Browsing by Author "Mohammad Zoladl"

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Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019
(Elsevier Ltd, 2022) Amy E. Peden; Patricia Cullen; Kate Louise Francis; Holger Moeller; Margaret M. Peden; Pengpeng Ye; Maoyi Tian; Zhiyong Zou; Susan M. Sawyer; Amirali Aali; Zeinab Abbasi-Kangevari; Mohsen Abbasi-Kangevari; Michael Abdelmasseh; Meriem Abdoun; Rami Abd-Rabu; Deldar Morad Abdulah; Ame Mehadi Abdurehman; Getachew Abebe; Ayele Mamo Abebe; Aidin Abedi; Hassan Abidi; Richard Gyan Aboagye; Hiwa Abubaker Ali; Eman Abu Gharbieh; Denberu Eshetie Adane; Tigist Demssew Adane; Isaac Yeboah Addo; Ololade Grace Adewole; Sangeet Adhikari; Mohammad Adnan; Qorinah Estiningtyas Sakilah Adnani; Aanuoluwapo Adeyimika Bachelor Afolabi; Saira Afzal; Muhammad Sohail Afzal; Zahra Babaei Aghdam; Bright Opoku Ahinkorah; Araz Ramazan Ahmad; Tauseef Ahmad; Sajjad Ahmad; Ali Ahmadi; Haroon Ahmed; Muktar Beshir Ahmed; Ali Ahmed; Ayman Ahmed; Jivan Qasim Ahmed; Tarik Ahmed Rashid; Janardhana P. Aithala; Budi Aji; Meisam Akhlaghdoust; Fares Alahdab; Fahad Mashhour Alanezi; Astawus Alemayehu; Hanadi Al Hamad; Syed Shujait Ali; Liaqat Ali; Yousef Alimohamadi; Vahid Alipour; Syed Mohamed Aljunid; Louay Almidani; Sami Almustanyir; Khalid A. Altirkawi; Nelson J. Alvis-Zakzuk; Edward Kwabena Ameyaw; Tarek Tawfik Amin; Mehrdad Amir-Behghadami; Sohrab Amiri; Hoda Amiri; Tadele Fentabil Anagaw; Tudorel Andrei; Catalina Liliana Andrei; Davood Anvari; Sumadi Lukman Anwar; Anayochukwu Edward Anyasodor; Jalal Arabloo; Morteza Arab-Zozani; Asrat Arja; Judie Arulappan; Ashokan Arumugam; Armin Aryannejad; Saeed Asgary; Tahira Ashraf; Seyyed Shamsadin Athari; Alok Atreya; Sameh Attia; Avinash Aujayeb; Atalel Fentahun Awedew; Sina Azadnajafabad; Mohammadreza Azangou-Khyavy; Samad Azari; Amirhossein Azari Jafari; Hosein Azizi; Ahmed Y. Azzam; Ashish D. Badiye; Nayereh Baghcheghi; Sara Bagherieh; Atif Amin Baig; Shankar M. Bakkannavar; Asaminew Birhanu Balta; MacIej Banach; Palash Chandra Banik; Hansi Bansal; Mainak Bardhan; Francesco BaroneAdesi; Amadou Barrow; Azadeh Bashiri; Pritish Baskaran; Saurav Basu; Nebiyou Simegnew Bayileyegn; Abebe Ayalew Bekel; Alehegn Bekele Bekele; Salaheddine Bendak; Isabela M. Bensenor; Alemshet Yirga Berhie; Devidas S. Bhagat; Akshaya Srikanth Bhagavathula; Pankaj Bhardwaj; Nikha Bhardwaj; Sonu Bhaskar; Ajay Nagesh Bhat; Krittika Bhattacharyya; Zulfiqar A. Bhutta; Sadia Bibi; Bagas Suryo Bintoro; Saeid Bitaraf; Belay Boda Abule Bodicha; Archith Boloor; Souad Bouaoud; Julie Brown; Katrin Burkart; Nadeem Shafique Butt; Muhammad Hammad Butt; Luis Alberto CÃ¡mera; Julio Cesar Campuzano Rincon; Chao Cao; Andre F. Carvalho; MÃ¡rcia Carvalho; Promit Ananyo Chakraborty; Eeshwar K. Chandrasekar; Jung-Chen Chang; Periklis Charalampous; Jaykaran Charan; Vijay Kumar Chattu; Bitew Mekonnen Chekole; Abdulaal Chitheer; Daniel Youngwhan Cho; Hitesh Chopra; Devasahayam J. Christopher; Isaac Sunday Chukwu; NatÃ¡lia Cruz-Martins; Omid Dadras; Saad M.A. Dahlawi; Xiaochen Dai; Giovanni Damiani; Gary L. Darmstadt; Reza Darvishi Cheshmeh Soltani; Aso Mohammad Darwesh; Saswati Das; Anna Dastiridou; Sisay Abebe Debela; Amin Dehghan; Getnet Makasha Demeke; Andreas K. Demetriades; Solomon Demissie; Fikadu Nugusu Dessalegn; Abebaw Alemayehu Desta; Mostafa Dianatinasab; Nancy Diao; Diana Dias Da Silva; Daniel Diaz; Lankamo Ena Digesa; Mengistie Diress; Shirin Djalalinia; Linh Phuong Doan; Milad Dodangeh; Paul Narh Doku; Deepa Dongarwar; Haneil Larson Dsouza; Ebrahim Eini; Michael Ekholuenetale; Temitope Cyrus Ekundayo; Ahmed Elabbas Mustafa Elagali; Mostafa Ahmed Elbahnasawy; Hala Rashad Elhabashy; Muhammed Elhadi; Maysaa El Sayed Zaki; Daniel Berhanie Enyew; Ryenchindorj Erkhembayar; Sharareh Eskandarieh; Farshid Etaee; Adeniyi Francis Fagbamigbe; Pawan Sirwan Faris; Abbas Farmany; Andre Faro; Farshad Farzadfar; Ali Fatehizadeh; Seyed Mohammad Fereshtehnejad; Abdullah Hamid Feroze; Getahun Fetensa; Bikila Regassa Feyisa; Irina Filip; Florian Fischer; Behzad Foroutan; Masoud Foroutan; Kayode Raphael Fowobaje; Richard Charles Franklin; Takeshi Fukumoto; Peter Andras Gaal; Muktar A. Gadanya; Yaseen Galali; Nasrin Galehdar; Balasankar Ganesan; Tushar Garg; Mesfin Gebrehiwot Damtew Gebrehiwot; Yosef Haile Gebremariam; Yibeltal Yismaw Gela; Urge Gerema; Mansour Ghafourifard; Seyyed-Hadi Ghamari; Reza Ghanbari; Mohammad Ghasemi Nour; Maryam Gholamalizadeh; Ali Gholami; Ali Gholamrezanezhad; Sherief Ghozy; Syed Amir Gilani; Tiffany K. Gill; Iago GinÃ©-VÃ¡zquez; Zeleke Abate Girma; James C. Glasbey; Franklin N. Glozah; Mahaveer Golechha; Pouya Goleij; Michal Grivna; Habtamu Alganeh Guadie; Damitha Asanga Gunawardane; Yuming Guo; Veer Bala Gupta; Sapna Gupta; Bhawna Gupta; Vivek Kumar Gupta; Arvin Haj-Mirzaian; Rabih Halwani; Randah R. Hamadeh; Sajid Hameed; Lolemo Kelbiso Hanfore; Asif Hanif; Arief Hargono; Netanja I. Harlianto; Mehdi Harorani; Ahmed I. Hasaballah; S.M. Mahmudul Hasan; Amr Hassan; Soheil Hassanipour; Hadi Hassankhani; Rasmus J. Havmoeller; Simon I. Hay; Mohammad Heidari; Delia Hendrie; Demisu Zenbaba Heyi; Yuta Hiraike; Ramesh Holla; Nobuyuki Horita; Sheikh Jamal Hossain; Mohammad Bellal Hossain Hossain; Sedighe Hosseini Shabanan; Mehdi Hosseinzadeh; Sorin Hostiuc; Amir Human Hoveidaei; Alexander Kevin Hsiao; Salman Hussain; Amal Hussein; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Behzad Imani; Mustapha Immurana; Leeberk Raja Inbaraj; Sheikh Mohammed Shariful Islam; Rakibul M. Islam; Mohammad Mainul Islam; Nahlah Elkudssiah Ismail; J. Linda Merin; Haitham Jahrami; Mihajlo Jakovljevic; Manthan Dilipkumar Janodia; Tahereh Javaheri; Sathish Kumar Jayapal; Umesh Umesh Jayarajah; Sudha Jayaraman; Jayakumar Jeganathan; Bedru Jemal; Ravi Prakash Jha; Jost B. Jonas; Tamas Joo; Nitin Joseph; Jacek Jerzy Jozwiak; Mikk JÃ¼risson; Ali Kabir; Vidya Kadashetti; Dler Hussein Kadir; Laleh R. Kalankesh; Leila R. Kalankesh; Rohollah Kalhor; Vineet Kumar Kamal; Rajesh Kamath; Himal Kandel; Rami S. Kantar; Neeti Kapoor; Hassan Karami; Ibraheem M. Karaye; Samad Karkhah; Patrick D.M.C. Katoto; Joonas H. Kauppila; Gbenga A. Kayode; Leila Keikavoosi-Arani; Cumali Keskin; Yousef Saleh Khader; Himanshu Khajuria; Mohammad Khammarnia; Ejaz Ahmad Khan; Md Nuruzzaman Khan; Maseer Khan; Yusra H. Khan; Imteyaz A. Khan; Abbas Khan; Moien A.B. Khan; Javad Khanali; Moawiah Mohammad Khatatbeh; Hamid Reza Khayat Kashani; Habibolah Khazaie; Jagdish Khubchandani; Zemene Demelash Kifle; Jihee Kim; Yun Jin Kim; Sezer Kisa; Adnan Kisa; Cameron J. Kneib; Farzad Kompani; Hamid Reza Koohestani; Parvaiz A. Koul; Sindhura Lakshmi Koulmane Laxminarayana; Ai Koyanagi; Kewal Krishan; Vijay Krishnamoorthy; Burcu Kucuk Bicer; Nithin Kumar; Naveen Kumar; Narinder Kumar; Manasi Kumar; Om P. Kurmi; Lucie Laflamme; Judit LÃ¡m; IvÃ¡n Landires; Bagher Larijani; Savita Lasrado; Paolo Lauriola; Carlo La Vecchia; Shaun Wen Huey Lee; Yo Han Lee; Sang-Woong Lee; Wei Chen Lee; Samson Mideksa Legesse; Shanshan Li; Stephen S. Lim; LÃ¡szlÃ³ Lorenzovici; Amana Ogeto Luke; Farzan Madadizadeh; Áurea M. Madureira-Carvalho; Muhammed Magdy Abd El Razek; Soleiman Mahjoub; Ata Mahmoodpoor; Razzagh Mahmoudi; Marzieh Mahmoudimanesh; Azeem Majeed; Alaa Makki; Elaheh Malakan Rad; Mohammad-Reza Malekpour; Ahmad Azam Malik; Tauqeer Hussain Mallhi; Deborah Carvalho Malta; Borhan Mansouri; Mohammad Ali Mansournia; Elezebeth Mathews; Sazan Qadir Maulud; Dennis Mazingi; Entezar Mehrabi Nasab; Oliver Mendoza-Cano; Ritesh G. Menezes; Dechasa Adare Mengistu; Alexios-Fotios A. Mentis; Atte Meretoja; Mohamed Kamal Mesregah; Tomislav Mestrovic; Ana Carolina Micheletti Gomide Nogueira de Sá; Ted R. Miller; Seyed Peyman Mirghaderi; Andreea Mirica; Seyyedmohammadsadeq Mirmoeeni; Erkin M. Mirrakhimov; Moonis Mirza; Sanjeev Misra; Prasanna Mithra; Chaitanya Mittal; Madeline E. Moberg; Mokhtar Mohammadi; Soheil Mohammadi; Esmaeil Mohammadi; Reza Mohammadpourhodki; Shafiu Mohammed; Teroj Abdulrahman Mohammed; Mohammad Mohseni; Ali H. Mokdad; Sara Momtazmanesh; Lorenzo Monasta; Mohammad Ali Moni; Rafael Silveira Moreira; Shane Douglas Morrison; Ebrahim Mostafavi; Haleh Mousavi Isfahani; Sumaira Mubarik; Lorenzo Muccioli; Soumyadeep Mukherjee; Francesk Mulita; Ghulam Mustafa; Ahamarshan Jayaraman Nagarajan; Mukhammad David Naimzada; Vinay Nangia; Hasan Nassereldine; Zuhair S. Natto; Biswa Prakash Nayak; Ionut Negoi; Seyed Aria Nejadghaderi; Samata Nepal; Sandhya Neupane Kandel; Nafise Noroozi; Virginia NuÃ±ez-Samudio; Ogochukwu Janet Nzoputam; Chimezie Igwegbe Nzoputam; Chimedsuren Ochir; Julius Nyerere Odhiambo; Oluwakemi Ololade Odukoya; Hassan Okati-Aliabad; Osaretin Christabel Okonji; Andrew T. Olagunju; Ahmed Omar Bali; Emad Omer; Adrian Otoiu; Stanislav