert; M. Rai
In this phase III trial for diagnostics for visceral leishmaniasis (VL) in India, we compared parasitological diagnosis with several serological tests: direct agglutination test (freeze dried; DAT-FD), rK-39 strip test, rK-26 strip test and a latex agglutination test for antigen detection in urine (KAtex) in 452 subjects from the endemic regions of Bihar, India. The subjects were segregated into four categories: 230 confirmed patients, 52 probable cases, 70 non-cases and 100 healthy endemic controls. The first two groups were used for estimating sensitivity, the latter two for specificity. Sensitivity of DAT-FD was 98.9%, rK-39: 98.9%, KAtex: 67.0% and rK-26: 21.3%. Sensitivity of DAT-FD on blood taken on filter paper (DAT-FDF) was 99.3%, which was comparable with that using serum. Specificity of serological tests was comparable and high (DAT-FD and DAT-FDF: 94%, rK-39 strip test: 97%, KAtex: 99% and rK-26 strip test: 100%). The classical 'gold standard' parasitological demonstration in splenic smear performed poorly as it missed 18.4% of cases that benefited from VL treatment. Reproducibility of the serological tests between field and central laboratories was excellent (κ = 1.0, 0.99, 0.96 and 0.94 respectively for microscopy, DAT-FD, rK-39 strip test and rK-26 strip test). A high degree of agreement was observed between DAT-FD and rK-39 strip test (κ = 0.986). Although DAT-FD and rK-39 strip test were highly sensitive with excellent specificity, the ease of use of the latter makes it most suitable for the diagnosis of VL in the field conditions. © 2007 Blackwell Publishing Ltd.
Controlled synthesis, bioimaging and toxicity assessments in strong red emitting Mn2+ doped NaYF4:Yb3+/Ho3+ nanophosphors
(Royal Society of Chemistry, 2016) K.L. Reddy; M. Rai; N. Prabhakar; R. Arppe; S.B. Rai; S.K. Singh; J.M. Rosenholm; V. Krishnan
Rare earth, Yb3+/Ho3+ doped NaYF4 nanophosphors showed augmentation of visible green and red light emission by the introduction of Mn2+ as a co-dopant. Nanophosphors were characterized for their morphology and upconversion (UC) fluorescence, as a function of co-dopant concentration. The effect of Mn2+ doping has been investigated to explore the UC mechanism of the phosphors. With the introduction of Mn2+, the intensity of all the emission bands was increased, in particular the red band, which was most significant at 40 mol% doping. A possible mechanism for the enhancement of the red emission has been proposed. The prepared UC nanoparticles were functionalized with polyethylene glycol-polyethylene imine co-polymer to make them water dispersible and successfully applied for cancer cell imaging. © 2016 The Royal Society of Chemistry.
Deep underground neutrino experiment (DUNE) near detector conceptual design report
(MDPI, 2021) A. Abed Abud; B. Abi; R. Acciarri; M.A. Acero; G. Adamov; D. Adams; M. Adinolfi; A. Aduszkiewicz; Z. Ahmad; J. Ahmed; T. Alion; S. Alonso Monsalve; M. Alrashed; C. Alt; A. Alton; P. Amedo; J. Anderson; C. Andreopoulos; M.P. Andrews; F. Andrianala; S. Andringa; N. Anfimov; A. Ankowski; M. Antonova; S. Antusch; A. Aranda-Fernandez; A. Ariga; L.O. Arnold; M.A. Arroyave; J. Asaadi; A. Aurisano; V. Aushev; D. Autiero; M. Ayala-Torres; F. Azfar; A. Back; H. Back; J.J. Back; C. Backhouse; P. Baesso; I. Bagaturia; L. Bagby; S. Balasubramanian; P. Baldi; B. Baller; B. Bambah; F. Barao; G. Barenboim; G.J. Barker; W. Barkhouse; C. Barnes; G. Barr; J. Barranco Monarca; N. Barros; J.L. Barrow; A. Basharina-Freshville; A. Bashyal; V. Basque; E. Belchior; J.B.R. Battat; F. Battisti; F. Bay; J. L. Bazo Alba; J.F. Beacom; E. Bechetoille; B. Behera; L. Bellantoni; G. Bellettini; V. Bellini; O. Beltramello; D. Belver; N. Benekos; F. Bento Neves; S. Berkman; P. Bernardini; R.M. Berner; H. Berns; S. Bertolucci; M. Betancourt; A. Betancur Rodríguez; M. Bhattacharjee; S. Bhuller; B. Bhuyan; S. Biagi; J. Bian; M. Biassoni; K. Biery; B. Bilki; M. Bishai; A. Bitadze; A. Blake; F.D.M. Blaszczyk; G.C. Blazey; E. Blucher; J. Boissevain; S. Bolognesi; T. Bolton; L. Bomben; M. Bonesini; M. Bongrand; F. Bonini; A. Booth; C. Booth; S. Bordoni; A. Borkum; T. Boschi; N. Bostan; P. Bour; C. Bourgeois; S.B. Boyd; D. Boyden; J. Bracinik; D. Braga; D. Brailsford; A. Brandt; J. Bremer; C. Brew; E. Brianne; S.J. Brice; C. Brizzolari; C. Bromberg; G. Brooijmans; J. Brooke; A. Bross; G. Brunetti; M. Brunetti; N. Buchanan; H. Budd; I. Cagnoli; D. Caiulo; P. Calafiura; J. Calcutt; M. Calin; S. Calvez; E. Calvo; A. Caminata; M. Campanelli; K. Cankocak; D. Caratelli; G. Carini; B. Carlus; P. Carniti; I. Caro Terrazas; H. Carranza; T. Carroll; J.F. Castaño Forero; A. Castillo; C. Castromonte; E. Catano-Mur; C. Cattadori; F. Cavalier; F. Cavanna; S. Centro; G. Cerati; A. Cervelli; A. Cervera Villanueva; M. Chalifour; A. Chappell; E. Chardonnet; N. Charitonidis; A. Chatterjee; S. Chattopadhyay; H. Chen; M. Chen; Y. Chen; Z. Chen; D. Cherdack; C. Chi; S. Childress; A. Chiriacescu; G. Chisnall; K. Cho; S. Choate; D. Chokheli; S. Choubey; A. Christensen; D. Christian; G. Christodoulou; A. Chukanov; E. Church; V. Cicero; P. Clarke; T.E. Coan; A.G. Cocco; J.A.B. Coelho; E. Conley; R. Conley; J.M. Conrad; M. Convery; S. Copello; L. Corwin; L. Cremaldi; L. Cremonesi; J.I. Crespo-Anadón; E. Cristaldo; R. Cross; A. Cudd; C. Cuesta; Y. Cui; D. Cussans; M. Dabrowski; O. Dalager; H. Da Motta; L. Da Silva Peres; C. David; Q. David; G.S. Davies; S. Davini; J. Dawson; K. De; R.M. De Almeida; P. Debbins; I. De Bonis; M.P. Decowski; A. De Gouvêa; P.C. De Holanda; I.L. De Icaza Astiz; A. Deisting; P. De Jong; A. Delbart; D. Delepine; M. Delgado; A. Dell’Acqua; P. De Lurgio; J.R.T. De Mello Neto; D.M. De Muth; S. Dennis; C. Densham; G.W. Deptuch; A. De Roeck; V. De Romeri; G. De Souza; R. Dharmapalan; F. Diaz; J.S. Díaz; S. Di Domizio; L. Di Giulio; P. Ding; L. Di Noto; C. Distefano; R. Diurba; M. Diwan; Z. Djurcic; N. Dokania; S. Dolan; M.J. Dolinski; L. Domine; D. Douglas; D. Douillet; G. Drake; F. Drielsma; D. Duchesneau; K. Duffy; P. Dunne; T. Durkin; H. Duyang; O. Dvornikov; D.A. Dwyer; A.S. Dyshkant; M. Eads; A. Earle; D. Edmunds; J. Eisch; L. Emberger; S. Emery; A. Ereditato; C.O. Escobar; G. Eurin; J.J. Evans; E. Ewart; A.C. Ezeribe; K. Fahey; A. Falcone; C. Farnese; Y. Farzan; J. Felix; M. Fernandes Carneiro Da Silva; E. Fernandez-Martinez; P. Fernandez Menendez; F. Ferraro; L. Fields; F. Filthaut; A. Fiorentini; R.S. Fitzpatrick; W. Flanagan; B. Fleming; R. Flight; D.V. Forero; J. Fowler; W. Fox; J. Franc; K. Francis; D. Franco; J. Freeman; J. Freestone; J. Fried; A. Friedland; S. Fuess; I. Furic; A.P. Furmanski; A. Gabrielli; A. Gago; H. Gallagher; A. Gallas; A. Gallego-Ros; N. Gallice; V. Galymov; E. Gamberini; T. Gamble; R. Gandhi; R. Gandrajula; F. Gao; S. Gao; D. Garcia-Gamez; M.