Browsing by Author "M. Rashika"

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Evaluation of nanofiber scaffolds laden Ashvakatri in the management of chronic periodontitis-a randomized, controlled split pocket study
(Elsevier B.V., 2025) Pragati Dubey; Neelam Mittal; Brahmeshwar Mishra; Anju Gautam; Naveen P.G. Kumar; M. Rashika
Background: The main objective of periodontal treatment is to stop the progression of periodontal disease. Controlled-release drugs yield promising outcomes when conventional treatment is proven to be insufficient in establishing periodontal health in chronic periodontitis. A low-dose controlled-release delivery method for the treatment of periodontal infection was attempted to be developed in this study. With effective electrospinning, a novel sustained-release medication system including polycaprolactone (PCL) nanofibers containing Ashvakatri (A2) and Tetracycline (TET) was accessed clinically for periodontitis. Method & materials: The electrospinning technique prepared nanofibers with A2 and TET in PCL and gelatin. The A2-loaded nanofiber followed the Higuchi model release and had a sustained impact of 9 days (220 h). 75 periodontal sites from 31 patients with chronic periodontitis (≥5 mm probing depth) followed by 3 groups: Group I received Scaling and root planning (SRP) and blank polymer mat whereas Group II treated with SRP and PCL-GE-A2 nanofiber scaffold/mat, and Group III received SRP + PCL-GE-TET (tetracycline) nanofiber scaffolds. Clinical evaluations of GI, PI, PPD, and CAL were performed on each patient group. Conclusion: Compared to the placebo and standard group, the test group was remarkably associated with improved GI, PI, PPD, and CAL at the end of the study. Therefore, drug-loaded nanofiber was found to be efficacious in treating periodontal diseases and may be appropriate as an alternative treatment. Clinical significance: The fabricated PCL-GE-A2 nanofiber mat was more cost-efficient, minimized the dosage amount, and dosage frequency, and showed no adverse effects or discomforts with increased patient compliance. © 2025 The Authors
Peri-Implant Esthetics in Focus: Comparing Anodized Titanium and Zirconium Dioxide Abutments in a Randomized Clinical Trial
(John Wiley and Sons Inc, 2025) Sakshi Agarwal; Farhan Durrani; Aishwarya Pandey; M. Rashika; Shraddha Shilpi; Dhanraj Meena
Objective: Achieving optimal esthetics remains challenging due to limited comparative evidence between pink-anodized titanium and zirconium dioxide abutments. The objective of this clinical study was to evaluate the optical outcomes of pink-anodized titanium and zirconium dioxide abutments in the esthetic region. Methods: Twenty-two subjects with an edentulous site in the maxillary esthetic region with a tooth present mesially and distally were selected for implant surgery along with hard and soft tissue augmentation. Group A received a pink-anodized titanium abutment with a layered lithium disilicate single crown. Group B received a zirconium dioxide abutment with the same prosthesis material. The contralateral natural tooth served as the control group. Optical outcomes were assessed using a spectrophotometer. The CIELAB color coordinates (Commission Internationale de l'Eclairage) were recorded to calculate ΔE values. Vernier calipers, along with an endodontic file, were used to measure the peri-implant soft tissue thickness. The Pink Esthetic Score (PES) was evaluated using digital images of 22 single-tooth implant crowns to assess the surrounding soft tissue esthetics. Results: Zirconia abutments (Group A) demonstrated superior optical outcomes compared to pink-anodized titanium abutments (Group B). The ΔE values for Group A at the peri-implant soft tissue, coronal, and midfacial crown levels were significantly lower compared to Group B. Soft tissue thickness (STT) increased over time in both groups, with a slight increase in Group B. The Pink Esthetic Score (PES) also improved with recall visits at each evaluation. Conclusion: Zirconia abutments provided superior esthetic outcomes compared to pink-anodized titanium abutments, with significantly lower color differences (ΔE) and higher Pink Esthetic Scores (PES). Although pink-anodized titanium abutments showed increased soft tissue thickening with time, zirconia abutments remained the more favorable option for esthetically demanding cases. Clinical Trials Registry: (CTRI No. CTRI/2024/03/064442). © 2025 Wiley Periodicals LLC.