S. Otstavnov; Nikita Otstavnov; Bilcha Oumer; Mayowa O. Owolabi; P.A. Mahesh; Alicia Padron-Monedero; Jagadish Rao Padubidri; Mohammad Taha Pahlevan Fallahy; Songhomitra Panda-Jonas; Seithikurippu R. Pandi-Perumal; Shahina Pardhan; Eun-Kee Park; Sangram Kishor Patel; Aslam Ramjan Pathan; Siddhartha Pati; Uttam Paudel; Shrikant Pawar; Paolo Pedersini; Mario F.P. Peres; Ionela-Roxana Petcu; Michael R. Phillips; Julian David Pillay; Zahra Zahid Piracha; Mohsen Poursadeqiyan; Naeimeh Pourtaheri; Ibrahim Qattea; Amir Radfar; Ata Rafiee; Pankaja Raghav Raghav; Fakher Rahim; Muhammad Aziz Rahman; Firman Suryadi Rahman; Mosiur Rahman; Amir Masoud Rahmani; Shayan Rahmani; Sheetal Raj Moolambally; Sheena Ramazanu; Kiana Ramezanzadeh; Juwel Rana; Saleem Muhammad Rana; Chythra R. Rao; Sowmya J. Rao; Vahid Rashedi; Mohammad Mahdi Rashidi; Prateek Rastogi; Azad Rasul; Salman Rawaf; David Laith Rawaf; Lal Rawal; Reza Rawassizadeh; Negar Rezaei; Nazila Rezaei; Mohsen Rezaeian; Aziz Rezapour; Abanoub Riad; Muhammad Riaz; Jennifer Rickard; Jefferson Antonio Buendia Rodriguez; Leonardo Roever; Luca Ronfani; Bedanta Roy; S. Manjula; Aly M.A. Saad; Siamak Sabour; Leila Sabzmakan; Basema Saddik; Malihe Sadeghi; Mohammad Reza Saeb; Umar Saeed; Sahar Saeedi Moghaddam; Sher Zaman Safi; Biniyam Sahiledengle; Harihar Sahoo; Mohammad Ali Sahraian; Morteza Saki; Payman Salamati; Sana Salehi; Marwa Rashad Salem; Abdallah M. Samy; Juan Sanabria; Milena M. Santric-Milicevic; Muhammad Arif Nadeem Saqib; Yaser Sarikhani; Arash Sarveazad; Brijesh Sathian; Maheswar Satpathy; Ganesh Kumar Saya; Ione Jayce Ceola Schneider; David C. Schwebel; Hamed Seddighi; Subramanian Senthilkumaran; Allen Seylani; Hosein Shabaninejad; Melika Shafeghat; Pritik A. Shah; Saeed Shahabi; Ataollah Shahbandi; Fariba Shahraki-Sanavi; Masood Ali Shaikh; Elaheh Shaker; Mehran Shams-Beyranvand; Mohd Shanawaz; Mohammed Shannawaz; Mequannent Melaku Sharew Sharew; Neeraj Sharma; Bereket Beyene Shashamo; Maryam Shayan; Rahim Ali Sheikhi; Jiabin Shen; B. Suresh Kumar Shetty; Pavanchand H. Shetty; Jae Il Shin; Nebiyu Aniley Shitaye; K.M. Shivakumar; Parnian Shobeiri; Seyed Afshin Shorofi; Sunil Shrestha; Soraya Siabani; Negussie Boti Sidemo; Wudneh Simegn; Ehsan Sinaei; Paramdeep Singh; Robert Sinto; Md Shahjahan Siraj; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; David A. Sleet; S.N. Chandan; Bogdan Socea; Marco Solmi; Yonatan Solomon; Yi Song; Raúl A.R.C. Sousa; Ireneous N. Soyiri; Mark A. Stokes; Muhammad Suleman; Rizwan Suliankatchi Abdulkader; Jing Sun; Rafael TabarÃ©s-Seisdedos; Seyyed Mohammad Tabatabaei; Mohammad Tabish; Ensiyeh Taheri; Moslem Taheri Soodejani; Mircea Tampa; KerKan Tan; Ingan Ukur Tarigan; Md Tariqujjaman; Nathan Y. Tat; Vivian Y. Tat; Arash Tavakoli; Belay Negash Tefera; Yibekal Manaye Tefera; Gebremaryam Temesgen; Mohamad-Hani Temsah; Pugazhenthan Thangaraju; Rekha Thapar; Nikhil Kenny Thomas; Jansje Henny Vera Ticoalu; Marius Belmondo Tincho; Amir Tiyuri; Munkhsaikhan Togtmol; Marcos Roberto Tovani-Palone; Mai Thi Ngoc Tran; Sana Ullah; Saif Ullah; Irfan Ullah; Srikanth Umakanthan; Bhaskaran Unnikrishnan; Era Upadhyay; Sahel Valadan Tahbaz; Pascual R. Valdez; Tommi Juhani Vasankari; Siavash Vaziri; Massimiliano Veroux; Dominique Vervoort; Francesco S. Violante; Vasily Vlassov; Linh Gia Vu; Yasir Waheed; Yanzhong Wang; Yuan-Pang Wang; Cong Wang; Taweewat Wiangkham; Nuwan Darshana Wickramasinghe; Abay Tadesse Woday; Ai-Min Wu; Gahin Abdulraheem Tayib Yahya; Seyed Hossein Yahyazadeh Jabbari; Lin Yang; Sanni Yaya; Arzu Yigit; Vahit Yigit; Eshetu Yisihak; Naohiro Yonemoto; Yuyi You; Mustafa Z. Younis; Chuanhua Yu; Ismaeel Yunusa; Hossein Yusefi; Mazyar Zahir; Sojib Bin Zaman; Iman Zare; Kourosh Zarea; Mikhail Sergeevich Zastrozhin; Zhi-Jiang Zhang; Yunquan Zhang; Arash Ziapour; Sanjay Zodpey; Mohammad Zoladl; George C. Patton; Rebecca Q. Ivers
Background: Globally, transport and unintentional injuries persist as leading preventable causes of mortality and morbidity for adolescents. We sought to report comprehensive trends in injury-related mortality and morbidity for adolescents aged 10–24 years during the past three decades. Methods: Using the Global Burden of Disease, Injuries, and Risk Factors 2019 Study, we analysed mortality and disability-adjusted life-years (DALYs) attributed to transport and unintentional injuries for adolescents in 204 countries. Burden is reported in absolute numbers and age-standardised rates per 100 000 population by sex, age group (10–14, 15–19, and 20–24 years), and sociodemographic index (SDI) with 95% uncertainty intervals (UIs). We report percentage changes in deaths and DALYs between 1990 and 2019. Findings: In 2019, 369 061 deaths (of which 214 337 [58%] were transport related) and 31·1 million DALYs (of which 16·2 million [52%] were transport related) among adolescents aged 10–24 years were caused by transport and unintentional injuries combined. If compared with other causes, transport and unintentional injuries combined accounted for 25% of deaths and 14% of DALYs in 2019, and showed little improvement from 1990 when such injuries accounted for 26% of adolescent deaths and 17% of adolescent DALYs. Throughout adolescence, transport and unintentional injury fatality rates increased by age group. The unintentional injury burden was higher among males than females for all injury types, except for injuries related to fire, heat, and hot substances, or to adverse effects of medical treatment. From 1990 to 2019, global mortality rates declined by 34·4% (from 17·5 to 11·5 per 100 000) for transport injuries, and by 47·7% (from 15·9 to 8·3 per 100 000) for unintentional injuries. However, in low-SDI nations the absolute number of deaths increased (by 80·5% to 42 774 for transport injuries and by 39·4% to 31 961 for unintentional injuries). In the high-SDI quintile in 2010–19, the rate per 100 000 of transport injury DALYs was reduced by 16·7%, from 838 in 2010 to 699 in 2019. This was a substantially slower pace of reduction compared with the 48·5% reduction between 1990 and 2010, from 1626 per 100 000 in 1990 to 838 per 100 000 in 2010. Between 2010 and 2019, the rate of unintentional injury DALYs per 100 000 also remained largely unchanged in high-SDI countries (555 in 2010 vs 554 in 2019; 0·2% reduction). The number and rate of adolescent deaths and DALYs owing to environmental heat and cold exposure increased for the high-SDI quintile during 2010–19. Interpretation: As other causes of mortality are addressed, inadequate progress in reducing transport and unintentional injury mortality as a proportion of adolescent deaths becomes apparent. The relative shift in the burden of injury from high-SDI countries to low and low–middle-SDI countries necessitates focused action, including global donor, government, and industry investment in injury prevention. The persisting burden of DALYs related to transport and unintentional injuries indicates a need to prioritise innovative measures for the primary prevention of adolescent injury. Funding: Bill & Melinda Gates Foundation. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019
(Elsevier Ltd, 2022) Hmwe Hmwe Kyu; Avina Vongpradith; Sarah Brooke Sirota; Amanda Novotney; Christopher E Troeger; Matthew C Doxey; Rose G Bender; Jorge R Ledesma; Molly H Biehl; Samuel B Albertson; Joseph Jon Frostad; Katrin Burkart; Fiona B Bennitt; Jeff T Zhao; William M Gardner; Hailey Hagins; Dana Bryazka; Regina-Mae Villanueva Dominguez; Semagn Mekonnen Abate; Michael Abdelmasseh; Amir Abdoli; Gholamreza Abdoli; Aidin Abedi; Vida Abedi; Tadesse M Abegaz; Hassan Abidi; Richard Gyan Aboagye; Hassan Abolhassani; Yonas Derso Abtew; Hiwa Abubaker Ali; Eman Abu-Gharbieh; Ahmed Abu-Zaid; Kidist Adamu; Isaac Yeboah Addo; Oyelola A Adegboye; Mohammad Adnan; Qorinah Estiningtyas Sakilah Adnani; Muhammad Sohail Afzal; Saira Afzal; Bright Opoku Ahinkorah; Aqeel Ahmad; Araz Ramazan Ahmad; Sajjad Ahmad; Ali Ahmadi; Sepideh Ahmadi; Haroon Ahmed; Jivan Qasim Ahmed; Tarik Ahmed Rashid; Mostafa Akbarzadeh-Khiavi; Hanadi Al Hamad; Luciana Albano; Mamoon A Aldeyab; Bezatu Mengistie Alemu; Kefyalew Addis Alene; Abdelazeem M Algammal; Fadwa Alhalaiqa Naji Alhalaiqa; Robert Kaba Alhassan; Beriwan Abdulqadir Ali; Liaqat Ali; Musa Mohammed Ali; Syed Shujait Ali; Yousef Alimohamadi; Vahid Alipour; Adel Al-Jumaily; Syed Mohamed Aljunid; Sami Almustanyir; Rajaa M Al-Raddadi; Rami H Hani Al-Rifai; Saif Aldeen S AlRyalat; Nelson Alvis-Guzman; Nelson J Alvis-Zakzuk; Edward Kwabena Ameyaw; Javad Javad Aminian Dehkordi; John H Amuasi; Dickson A Amugsi; Etsay Woldu Anbesu; Adnan Ansar; Anayochukwu Edward Anyasodor; Jalal Arabloo; Demelash Areda; Ayele Mamo Argaw; Zeleke Gebru Argaw; Judie Arulappan; Raphael