Á. García-Peris; S. Gardiner; D. Gastler; G. Ge; B. Gelli; A. Gendotti; S. Gent; Z. Ghorbani-Moghaddam; D. Gibin; I. Gil-Botella; S. Gilligan; C. Girerd; A.K. Giri; D. Gnani; O. Gogota; M. Gold; S. Gollapinni; K. Gollwitzer; R.A. Gomes; L.V. Gomez Bermeo; L.S. Gomez Fajardo; F. Gonnella; J.A. Gonzalez-Cuevas; D. Gonzalez-Diaz; M. Gonzalez-Lopez; M.C. Goodman; O. Goodwin; S. Goswami; C. Gotti; E. Goudzovski; C. Grace; M. Graham; R. Gran; E. Granados; P. Granger; A. Grant; C. Grant; D. Gratieri; P. Green; L. Greenler; J. Greer; W.C. Griffith; M. Groh; J. Grudzinski; K. Grzelak; W. Gu; V. Guarino; R. Guenette; E. Guerard; M. Guerzoni; A. Guglielmi; B. Guo; K.K. Guthikonda; R. Gutierrez; P. Guzowski; M.M. Guzzo; S. Gwon; A. Habig; H. Hadavand; R. Haenni; A. Hahn; J. Haiston; P. Hamacher-Baumann; T. Hamernik; P. Hamilton; J. Han; D.A. Harris; J. Hartnell; J. Harton; T. Hasegawa; C. Hasnip; R. Hatcher; K.W. Hatfield; A. Hatzikoutelis; C. Hayes; E. Hazen; A. Heavey; K.M. Heeger; J. Heise; K. Hennessy; S. Henry; M.A. Hernandez Morquecho; K. Herner; L. Hertel; J. Hewes; A. Higuera; T. Hill; S.J. Hillier; A. Himmel; J. Hoff; C. Hohl; A. Holin; E. Hoppe; G.A. Horton-Smith; M. Hostert; A. Hourlier; B. Howard; R. Howell; J. Huang; J. Huang; J. Hugon; G. Iles; N. Ilic; A.M. Iliescu; R. Illingworth; G. Ingratta; A. Ioannisian; L. Isenhower; R. Itay; A. Izmaylov; S. Jackson; V. Jain; E. James; B. Jargowsky; F. Jediny; D. Jena; Y.S. Jeong; C. Jesús-Valls; X. Ji; L. Jiang; S. Jiménez; A. Jipa; R. Johnson; N. Johnston; B. Jones; S.B. Jones; M. Judah; C.K. Jung; T. Junk; Y. Jwa; M. Kabirnezhad; A. Kaboth; I. Kadenko; I. Kakorin; F. Kamiya; N. Kaneshige; G. Karagiorgi; G. Karaman; A. Karcher; M. Karolak; Y. Karyotakis; S. Kasai; S.P. Kasetti; L. Kashur; N. Kazaryan; E. Kearns; P. Keener; K.J. Kelly; E. Kemp; O. Kemularia; W. Ketchum; S.H. Kettell; M. Khabibullin; A. Khotjantsev; A. Khvedelidze; D. Kim; B. King; B. Kirby; M. Kirby; J. Klein; K. Koehler; L.W. Koerner; S. Kohn; P.P. Koller; L. Kolupaeva; M. Kordosky; T. Kosc; U. Kose; V.A. Kostelecký; K. Kothekar; F. Krennrich; I. Kreslo; Y. Kudenko; V.A. Kudryavtsev; S. Kulagin; J. Kumar; P. Kumar; R. Kumar; P. Kunze; N. Kurita; C. Kuruppu; V. Kus; T. Kutter; A. Lambert; B. Land; K. Lande; C.E. Lane; K. Lang; T. Langford; J. Larkin; P. Lasorak; D. Last; C. Lastoria; A. Laundrie; G. Laurenti; A. Lawrence; I. Lazanu; R. Lazur; T. Le; S. Leardini; J. Learned; P. Lebrun; T. Lecompte; G. Lehmann Miotto; R. Lehnert; M.A. Leigui De Oliveira; M. Leitner; L. Li; S.W. Li; T. Li; Y. Li; H. Liao; C.S. Lin; Q. Lin; S. Lin; A. Lister; B.R. Littlejohn; J. Liu; S. Lockwitz; T. Loew; M. Lokajicek; I. Lomidze; K. Long; K. Loo; D. Lorca; T. Lord; J.M. Losecco; W.C. Louis; X.-G. Lu; K.B. Luk; X. Luo; N. Lurkin; T. Lux; V.P. Luzio; D. Macfarlane; A.A. Machado; P. Machado; C.T. Macias; J.R. Macier; A. Maddalena; A. Madera; P. Madigan; S. Magill; K. Mahn; A. Maio; A. Major; J.A. Maloney; G. Mandrioli; R.C. Mandujano; J. Maneira; L. Manenti; S. Manly; A. Mann; K. Manolopoulos; M. Manrique Plata; V.N. Manyam; L. Manzanillas; M. Marchan; A. Marchionni; W. Marciano; D. Marfatia; C. Mariani; J. Maricic; R. Marie; F. Marinho; A.D. Marino; D. Marsden; M. Marshak; C.M. Marshall; J. Marshall; J. Marteau; J. Martin-Albo; N. Martinez; D.A. Martinez Caicedo; S. Martynenko; K. Mason; A. Mastbaum; M. Masud; S. Matsuno; J. Matthews; C. Mauger; N. Mauri; K. Mavrokoridis; I. Mawby; R. Mazza; A. Mazzacane; E. Mazzucato; T. McAskill; E. McCluskey; N. McConkey; K.S. McFarland; C. McGrew; A. McNab; A. Mefodiev; P. Mehta; P. Melas; O. Mena; S. Menary; H. Mendez; D.P. Méndez; A. Menegolli; G. Meng; M.D. Messier; W. Metcalf; T. Mettler; M. Mewes; H. Meyer; T. Miao; G. Michna; T. Miedema; J. Migenda; V. Mikola; R. Milincic; W. Miller; J. Mills; C. Milne; O. Mineev; O.G. Miranda; S. Miryala; C.S. Mishra; S.R. Mishra; A. Mislivec; D. Mladenov; I. Mocioiu; K. Moffat; N. Moggi; R. Mohanta; T.A. Mohayai; N. Mokhov; J. Molina; L. Molina Bueno; A. Montanari; C. Montanari; D. Montanari; E. Montagna; L.M. Montano Zetina; J. Moon; M. Mooney; A.F. Moor; D. Moreno; C. Morris; C. Mossey; E. Motuk; C.A. Moura; J. Mousseau; W. Mu; L. Mualem; J. Mueller; M. Muether; S. Mufson; F. Muheim; A. Muir; M. Mulhearn; D. Munford; H. Muramatsu; S. Murphy; J. Musser; J. Nachtman; S. Nagu; M. Nalbandyan; R. Nandakumar; D. Naples; S. Narita; D. Navas-Nicolás; A. Navrer-Agasson; N. Nayak; M. Nebot-Guinot; K. Negishi; J.K. Nelson; J. Nesbit; M. Nessi; D. Newbold; M. Newcomer; D. Newhart; H. Newton; M. Niccolo; R. Nichol; F. Nicolas-Arnaldos; M. Nicoletta; E. Niner; K. Nishimura; A. Norman; A. Norrick; R. Northrop; P. Novella; J.A. Nowak; M. Oberling; J.P. Ochoa-Ricoux; A. Olivares Del Campo; A. Olivier; A. Olshevskiy; Y. Onel; Y. Onishchuk; J. Ott; L. Pagani; S. Pakvasa; G. Palacio; O. Palamara; S. Palestini; J.M. Paley; M. Pallavicini; C. Palomares; J.L. Palomino-Gallo; E. Pantic; V. Paolone; V. Papadimitriou; R. Papaleo; A. Papanestis; S. Paramesvaran; S. Parke; Z. Parsa; M. Parvu; S. Pascoli; L. Pasqualini; J. Pasternak; J. Pater; C. Patrick; L. Patrizii; R.B. Patterson; S.J. Patton; T. Patzak; A. Paudel; B. Paulos; L. Paulucci; Z. Pavlovic; G. Pawloski; D. Payne; V. Pec; S.J.M. Peeters; E. Pennacchio; A. Penzo; O.L.G. Peres; J. Perry; D. Pershey; G. Pessina; G. Petrillo; C. Petta; R. Petti; F. Piastra; L. Pickering; F. Pietropaolo; R. Plunkett; R. Poling; X. Pons; N. Poonthottathil; F. Poppi; S. Pordes; J. Porter; M. Potekhin; R. Potenza; B.V.K.S. Potukuchi; J. Pozimski; M. Pozzato; S. Prakash; T. Prakash; S. Prince; D. Pugnere; X. Qian; M.C. Queiroga