Browsing by Author "M.K. Misra"

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Association of HLA-G promoter and 14-bp insertion-deletion variants with acute allograft rejection and end-stage renal disease
(2013) M.K. Misra; S. Prakash; R. Kapoor; S.K. Pandey; R.K. Sharma; S. Agrawal
The aim of this study was to investigate the HLA-G 14-bp insertion/deletion (I/D) polymorphism among end-stage renal disease (ESRD) patients. Cytomegalovirus (CMV) infection, acute allograft rejection (AR) and overall survival after renal transplantation was investigated in 300 ESRD patients and 302 age, sex and ethnicity-matched controls. Sequencing was performed to evaluate the impact of HLA-G promoter region single-nucleotide polymorphisms (SNPs) whereas semi-quantitative PCR method was used to determine the probable HLA-G expression pattern among ESRD and AR cases. Further, soluble human leukocyte antigen (HLA)-G (sHLA-G) expression levels were compared in AR vs non-AR cases in the light of HLA-G 14-bp I/D polymorphism. Increased risk was found for 14-bp D/D (deletion-DD) genotype and 14-bp D allele [DD: odds ratio (OR)=1.46, 95% confidence interval (CI)=1.03-2.06, P value=0.0358; D: OR=1.29, 95% CI=1.03-1.62, P value=0.0277], respectively for ESRD and CMV infection (DD: OR=2.70, 95% CI=1.45-5.05, P value=0.0021; D: OR=1.94, 95% CI=1.22-3.08, P value=0.0052). Nearly fourfold (OR = 3.62, 95%CI=1.61-8.14, p=0.0039) risk was observed for 14-bp I/I (insertion-II) genotype for AR. Survival analysis showed increased overall survival (OS) (AR or death) for 14-bp D/D genotype. HLA-G promoter region sequencing was carried out among 60 ESRD patients and 100 normal controls which showed increased risk for -964 G>A, -725 C>G/T and -486 A>C SNPs. -964 G>A and -725 C>G/T SNPs showed risk association for AR patients. High level of HLA-G transcripts was observed among non-AR patients. Further soluble HLA-G (sHLA-G) showed increased levels in ESRD patients (mean±SEM; 62.16±2.43U/ml) as compared to controls (mean±SEM; 21.06±3.89U/ml) (P=<0.0001). The 14-bp I/I, 14-bp I/D and 14-bp D/D genotypes showed significantly higher levels of sHLA-G among non-AR as compared to AR patients. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Asymptomatic ossified solitary cyst of kidney associated with duodenal ulcer
(1977) S. Khanna; S. Gupta; M.K. Misra; I.M. Gupta
[No abstract available]
Canine shock: Irreversibility and coagulopathy
(1979) B. Dube; M.K. Misra; D. Nayadamma
Canine shock was experimentally induced by 'superior mesenteric artery occlusion followed by release:' two hours of occlusion produced reversible shock while four hours of occlusion caused irreversible shock. In both situations, the animals showed coagulopathy but the magnitude of same was more severe in animals with irreversible shock. The nature of coagulation changes was suggestive of intravascular coagulation. Histological changes showed widespread intravascular fibrin thrombi in the liver and the kidney in animals with irreversible shock and only limited local intravascular coagulation in the subcapsular region of the liver in those with reversible shock. The importance of diffuse intravascular coagulation in the irreversibility of shock was also corroborated by the 'reversion' of shock by prior heparinization.
Efficacy of povidone-iodine (5%) in control of abdominal wound infection
(1984) A.K. Khanna; S.K. Roy; M.K. Misra
[No abstract available]
Evaluation of early results of truncal vagotomy and drainage with that of highly selective vagotomy without drainage
(1978) M.K. Misra; A.L. Pasricha; J.P. Gupta
[No abstract available]
Foreign bodies in the stomach and duodenum
(1978) D.N. Verma; S.K. Gupta; M.K. Misra; N.N. Khanna
[No abstract available]
Giant hydronephrosis in fused crossed ectopic kidney
(1974) M.K. Misra; S.K. Gupta; B.S. Murthi
[No abstract available]
Mitomycin C extravasation ulcers
(1985) A.K. Khanna; A.K. Asthana; M.K. Misra
In a four‐year period, eight patients with mitomycin C extravasation ulcers were encountered. Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal. If extravasation of the drug is recognized, infusion should be stopped immediately, and the site of infusion should be changed. The ulcers should be excised, and primary closure is recommended; if it is not possible then the defect is covered by a partial thickness skin graft. Copyright © 1985 Wiley‐Liss, Inc., A Wiley Company
New vegetation type map of India prepared using satellite remote sensing: Comparison with global vegetation maps and utilities