Taiwo Aruleba; Mulusew A Asemahagn; Seyyed Shamsadin Athari; Daniel Atlaw; Engi F Attia; Sameh Attia; Avinash Aujayeb; Tewachew Awoke; Tegegn Mulatu Ayana; Martin Amogre Ayanore; Sina Azadnajafabad; Mohammadreza Azangou-Khyavy; Samad Azari; Amirhossein Azari Jafari; Muhammad Badar; Ashish D Badiye; Nayereh Baghcheghi; Sara Bagherieh; Atif Amin Baig; MacIej Banach; Indrajit Banerjee; Mainak Bardhan; Francesco Barone-Adesi; Hiba Jawdat Barqawi; Amadou Barrow; Azadeh Bashiri; Quique Bassat; Abdul-Monim Mohammad Batiha; Abate Bekele Belachew; Melaku Ashagrie Belete; Uzma Iqbal Belgaumi; Akshaya Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Parth Bhatt; Vijayalakshmi S Bhojaraja; Zulfiqar A Bhutta; Soumitra S Bhuyan; Ali Bijani; Saeid Bitaraf; Belay Boda Abule Bodicha; Nikolay Ivanovich Briko; Danilo Buonsenso; Muhammad Hammad Butt; Jiao Cai; Paulo Camargos; Luis Alberto Cámera; Promit Ananyo Chakraborty; Muluken Genetu Chanie; Jaykaran Charan; Vijay Kumar Chattu; Patrick R Ching; Sungchul Choi; Yuen Yu Chong; Sonali Gajanan Choudhari; Enayet Karim Chowdhury; Devasahayam J Christopher; Dinh-Toi Chu; Natalie L Cobb; Aaron J Cohen; Natália Cruz-Martins; Omid Dadras; Fentaw Teshome Dagnaw; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; An Thi Minh Dao; Sisay Abebe Debela; Biniyam Demisse; Fitsum Wolde Demisse; Solomon Demissie; Diriba Dereje; Hardik Dineshbhai Desai; Abebaw Alemayehu Desta; Belay Desye; Sameer Dhingra; Nancy Diao; Daniel Diaz; Lankamo Ena Digesa; Linh Phuong Doan; Milad Dodangeh; Deepa Dongarwar; Fariba Dorostkar; Wendel Mombaque Dos Santos; Haneil Larson Dsouza; Eleonora Dubljanin; Oyewole Christopher Durojaiye; Hisham Atan Edinur; Elham Ehsani-Chimeh; Ebrahim Eini; Michael Ekholuenetale; Temitope Cyrus Ekundayo; Eman D El Desouky; Iman El Sayed; Maysaa El Sayed Zaki; Muhammed Elhadi; Ahmed Mahmoud Rabie Elkhapery; Amir Emami; Luchuo Engelbert Bain; Ryenchindorj Erkhembayar; Farshid Etaee; Mohamad Ezati Asar; Adeniyi Francis Fagbamigbe; Shahab Falahi; Aida Fallahzadeh; Anwar Faraj; Emerito Jose A Faraon; Ali Fatehizadeh; Pietro Ferrara; Allegra Allegra Ferrari; Getahun Fetensa; Florian Fischer; Joanne Flavel; Masoud Foroutan; Peter Andras Gaal; Abhay Motiramji Gaidhane; Santosh Gaihre; Nasrin Galehdar; Alberto L Garcia-Basteiro; Tushar Garg; Mesfin Damtew Gebrehiwot; Mathewos Alemu Gebremichael; Yibeltal Yismaw Gela; Belete Negese Belete Gemeda; Bradford D Gessner; Melaku Getachew; Asmare Getie; Seyyed-Hadi Ghamari; Mohammad Ghasemi Nour; Ahmad Ghashghaee; Ali Gholamrezanezhad; Abdolmajid Gholizadeh; Rakesh Ghosh; Sherief Ghozy; Pouya Goleij; Mohamad Golitaleb; Giuseppe Gorini; Alessandra C Goulart; Girma Garedew Goyomsa; Habtamu Alganeh Guadie; Zewdie Gudisa; Rashid Abdi Guled; Sapna Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Alemu Guta; Parham Habibzadeh; Arvin Haj-Mirzaian; Rabih Halwani; Samer Hamidi; Md Abdul Hannan; Mehdi Harorani; Ahmed I Hasaballah; Hamidreza Hasani; Abbas M Hassan; Shokoufeh Hassani; Hossein Hassanian-Moghaddam; Hadi Hassankhani; Khezar Hayat; Behzad Heibati; Mohammad Heidari; Demisu Zenbaba Heyi; Kamal Hezam; Ramesh Holla; Sung Hwi Hong; Nobuyuki Horita; Mohammad-Salar Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Mowafa Househ; Soodabeh Hoveidamanesh; Junjie Huang; Nawfal R Hussein; Ivo Iavicoli; Segun Emmanuel Ibitoye; Kevin S Ikuta; Olayinka Stephen Ilesanmi; Irena M Ilic; Milena D Ilic; Mustapha Immurana; Nahlah Elkudssiah Ismail; Masao Iwagami; Jalil Jaafari; Elham Jamshidi; Sung-In Jang; Amirreza Javadi Mamaghani; Tahereh Javaheri; Fatemeh Javanmardi; Javad Javidnia; Sathish Kumar Jayapal; Umesh Jayarajah; Shubha Jayaram; Alelign Tasew Jema; Wonjeong Jeong; Jost B Jonas; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; V. K; Zubair Kabir; Salah Eddine Oussama Kacimi; Vidya Kadashetti; Laleh R Kalankesh; Rohollah Kalhor; Ashwin Kamath; Bhushan Dattatray Kamble; Himal Kandel; Tesfaye K Kanko; Ibraheem M Karaye; André Karch; Samad Karkhah; Bekalu Getnet Kassa; Patrick D M C Katoto; Harkiran Kaur; Rimple Jeet Kaur; Leila Keikavoosi-Arani; Mohammad Keykhaei; Yousef Saleh Khader; Himanshu Khajuria; Ejaz Ahmad Khan; Gulfaraz Khan; Imteyaz A Khan; Maseer Khan; Md Nuruzzaman Khan; Moien A B Khan; Yusra H Khan; Moawiah Mohammad Khatatbeh; Mina Khosravifar; Jagdish Khubchandani; Min Seo Kim; Ruth W Kimokoti; Adnan Kisa; Sezer Kisa; Niranjan Kissoon; Luke D Knibbs; Sonali Kochhar; Farzad Kompani; Hamid Reza Koohestani; Vladimir Andreevich Korshunov; Soewarta Kosen; Parvaiz A Koul; Ai Koyanagi; Kewal Krishan; Barthelemy Kuate Defo; G Anil Kumar; Om P Kurmi; Ambily Kuttikkattu; Dharmesh Kumar Lal; Judit Lám; Iván Landires; Caterina Ledda; Sang-Woong Lee; Miriam Levi; Sonia Lewycka; Gang Liu; Wei Liu; Rakesh Lodha; László Lorenzovici; Mojgan Lotfi; Joana A Loureiro; Farzan Madadizadeh; Ata Mahmoodpoor; Razzagh Mahmoudi; Marzieh Mahmoudimanesh; Jamal Majidpoor; Alaa Makki; Elaheh Malakan Rad; Ahmad Azam Malik; Tauqeer Hussain Mallhi; Yosef Manla; Clara N Matei; Alexander G Mathioudakis; Richard James Maude; Entezar Mehrabi Nasab; Addisu Melese; Ziad A Memish; Oliver Mendoza-Cano; Alexios-Fotios A Mentis; Tuomo J Meretoja; Mehari Woldemariam Merid; Tomislav Mestrovic; Ana Carolina Micheletti Gomide Nogueira De Sá; Gelana Fekadu Worku Mijena; Le Huu Nhat Minh; Shabir Ahmad Mir; Reza Mirfakhraie; Seyyedmohammadsadeq Mirmoeeni; Agha Zeeshan Mirza; Moonis Mirza; Mohammad Mirza-Aghazadeh-Attari; Abay Sisay Misganaw; Awoke Temesgen Misganaw; Esmaeil Mohammadi; Mokhtar Mohammadi; Arif Mohammed; Shafiu Mohammed; Syam Mohan; Mohammad Mohseni; Nagabhishek Moka; Ali H Mokdad; Sara Momtazmanesh; Lorenzo Monasta; Md Moniruzzaman; Fateme Montazeri; Catrin E Moore; Abdolvahab Moradi; Lidia Morawska; Jonathan F Mosser; Ebrahim Mostafavi; Majid Motaghinejad; Haleh Mousavi Isfahani; Seyed Ali Mousavi-Aghdas; Sumaira Mubarik; Efrén Murillo-Zamora; Ghulam Mustafa; Sanjeev Nair; Tapas Sadasivan Nair; Houshang Najafi; Atta Abbas Naqvi; Sreenivas Narasimha Swamy; Zuhair S Natto; Biswa Prakash Nayak; Seyed Aria Nejadghaderi; Huy Van Nguyen Nguyen; Robina Khan Niazi; Antonio Tolentino Nogueira De Sá; Hasti Nouraei; Ali Nowroozi; Virginia Nuñez-Samudio; Chimezie Igwegbe Nzoputam; Ogochukwu Janet Nzoputam; Bogdan Oancea; Chimedsuren Ochir; Oluwakemi Ololade Odukoya; Hassan Okati-Aliabad; Akinkunmi Paul Okekunle; Osaretin Christabel Okonji; Andrew T Olagunju; Isaac Iyinoluwa Olufadewa; Ahmed Omar Bali; Emad Omer; Eyal Oren; Erika Ota; Nikita Otstavnov; Abderrahim Oulhaj; P.A. 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Background: The global burden of lower respiratory infections (LRIs) and corresponding risk factors in children older than 5 years and adults has not been studied as comprehensively as it has been in children younger than 5 years. We assessed the burden and trends of LRIs and risk factors across all age groups by sex, for 204 countries and territories. Methods: In this analysis of data for the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we used clinician-diagnosed pneumonia or bronchiolitis as our case definition for LRIs. We included International Classification of Diseases 9th edition codes 079.6, 466–469, 470.0, 480–482.8, 483.0–483.9, 484.1–484.2, 484.6–484.7, and 487–489 and International Classification of Diseases 10th edition codes A48.1, A70, B97.4–B97.6, J09–J15.8, J16–J16.9, J20–J21.9, J91.0, P23.0–P23.4, and U04–U04.9. We used the Cause of Death Ensemble modelling strategy to analyse 23 109 site-years of vital registration data, 825 site-years of sample vital registration data, 1766 site-years of verbal autopsy data, and 681 site-years of mortality surveillance data. We used DisMod-MR 2.1, a Bayesian meta-regression tool, to analyse age–sex-specific incidence and prevalence data identified via systematic reviews of the literature, population-based survey data, and claims and inpatient data. Additionally, we estimated age–sex-specific LRI mortality that is attributable to the independent effects of 14 risk factors. Findings: Globally, in 2019, we estimated that there were 257 million (95% uncertainty interval [UI] 240–275) LRI incident episodes in males and 232 million (217–248) in females. In the same year, LRIs accounted for 1·30 million (95% UI 1·18–1·42) male deaths and 1·20 million (1·07–1·33) female deaths. Age-standardised incidence and mortality rates were 1·17 times (95% UI 1·16–1·18) and 1·31 times (95% UI 1·23–1·41) greater in males than in females in 2019. Between 1990 and 2019, LRI incidence and mortality rates declined at different rates across age groups and an increase in LRI episodes and deaths was estimated among all adult age groups, with males aged 70 years and older having the highest increase in LRI