Bazetto; J.L. Raaf; V. Radeka; J. Rademacker; B. Radics; A. Rafique; E. Raguzin; M. Rai; M. Rajaoalisoa; I. Rakhno; A. Rakotonandrasana; L. Rakotondravohitra; Y.A. Ramachers; R. Rameika; M.A. Ramirez Delgado; B. Ramson; A. Rappoldi; G. Raselli; P. Ratoff; S. Raut; R.F. Razakamiandra; J.S. Real; B. Rebel; M. Reggiani-Guzzo; T. Rehak; J. Reichenbacher; S.D. Reitzner; H. Rejeb Sfar; A. Renshaw; S. Rescia; F. Resnati; A. Reynolds; C. Riccio; G. Riccobene; L.C.J. Rice; J. Ricol; A. Rigamonti; Y. Rigaut; D. Rivera; L. Rochester; M. Roda; P. Rodrigues; M.J. Rodriguez Alonso; E. Rodriguez Bonilla; J. Rodriguez Rondon; S. Rosauro-Alcaraz; M. Rosenberg; P. Rosier; B. Roskovec; M. Rossella; J. Rout; P. Roy; S. Roy; A. Rubbia; C. Rubbia; F.C. Rubio; B. Russell; D. Ruterbories; R. Saakyan; S. Sacerdoti; T. Safford; R. Sahay; N. Sahu; P. Sala; N. Samios; O. Samoylov; M.C. Sanchez; D.A. Sanders; D. Sankey; S. Santana; M. Santos-Maldonado; N. Saoulidou; P. Sapienza; C. Sarasty; I. Sarcevic; G. Savage; V. Savinov; A. Scaramelli; A. Scarff; A. Scarpelli; T. Schaffer; H. Schellman; P. Schlabach; D. Schmitz; K. Scholberg; A. Schukraft; E. Segreto; J. Sensenig; I. Seong; A. Sergi; D. Sgalaberna; M.H. Shaevitz; S. Shafaq; M. Shamma; R. Sharankova; H.R. Sharma; R. Sharma; T. Shaw; C. Shepherd-Themistocleous; S. Shin; D. Shooltz; R. Shrock; L. Simard; F. Simon; N. Simos; J. Sinclair; G. Sinev; J. Singh; J. Singh; V. Singh; R. Sipos; F.W. Sippach; G. Sirri; A. Sitraka; K. Siyeon; K. Skarpaas; A. Smith; E. Smith; P. Smith; J. Smolik; M. Smy; E.L. Snider; P. Snopok; M. Soares Nunes; H. Sobel; M. Soderberg; C.J. Solano Salinas; S. Söldner-Rembold; S. Soleti; N. Solomey; V. Solovov; W.E. Sondheim; M. Sorel; J. Soto-Oton; A. Sousa; K. Soustruznik; F. Spagliardi; M. Spanu; J. Spitz; N.J.C. Spooner; K. Spurgeon; R. Staley; M. Stancari; L. Stanco; R. Stanley; R. Stein; H.M. Steiner; J. Stewart; B. Stillwell; J. Stock; F. Stocker; T. Stokes; M. Strait; T. Strauss; S. Striganov; A. Stuart; J.G. Suarez; H. Sullivan; D. Summers; A. Surdo; V. Susic; L. Suter; C.M. Sutera; R. Svoboda; B. Szczerbinska; A.M. Szelc; R. Talaga; H.A. Tanaka; B. Tapia Oregui; A. Tapper; S. Tariq; E. Tatar; R. Tayloe; A.M. Teklu; M. Tenti; K. Terao; C.A. Ternes; F. Terranova; G. Testera; A. Thea; J.L. Thompson; C. Thorn; S.C. Timm; J. Todd; A. Tonazzo; D. Torbunov; M. Torti; M. Tortola; F. Tortorici; D. Totani; M. Toups; C. Touramanis; N. Tosi; R. Travaglini; J. Trevor; S. Trilov; W.H. Trzaska; Y.T. Tsai; Z. Tsamalaidze; K.V. Tsang; N. Tsverava; S. Tufanli; C. Tull; E. Tyley; M. Tzanov; M.A. Uchida; J. Urheim; T. Usher; S. Uzunyan; M.R. Vagins; P. Vahle; G.A. Valdiviesso; E. Valencia; P. Valerio; Z. Vallari; J.W.F. Valle; S. Vallecorsa; R. Van Berg; R.G. Van De Water; F. Varanini; D. Vargas; G. Varner; J. Vasel; S. Vasina; G. Vasseur; N. Vaughan; K. Vaziri; S. Ventura; A. Verdugo; S. Vergani; M.A. Vermeulen; M. Verzocchi; M. Vicenzi; H. Vieira De Souza; C. Vignoli; C. Vilela; B. Viren; T. Vrba; T. Wachala; A.V. Waldron; M. Wallbank; H. Wang; J. Wang; L. Wang; M.H.L.S. Wang; Y. Wang; Y. Wang; K. Warburton; D. Warner; M. Wascko; D. Waters; A. Watson; P. Weatherly; A. Weber; M. Weber; H. Wei; A. Weinstein; D. Wenman; M. Wetstein; A. White; L.H. Whitehead; D. Whittington; M.J. Wilking; C. Wilkinson; Z. Williams; F. Wilson; R.J. Wilson; J. Wolcott; T. Wongjirad; A. Wood; K. Wood; E. Worcester; M. Worcester; C. Wret; W. Wu; W. Wu; Y. Xiao; E. Yandel; G. Yang; K. Yang; S. Yang; T. Yang; A. Yankelevich; N. Yershov; K. Yonehara; T. Young; B. Yu; H. Yu; J. Yu; W. Yuan; R. Zaki; J. Zalesak; L. Zambelli; B. Zamorano; A. Zani; L. Zazueta; G. Zeit; G.P. Zeller; J. Zennamo; K. Zeug; C. Zhang; M. Zhao; E. Zhivun; G. Zhu; P. Zilberman; E.D. Zimmerman; M. Zito; S. Zucchelli; J. Zuklin; V. Zutshi; R. Zwaska
The Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are at the forefront of astrophysics and particle physics research. DUNE will study questions pertaining to the preponderance of matter over antimatter in the early universe, the dynamics of supernovae, the subtleties of neutrino interaction physics, and a number of beyond the Standard Model topics accessible in a powerful neutrino beam. A critical component of the DUNE physics program involves the study of changes in a powerful beam of neutrinos, i.e., neutrino oscillations, as the neutrinos propagate a long distance. The experiment consists of a near detector, sited close to the source of the beam, and a far detector, sited along the beam at a large distance. This document, the DUNE Near Detector Conceptual Design Report (CDR), describes the design of the DUNE near detector and the science program that drives the design and technology choices. The goals and requirements underlying the design, along with projected performance are given. It serves as a starting point for a more detailed design that will be described in future documents. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Design, construction and operation of the ProtoDUNE-SP Liquid Argon TPC
(IOP Publishing Ltd, 2022) A. Abed Abud; B. Abi; R. Acciarri; M.A. Acero; M.R. Adames; G. Adamov; D. Adams; M. Adinolfi; A. Aduszkiewicz; J. Aguilar; Z. Ahmad; J. Ahmed; B. Ali-Mohammadzadeh; T. Alion; K. Allison; S. Alonso Monsalve; M. Alrashed; C. Alt; A. Alton; P. Amedo; J. Anderson; C. Andreopoulos; M. Andreotti; M.P. Andrews; F. Andrianala; S. Andringa; N. Anfimov; A. Ankowski; M. Antoniassi; M. Antonova; A. Antoshkin; S. Antusch; A. Aranda-Fernandez; A. Ariga; L.O. Arnold; M.A. Arroyave; J. Asaadi; L. Asquith; A. Aurisano; V. Aushev; D. Autiero; M. Ayala-Torres; F. Azfar; A. Back; H. Back; J.J. Back; C. Backhouse; P. Baesso; I. Bagaturia; L. Bagby; N. Balashov; S. Balasubramanian; P. Baldi; B. Baller; B. Bambah; F. Barao; G. Barenboim; G.J. Barker; W. Barkhouse; C. Barnes; G. Barr; J. Barranco Monarca; A. Barros; N. Barros; J.L. Barrow; A. Basharina-Freshville; A. Bashyal; V. Basque; E. Belchior; J.B.R. Battat; F. Battisti; F. Bay; J.L. Bazo Alba; J.F. Beacom; E. Bechetoille; B. 