Browsing by Author "Md. Bayazeed Alam"

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Carbon dots from an immunomodulatory plant for cancer cell imaging, free radical scavenging and metal sensing applications
(Future Medicine Ltd., 2021) Debadatta Mohapatra; Md. Bayazeed Alam; Vivek Pandey; Ravi Pratap; Pawan K. Dubey; Avanish S. Parmar; Alakh N. Sahu
Aim: This work aimed to develop Tinospora cordifolia stem-derived carbon dots (TCSCD) for cancer cell imaging, free radical scavenging and metal sensing applications. Method: The TCSCDs were synthesized by a simple, one-step, and ecofriendly hydrothermal carbonization method and characterized for their optical properties, morphology, hydrodynamic size, surface functionality, crystallinity, stability, bacterial biocompatibility, in vitro cellular imaging, free radical scavenging and metal sensing ability. Results: The TCSCDs exhibited excellent biocompatibility with dose-dependent bioimaging results in melanoma (B16F10) and cervical cancer (SiHa) cell lines. They exerted good free radical scavenging, Fe3+ sensing, bacterial biocompatibility, photostability, colloidal dispersion stability and thermal stability. Conclusion: The results reflect the potential of TCSCDs for biomedical and pharmaceutical applications. © 2021
Carbon Quantum Dot as Electron Transporting Layer in Organic Light Emitting Diode
(Wiley-Blackwell, 2019) Md. Bayazeed Alam; Kanchan Yadav; Devyani Shukla; Ritu Srivastava; Jayeeta Lahiri; Avanish. S. Parmar
Carbon quantum dots derived from banana leaves by a simple hydrothermal process has been used as an electron transport layer to fabricate Organic Light Emitting Diodes. To the best of our knowledge, this is the first report of Carbon QD utilized as an electron transport layer inOLED. Devices with multilayered structureITO/PEDOT: PSS/PFO/CQD/LiF/Al are fabricated on indium tin oxide (ITO) coated glass substrates. Current-Voltage (I−V) curves reveal that the turn-on voltages are reduced from 8 V to 6 V as compared with pristine PFO device.Results show CQD as an ETL has enhanced the performance and efficiency of the OLEDs. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Multi-Functional Carbon Dots from an Ayurvedic Medicinal Plant for Cancer Cell Bioimaging Applications
(Springer, 2020) Gaurav Gopal Naik; Md. Bayazeed Alam; Vivek Pandey; Debadatta Mohapatra; Pawan K. Dubey; Avanish S. Parmar; Alakh N. Sahu
The combination of an Ayurvedic wisdom and nanotechnology may help us to resolve the complex healthcare challenges. A facile and economical one-pot hydrothermal synthesis method has been adopted for preparing a blue fluorescent carbon dots (CDs) with a quantum yield of 15.10% from an Ayurvedic medicinal plant Andrographis paniculata (AP). The Andrographis paniculata derived CDs (AAPCDs) were then characterized using different techniques. Through High Performance Thin Layer Chromatography (HPTLC) profiling of the AP extract and the CDs, it was found that some of the phytoconstituents are retained as such while others may have been converted into their derivatives during the process of formation of CDs. The CDs are designed to possess cellular imaging of human breast carcinoma cells (MCF-7), apart from free radicals sensing and scavenging capabilities. AAPCDs showed minimal cytotoxicity in Multi Drug Resistant clinically isolated strains of gram positive and gram negative bacteria which may be employed for microbiology oriented experiments. These results suggest potential of multi-functional AAPCDs as nano-probes for various pharmaceutical, biomedical and bioengineering applications. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.