episodes (126·0% [95% UI 121·4–131·1]) and deaths (100·0% [83·4–115·9]). During the same period, LRI episodes and deaths in children younger than 15 years were estimated to have decreased, and the greatest decline was observed for LRI deaths in males younger than 5 years (–70·7% [–77·2 to –61·8]). The leading risk factors for LRI mortality varied across age groups and sex. More than half of global LRI deaths in children younger than 5 years were attributable to child wasting (population attributable fraction [PAF] 53·0% [95% UI 37·7–61·8] in males and 56·4% [40·7–65·1] in females), and more than a quarter of LRI deaths among those aged 5–14 years were attributable to household air pollution (PAF 26·0% [95% UI 16·6–35·5] for males and PAF 25·8% [16·3–35·4] for females). PAFs of male LRI deaths attributed to smoking were 20·4% (95% UI 15·4–25·2) in those aged 15–49 years, 30·5% (24·1–36·9) in those aged 50–69 years, and 21·9% (16·8–27·3) in those aged 70 years and older. PAFs of female LRI deaths attributed to household air pollution were 21·1% (95% UI 14·5–27·9) in those aged 15–49 years and 18·2% (12·5–24·5) in those aged 50–69 years. For females aged 70 years and older, the leading risk factor, ambient particulate matter, was responsible for 11·7% (95% UI 8·2–15·8) of LRI deaths. Interpretation: The patterns and progress in reducing the burden of LRIs and key risk factors for mortality varied across age groups and sexes. The progress seen in children younger than 5 years was clearly a result of targeted interventions, such as vaccination and reduction of exposure to risk factors. Similar interventions for other age groups could contribute to the achievement of multiple Sustainable Development Goals targets, including promoting wellbeing at all ages and reducing health inequalities. Interventions, including addressing risk factors such as child wasting, smoking, ambient particulate matter pollution, and household air pollution, would prevent deaths and reduce health disparities. Funding: Bill & Melinda Gates Foundation. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019
(Nature Research, 2025) Yves Miel H. Zuñiga; Alimudin I. Zumla; Liesl Joanna Zühlke; Mohammad Zoladl; Boback Ziaeian; Claire Chenwen Zhong; Xiu Ju George Zhao; Zhijiang Zhang; Jianrong Zhang; Nejimu Biza Zepro; Getachew Assefa; Jean David Zeitoun; Zelalem Banjaw Zegeye; Michael Sergeevich Zastrozhin; Zahra Zareshahrabadi; Kourosh Zarea; Ali Zare Dehnavi; Iman Zare; Moein Zangiabadian; Alireza Zangeneh; Nelson Zamora; Sojib Bin Zaman; Nazar Zaki; Farima Zakaryaei; Mazyar Zahir; Farbod Zahedi Tajrishi; Vesna Zadnik; Siddhesh Zadey; Hossein Yusefi; Taraneh Yousefinezhadi; Zabihollah Allah Yousefi; Mustafa Zeedan Younis; Yuyi You; Naohiro Yonemoto; Dong Keon Yon; Eshetu Yisihak Ukumo; Paul Siu Fai Yip; Vahit Yigit; Arzu Yigit; Siyan Yi; Pengpeng Ye; Fereshteh Yazdanpanah; Sanni Yaya; Tetsuhiro Yokonishi; Lin Yang; Kazumasa Yamagishi; Tomohide Yamada; Seyed Hossein Yahyazadeh Jabbari; Gahin Abdulraheem Tayib Yahya; Sajad Yaghoubi; Xiaoyue Xu; Suowen Xu; Hanzhang Xu; Yang Xie; Hong Xiao; Ratna Dwi Wulandari; Gedif Ashebir Wubetie; Aimin Wu; Anthony D. Woolf; Charles David Alexander Wolfe; Melat K. Woldemariam; Daniel Sisay Wolde Tsadik; Abay Woday Woday Tadesse; Nuwan Darshana Wickramasinghe; Taweewat Wiangkham; Ronny Westerman; Yifeng Wen; Melissa Y.Wei Wei; Abdul Waris; Paul R. Ward; Ziyue Wang; Yuan Pang Wang; Yu Wang; Yanzhong Wang; Linh Gia Vu; Victor Volovici; Bay Vo; Vasiliy V. Vlassov; Prashant M. Vishwanath; Francesco Saverio Violante; Jorge Hugo Villafañe; Dominique Vervoort; Massimiliano Veroux; Madhur Verma; Narayanaswamy Venketasubramanian; Siavash Vaziri; Milena Vasić; Tommi Juhani Vasankari; Santosh Varughese; Priya Vart; Ravi Prasad Varma; Constantine Ilias Vardavas; Jef Van den Eynde; Rohollah Valizadeh; Pascual Rubén Valdez; Sahel Valadan Tahbaz; Alireza Vakilian; Marco Vacante; Era Upadhyay; Unnikrishnan Bhaskaran
Chronic care manages long-term, progressive conditions, while acute care addresses short-term conditions. Chronic conditions increasingly strain health systems, which are often unprepared for these demands. This study examines the burden of conditions requiring acute versus chronic care, including sequelae. Conditions and sequelae from the Global Burden of Diseases Study 2019 were classified into acute or chronic care categories. Data were analysed by age, sex, and socio-demographic index, presenting total numbers and contributions to burden metrics such as Disability-Adjusted Life Years (DALYs), Years Lived with Disability (YLD), and Years of Life Lost (YLL). Approximately 68% of DALYs were attributed to chronic care, while 27% were due to acute care. Chronic care needs increased with age, representing 86% of YLDs and 71% of YLLs, and accounting for 93% of YLDs from sequelae. These findings highlight that chronic care needs far exceed acute care needs globally, necessitating health systems to adapt accordingly. © The Author(s) 2025.
Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019
(Elsevier B.V., 2022) Kevin S Ikuta; Lucien R Swetschinski; Gisela Robles Aguilar; Fablina Sharara; Tomislav Mestrovic; Authia P Gray; Nicole Davis Weaver; Eve E Wool; Chieh Han; Anna Gershberg Hayoon; Amirali Aali; Semagn Mekonnen Abate; Mohsen Abbasi-Kangevari; Zeinab Abbasi-Kangevari; Sherief Abd-Elsalam; Getachew Abebe; Aidin Abedi; Amir Parsa Abhari; Hassan Abidi; Richard Gyan Aboagye; Abdorrahim Absalan; Hiwa Abubaker Ali; Juan Manuel Acuna; Tigist Demssew Adane; Isaac Yeboah Addo; Oyelola A Adegboye; Mohammad Adnan; Qorinah Estiningtyas Sakilah Adnani; Muhammad Sohail Afzal; Saira Afzal; Zahra Babaei Aghdam; Bright Opoku Ahinkorah; Aqeel Ahmad; Araz Ramazan Ahmad; Rizwan Ahmad; Sajjad Ahmad; Sohail Ahmad; Sepideh Ahmadi; Ali Ahmed; Haroon Ahmed; Jivan Qasim Ahmed; Tarik Ahmed Rashid; Marjan Ajami; Budi Aji; Mostafa Akbarzadeh-Khiavi; Chisom Joyqueenet Akunna; Hanadi Al Hamad; Fares Alahdab; Ziyad Al-Aly; Mamoon A Aldeyab; Alicia V Aleman; Fadwa Alhalaiqa Naji Alhalaiqa; Robert Kaba Alhassan; Beriwan Abdulqadir Ali; Liaqat Ali; Syed Shujait Ali; Yousef Alimohamadi; Vahid Alipour; Atiyeh Alizadeh; Syed Mohamed Aljunid; Kasim Allel; Sami Almustanyir; Edward Kwabena Ameyaw; Arianna Maever L Amit; Nivedita Anandavelane; Robert Ancuceanu; Catalina Liliana Andrei; Tudorel Andrei; Dewi Anggraini; Adnan Ansar; Anayochukwu Edward Anyasodor; Jalal Arabloo; Aleksandr Y Aravkin; Demelash Areda; Timur Aripov; Anton A Artamonov; Judie Arulappan; Raphael Taiwo Aruleba; Muhammad Asaduzzaman; Tahira Ashraf; Seyyed Shamsadin Athari; Daniel Atlaw; Sameh Attia; Marcel Ausloos; Tewachew Awoke; Beatriz Paulina Ayala Quintanilla; Tegegn Mulatu Ayana; Sina Azadnajafabad; Amirhossein Azari Jafari; B. Darshan; Muhammad Badar; Ashish D Badiye; Nayereh Baghcheghi; Sara Bagherieh; Atif Amin Baig; Indrajit Banerjee; Aleksandra Barac; Mainak Bardhan; Francesco Barone-Adesi; Hiba Jawdat Barqawi; Amadou Barrow; Pritish Baskaran; Saurav Basu; Abdul-Monim Mohammad Batiha; Neeraj Bedi; Melaku Ashagrie Belete; Uzma Iqbal Belgaumi; Rose G Bender; Bharti Bhandari; Dinesh Bhandari; Pankaj Bhardwaj; Sonu Bhaskar; Krittika Bhattacharyya; Suraj Bhattarai; Saeid Bitaraf; Danilo Buonsenso; Zahid A Butt; Florentino Luciano Caetano Dos Santos; Jiao Cai; Daniela Calina; Paulo Camargos; Luis Alberto Cámera; Rosario Cárdenas; Muge Cevik; Joshua Chadwick; Jaykaran Charan; Akhilanand Chaurasia; Patrick R Ching; Sonali Gajanan Choudhari; Enayet Karim Chowdhury; Fazle Rabbi Chowdhury; Dinh-Toi Chu; Isaac Sunday Chukwu; Omid Dadras; Fentaw Teshome Dagnaw; Xiaochen Dai; Saswati Das; Anna Dastiridou; Sisay Abebe Debela; Fitsum Wolde Demisse; Solomon Demissie; Diriba Dereje; Msganaw Derese; Hardik Dineshbhai Desai; Fikadu Nugusu Dessalegn; Samuel Abebe A Dessalegni; Belay Desye; Kartik Dhaduk; Meghnath Dhimal; Sameer Dhingra; Nancy Diao; Daniel Diaz; Shirin Djalalinia; Milad Dodangeh; Deepa Dongarwar; Bezabih Terefe Dora; Fariba Dorostkar; Haneil Larson Dsouza; Eleonora Dubljanin; Susanna J Dunachie; Oyewole Christopher Durojaiye; Hisham Atan Edinur; Habtamu Bekele Ejigu; Michael Ekholuenetale; Temitope Cyrus Ekundayo; Hassan El-Abid; Muhammed Elhadi; Mohamed A Elmonem; Amir Emami; Luchuo Engelbert Bain; Daniel Berhanie Enyew; Ryenchindorj Erkhembayar; Babak Eshrati; Farshid Etaee; Adeniyi Francis Fagbamigbe; Shahab Falahi; Aida Fallahzadeh; Emerito Jose A Faraon; Ali Fatehizadeh; Ginenus Fekadu; João C Fernandes; Allegra Ferrari; Getahun Fetensa; Irina Filip; Florian Fischer; Masoud Foroutan; Peter Andras Gaal; Muktar A Gadanya; Abhay Motiramji Gaidhane; Balasankar Ganesan; Mesfin Gebrehiwot; Reza Ghanbari; Mohammad Ghasemi Nour; Ahmad Ghashghaee; Ali Gholamrezanezhad; Abdolmajid