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Ferraro; L. Fields; P. Filip; F. Filthaut; A. Fiorentini; M. Fiorini; R.S. Fitzpatrick; W. Flanagan; B. Fleming; R. Flight; D.V. Forero; J. Fowler; W. Fox; J. Franc; K. Francis; D. Franco; J. Freeman; J. Freestone; J. Fried; A. Friedland; F. Fuentes Robayo; S. Fuess; I. Furic; A.P. Furmanski; A. Gabrielli; A. Gago; H. Gallagher; A. Gallas; A. Gallego-Ros; N. Gallice; V. Galymov; E. Gamberini; T. Gamble; F. Ganacim; R. Gandhi; R. Gandrajula; F. Gao; S. Gao; A.C.B. Garcia; D. Garcia-Gamez; M.Á. García-Peris; S. Gardiner; D. Gastler; J. Gauvreau; G. Ge; B. Gelli; A. Gendotti; S. Gent; Z. Ghorbani-Moghaddam; P. Giammaria; T. Giammaria; D. Gibin; I. Gil-Botella; S. Gilligan; C. Girerd; A.K. Giri; D. Gnani; O. Gogota; M. Gold; S. Gollapinni; K. Gollwitzer; R.A. Gomes; L.V. Gomez Bermeo; L.S. Gomez Fajardo; F. Gonnella; J.A. Gonzalez-Cuevas; D. Gonzalez Diaz; M. Gonzalez-Lopez; M.C. Goodman; O. Goodwin; S. Goswami; C. Gotti; E. Goudzovski; C. Grace; M. Graham; R. Gran; E. Granados; P. 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Shin; I. Shoemaker; D. Shooltz; R. Shrock; H. Siegel; L. Simard; F. Simon; N. Simos; J. Sinclair; G. Sinev; J. Singh; J. Singh; L. Singh; V. Singh; R. Sipos; F.W. Sippach; G. Sirri; A. Sitraka; K. Siyeon; K. Skarpaas; A. Smith; E. Smith; P. Smith; J. Smolik; M. Smy; E.L. Snider; P. Snopok; D. Snowden-Ifft; M. Soares Nunes; H. Sobel; M. Soderberg; S. Sokolov; C.J. Solano Salinas; S. Söldner-Rembold; S.R. Soleti; N. Solomey; V. Solovov; W.E. Sondheim; M. Sorel; A. Sotnikov; J. Soto-Oton; A. Sousa; K. Soustruznik; F. Spagliardi; M. Spanu; J. Spitz; N.J.C. Spooner; K. Spurgeon; R. Staley; M. Stancari; L. Stanco; R. Stanley; R. Stein; H.M. Steiner; A.F. Steklain Lisbôa; J. Stewart; B. Stillwell; J. Stock; F. Stocker; T. Stokes; M. Strait; T. Strauss; S. Striganov; A. Stuart; J.G. Suarez; H. Sullivan; D. Summers; A. Surdo; V. Susic; L. Suter; C.M. Sutera; R. Svoboda; B. Szczerbinska; A.M. Szelc; H.A. Tanaka; B. Tapia Oregui; A. Tapper; S. Tariq; E. Tatar; R. Tayloe; A.M. Teklu; M. Tenti; K. Terao; C.A. Ternes; F. Terranova; G. Testera; T. Thakore; A. Thea; J.L. Thompson; C. Thorn; S.C. Timm; V. Tishchenko; J. Todd; L. Tomassetti; A. Tonazzo; D. Torbunov; M. Torti; M. Tortola; F. Tortorici; N. Tosi; D. Totani; M. Toups; C. Touramanis; R. Travaglini; J. Trevor; S. Trilov; W.H. Trzaska; Y. Tsai; Y.-T. Tsai; Z. Tsamalaidze; K.V. Tsang; N. Tsverava; S. Tufanli; C. Tull; E. Tyley; M. Tzanov; L. Uboldi; M.A. Uchida; J. Urheim; T. Usher; S. Uzunyan; M.R. Vagins; P. Vahle; G.A. Valdiviesso; E. Valencia; V. Pia; Z. Vallari; E. Vallazza; J.W.F. Valle; S. Vallecorsa; R. van Berg; R.G. van de Water; F. Varanini; D. Vargas; G. Varner; J. Vasel; S. Vasina; G. Vasseur; N. Vaughan; K. Vaziri; S. Ventura; A. Verdugo; S. Vergani; M.A. Vermeulen; M. Verzocchi; M. Vicenzi; H. Vieira de Souza; C. Vignoli; C. Vilela; B. Viren; T. Vrba; T. Wachala; A.V. Waldron; M. Wallbank; C. Wallis; H. Wang; J. Wang; L. Wang; M.H.L.S. Wang; Y. Wang; Y. Wang; K. Warburton; D. Warner; M.O. Wascko; D. Waters; A. Watson; P. Weatherly; A. Weber; M. Weber; H. Wei; A. Weinstein; D. Wenman; M. Wetstein; A. White; L.H. Whitehead; D. Whittington; M.J. Wilking; C. Wilkinson; Z. Williams; F. Wilson; R.J. Wilson; W. Wisniewski; J. Wolcott; T. Wongjirad; A. Wood; K. Wood; E. Worcester; M. Worcester; C. Wret; W. Wu; W. Wu; Y. Xiao; F. Xie; E. Yandel; G. Yang; K. Yang; S. Yang; T. Yang; A. Yankelevich; N. Yershov; K. Yonehara; T. Young; B. Yu; H. Yu; H. Yu; J. Yu; W. Yuan; R. Zaki; J. Zalesak; L. Zambelli; B. Zamorano; A. Zani; L. Zazueta; G.P. Zeller; J. Zennamo; K. Zeug; C. Zhang; M. Zhao; E. Zhivun; G. Zhu; P. Zilberman; E.D. Zimmerman; M. Zito; S. Zucchelli; J. Zuklin; V. Zutshi; R. Zwaska
The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber (LArTPC) that was constructed and operated in the CERN North Area at the end of the H4 beamline. This detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment (DUNE), which will be constructed at the Sandford Underground Research Facility (SURF) in Lead, South Dakota, U.S.A. The ProtoDUNE-SP detector incorporates full-size components as designed for DUNE and has an active volume of 7 × 6 × 7.2 m3. The H4 beam delivers incident particles with well-measured momenta and high-purity particle identification. ProtoDUNE-SP's successful operation between 2018 and 2020 demonstrates the effectiveness of the single-phase far detector design. This paper describes the design, construction, assembly and operation of the detector components. © 2022 CERN
Diarrhea, CD4 counts and enteric infections in a hospital - Based cohort of HIV-infected patients around Varanasi, India
(2006) Suresh V.S. Attili; A.K. Gulati; V.P. Singh; Datla Vivek Varma; M. Rai; Shyam Sundar
Background: As most of the studies in HIV patients with diarrhea were cross sectional, focusing on the etiological agents, we are reporting data on the rate of diarrhea, associations between diarrhea and CD4 counts and variation in frequency of identifying a pathogen with consistency of diarrhea and duration in a prospective hospital based study. Methods: Stool specimens were obtained between Jan 2001 and April 2003 from HIV infected adults with diarrhea presenting to Infectious Disease clinic, Banaras Hindu University, Varanasi. In all patients with diarrhea, specimens were examined by microscopy and cultures to identify pathogens. Results: During the study, 630 person years of observations with diarrhea were analyzed, 140 stool samples were collected representing 43% of episodes of reported diarrhea. Positivity of finding a pathogen from watery stools and formed stools were 40%&24% respectively (p < 0.01) probably due to associated inflammation is more in watery diarrhea. Patients having chronic diarrhea are 2.25 (95%Cl 1.52-2.81) times at more risk of developing other opportunistic infections compared to those who don't have. However this is not true with the acute diarrhea where risk of harboring the opportunistic infections remain same. Conclusion: Diarrhea was most strongly associated with low CD4 counts. Over two-thirds of diarrheal episodes were undiagnosed, suggesting that unidentified agents or primary HIV enteropathy are important causes of diarrhea in this population. There is a strong negative association between duration of diarrhea and CD4 levels. © 2006 Attili et al; licensee BioMed Central Ltd.
