Browsing by Author "Mohammad Imran"

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Aetiopathogenesis in Lower Limb Oedema
(Springer Nature, 2022) Vaibhav Pandey; Mohammad Imran
Edema of lower limb is a common clinical presentation of local and systemic disorders. The word “edema” is derived from the Greek word “oidēma, " where oidein means “to swell.” The swelling of the lower limbs may result from an increase in the amount of any of the tissue components, i.e., muscle, fat, blood, etc. From a clinical point of view, all the conditions which result in excessive accumulation of fluid in the lower limbs lead to edema. The etiology of edema of lower limb varies, and it is important to assess whether the swelling is congenital or acquired, acute or chronic, symmetric or asymmetric and is localized or part of generalized edema [1]. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.
Impact of Dual‑coated Silver Nanoparticle and Antibiotic Sutures on Wound Healing in Inflammatory Mouse Models
(Wolters Kluwer Medknow Publications, 2024) Vaibhav Pandey; Amit Gupta; Indra Singh Choudhary; Mohammad Imran; Shyam Lal Mudavath; Amrita Ghosh Kar; Ruchira Nandan
Background: The use of silver nanoparticles (AgNPs) in biomedicine has emerged in a big way owing to its antibacterial and anti‑inflammatory properties. We hypothesize that combining the AgNPs with antibiotics for coating sutures will enhance the antibacterial property of sutures with the added advantage of the immunomodulatory effect of AgNPs on tissue healing. Materials and Methods: Polyglactin sutures were coated with AgNPs using the dip‑coating method. The uniform coating and morphology of AgNPs on the suture surface were confirmed using scanning electron microscopy (SEM). Each type of suture – polyglactin plain, antibiotic coated (Triclosan), AgNP coated, and dually coated (antibiotic and AgNP) – was assessed for their antibacterial properties against Gram‑positive bacteria, Gram‑negative bacteria, and anaerobes. These sutures were utilized in an abdominal and systemic inflammatory mice model for ileal anastomosis. The intestinal tissue was evaluated for acute and chronic inflammation and collagen deposition to assess the healing and inflammatory response. Results: The SEM and energy dispersive X‑ray analysis showed successful coating of AgNPs on plain and antibiotic‑coated sutures. In comparison with the other groups, the dually coated suture had the best in vitro antibacterial efficacy. The AgNP‑coated sutures were able to decrease both acute and chronic inflammatory cell infiltration, but the collagen synthesis and deposition were enhanced. Conclusion: AgNPs can be coated on Polyglactin suture either alone or in combination with antibiotics with preserved antibacterial effects. The dual coating of sutures gives a synergistic antibacterial effect. The AgNP diminishes immune response in the presence of preserved extracellular matrix generation. © 2024 Journal of Indian Association of Pediatric Surgeons.
Masquerades of a Traumatic Spigelian Hernia: Lessons Learnt
(Springer, 2021) Mohammad Imran; Vivek Srivastava; Vaibhav Pandey
Post-traumatic spigelian hernia is a rare entity and requires a high index of suspicion for its detection. Mostly the cases are diagnosed at the time of first presentation when a swelling is seen at the site of injury. We report a case of missed post-traumatic abdominal wall hernia at the left spigelian point in a 3-year child missed during initial exploration for traumatic jejunal perforation which led to re-exploration for incarceration of hernia. The rarity of presentation as a post-operative complication has not been reported in literature. © 2021, Association of Surgeons of India.