Gholizadeh; Mahaveer Golechha; Pouya Goleij; Davide Golinelli; Amador Goodridge; Damitha Asanga Gunawardane; Yuming Guo; Rajat Das Gupta; Sapna Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Alemu Guta; Parham Habibzadeh; Atlas Haddadi Avval; Rabih Halwani; Asif Hanif; Md Abdul Hannan; Harapan Harapan; Shoaib Hassan; Hadi Hassankhani; Khezar Hayat; Behzad Heibati; Golnaz Heidari; Mohammad Heidari; Reza Heidari-Soureshjani; Claudiu Herteliu; Demisu Zenbaba Heyi; Kamal Hezam; Praveen Hoogar; Nobuyuki Horita; Md Mahbub Hossain; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Soodabeh Hoveidamanesh; Junjie Huang; Salman Hussain; Nawfal R Hussein; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena M Ilic; Milena D Ilic; Mohammad Tarique Imam; Mustapha Immurana; Leeberk Raja Inbaraj; Arnaud Iradukunda; Nahlah Elkudssiah Ismail; Chidozie C D Iwu; Chinwe Juliana Iwu; Merin J. Linda; Mihajlo Jakovljevic; Elham Jamshidi; Tahereh Javaheri; Fatemeh Javanmardi; Javad Javidnia; Sathish Kumar Jayapal; Umesh Jayarajah; Rime Jebai; Ravi Prakash Jha; Tamas Joo; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; Salah Eddine Oussama Kacimi; Vidya Kadashetti; Laleh R Kalankesh; Rohollah Kalhor; Vineet Kumar Kamal; Himal Kandel; Neeti Kapoor; Samad Karkhah; Bekalu Getnet Kassa; Nicholas J Kassebaum; Patrick D.M.C. Katoto; Mohammad Keykhaei; Himanshu Khajuria; Abbas Khan; Imteyaz A. Khan; Maseer Khan; Md Nuruzzaman Khan; Moien A.B. Khan; Moawiah Mohammad Khatatbeh; Mona M Khater; Hamid Reza Khayat Kashani; Jagdish Khubchandani; Hanna Kim; Min Seo Kim; Ruth W Kimokoti; Niranjan Kissoon; Sonali Kochhar; Farzad Kompani; Soewarta Kosen; Parvaiz A Koul; Sindhura Lakshmi Koulmane Laxminarayana; Fiorella Krapp Lopez; Kewal Krishan; Vijay Krishnamoorthy; Vishnutheertha Kulkarni; Naveen Kumar; Om P Kurmi; Ambily Kuttikkattu; Hmwe Hmwe Kyu; Dharmesh Kumar Lal; Judit Lám; Iván Landires; Savita Lasrado; Sang-Woong Lee; Jacopo Lenzi; Sonia Lewycka; Shanshan Li; Stephen S Lim; Wei Liu; Rakesh Lodha; Michael J Loftus; Ayush Lohiya; Lászl Lorenzovici; Mojgan Lotfi; Ata Mahmoodpoor; Mansour Adam Mahmoud; Razzagh Mahmoudi; Azeem Majeed; Jamal Majidpoor; Alaa Makki; Galana Ayana Mamo; Yosef Manla; Miquel Martorell; Clara N Matei; Barney Mcmanigal; Entezar Mehrabi Nasab; Ravi Mehrotra; Addisu Melese; Oliver Mendoza-Cano; Ritesh G Menezes; Alexios-Fotios A Mentis; Georgia Micha; Irmina Maria Michalek; Ana Carolina Micheletti Gomide Nogueira Des; Neda Milevska Kostova; Shabir Ahmad Mir; Mojgan Mirghafourvand; Seyyedmohammadsadeq Mirmoeeni; Erkin M Mirrakhimov; Mohammad Mirza-Aghazadeh-attari; Abay Sisay Misganaw; Awoke Misganaw; Sanjeev Misra; Esmaeil Mohammadi; Mokhtar Mohammadi; Abdollah Mohammadian-Hafshejani; Shafiu Mohammed; Syam Mohan; Mohammad Mohseni; Ali H Mokdad; Sara Momtazmanesh; Lorenzo Monasta; Catrin E Moore; Maryam Moradi; Mostafa Moradi Sarabi; Shane Douglas Morrison; Majid Motaghinejad; Haleh Mousavi Isfahani; Amin Mousavi Khaneghah; Seyed Ali Mousavi-Aghdas; Sumaira Mubarik; Francesk Mulita; Getaneh Baye B Mulu; Sandra B Munro; Saravanan Muthupandian; Tapas Sadasivan Nair; Atta Abbas Naqvi; Himanshi Narang; Zuhair S Natto; Muhammad Naveed; Biswa Prakash Nayak; Shumaila Naz; Ionut Negoi; Seyed Aria Nejadghaderi; Sandhya Neupane Kandel; Che Henry Ngwa; Robina Khan Niazi; Antonio Tolentino Nogueira Des; Nafise Noroozi; Hasti Nouraei; Ali Nowroozi; Virginia Nuñez-Samudio; Jerry John Nutor; Chimezie Igwegbe Nzoputam; Ogochukwu Janet Nzoputam; Bogdan Oancea; Rahman Md Obaidur; Vivek Anand Ojha; Akinkunmi Paul Okekunle; Osaretin Christabel Okonji; Andrew T Olagunju; Bolajoko Olubukunola Olusanya; Ahmed Omar Bali; Emad Omer; Nikita Otstavnov; Bilcha Oumer; Jagadish Rao Padubidri; Keyvan Pakshir; Tamás Palicz; Adrian Pana; Shahina Pardhan; Jose L Paredes; Utsav Parekh; Eun-Cheol Park; Seoyeon Park; Ashish Pathak; Rajan Paudel; Uttam Paudel; Shrikant Pawar; Hamidreza Pazoki Toroudi; Minjin Peng; Umberto Pensato; Veincent Christian Filipino Pepito; Marcos Pereira; Mario F P Peres; Norberto Perico; Ionela-Roxana Petcu; Zahra Zahid Piracha; Indrashis Podder; Nayanum Pokhrel; Ramesh Poluru; Maarten J Postma; Naeimeh Pourtaheri; Akila Prashant; Ibrahim Qattea; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Saber Raeghi; Sima Rafiei; Pankaja Raghav Raghav; Leila Rahbarnia; Vafa Rahimi-Movaghar; Mosiur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Vahid Rahmanian; Pradhum Ram; Muhammad Modassar Ali Nawaz Ranjha; Sowmya J Rao; Mohammad-Mahdi Rashidi; Azad Rasul; Zubair Ahmed Ratan; Salman Rawaf; Reza Rawassizadeh; Mohammad Sadegh Razeghinia; Elrashdy Moustafa Mohamed Redwan; Misganu Teshoma Regasa; Giuseppe Remuzzi; Melese Abate Reta; Nazila Rezaei; Aziz Rezapour; Abanoub Riad; Rezaul Karim Ripon; Kristina E Rudd; Basema Saddik; Saeid Sadeghian; Umar Saeed; Mohsen Safaei; Azam Safary; Sher Zaman Safi; Maryam Sahebazzamani; Amirhossein Sahebkar; Harihar Sahoo; Saina Salahi; Sarvenaz Salahi; Hedayat Salari; Sana Salehi; Hossein Samadi Kafil; Abdallah M Samy; Nima Sanadgol; Senthilkumar Sankararaman; Francesco Sanmarchi; Brijesh Sathian; Monika Sawhney; Ganesh Kumar Saya; Subramanian Senthilkumaran; Allen Seylani; Pritik A Shah; Masood Ali Shaikh; Elaheh Shaker; Murad Ziyaudinovich Shakhmardanov; Mequannent Melaku Sharew; Athena Sharifi-Razavi; Purva Sharma; Rahim Ali Sheikhi; Ali Sheikhy; Pavanchand H Shetty; Mika Shigematsu; Jae Il Shin; Hesamaddin Shirzad-Aski; K.M. Shivakumar; Parnian Shobeiri; Seyed Afshin Shorofi; Sunil Shrestha; Migbar Mekonnen Sibhat; Negussie Boti Sidemo; Mustafa Kamal Sikder; Luís Manuel Lopes Rodrigues Silva; Jasvinder A Singh; Paramdeep Singh; Surjit Singh; Md Shahjahan Siraj; Samarjeet Singh Siwal; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Bogdan Socea; Damtew Damtew Solomon; Yimeng Song; Chandrashekhar T Sreeramareddy; Muhammad Suleman; Rizwan Suliankatchi Abdulkader; Saima Sultana; Miklós Szócska; Seyed-Amir Tabatabaeizadeh; Mohammad Tabish; Majid Taheri; Elahe Taki; Ker-Kan Tan; Sarmila Tandukar; Nathan Y Tat; Vivian Y Tat; Belay Negash Tefera; Yibekal Manaye Tefera; Gebremaryam Temesgen; Mohamad-Hani Temsah; Samar Tharwat; Arulmani Thiyagarajan; Imad I Tleyjeh; Christopher E Troeger; Krishna Kishore Umapathi; Era Upadhyay; Sahel Valadan Tahbaz; Pascual R Valdez; Jef Van Den Eynde; H Rogier Van Doorn; Siavash Vaziri; Georgios-Ioannis Verras; Harimadhav Viswanathan; Bay Vo; Abdul Waris; Gizachew Tadesse Wassie; Nuwan Darshana Wickramasinghe; Sajad Yaghoubi; Gahin Abdulraheem Tayib Yahya Yahya; Seyed Hossein Yahyazadeh Jabbari; Arzu Yigit; Vahit Yigit; Dong Keon Yon; Naohiro Yonemoto; Mazyar Zahir; Burhan Abdullah Zaman; Sojib Bin Zaman; Moein Zangiabadian; Iman Zare; Mikhail Sergeevich Zastrozhin; Zhi-Jiang Zhang; Peng Zheng; Chenwen Zhong; Mohammad Zoladl; Alimuddin Zumla; Simon I Hay; Christiane Dolecek; Benn Sartorius; Christopher J L Murray; Mohsen Naghavi
Background: Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated the number of deaths associated with drug-resistant infections and sepsis and found that infections remain a leading cause of death globally. Understanding the global burden of common bacterial pathogens (both susceptible and resistant to antimicrobials) is essential to identify the greatest threats to public health. To our knowledge, this is the first study to present global comprehensive estimates of deaths associated with 33 bacterial pathogens across 11 major infectious syndromes. Methods: We estimated deaths associated with 33 bacterial genera or species across 11 infectious syndromes in 2019 using methods from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, in addition to a subset of the input data described in the Global Burden of Antimicrobial Resistance 2019 study. This study included 343 million individual records or isolates covering 11 361 study-location-years. We used three modelling steps to estimate the number of deaths associated with each pathogen: deaths in which infection had a role, the fraction of deaths due to infection that are attributable to a given infectious syndrome, and the fraction of deaths due to an infectious syndrome that are attributable to a given pathogen. Estimates were produced for all ages and for males and females across 204 countries and territories in 2019. 