Effect of seed maturity and priming on viability and vigour in tomato (Lycopersicon esculentum L.)
(2005) R.G.S. Rao; P.M. Singh; M. Rai
The influence of seed maturity and osmopriming on germination and vigour variations in developing tomato seeds was analysed. Seeds were harvested at various maturity classes based on fruit colour. Results revealed that the physiologically mature seeds showed higher percentage germination, robust and healthy seedlings, greater seedling vigour index (SVI) and longer storability. Priming enhanced the germination behaviour of low vigour and ageing seeds. The seedling mortality and abnormal seedlings were higher in the overmature, mature and immature classes, respectively. © Verlag Eugen Ulmer GmbH & Co.
Endocrine changes in male HIV patients
(2011) L.P. Meena; M. Rai; S.K. Singh; J. Chakravarty; A. Singh; R. Goel; A. Pathak; Shyam Sundar
Aims and objectives: To determine the frequency of adrenal, thyroid and gonadal dysfunction in HIV positive male patients and to evaluate the endocrine function at different level of CD4 cell counts. Material and Methods: A total of 150 male HIV positive subjects were included in study. The patients were divided in three groups on the basis of CD4 cell counts. "Group A": HIV positive with CD4 count < 200/mm, "Group B": HIV positive with CD4 count 200-350/mm3 and "Group C": HIV positive with CD4 count > 350/ mm3. Results: In "group A" (n=50) 2 patients had basal cortisol < 5μg/dl while 23 patients had basal cortisol > 25 \xg/ dl. 15 patients had subclinical hypothyroidism while 11 patients had overt hypothyroidism.25 patients in this group had gonadal dysfunction: majority of them(24) had primary gonadal dysfunction (elevated LH). None of the patients in "group B" (n=50) had hypocortisolism while 11 patients had elevated cortisol; 18 had subclinical hypothyroidism while 4 had overt hypothyroidism while 17patinets were hypogonad, all having elevated LH. In"group C" (n=50) 2 patients had hypocortisolism and 5 had elevated cortisol; 12 patients had subclinical and one had overt hypothyroidism; 7 patients had primary hypogonadism and one had secondary hypogonadism. Overall 4(2.66%) had hypocortisolism while 39 (26%) had elevated cortisol; 45 (30%) had subclinical hypothyroidism while 16(10.66%) had overt hypothyroidism. Gonadal dysfunction was observed in 50 patients (33%) majority of them(48) had primary hypogonadism. On analysis of Pearson's correlation coefficient CD4 count has strong inverse correlation with basal cortisol (r=-0.301, p <0.0001), TSH (r=-0.257,p=0.002)and LH (r=-0.228, p=0.006), while there was a direct correlation with serum testosterone (r=0.175, p=0.037), Conclusion: This pilot study has demonstrated a high incidence of endocrine dysfunction in HIV infected patient in this part of country. High incidence of thyroid and gonadal dysfunction may contribute to morbidity of the patients and have a bearing on quality of life of the HIV infected patients. Hypocortisolism was not that common but high level of cortisol may be a marker of stress due to HIV per se or due to associated infection. Many of these dysfunctions might be transient and a large longitudinal study should be undertaken to substantiate the finding of the present study. © JAPI.
Eu3+-activated CaGa2O4 wide band gap (WBG) material for solar blind UV conversion: Fluorescence and photo-conductivity performance
(Royal Society of Chemistry, 2014) M. Rai; S.K. Singh; K. Mishra; R. Shankar; R.K. Srivastava; S.B. Rai
Herein, we have probed a wide band gap material, CaGa2O4 co-doped with Eu3+/Na+, which is fairly transparent (≥95%) in the visible region and efficiently absorbs solar blind UV radiation. Importantly, the absorbed UV energy can be realized both in terms of fluorescence and photoconductivity as well. X-ray diffraction studies confirmed that CaGa2O4 exhibits two orthorhombic polymorphs: CaO·Ga2O3 I (major) and CaO·Ga2O3II (minor). Vibrational spectroscopy provided the first quantitative insight into the phonon frequency of the material. Upon UV illumination the host itself gives UV-blue and red emissions due to band to band and trap level transitions, respectively. (no additional dopant or activator ion were present). A substantial overlap between the emission spectrum of the host and the excitation spectrum of Eu3+; decrease in emission intensity and decay time (8.82 μs from 9.2 μs) of the host emission, after Eu3+ doping; and evolution of a short rise-time (∼10 μs) in decay curve of Eu3+ revealed that the host efficiently transfers its energy to the Eu3+ ions. Co-doping of Na+ further enhances the emission intensity (∼7 times), decay time and rise-time of the Eu3+ emission. Likewise the intrinsic behavior of Ga2O3 this material also shows significant transient photoconductivity under UV illumination, photocurrent is of the order of μA, but with slow time constant ∼40 min. Thus, the excellent optical properties prove to be superior for photoconductivity for UV-to-visible converter applications. Such WBG optical materials can be coupled to silicon-based commercial detectors for their wide use in areas ranging from invisible flame sensing to UV astronomy. This journal is © the Partner Organisations 2014.
Evaluation of PCR for diagnosis of Indian kala-azar and assessment of cure
(2005) R. Maurya; R.K. Singh; B. Kumar; P. Salotra; M. Rai; S. Sundar
This study was done to evaluate PCR with Ld1 primers for the diagnosis of Indian visceral leishmaniasis (VL) and to assess its role in prediction of the disease outcome. The PCR assay was performed with DNA isolated from the peripheral blood of parasitologically confirmed cases of VL before the initiation of treatment, just after the end of treatment, and at 3 and 6 months of follow-up. The pretreatment PCR result was positive for 100 of 101 patients (sensitivity, 99%; confidence interval [CI], 94 to 100%). None of the 150 negative controls tested were PCR positive (specificity, 100%; CI, 96.8 to 100%). Of 60 patients who were treated at our center, 51 (85%; CI, 73 to 93%) became negative immediately after treatment and continued to be negative at 3 and 6 months of follow-up. At the 3-month follow-up, two of the remaining nine patients were PCR positive, making 58 (96.7%; CI, 87 to 100%) patients PCR negative. At the 6-month follow-up, all patients became PCR negative. One patient who was PCR negative immediately after the end of treatment relapsed 11 months later. This limited prospective study with VL patients suggests that the PCR assay is a highly sensitive and specific (99% and 100%, respectively) tool for the diagnosis of VL. In the majority of patients, it can identify a successful disease outcome; however, its translation into the field setting remains a major challenge.
Evaluation of the status of tuberculosis as part of the clinical case definition of AIDS in India
(2005) V.S.S. Attili; V.P. Singh; M. Rai; D.V. Varma; S. Sundar
Aim: To assess HIV associated tuberculosis in a high tuberculosis prevalence setting and its status in the clinical case definition of AIDS. Methods: All HIV patients attending the infectious disease clinic, Varanasi, India between January 2001 and December 2003 were included in the study. They were stratified into three distinct immunological categories depending on their CD4 levels in accordance to Centers for Disease Control (CDC) classification. Tuberculosis of different organs was defined as detailed below. Results: Tuberculosis was the commonest opportunistic disease, seen in 163 patients. Of these, 68 had exclusively pulmonary tuberculosis, 55 extrapulmonary disease, and 40 the disseminated form. Pulmonary and extrapulmonary tuberculosis had low positive predictive value (PPV) (51% and 42%) for CD4 levels of <200 when compared with the disseminated form (specificity 87% and PPV 75%). Among 86 patients with radiological evidence of tuberculosis, typical radiological features of post-primary tuberculosis were present in 60 cases (70%). Other features such as effusion (14 patients, 16%) and miliary shadows (12 patients, 14%) were comparatively rare. Conclusion: Keeping pulmonary and extrapulmonary forms of tuberculosis in AIDS defining illness should be reconsidered. In a similar way tuberculosis in HIV patients from areas endemic with tuberculosis occurs in patients with a wide range of immune status and has a better prognosis than other AIDS defining illnesses. Therefore the inclusion of tuberculosis in clinical case definition of AIDS is not justified.
