Browsing by Author "Meena Rani"

Now showing 1 - 5 of 5

Development and biopharmaceutical evaluation of osmotic pump tablets for controlled delivery of diclofenac sodium
(Croatian Pharmaceutical Society, 2003) Meena Rani; Rahul Surana; Chelladurai Sankar; Brahmeshwar Mishra
Based on the principles of an elementary osmotic pump (OP), OP tablets were designed and evaluated with the aim to deliver diclofenac sodium (DS) in a controlled manner. In vitro evaluation was done in various release media and kinetics was evaluated using the regression coefficient analysis. Effects of orifice size, coating membrane type, coating thickness, static and stirred conditions and pH variation were studied. In vivo evaluation was performed on six healthy human volunteers and various pharmacokinetic parameters (C max, tmax, AUC0-24, MRT) and relative bioavailability were calculated. The results were compared with the performance of two commercial tablets of DS. The drug release from OP tablets was dependent on the type and thickness of the coating membrane, but was independent of the orifice size and static and stirred conditions of the release medium. The OP tablets provided a prolonged and controlled DS release compared to commercial sustained-release and conventional tablets of DS.
Development and evaluation of carbomer based matrices for the controlled delivery of diclofenac sodium
(2003) Meena Rani; B. Mishra
Diclofenac Sodium (DS) is a potent non-steroidal anti-inflammatory drug used in treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. An investigation was carried out to develop sustained and controlled release carbomer matrices of DS using Carbopol 974P alone as well as in combinations with Hydroxypropylmethylcellulose (HPMC) and Carboxymethylcellulose (CMC) and to evaluate them for physical characteristics like thickness, weight variation, hardness, drug content uniformity and drug delivery performance. The in vitro study was carried out in pH 7.4 buffer medium (Simulated Intestinal Fluid) using USP XXI dissolution apparatus II. The kinetics of release data were evaluated using regression coefficient analysis and mechanism of release by Peppas exponential equation, Mt / M∞ = Ktn. The observation of results clearly indicated that carbomer matrices of DS provided greater control over drug delivery for longer duration and followed non-Fickian diffusion mechanism, with zero order release kinetics.
Effect of seed rate and integrated nutrient management on growth, yield and economics of direct seeded hybrid rice (Oryza sativa)
(Indian Society of Agronomy, 2019) Hemraj Meena; M.K. Singh; Meena Rani; R.N. Meena
A field experiment was conducted during the rainy seasons of 2016 and 2017 at Agricultural Research Farm, Banaras Hindu University, Varanasi, Uttar Pradesh, to evaluate the effect of integrated nutrient management and seed rate on growth, yield and economics of direct-seeded hybrid rice (Oryza sativa L.). The treatments comprised 3 seed rates (16 kg, 20 kg and 24 kg/ha) and 5 nutrient management, i.e. 100% recommended dose of fertilizer (RDF) through inorganic fertilizer, 100% RDF through inorganic fertilizer + ZnSO4.7H2O 25 kg/ha followed by (fb) 0.2% FeSO4 and 0.2% Borax foliar spray at 20 and 40 days after sowing (DAS), 75% recommended dose of nitrogen (RDN) through inorganic fertilizer + 25% N through FYM, 50% RDN through inorganic fertilizer + 50% N through FYM, and 75% RDN through inorganic fertilizer + 25% N through vermicompost. The experiment was laid out in split plot design with 3 replications. Rice hybrid sown at seed rate of 20 kg/ha showed superior performance in respect of tillers/m2, dry-matter accumulation, leaf-area index (LAI), soil plant analysis development (SPAD) value and yield parameters, i.e. grain and straw yields, net returns and benefit–cost ratio as compared to seed rate of 16 and 24 kg/ha. Amongst the integrated nutrient management options, an application of 50% RDN by urea + 50% N by FYM resulted in better performance, being comparable with those of 75% RDN through inorganic fertilizer + 25 % N through FYM. However, 100% RDF through inorganic fertilizer recorded the lowest growth and yield parameters. Seed rate of 20 kg/ha along with 50% RDN through inorganic fertilizer + 50% N through FYM was found to be a better option for obtaining optimum crop plants and nutrient-management practices in direct-seeded hybrid rice. © 2019, Indian Society of Agronomy. All rights reserved.
Effect of weed management practices on yield and economics of semidry rice
(Journal of Pure and Applied Microbiology, 2017) K. Hemalatha; A.V. Ramana; Neelam Bisen; Meena Rani
A field experiment was conducted during khari f, 2014 in sandy loam soils of Agricultural College Farm, Naira, to find out the effect of weed management practices on yield attributes, yield and economics of semidry rice. The experiment was laid out in randomized block design with ten treatments, each replicated thrice. It was found that superior performance of rice in terms of yield attributes and yield was observed with pre-emergence application of pendimethalin @ 0.75 kg a.i ha-1 at 3-5 DAS fb post-emergence application of metsulfuron methyl + chlorimuron ethyl @ 4 g a.i ha-1 at 20-25 DAS (T10) which was comparable with weed free check (T2). Maximum grain yield, net returns and B: C ratio were also associated with pre-emergence application of pendimethalin @ 0.75 kg a.i ha-1 at 3-5 DAS fb post-emergence application of metsulfuron methyl + chlorimuron ethyl @ 4 g a.i ha-1 at 20-25 DAS (T10) .
Influence of varying seed rates and integrated nutrient management on performance of direct-seeded hybrid rice (Otyza sativa)
(Indian Council of Agricultural Research, 2020) Hemraj Meena; M.K. Singh; Meena Rani
A field experiment was conducted during kharif season of 2016 and 2017 in direct-seeded hybrid rice (Oryza sativa L .) under varying seeding rates and integrated nutrient management. The experiment consisted of three seed rates (16, 20 and 24 kg/ha) and five nutrient management, viz. 100% RDF through inorganic fertilizer, 100% RDF through inorganic fertilizer + ZnSO4.7H2O 25 kg/ha fb 0.2% FeSO4 and 0.2% Borax foliar spray at 20 and 40 DAS, 75% RDN through inorganic fertilizer + 25% N through FYM, 50% RDN through inorganic fertilizer + 50% N through F Y M, 75% RDN through inorganic fertilizer + 25% N through vermicompost. Seed rate of 20 kg/ha recorded superior performance with respect to number of tillers/m2, dry matter accumulation, L A I, SPAD value, grain and straw yields and nutrient uptake as compared to seed rate of 16 and 24 kg/ha. Amongst integrated nutrient management treatments, application of 50% RDN by urea + 50% N by FYM recorded better performance with respect to tillers/ m2, dry matter accumulation, LAI, SPAD value, grain and straw yields and nutrient uptake while 100% RDF through inorganic fertilizer recorded lowest growth and yield. © 2020 Indian Council of Agricultural Research. All rights reserved.