95% uncertainty intervals (UIs) were calculated for final estimates of deaths and infections associated with the 33 bacterial pathogens following standard GBD methods by taking the 2·5th and 97·5th percentiles across 1000 posterior draws for each quantity of interest. Findings: From an estimated 13·7 million (95% UI 10·9–17·1) infection-related deaths in 2019, there were 7·7 million deaths (5·7–10·2) associated with the 33 bacterial pathogens (both resistant and susceptible to antimicrobials) across the 11 infectious syndromes estimated in this study. We estimated deaths associated with the 33 bacterial pathogens to comprise 13·6% (10·2–18·1) of all global deaths and 56·2% (52·1–60·1) of all sepsis-related deaths in 2019. Five leading pathogens—Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa—were responsible for 54·9% (52·9–56·9) of deaths among the investigated bacteria. The deadliest infectious syndromes and pathogens varied by location and age. The age-standardised mortality rate associated with these bacterial pathogens was highest in the sub-Saharan Africa super-region, with 230 deaths (185–285) per 100 000 population, and lowest in the high-income super-region, with 52·2 deaths (37·4–71·5) per 100 000 population. S aureus was the leading bacterial cause of death in 135 countries and was also associated with the most deaths in individuals older than 15 years, globally. Among children younger than 5 years, S pneumoniae was the pathogen associated with the most deaths. In 2019, more than 6 million deaths occurred as a result of three bacterial infectious syndromes, with lower respiratory infections and bloodstream infections each causing more than 2 million deaths and peritoneal and intra-abdominal infections causing more than 1 million deaths. Interpretation: The 33 bacterial pathogens that we investigated in this study are a substantial source of health loss globally, with considerable variation in their distribution across infectious syndromes and locations. Compared with GBD Level 3 underlying causes of death, deaths associated with these bacteria would rank as the second leading cause of death globally in 2019; hence, they should be considered an urgent priority for intervention within the global health community. Strategies to address the burden of bacterial infections include infection prevention, optimised use of antibiotics, improved capacity for microbiological analysis, vaccine development, and improved and more pervasive use of available vaccines. These estimates can be used to help set priorities for vaccine need, demand, and development. Funding: Bill & Melinda Gates Foundation, Wellcome Trust, and Department of Health and Social Care, using UK aid funding managed by the Fleming Fund. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019
(John Wiley and Sons Inc, 2023) Youn Ho Shin; Jimin Hwang; Rosie Kwon; Seung Won Lee; Min Seo Kim; Jae Il Shin; Dong Keon Yon; Yohannes Habtegiorgis Abate; Mohsen Abbasi-Kangevari; Zeinab Abbasi-Kangevari; Michael Abdelmasseh; Deldar Morad Abdulah; Richard Gyan Aboagye; Hassan Abolhassani; Elissa M. Abrams; Yonas Derso Abtew; Eman Abu-Gharbieh; Denberu Eshetie Adane Adane; Tigist Demssew Adane; Isaac Yeboah Addo; Rishan Adha; Amin Adibi; Qorinah Estiningtyas Sakilah Adnani; Anurag Agrawal; Sohail Ahmad; Ali Ahmadi; Ali Ahmed; Ayman Ahmed; Sayer Al-Azzam; Fadwa Alhalaiqa Naji Alhalaiqa; Sheikh Mohammad Alif; Vahid Alipour; Zaid Altaany; Khalid A. Altirkawi; Nelson Alvis-Guzman; Hany Aly; Adnan Ansar; Judie Arulappan; Mohammad Asghari-Jafarabadi; Tahira Ashraf; Seyyed Shamsadin Athari; Daniel Atlaw; Avinash Aujayeb; Sina Azadnajafabad; Mahsa Babaei; Hassan Babamohamadi; Alaa Badawi; Nayereh Baghcheghi; Sara Bagherieh; Khuloud Bajbouj; Maciej Banach; Mainak Bardhan; Francesco Barone-Adesi; Amadou Barrow; Azadeh Bashiri; Nebiyou Simegnew Bayileyegn; Isabela M. Bensenor; Alemshet Yirga Berhie; Kebede A. Beyene; Akshaya Srikanth Bhagavathula; Pankaj Bhardwaj; Ajay Nagesh Bhat; Vijayalakshmi S. Bhojaraja; Ali Bijani; Andras Bikov; Jiao Cai; Paulo Camargos; Josip Car; Sinclair Carr; Andrea Carugno; Promit Ananyo Chakraborty; Jeffrey Shi Kai Chan; Periklis Charalampous; Mohammadreza Chashmyazdan; Vijay Kumar Chattu; Mohiuddin Ahsanul Kabir Chowdhury; Dinh-Toi Chu; Barbara Corso; Natália Cruz-Martins; Omid Dadras; Xiaochen Dai; Giovanni Damiani; Lalit Dandona; Rakhi Dandona; Dessalegn Demeke; Biniyam Demisse; Daniel Diaz; Mengistie Diress; Deepa Dongarwar; Michael Ekholuenetale; Temitope Cyrus Ekundayo; Muhammed Elhadi; Omar Abdelsadek Abdou Elmeligy; Habtamu Esubalew; Farshid Etaee; Azin Etemadimanesh; Adeniyi Francis Fagbamigbe; Ildar Ravisovich Fakhradiyev; Ali Fatehizadeh; Syeda Anum Fatima Fatima; Xiaoqi Feng; Mohammad Fereidouni; Nuno Ferreira; Getahun Fetensa; Florian Fischer; Masoud Foroutan; Takeshi Fukumoto; Abduzhappar Gaipov; Yibeltal Yismaw Gela; Abera Getachew Obsa; Fataneh Ghadirian; Seyyed-Hadi Ghamari; Sherief Ghozy; Richard F. Gillum; Abraham Tamirat Gizaw; Admasu Belay AB Gizaw; Mohamad Goldust; Mahaveer Golechha; Pouya Goleij; Sapna Gupta; Vivek Kumar Gupta; Arvin Haj-Mirzaian; Rabih Halwani; Samer Hamidi; Md Abdul Hannan; Ahmed I. Hasaballah; Hamidreza Hasani; Abdiwahab Hashi; Mohammed Bheser Hassen; Behzad Heibati; Golnaz Heidari; Mohammad Heidari; Mahsa Heidari-Foroozan; Ramesh Holla; Nobuyuki Horita; Md Shakhaoat Hossain; Salman Hussain; Bing-Fang Hwang; Irena M. Ilic; Milena D. Ilic; Rana Irilouzadian; Nahlah Elkudssiah Ismail; Zhanat Bakhitovna I. Z. B. Ispayeva; Chidozie C. D. Iwu; Linda Merin J; Maziar Jajarmi; Elham Jamshidi; Manthan Dilipkumar Janodia; Shubha Jayaram; Rime Jebai; Jost B. Jonas; Nitin Joseph; Billingsley Kaambwa; Zubair Kabir; Feroze Kaliyadan; Himal Kandel; Rami S. Kantar; Ibraheem M. Karaye; Hanie Karimi; Harkiran Kaur; Leila Keikavoosi-Arani; Mohammad Keykhaei; Yousef Saleh Khader; Himanshu Khajuria; Imteyaz A. Khan; Maseer Khan; Moien A. B. Khan; Saval Khanal; Moawiah Mohammad Khatatbeh; Jagdish Khubchandani; Biruk Getahun Kibret; Adnan Kisa; Sezer Kisa; Pavel Kolkhir; Farzad Kompani; Hamid Reza Koohestani; Oleksii Korzh; Parvaiz A. Koul; Ai Koyanagi; Kewal Krishan; Claudia E. Kuehni; G. Anil Kumar; Om P. Kurmi; L. V. Simhachalam Kutikuppala; Ambily Kuttikkattu; Judit Lám; Bagher Larijani; Kamaluddin Latief; Paolo Lauriola; Thao Thi Thu Le; Yo Han Lee; Jacopo Lenzi; Ming-Chieh Li; Shanshan Li; Virendra S. Ligade; Stephen S. Lim; Gang Liu; Wei Liu; Xuefeng Liu; Chun-Han Lo; Graciliana Lopes; Soundarya Mahalingam; Sandeep B. Maharaj; Mansour Adam Mahmoud; Azeem Majeed; Mohammad-Reza Malekpour; Ahmad Azam Malik; Tauqeer Hussain Mallhi; Deborah Carvalho Malta; Abdullah A. Mamun; Seyedeh Zahra Masoumi; Andrea Maugeri; John Robert Carabeo Medina; Ritesh G. Menezes; George A. Mensah; Alexios-Fotios A. Mentis; Tomislav Mestrovic; Irmina Maria Michalek; Le Huu Nhat Minh; Erkin M. Mirrakhimov; Awoke Misganaw; Manish Mishra; Shafiu Mohammed; Ali H. Mokdad; Sara Momtazmanesh; Lorenzo Monasta; Md Moniruzzaman; Temesgen Mulugeta; Daniel Munblit; Efrén Murillo-Zamora; Ghulam Mustafa; Tapas Sadasivan Nair; Vinay Nangia; Sreenivas Narasimha Swamy; Hasan Nassereldine; Zuhair S. Natto; Biswa Prakash Nayak; Javad Nazari; Tze Pin Ng; Dang H. Nguyen; Van Thanh Nguyen; Robina Khan Niazi; Hasti Nouraei; Ogochukwu Janet Nzoputam; Bogdan Oancea; Rahman Md Obaidur; Hassan Okati-Aliabad; Osaretin Christabel Okonji; Patrick Godwin Okwute; Andrew T. Olagunju; Isaac Iyinoluwa Olufadewa; Hans Orru; P.A. Mahesh; Jagadish Rao Padubidri; Anamika Pandey; Shahina Pardhan; Eun-Kee Park; Jay Patel; Shankargouda Patil; Venkata Suresh Patthipati; Uttam Paudel; Marcos Pereira; Renato B. Pereira; Ionela-Roxana Petcu; Indrashis Podder; Vivek Podder; Arash Pour Mohammad; Ibrahim Qattea; Navid Rabiee; Mehran Rahimi; Mosiur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Shayan Rahmani; Vahid Rahmanian; Prashant Rajput; Pradhum Ram; Premkumar Ramasubramani; Indu Ramachandra Rao; Ahmed Mustafa Rashid; Zubair Ahmed Ratan; Nakul Ravikumar; Salman Rawaf; Lal Rawal; Elrashdy Moustafa Mohamed Redwan; Aavishkar Raj Regmi; Nazila Rezaei; Negar Rezaei; Nima Rezaei; Saeid Rezaei; Mohsen Rezaeian; Jefferson Antonio Buendia Rodriguez; Leonardo Roever; Esperanza Romero-Rodríguez; Luca Ronfani; Aly M. A. Saad; Basema Saddik; Umar Saeed; Dominic Sagoe; Fatemeh Saheb Sharif-Askari; Amirhossein Sahebkar; Harihar Sahoo; Mirza Rizwan Sajid; Joseph W. Sakshaug; Saina Salahi; Sana Salehi; Abdallah M. Samy; Milena M. Santric-Milicevic; Made Ary Sarasmita; Maryam Sarkhosh; Ganesh Kumar Saya; Subramanian Senthilkumaran; Humaira Shah; Masood Ali Shaikh; Mohd Shanawaz; Aziz Sheikh; Shashank Shekhar; Mika Shigematsu; Parnian Shobeiri; Seyed Afshin Shorofi; Migbar Mekonnen Sibhat; Colin R. Simpson; Jasvinder A. Singh; Paramdeep Singh; Surjit Singh; Virendra Singh; Md Shahjahan Siraj; Anna Aleksandrovna Skryabina; Yonatan Solomon; Suhang Song; Sergey Soshnikov; Ireneous N. Soyiri; Paschalis Steiropoulos; Mindy D. Szeto; Iman M. Talaat; Jacques J. L. Lukenze Tamuzi; Ker-Kan Tan; Nathan Y. Tat; Mohamad-Hani Temsah; Dufera Rikitu Terefa; Riki Tesler; Pugazhenthan Thangaraju; Jansje Henny Vera Ticoalu; Tala Tillawi; Mai Thi Ngoc Tran; Biruk Shalmeno Tusa; Irfan Ullah; Saif Ullah; Sana Ullah; Era Upadhyay; Seyed Mohammad Vahabi; Job F. M. van Boven; Tommi Juhani Vasankari; Georgios-Ioannis Verras; Rafael José Vieira; Francesco S. Violante; Theo Vos; Ronny Westerman; Nuwan Darshana Wickramasinghe; Hywel C. Williams; Dereje Y. Yada; Yazachew Yismaw; Naohiro Yonemoto; Chuanhua Yu; Ismaeel Yunusa; Mazyar Zahir; Heather J. Zar; Iman Zare; Mikhail Sergeevich Zastrozhin; Mohammad A. Zeineddine; Getachew Assefa Zenebe; Zhi-Jiang Zhang; Hanqing Zhao; Mohammad Zoladl