First results on ProtoDUNE-SP liquid argon time projection chamber performance from a beam test at the CERN Neutrino Platform
(IOP Publishing Ltd, 2020) B. Abi; A. Abed Abud; R. Acciarri; M.A. Acero; G. Adamov; M. Adamowski; D. Adams; P. Adrien; M. Adinolfi; Z. Ahmad; J. Ahmed; T. Alion; S. Alonso Monsalve; C. Alt; J. Anderson; C. Andreopoulos; M.P. Andrews; F. Andrianala; S. Andringa; A. Ankowski; M. Antonova; S. Antusch; A. Aranda-Fernandez; A. Ariga; L.O. Arnold; M.A. Arroyave; J. Asaadi; A. Aurisano; V. Aushev; D. Autiero; F. Azfar; H. Back; J.J. Back; C. Backhouse; P. Baesso; L. Bagby; R. Bajou; S. Balasubramanian; P. Baldi; B. Bambah; F. Barao; G. Barenboim; G.J. Barker; W. Barkhouse; C. Barnes; G. Barr; J. Barranco Monarca; N. Barros; J.L. Barrow; A. Bashyal; V. Basque; F. Bay; J.L. Bazo Alba; J.F. Beacom; E. Bechetoille; B. Behera; L. Bellantoni; G. Bellettini; V. Bellini; O. Beltramello; D. Belver; N. Benekos; F. Bento Neves; J. Berger; S. Berkman; P. Bernardini; R.M. Berner; H. Berns; S. Bertolucci; M. Betancourt; Y. Bezawada; M. Bhattacharjee; B. Bhuyan; S. Biagi; J. Bian; M. Biassoni; K. Biery; B. Bilki; M. Bishai; A. Bitadze; A. Blake; B. Blanco Siffert; F.D.M. Blaszczyk; G.C. Blazey; E. Blucher; J. Boissevain; S. Bolognesi; T. Bolton; M. Bonesini; M. Bongrand; F. Bonini; A. Booth; C. Booth; S. Bordoni; A. Borkum; T. Boschi; N. Bostan; P. Bour; S.B. Boyd; D. Boyden; J. Bracinik; D. Braga; D. Brailsford; A. Brandt; J. Bremer; C. Brew; E. Brianne; S.J. Brice; C. Brizzolari; C. Bromberg; G. Brooijmans; J. Brooke; A. Bross; G. Brunetti; N. Buchanan; H. Budd; D. Caiulo; P. Calafiura; J. Calcutt; M. Calin; S. Calvez; E. Calvo; L. Camilleri; A. Caminata; M. Campanelli; D. Caratelli; G. Carini; B. Carlus; P. Carniti; I. Caro Terrazas; H. Carranza; A. Castillo; C. Castromonte; C. Cattadori; F. Cavalier; F. Cavanna; S. Centro; G. Cerati; A. Cervelli; A. Cervera Villanueva; M. Chalifour; C. Chang; E. Chardonnet; N. Charitonidis; A. Chatterjee; S. Chattopadhyay; P. Chatzidaki; J. Chaves; H. Chen; M. Chen; Y. Chen; D. Cherdack; C. Chi; S. Childress; A. Chiriacescu; K. Cho; S. Choubey; A. Christensen; D. Christian; G. Christodoulou; E. Church; P. Clarke; T.E. Coan; A.G. Cocco; J.A.B. Coelho; E. Conley; J.M. Conrad; M. Convery; L. Corwin; P. Cotte; L. Cremaldi; L. Cremonesi; J.I. Crespo-Anadón; E. Cristaldo; R. Cross; C. Cuesta; Y. Cui; D. Cussans; M. Dabrowski; H. Da Motta; L. Da Silva Peres; C. David; Q. David; G.S. Davies; S. Davini; J. Dawson; K. De; R.M. De Almeida; P. Debbins; I. De Bonis; M.P. Decowski; A. De Gouv a; P.C. De Holanda; I.L. De Icaza Astiz; A. Deisting; P. De Jong; A. Delbart; D. Delepine; M. Delgado; A. Dell'Acqua; P. De Lurgio; J.R. T. De Mello Neto; D.M. Demuth; S. Dennis; C. Densham; G. Deptuch; A. De Roeck; V. De Romeri; J.J. De Vries; R. Dharmapalan; M. DIas; F. DIaz; J.S. DIáz; S. DI Domizio; L. DI Giulio; P. DIng; L. DI Noto; C. DIstefano; R. DIurba; M. DIwan; Z. Djurcic; N. Dokania; M.J. Dolinski; L. Domine; D. Douglas; F. Drielsma; D. Duchesneau; K. Duffy; P. Dunne; T. Durkin; H. Duyang; O. Dvornikov; D.A. Dwyer; A.S. Dyshkant; M. Eads; D. Edmunds; J. Eisch; S. Emery; A. Ereditato; C.O. Escobar; L. Escudero Sanchez; J.J. Evans; E. Ewart; A.C. Ezeribe; C. Fabre; K. Fahey; A. Falcone; C. Farnese; Y. Farzan; J. Felix; E. Fernandez-Martinez; P. Fernandez Menendez; F. Ferraro; L. Fields; A. Filkins; F. Filthaut; R.S. Fitzpatrick; W. Flanagan; B. Fleming; R. Flight; J. Fowler; W. Fox; J. Franc; K. Francis; D. Franco; J. Freeman; J. Freestone; J. Fried; A. Friedland; S. Fuess; I. Furic; A.P. Furmanski; A. Gago; H. Gallagher; A. Gallego-Ros; N. Gallice; V. Galymov; E. Gamberini; T. Gamble; R. Gandhi; R. Gandrajula; S. Gao; D. Garcia-Gamez; M. Garciá-Peris; S. Gardiner; D. Gastler; G. Ge; B. Gelli; A. Gendotti; S. Gent; Z. Ghorbani-Moghaddam; D. Gibin; I. Gil-Botella; C. Girerd; A.K. Giri; D. Gnani; O. Gogota; M. Gold; S. Gollapinni; K. Gollwitzer; R.A. Gomes; L.V. Gomez Bermeo; L.S. Gomez Fajardo; F. Gonnella; J.A. Gonzalez-Cuevas; M.C. Goodman; O. Goodwin; S. Goswami; C. Gotti; E. Goudzovski; C. Grace; M. Graham; E. Gramellini; R. Gran; E. Granados; A. Grant; C. Grant; D. Gratieri; P. Green; S. Green; L. Greenler; M. Greenwood; J. Greer; W.C. Griffith; M. Groh; J. Grudzinski; K. Grzelak; W. Gu; V. Guarino; R. Guenette; A. Guglielmi; B. Guo; K.K. Guthikonda; R. Gutierrez; P. Guzowski; M.M. Guzzo; S. Gwon; K. Haaf; A. Habig; A. Hackenburg; H. Hadavand; R. Haenni; A. Hahn; J. Haigh; J. Haiston; T. Hamernik; P. Hamilton; J. Han; K. Harder; D.A. Harris; J. Hartnell; T. Hasegawa; R. Hatcher; E. Hazen; A. Heavey; K.M. Heeger; J. Heise; K. Hennessy; S. Henry; M.A. Hernandez Morquecho; K. Herner; L. Hertel; A.S. Hesam; J. Hewes; A. Higuera; T. Hill; S.J. Hillier; A. Himmel; J. Hoff; C. Hohl; A. Holin; E. Hoppe; G.A. Horton-Smith; M. Hostert; A. Hourlier; B. Howard; R. Howell; J. Hrivnak; J. Huang; J. Huang; J. Hugon; G. Iles; N. Ilic; A.M. Iliescu; R. Illingworth; A. Ioannisian; R. Itay; A. Izmaylov; E. James; B. Jargowsky; F. Jediny; C. Jes s-Valls; X. Ji; L. Jiang; S. Jiménez; A. Jipa; A. Joglekar; C. Johnson; R. Johnson; B. Jones; S. Jones; C.K. Jung; T. Junk; Y. Jwa; M. Kabirnezhad; A. Kaboth; I. Kadenko; F. Kamiya; G. Karagiorgi; A. Karcher; M. Karolak; Y. Karyotakis; S. Kasai; S.P. Kasetti; L. Kashur; N. Kazaryan; E. Kearns; P. Keener; K.J. Kelly; E. Kemp; C. Kendziora; W. Ketchum; S.H. Kettell; M. Khabibullin; A. Khotjantsev; A. Khvedelidze; D. Kim; B. King; B. Kirby; M. Kirby; J. Klein; K. Koehler; L.W. Koerner; S. Kohn; P.P. Koller; M. Kordosky; T. Kosc; U. Kose; V.A. Kostelecký; K. Kothekar; F. Krennrich; I. Kreslo; Y. Kudenko; V.A. Kudryavtsev; S. Kulagin; J. Kumar; R. Kumar; C. Kuruppu; V. Kus; T. Kutter; B. Lacarelle; A. Lambert; K. Lande; C.E. Lane; K. Lang; T. Langford; P. Lasorak; D. Last; C. Lastoria; A. Laundrie; A. Lawrence; I. Lazanu; R. Lazur; T. Le; J. Learned; P. Lebrun; G. Lehmann Miotto; R. Lehnert; M.A. Leigui De Oliveira; M. Leitner; M. Leyton; L. Li; S. Li; S.W. Li; T. Li; Y. Li; H. Liao; C.S. Lin; S. Lin; A. Lister; B.R. Littlejohn; J. Liu; T. Liu; S. Lockwitz; T. Loew; M. Lokajicek; I. Lomidze; K. Long; K. Loo; D. Lorca; T. Lord; J.M. Losecco; W.C. Louis; K.B. Luk; X. Luo; N. Lurkin; T. Lux; V.P. Luzio; D. MacFarland; A.A. MacHado; P. MacHado; C.T. MacIas; J.R. MacIer; A. Maddalena; P. Madigan; S. Magill; K. Mahn; A. Maio; J.A. Maloney; G. Mandrioli; J. Maneira; L. Manenti; S. Manly; A. Mann; K. Manolopoulos; M. Manrique