(Elsevier B.V., 2015) P.S. Roy; M.D. Behera; M.S.R. Murthy; Arijit Roy; Sarnam Singh; S.P.S. Kushwaha; C.S. Jha; S. Sudhakar; P.K. Joshi; Ch. Sudhakar Reddy; Stutee Gupta; Girish Pujar; C.B.S. Dutt; V.K. Srivastava; M.C. Porwal; Poonam Tripathi; J.S. Singh; Vishwas Chitale; A.K. Skidmore; G. Rajshekhar; Deepak Kushwaha; Harish Karnatak; Sameer Saran; A. Giriraj; Hitendra Padalia; Manish Kale; Subrato Nandy; C. Jeganathan; C.P. Singh; C.M. Biradar; Chiranjibi Pattanaik; D.K. Singh; G.M. Devagiri; Gautam Talukdar; Rabindra K. Panigrahy; Harnam Singh; J.R. Sharma; K. Haridasan; Shivam Trivedi; K.P. Singh; L. Kannan; M. Daniel; M.K. Misra; Madhura Niphadkar; Nidhi Nagabhatla; Nupoor Prasad; O.P. Tripathi; P. Rama Chandra Prasad; Pushpa Dash; Qamer Qureshi; S.K. Tripathi; B.R. Ramesh; Balakrishnan Gowda; Sanjay Tomar; Shakil Romshoo; Shilpa Giriraj; Shirish A. Ravan; Soumit Kumar Behera; Subrato Paul; Ashesh Kumar Das; B.K. Ranganath; T.P. Singh; T.R. Sahu; Uma Shankar; A.R.R. Menon; Gaurav Srivastava; Neeti; Subrat Sharma; U.B. Mohapatra; Ashok Peddi; Humayun Rashid; Irfan Salroo; P. Hari Krishna; P.K. Hajra; A.O. Vergheese; Shafique Matin; Swapnil A. Chaudhary; Sonali Ghosh; Udaya Lakshmi; Deepshikha Rawat; Kalpana Ambastha; Akhtar H. Malik; B.S.S. Devi; K.C. Sharma; Prashant Mukharjee; Ajay Sharma; Priya Davidar; R.R. Venkata Raju; S.S. Katewa; Shashi Kant; Vatsavaya S. Raju; B.P. Uniyal; Bijan Debnath; D.K. Rout; Rajesh Thapa; Shijo Joseph; Pradeep Chhetri; Reshma M. Ramachandran
A seamless vegetation type map of India (scale 1: 50,000) prepared using medium-resolution IRS LISS-III images is presented. The map was created using an on-screen visual interpretation technique and has an accuracy of 90%, as assessed using 15,565 ground control points. India has hitherto been using potential vegetation/forest type map prepared by Champion and Seth in 1968. We characterized and mapped further the vegetation type distribution in the country in terms of occurrence and distribution, area occupancy, percentage of protected area (PA) covered by each vegetation type, range of elevation, mean annual temperature and precipitation over the past 100 years. A remote sensing-amenable hierarchical classification scheme that accommodates natural and semi-natural systems was conceptualized, and the natural vegetation was classified into forests, scrub/shrub lands and grasslands on the basis of extent of vegetation cover. We discuss the distribution and potential utility of the vegetation type map in a broad range of ecological, climatic and conservation applications from global, national and local perspectives. Weused 15,565 ground control points to assess the accuracy of products available globally (i.e., GlobCover, Holdridge's life zone map and potential natural vegetation (PNV) maps). Hence we recommend that the map prepared herein be used widely. This vegetation type map is the most comprehensive one developed for India so far. It was prepared using 23.5m seasonal satellite remote sensing data, field samples and information relating to the biogeography, climate and soil. The digital map is now available through a web portal (http://bis.iirs.gov.in). © 2015 Elsevier B.V.
Patterns of portal hypertension and results of treatment: A study from the economically poor and rural area of Varanasi, India
(1984) M.K. Misra; A.K. Khanna; D. Saha
[No abstract available]
Role of mucin and acid-pepsin factors in duodenal ulcer
(1981) M.K. Misra; P. Chandra; A.K. Sanyal; J.P. Gupta
[No abstract available]
Serum malate dehydrogenase (MDH) in portal hypertension--its value as a diagnostic and prognostic indicator.
(1991) M.K. Misra; A.K. Khanna; R. Sharma; S. Srinivasan
Serum MDH levels were estimated in 29 consecutive patients of portal hypertension with the objective of ascertaining its diagnostic value as to the cause of portal hypertension and its prognostic significance. Higher levels of serum MDH were found in cirrhotic patients as compared to noncirrhotic ones. There were however no significant differences found in the values when extrahepatic obstruction group was compared with controls. Furthermore, higher MDH activity was found in those patients who died as compared to the surviving ones.
Spectrum of benign breast disorders in a university hospital.
(1997) A.K. Khanna; J. Tapodar; M.K. Misra
In a period of 2 years, 234 cases of benign breast disorder were studied. Breast pain and modularity was the commonest group (70.1%) followed by fibroadenoma (17.5%). Cyclical mastalgia (61.5%) is more common than non-cyclical mastalgia (38.5%). The age of the patients with cyclical mastalgia was significantly lesser than patients with non-cyclical mastalgia. Cyclical mastalgia was seen only in premenopausal females while non-cyclical mastalgia was also seen in postmenopausal females. Treatment with vitamin E showed 41% response rate with minimal side-effects while treatment with danazol showed 72.1% response rate but was associated with side-effects in one third of the patients.
Typhoid perforation of the gut
(BMJ Publishing Group, 1984) A.K. Khanna; M.K. Misra
One-hundred consecutive patients with typhoid perforation of the gut admitted In the same surgical unit of the University Hospital have been studied. The cases were diagnosed on the basis of history, clinical examination, exploratory findings, histopathological examination, Widal test and bloodculture. Forty-six patients had perforation In the second week of fever. Sixty-one patients presented 48-96 hr after perforation. All the patients were subjected to surgery, 16 under local anaesthesia. Mortality rate increased from 25% to 83% as the duration between perforation and operation increased.