Background: Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with allergic rhinitis and food allergy and cause high morbidity and mortality both in children and adults. This study aims to evaluate the global, regional, national, and temporal trends of the burden of asthma and AD from 1990 to 2019 and analyze their associations with geographic, demographic, social, and clinical factors. Methods: Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2019, we assessed the age-standardized prevalence, incidence, mortality, and disability-adjusted life years (DALYs) of both asthma and AD from 1990 to 2019, stratified by geographic region, age, sex, and socio-demographic index (SDI). DALYs were calculated as the sum of years lived with disability and years of life lost to premature mortality. Additionally, the disease burden of asthma attributable to high body mass index, occupational asthmagens, and smoking was described. Results: In 2019, there were a total of 262 million [95% uncertainty interval (UI): 224–309 million] cases of asthma and 171 million [95% UI: 165–178 million] total cases of AD globally; age-standardized prevalence rates were 3416 [95% UI: 2899–4066] and 2277 [95% UI: 2192–2369] per 100,000 population for asthma and AD, respectively, a 24.1% [95% UI: −27.2 to −20.8] decrease for asthma and a 4.3% [95% UI: 3.8–4.8] decrease for AD compared to baseline in 1990. Both asthma and AD had similar trends according to age, with age-specific prevalence rates peaking at age 5–9 years and rising again in adulthood. The prevalence and incidence of asthma and AD were both higher for individuals with higher SDI; however, mortality and DALYs rates of individuals with asthma had a reverse trend, with higher mortality and DALYs rates in those in the lower SDI quintiles. Of the three risk factors, high body mass index contributed to the highest DALYs and deaths due to asthma, accounting for a total of 3.65 million [95% UI: 2.14–5.60 million] asthma DALYs and 75,377 [95% UI: 40,615–122,841] asthma deaths. Conclusions: Asthma and AD continue to cause significant morbidity worldwide, having increased in total prevalence and incidence cases worldwide, but having decreased in age-standardized prevalence rates from 1990 to 2019. Although both are more frequent at younger ages and more prevalent in high-SDI countries, each condition has distinct temporal and regional characteristics. Understanding the temporospatial trends in the disease burden of asthma and AD could guide future policies and interventions to better manage these diseases worldwide and achieve equity in prevention, diagnosis, and treatment. © 2023 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021
(Elsevier Ltd, 2023) Manuela L Ferreira; Katie De Luca; Lydia M Haile; Jaimie D Steinmetz; Garland T Culbreth; Marita Cross; Jacek A Kopec; Paulo H Ferreira; Fiona M Blyth; Rachelle Buchbinder; Jan Hartvigsen; Ai-Min Wu; Saeid Safiri; Anthony D Woolf; Gary S Collins; Kanyin Liane Ong; Stein Emil Vollset; Amanda E Smith; Jessica A Cruz; Kai Glenn Fukutaki; Semagn Mekonnen Abate; Mitra Abbasifard; Mohsen Abbasi-Kangevari; Zeinab Abbasi-Kangevari; Ahmed Abdelalim; Aidin Abedi; Hassan Abidi; Qorinah Estiningtyas Sakilah Adnani; Ali Ahmadi; Rufus Olusola Akinyemi; Abayneh Tadesse Alamer; Adugnaw Zeleke Alem; Yousef Alimohamadi; Mansour Abdullah Alshehri; Mohammed Mansour Alshehri; Hosam Alzahrani; Saeed Amini; Sohrab Amiri; Hubert Amu; Catalina Liliana Andrei; Tudorel Andrei; Benny Antony; Jalal Arabloo; Judie Arulappan; Ashokan Arumugam; Tahira Ashraf; Seyyed Shamsadin Athari; Nefsu Awoke; Sina Azadnajafabad; Till Winfried Bärnighausen; Lope H Barrero; Amadou Barrow; Akbar Barzegar; Lindsay M Bearne; Isabela M Bensenor; Alemshet Yirga Berhie; Bharti Bhandari Bhandari; Vijayalakshmi S Bhojaraja; Ali Bijani; Belay Boda Abule Bodicha; Srinivasa Rao Bolla; Javier Brazo-Sayavera; Andrew M Briggs; Chao Cao; Periklis Charalampous; Vijay Kumar Chattu; Flavia M Cicuttini; Benjamin Clarsen; Sarah Cuschieri; Omid Dadras; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Azizallah Dehghan; Takele Gezahegn G Demie; Edgar Denova-Gutiérrez; Syed Masudur Rahman Dewan; Samath Dhamminda Dharmaratne; Mandira Lamichhane Dhimal; Meghnath Dhimal; Daniel Diaz; Mojtaba Didehdar; Lankamo Ena Digesa; Mengistie Diress; Hoa Thi Do; Linh Phuong Doan; Michael Ekholuenetale; Muhammed Elhadi; Sharareh Eskandarieh; Shahriar Faghani; Jawad Fares; Ali Fatehizadeh; Getahun Fetensa; Irina Filip; Florian Fischer; Richard Charles Franklin; Balasankar Ganesan; Belete Negese Belete Gemeda; Motuma Erena Getachew; Ahmad Ghashghaee; Tiffany K Gill; Mahaveer Golechha; Pouya Goleij; Bhawna Gupta; Nima Hafezi-Nejad; Arvin Haj-Mirzaian; Pawan Kumar Hamal; Asif Hanif; Netanja I Harlianto; Hamidreza Hasani; Simon I Hay; Jeffrey J Hebert; Golnaz Heidari; Mohammad Heidari; Reza Heidari-Soureshjani; Mbuzeleni Mbuzeleni Hlongwa; Mohammad-Salar Hosseini; Alexander Kevin Hsiao; Ivo Iavicoli; Segun Emmanuel Ibitoye; Irena M Ilic; Milena D Ilic; Sheikh Mohammed Shariful Islam; Manthan Dilipkumar Janodia; Ravi Prakash Jha; Har Ashish Jindal; Jost B Jonas; Gebisa Guyasa Kabito; Himal Kandel; Rimple Jeet Kaur; Vikash Ranjan Keshri; Yousef Saleh Khader; Ejaz Ahmad Khan; Md Jobair Khan; Moien A B Khan; Hamid Reza Khayat Kashani; Jagdish Khubchandani; Yun Jin Kim; Adnan Kisa; Jitka Klugarová; Ali-Asghar Kolahi; Hamid Reza Koohestani; Ai Koyanagi; G Anil Kumar; Narinder Kumar; Tea Lallukka; Savita Lasrado; Wei-Chen Lee; Yo Han Lee; Ata Mahmoodpoor; Jeadran N Malagón-Rojas; Mohammad-Reza Malekpour; Reza Malekzadeh; Narges Malih; Man Mohan Mehndiratta; Entezar Mehrabi Nasab; Ritesh G Menezes; Alexios-Fotios A Mentis; Mohamed Kamal Mesregah; Ted R Miller; Mohammad Mirza-Aghazadeh-Attari; Maryam Mobarakabadi; Yousef Mohammad; Esmaeil Mohammadi; Shafiu Mohammed; Ali H Mokdad; Sara Momtazmanesh; Lorenzo Monasta; Mohammad Ali Moni; Ebrahim Mostafavi; Christopher J L Murray; Tapas Sadasivan Nair; Javad Nazari; Seyed Aria Nejadghaderi; Subas Neupane; Sandhya Neupane Kandel; Cuong Tat Nguyen; Ali Nowroozi; Hassan Okati-Aliabad; Emad Omer; Abderrahim Oulhaj; Mayowa O Owolabi; Songhomitra Panda-Jonas; Anamika Pandey; Eun-Kee Park; Shrikant Pawar; Paolo Pedersini; Jeevan Pereira; Mario F P Peres; Ionela-Roxana Petcu; Mohammadreza Pourahmadi; Amir Radfar; Shahram Rahimi-Dehgolan; Vafa Rahimi-Movaghar; Mosiur Rahman; Amir Masoud Rahmani; Nazanin Rajai; Chythra R Rao; Vahid Rashedi; Mohammad-Mahdi Rashidi; Zubair Ahmed Ratan; David Laith Rawaf; Salman Rawaf; Andre M N Renzaho; Negar Rezaei; Zahed Rezaei; Leonardo Roever; Guilherme De Andrade Ruela; Basema Saddik; Amirhossein Sahebkar; Sana Salehi; Francesco Sanmarchi; Sadaf G Sepanlou; Saeed Shahabi; Shayan Shahrokhi; Elaheh Shaker; Mohammad Bagher Shamsi; Mohammed Shannawaz; Saurab Sharma; Maryam Shaygan; Rahim Ali Sheikhi; Jeevan K Shetty; Rahman Shiri; Siddharudha Shivalli; Parnian Shobeiri; Migbar Mekonnen Sibhat; Ambrish Singh; Jasvinder A Singh; Helen Slater; Marco Solmi; Ranjani Somayaji; Ker-Kan Tan; Rekha Thapar; Seyed Abolfazl Tohidast; Sahel Valadan Tahbaz; Rohollah Valizadeh; Tommi Juhani Vasankari; Narayanaswamy Venketasubramanian; Vasily Vlassov; Bay Vo; Yuan-Pang Wang; Taweewat Wiangkham; Lalit Yadav; Ali Yadollahpour; Seyed Hossein Yahyazadeh Jabbari; Lin Yang; Fereshteh Yazdanpanah; Naohiro Yonemoto; Mustafa Z Younis; Iman Zare; Armin Zarrintan; Mohammad Zoladl; Theo Vos; Lyn M March