Plata; A. Marchionni; W. Marciano; D. Marfatia; C. Mariani; J. Maricic; F. Marinho; A.D. Marino; M. Marshak; C. Marshall; J. Marshall; J. Marteau; J. Martin-Albo; N. Martinez; D.A. Martinez Caicedo; S. Martynenko; K. Mason; A. Mastbaum; M. Masud; S. Matsuno; J. Matthews; C. Mauger; N. Mauri; K. Mavrokoridis; R. Mazza; A. Mazzacane; E. Mazzucato; E. McCluskey; N. McConkey; K.S. McFarland; C. McGrew; A. McNab; A. Mefodiev; P. Mehta; P. Melas; M. Mellinato; O. Mena; S. Menary; H. Mendez; A. Menegolli; G. Meng; M.D. Messier; W. Metcalf; M. Mewes; H. Meyer; T. Miao; G. Michna; T. Miedema; J. Migenda; R. Milincic; W. Miller; J. Mills; C. Milne; O. Mineev; O.G. Miranda; S. Miryala; C.S. Mishra; S.R. Mishra; A. Mislivec; D. Mladenov; I. Mocioiu; K. Moffat; N. Moggi; R. Mohanta; T.A. Mohayai; N. Mokhov; J. Molina; L. Molina Bueno; A. Montanari; C. Montanari; D. Montanari; L.M. Montano Zetina; J. Moon; M. Mooney; A. Moor; D. Moreno; B. Morgan; C. Morris; C. Mossey; E. Motuk; C.A. Moura; J. Mousseau; W. Mu; L. Mualem; J. Mueller; M. Muether; S. Mufson; F. Muheim; A. Muir; M. Mulhearn; H. Muramatsu; S. Murphy; J. Musser; J. Nachtman; S. Nagu; M. Nalbandyan; R. Nandakumar; D. Naples; S. Narita; D. Navas-Nicolás; N. Nayak; M. Nebot-Guinot; L. Necib; K. Negishi; J.K. Nelson; J. Nesbit; M. Nessi; D. Newbold; M. Newcomer; D. Newhart; R. Nichol; E. Niner; K. Nishimura; A. Norman; A. Norrick; R. Northrop; P. Novella; J.A. Nowak; M. Oberling; A. Olivares Del Campo; A. Olivier; Y. Onel; Y. Onishchuk; J. Ott; L. Pagani; S. Pakvasa; O. Palamara; S. Palestini; J.M. Paley; M. Pallavicini; C. Palomares; E. Pantic; V. Paolone; V. Papadimitriou; R. Papaleo; A. Papanestis; S. Paramesvaran; S. Parke; Z. Parsa; M. Parvu; S. Pascoli; L. Pasqualini; J. Pasternak; J. Pater; C. Patrick; L. Patrizii; R.B. Patterson; S.J. Patton; T. Patzak; A. Paudel; B. Paulos; L. Paulucci; Z. Pavlovic; G. Pawloski; D. Payne; V. Pec; S.J.M. Peeters; Y. Penichot; E. Pennacchio; A. Penzo; O.L.G. Peres; J. Perry; D. Pershey; G. Pessina; G. Petrillo; C. Petta; R. Petti; F. Piastra; L. Pickering; F. Pietropaolo; J. Pillow; J. Pinzino; R. Plunkett; R. Poling; X. Pons; N. Poonthottathil; S. Pordes; M. Potekhin; R. Potenza; B.V.K.S. Potukuchi; J. Pozimski; M. Pozzato; S. Prakash; T. Prakash; S. Prince; G. Prior; D. Pugnere; K. Qi; X. Qian; J.L. Raaf; R. Raboanary; V. Radeka; J. Rademacker; B. Radics; A. Rafique; E. Raguzin; M. Rai; M. Rajaoalisoa; I. Rakhno; H.T. Rakotondramanana; L. Rakotondravohitra; Y.A. Ramachers; R. Rameika; M.A. Ramirez Delgado; B. Ramson; A. Rappoldi; G. Raselli; P. Ratoff; S. Ravat; H. Razafinime; J.S. Real; B. Rebel; D. Redondo; M. Reggiani-Guzzo; T. Rehak; J. Reichenbacher; S.D. Reitzner; A. Renshaw; S. Rescia; F. Resnati; A. Reynolds; G. Riccobene; L.C.J. Rice; K. Rielage; A. Rigamonti; Y. Rigaut; D. Rivera; L. Rochester; M. Roda; P. Rodrigues; M.J. Rodriguez Alonso; J. Rodriguez Rondon; A.J. Roeth; H. Rogers; S. Rosauro-Alcaraz; M. Rosenthal; M. Rossella; J. Rout; S. Roy; A. Rubbia; C. Rubbia; B. Russell; J. Russell; D. Ruterbories; R. Saakyan; S. Sacerdoti; T. Safford; N. Sahu; P. Sala; G. Salukvadze; N. Samios; M.C. Sanchez; D.A. Sanders; D. Sankey; S. Santana; M. Santos-Maldonado; N. Saoulidou; P. Sapienza; C. Sarasty; I. Sarcevic; G. Savage; V. Savinov; A. Scaramelli; A. Scarff; A. Scarpelli; H. Schellman; P. Schlabach; D. Schmitz; K. Scholberg; A. Schukraft; E. Segreto; E. Seltskaya; J. Sensenig; I. Seong; A. Sergi; F. Sergiampietri; D. Sgalaberna; M.H. Shaevitz; S. Shafaq; M. Shamma; H.R. Sharma; R. Sharma; T. Shaw; C. Shepherd-Themistocleous; S. Shin; D. Shooltz; R. Shrock; L. Simard; N. Simos; J. Sinclair; G. Sinev; J. Singh; J. Singh; V. Singh; R. Sipos; F.W. Sippach; G. Sirri; A. Sitraka; K. Siyeon; D. Smargianaki; A. Smith; A. Smith; E. Smith; P. Smith; J. Smolik; M. Smy; P. Snopok; M. Soares Nunes; H. Sobel; M. Soderberg; C.J. Solano Salinas; S. Söldner-Rembold; N. Solomey; V. Solovov; W.E. Sondheim; M. Sorel; J. Soto-Oton; A. Sousa; K. Soustruznik; F. Spagliardi; M. Spanu; J. Spitz; N.J.C. Spooner; K. Spurgeon; R. Staley; M. Stancari; L. Stanco; D. Stefan; H.M. Steiner; J. Stewart; B. Stillwell; J. Stock; F. Stocker; T. Stokes; M. Strait; T. Strauss; S. Striganov; A. Stuart; R. Sulej; D. Summers; A. Surdo; V. Susic; L. Suter; C.M. Sutera; R. Svoboda; B. Szczerbinska; A.M. Szelc; R. Talaga; H.A. Tanaka; B. Tapia Oregui; A. Tapper; S. Tariq; E. Tatar; R. Tayloe; A.M. Teklu; M. Tenti; K. Terao; C.A. Ternes; F. Terranova; G. Testera; A. Thea; J.L. Thompson; C. Thorn; S.C. Timm; A. Tonazzo; M. Torti; M. Tortola; F. Tortorici; D. Totani; M. Toups; C. Touramanis; J. Trevor; W.H. Trzaska; Y.T. Tsai; Z. Tsamalaidze; K.V. Tsang; N. Tsverava; S. Tufanli; C. Tull; E. Tyley; M. Tzanov; M.A. Uchida; J. Urheim; T. Usher; M.R. Vagins; P. Vahle; G.A. Valdiviesso; E. Valencia; Z. Vallari; J.W.F. Valle; S. Vallecorsa; R. Van Berg; R.G. Van De Water; D. Vanegas Forero; F. Varanini; D. Vargas; G. Varner; J. Vasel; G. Vasseur; K. Vaziri; S. Ventura; A. Verdugo; S. Vergani; M.A. Vermeulen; M. Verzocchi; H. Vieira De Souza; C. Vignoli; C. Vilela; B. Viren; T. Vrba; T. Wachala; A.V. Waldron; M. Wallbank; H. Wang; J. Wang; Y. Wang; Y. Wang; K. Warburton; D. Warner; M. Wascko; D. Waters; A. Watson; P. Weatherly; A. Weber; M. Weber; H. Wei; A. Weinstein; D. Wenman; M. Wetstein; M.R. While; A. White; L.H. Whitehead; D. Whittington; M.J. Wilking; C. Wilkinson; Z. Williams; F. Wilson; R.J. Wilson; J. Wolcott; T. Wongjirad; K. Wood; L. Wood; E. Worcester; M. Worcester; C. Wret; W. Wu; W. Wu; Y. Xiao; G. Yang; T. Yang; N. Yershov; K. Yonehara; T. Young; B. Yu; H.W. Yu; H.Z. Yu; J. Yu; Z.Y. Yu; R. Zaki; J. Zalesak; L. Zambelli; B. Zamorano; A. Zani; L. Zazueta; G.P. Zeller; J. Zennamo; K. Zeug; C. Zhang; M. Zhao; E. Zhivun; G. Zhu; E.D. Zimmerman; M. Zito; S. Zucchelli; J. Zuklin; V. Zutshi; R. Zwaska
The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber with an active volume of 7.2× 6.1× 7.0 m3. It is installed at the CERN Neutrino Platform in a specially-constructed beam that delivers charged pions, kaons, protons, muons and electrons with momenta in the range 0.3 GeV/c to 7 GeV/c. Beam line instrumentation provides accurate momentum measurements and particle identification. The ProtoDUNE-SP detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment, and it incorporates full-size components as designed for that module. This paper describes the beam line, the time projection chamber, the photon detectors, the cosmic-ray tagger, the signal processing and particle reconstruction. It presents the first results on ProtoDUNE-SP's performance, including noise and gain measurements, dE/dx calibration for muons, protons, pions and electrons, drift electron lifetime measurements, and photon detector noise, signal sensitivity and time resolution measurements. The measured values meet or exceed the specifications for the DUNE far detector, in several cases by large margins. ProtoDUNE-SP's successful operation starting in 2018 and its production of large samples of high-quality data demonstrate the effectiveness of the single-phase far detector design. © 2020 CERN.
From QTL to variety-harnessing the benefits of QTLs for drought, flood and salt tolerance in mega rice varieties of India through a multi-institutional network
(Elsevier Ireland Ltd, 2015) Renu Singh; Yashi Singh; Suchit Xalaxo; S. Verulkar; Neera Yadav; Shweta Singh; Nisha Singh; K.S.N. Prasad; K. Kondayya; P.V. Ramana Rao; M. Girija Rani; T. Anuradha; Y. Suraynarayana; P.C. Sharma; S.L. Krishnamurthy; S.K. Sharma; J.L. Dwivedi; A.K. Singh; P.K. Singh; Nilanjay; N.K. Singh; Rajesh Kumar; S.K. Chetia; T. Ahmad; M. Rai; P. Perraju; Anita Pande; D.N. Singh; N.P. Mandal; J.N. Reddy; O.N. Singh; J.L. Katara; B. Marandi; P. Swain; R.K. Sarkar; D.P. Singh; T. Mohapatra; G. Padmawathi; T. Ram; R.M. Kathiresan; K. Paramsivam; S. Nadarajan; S. Thirumeni; M. Nagarajan; A.K. Singh; Prashant Vikram; Arvind Kumar; E. Septiningshih; U.S. Singh; A.M. Ismail; D. Mackill; Nagendra K. Singh
Rice is a staple cereal of India cultivated in about 43.5Mha area but with relatively low average productivity. Abiotic factors like drought, flood and salinity affect rice production adversely in more than 50% of this area. Breeding rice varieties with inbuilt tolerance to these stresses offers an economically viable and sustainable option to improve rice productivity. Availability of high quality reference genome sequence of rice, knowledge of exact position of genes/QTLs governing tolerance to abiotic stresses and availability of DNA markers linked to these traits has opened up opportunities for breeders to transfer the favorable alleles into widely grown rice varieties through marker-assisted backcross breeding (MABB). A large multi-institutional project, "From QTL to variety: marker-assisted breeding of abiotic stress tolerant rice varieties with major QTLs for drought, submergence and salt tolerance" was initiated in 2010 with funding support from Department of Biotechnology, Government of India, in collaboration with International Rice Research Institute, Philippines. The main focus of this project is to improve rice productivity in the fragile ecosystems of eastern, northeastern and southern part of the country, which bear the brunt of one or the other abiotic stresses frequently. Seven consistent QTLs for grain yield under drought, namely, qDTY1.1, qDTY2.1, qDTY2.2, qDTY3.1, qDTY3.2, qDTY9.1 and qDTY12.1 are being transferred into submergence tolerant versions of three high yielding mega rice varieties, Swarna-Sub1, Samba Mahsuri-Sub1 and IR 64-Sub1. To address the problem of complete submergence due to flash floods in the major river basins, the Sub1 gene is being transferred into ten highly popular locally adapted rice varieties namely, ADT 39, ADT 46, Bahadur, HUR 105, MTU 1075, Pooja, Pratikshya, Rajendra Mahsuri, Ranjit, and Sarjoo 52. Further, to address the problem of soil salinity, Saltol, a major QTL for salt tolerance is being transferred into seven popular locally adapted rice varieties, namely, ADT 45, CR 1009, Gayatri, MTU 1010, PR 114, Pusa 44 and Sarjoo 52. Genotypic background selection is being done after BC2F2 stage using an in-house designed 50K SNP chip on a set of twenty lines for each combination, identified with phenotypic similarity in the field to the recipient parent. Near-isogenic lines with more than 90% similarity to the recipient parent are now in advanced generation field trials. These climate smart varieties are expected to improve rice productivity in the adverse ecologies and contribute to the farmer's livelihood. © 2015 Elsevier Ireland Ltd.
Genetic relationship among Hyacinth bean (Lablab purpureus) genotypes cultivars from different races based on quantitative traits and random amplified polymorphic DNA marker
(2010) N. Rai; Ashish Kumar; P.K. Singh; M. Singh; D. Datta; M. Rai
Genetic improvement of the thirty Hyacinth bean cultivars from different races were evaluated using RAPD markers which is essential to enhance the crop for economically and agriculturally important traits. RAPD markers were efficient in separating cultivars according to different races. Twenty six decamer primers could generate a total number of 148 bands out which 70.27% (104) were polymorphic. The number of amplification products produced by each primer varied from 4 to 9 with an average of 5.69 bands per primer. The size of amplified fragments ranged from 250 to 3000 bp. RAPD based dendrogram showed similarity ranged from 0.38 to 0.96. Genetic distances were concluded using Sorenson Dices similarity coefficient. The genetic relationship obtained with these markers was dissimilar to that provided by morpho-agronomical trait. Genetically distinct cultivars were identified that could be potentially important source of germplasm for further crop improvement programme in the country. © 2010 Academic Journals.
Growth failure: An unusual clinical problem
(BMJ Publishing Group, 1999) Shailendra Kumar Singh; Santosh Kumar Singh; Richa Chaturvedi; Manoj Chaudhari; M. Rai; J.K. Agrawal
[No abstract available]
Growth hormone response to clonidine in obese children
(1991) S.K. Singh; J.K. Agrawal; M. Rai; S.S. Gupta
[No abstract available]
Intracerebral hemorrhage following scorpion bite
(1990) M. Rai; R.C. Shukla; D.N. Varma; H.S. Bajpai; S.K. Gupta
[No abstract available]