Background: Low back pain is highly prevalent and the main cause of years lived with disability (YLDs). We present the most up-to-date global, regional, and national data on prevalence and YLDs for low back pain from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021. Methods: Population-based studies from 1980 to 2019 identified in a systematic review, international surveys, US medical claims data, and dataset contributions by collaborators were used to estimate the prevalence and YLDs for low back pain from 1990 to 2020, for 204 countries and territories. Low back pain was defined as pain between the 12th ribs and the gluteal folds that lasted a day or more; input data using alternative definitions were adjusted in a network meta-regression analysis. Nested Bayesian meta-regression models were used to estimate prevalence and YLDs by age, sex, year, and location. Prevalence was projected to 2050 by running a regression on prevalence rates using Socio-demographic Index as a predictor, then multiplying them by projected population estimates. Findings: In 2020, low back pain affected 619 million (95% uncertainty interval 554–694) people globally, with a projection of 843 million (759–933) prevalent cases by 2050. In 2020, the global age-standardised rate of YLDs was 832 per 100 000 (578–1070). Between 1990 and 2020, age-standardised rates of prevalence and YLDs decreased by 10·4% (10·9–10·0) and 10·5% (11·1–10·0), respectively. A total of 38·8% (28·7–47·0) of YLDs were attributed to occupational factors, smoking, and high BMI. Interpretation: Low back pain remains the leading cause of YLDs globally, and in 2020, there were more than half a billion prevalent cases of low back pain worldwide. While age-standardised rates have decreased modestly over the past three decades, it is projected that globally in 2050, more than 800 million people will have low back pain. Challenges persist in obtaining primary country-level data on low back pain, and there is an urgent need for more high-quality, primary, country-level data on both prevalence and severity distributions to improve accuracy and monitor change. Funding: Bill and Melinda Gates Foundation. © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019
(Elsevier Ltd, 2022) Elysia M. Alvarez; Lisa M. Force; Rixing Xu; Kelly Compton; Dan Lu; Hannah Jacqueline Henrikson; Jonathan M. Kocarnik; James D. Harvey; Alyssa Pennini; Frances E. Dean; Weijia Fu; Martina T. Vargas; Theresa H. M. Keegan; Hany Ariffin; Ronald D. Barr; Yana Arturovna Erdomaeva; D. Sanjeeva Gunasekera; Yetunde O. John-Akinola; Tyler G. Ketterl; Tezer Kutluk; Marcio Henrique Malogolowkin; Prashant Mathur; Venkatraman Radhakrishnan; Lynn Ann Gloeckler Ries; Carlos Rodriguez-Galindo; Garik Barisovich Sagoyan; Iyad Sultan; Behzad Abbasi; Mohsen Abbasi-Kangevari; Zeinab Abbasi-Kangevari; Hedayat Abbastabar; Michael Abdelmasseh; Sherief Abd-Elsalam; Amir Abdoli; Haimanot Abebe; Aidin Abedi; Hassan Abidi; Hassan Abolhassani; Hiwa Abubaker Ali; Eman Abu-Gharbieh; Basavaprabhu Achappa; Juan Manuel Acuna; Isaac Akinkunmi Adedeji; Oyelola A. Adegboye; Qorinah Estiningtyas Sakilah Adnani; Shailesh M. Advani; Muhammad Sohail Afzal; Mohamad Aghaie Meybodi; Bahman Ahadinezhad; Bright Opoku Ahinkorah; Sajjad Ahmad; Sepideh Ahmadi; Muktar Beshir Ahmed; Tarik Ahmed Rashid; Yusra Ahmed Salih; Wajeeha Aiman; Gizachew Taddesse Akalu; Hanadi Al Hamad; Fares Alahdab; Abdulhadi A. AlAmodi; Fahad Mashhour Alanezi; Turki M. Alanzi; Adugnaw Zeleke Alem; Dejene Tsegaye Alem; Yosef Alemayehu; Fadwa Naji Alhalaiqa; Robert Kaba Alhassan; Saqib Ali; Gianfranco Alicandro; Vahid Alipour; Syed Mohamed Aljunid; Motasem Alkhayyat; Sunitha Alluri; Nihad A. Almasri; Sadeq Ali Al-Maweri; Sami Almustanyir; Rajaa M. Al-Raddadi; Nelson Alvis-Guzman; Edward Kwabena Ameyaw; Saeed Amini; Hubert Amu; Robert Ancuceanu; Catalina Liliana Andrei; Tudorel Andrei; Fereshteh Ansari; Alireza Ansari-Moghaddam; Davood Anvari; Anayochukwu Edward Anyasodor; Jalal Arabloo; Morteza Arab-Zozani; Ayele Mamo Argaw; Muhammad Arshad; Judie Arulappan; Armin Aryannejad; Zatollah Asemi; Mohammad Asghari Jafarabadi; Mohammad Reza Atashzar; Prince Atorkey; Alok Atreya; Sameh Attia; Avinash Aujayeb; Marcel Ausloos; Leticia Avila-Burgos; Atalel Fentahun Awedew; Beatriz Paulina Ayala Quintanilla; Alemu Degu Ayele; Solomon Shitu Ayen; Mohammed A. Azab; Sina Azadnajafabad; Hiva Azami; Mohammadreza Azangou-Khyavy; Amirhossein Azari Jafari; Ghasem Azarian; Ahmed Y. Azzam; Saeed Bahadory; Jianjun Bai; Atif Amin Baig; Jennifer L. Baker; Maciej Banach; Till Winfried Bärnighausen; Francesco Barone-Adesi; Fabio Barra; Amadou Barrow; Huda Basaleem; Abdul-Monim Mohammad Batiha; Masoud Behzadifar; Niguss Cherie Bekele; Rebuma Belete; Uzma Iqbal Belgaumi; Arielle Wilder Bell; Alemshet Yirga Berhie; Devidas S. Bhagat; Akshaya Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Sonu Bhaskar; Krittika Bhattacharyya; Vijayalakshmi S. Bhojaraja; Sadia Bibi; Ali Bijani; Antonio Biondi; Setognal Birara; Tone Bjørge; Obasanjo Afolabi Bolarinwa; Srinivasa Rao Bolla; Archith Boloor; Dejana Braithwaite; Hermann Brenner; Norma B. Bulamu; Katrin Burkart; Maria Teresa Bustamante-Teixeira; Nadeem Shafique Butt; Zahid A. Butt; Florentino Luciano Caetano Dos Santos; Chao Cao; Yin Cao; Giulia Carreras; Ferrán Catalá-López; Francieli Cembranel; Ester Cerin; Raja Chandra Chakinala; Promit Ananyo Chakraborty; Vijay Kumar Chattu; Pankaj Chaturvedi; Akhilanand Chaurasia; Prachi P. Chavan; Odgerel Chimed-Ochir; Jee-Young Jasmine Choi; Devasahayam J. Christopher; Dinh-Toi Chu; Michael T. Chung; Joao Conde; Vera Marisa Costa; Omar B. Da; Omid Dadras; Saad M. A. Dahlawi; Xiaochen Dai; Giovanni Damiani; Emanuele D'Amico; Lalit Dandona; Rakhi Dandona; Parnaz Daneshpajouhnejad; Amira Hamed Darwish; Ahmad Daryani; Fernando Pio De La Hoz; Sisay Abebe Debela; Takele Gezahegn G. Demie; Getu Debalkie Demissie; Zeleke Geto Demissie; Edgar Denova-Gutiérrez; Meseret Derbew Molla; Rupak Desai; Abebaw Alemayehu Desta; Deepak Dhamnetiya; Samath Dhamminda Dharmaratne; Mandira Lamichhane Dhimal; Meghnath Dhimal; Mostafa Dianatinasab; Mojtaba Didehdar; Mengistie Diress; Shirin Djalalinia; Huyen Phuc Do; Saeid Doaei; Fariba Dorostkar; Wendel Mombaque Dos Santos; Thomas M. Drake; Michael Ekholuenetale; Iman El Sayed; Maysaa El Sayed Zaki; Maha El Tantawi; Hassan El-Abid; Mostafa Ahmed Elbahnasawy; Iffat Elbarazi; Hala Rashad Elhabashy; Muhammed Elhadi; Shaimaa I. El-Jaafary; Daniel Berhanie Enyew; Ryenchindorj Erkhembayar; Babak Eshrati; Sharareh Eskandarieh; Mohammed Faisaluddin; Jawad Fares; Umar Farooque; Abidemi Omolara Fasanmi; Wafa Fatima; José Miguel P. Ferreira De Oliveira; Simone Ferrero; Lorenzo Ferro Desideri; Getahun Fetensa; Irina Filip; Florian Fischer; James L. Fisher; Masoud Foroutan; Takeshi Fukumoto; Peter Andras Gaal; Mohamed M. Gad; Piyada Gaewkhiew; Silvano Gallus; Tushar Garg; Teferi Gebru Gebremeskel; Belete Negese Belete Gemeda; Tamiru Getachew; Mansour Ghafourifard; Seyyed-Hadi Ghamari; Ahmad Ghashghaee; Fariba Ghassemi; Nermin Ghith; Ali Gholami; Jamshid Gholizadeh Navashenaq; Syed Amir Gilani; Themba G. Ginindza; Abraham Tamirat Gizaw; James C. Glasbey; Amit Goel; Mahaveer Golechha; Pouya Goleij; Davide Golinelli; Sameer Vali Gopalani; Giuseppe Gorini; Houman Goudarzi; Bárbara Niegia Garcia Goulart; Ayman Grada; Mohammed Ibrahim Mohialdeen Gubari; Maximiliano Ribeiro Guerra; Avirup Guha; Bhawna Gupta; Sapna Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Rasool Haddadi; Nima Hafezi-Nejad; Alemayehu Hailu; Arvin Haj-Mirzaian; Rabih Halwani; Randah R. Hamadeh; Mitiku Teshome Hambisa; Sajid Hameed; Samer Hamidi; Shafiul Haque; Sanam Hariri; Josep Maria Haro; Ahmed I. Hasaballah; S M. Mahmudul Hasan; Seyedeh Melika Hashemi; Treska S. Hassan; Soheil Hassanipour; Simon I. Hay; Khezar Hayat; Sultan H. Hebo; Golnaz Heidari; Mohammad Heidari; Brenda Yuliana Herrera-Serna; Claudiu Herteliu; Demisu Zenbaba Heyi; Kamal Hezam; Michael K. Hole; Ramesh Holla; Nobuyuki Horita; Md Mahbub Hossain; Mohammad Bellal Hossain; Mohammad-Salar Hosseini; Mostafa Hosseini; Ali Hosseinzadeh; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mowafa Househ; Mohamed Hsairi; Junjie Huang; Nawfal R. Hussein; Bing-Fang Hwang; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Kaire Innos; Lalu Muhammad Irham; Rakibul M. Islam; Sheikh Mohammed Shariful Islam; Nahlah Elkudssiah Ismail; Gaetano Isola; Masao Iwagami; Louis Jacob; Farhad Jadidi-Niaragh; Vardhmaan Jain; Mihajlo Jakovljevic; Roksana Janghorban; Amirreza Javadi Mamaghani; Shubha Jayaram; Ranil Jayawardena; Seyed Behzad Jazayeri; Rime Jebai; Ravi Prakash Jha; Tamas Joo; Nitin Joseph; Farahnaz Joukar; Mikk Jürisson; Billingsley Kaambwa; Ali Kabir; Leila R. Kalankesh; Feroze Kaliyadan; Zul Kamal; Ashwin Kamath; Himal Kandel; Sitanshu Sekhar Kar; Ibraheem M. Karaye; Amirali Karimi; Bekalu Getnet Kassa; Joonas H. Kauppila; Phillip M. Kemp Bohan; Andre Pascal Kengne; Amene Abebe Kerbo; Mohammad Keykhaei; Yousef Saleh Khader; Himanshu Khajuria; Nastaran Khalili; Neda Khalili; Ejaz Ahmad Khan; Gulfaraz Khan; Maseer Khan; Md Nuruzzaman Khan; Moien A. B. Khan; Javad Khanali; Maryam Khayamzadeh; Omid Khosravizadeh; Jagdish Khubchandani; Roba Khundkar; Min Seo Kim; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Katarzyna Kissimova-Skarbek; Ali-Asghar Kolahi; Jacek A. Kopec; Rajasekaran Koteeswaran; Sindhura Lakshmi Koulmane Laxminarayana; Ai Koyanagi; Nuworza Kugbey; G. Anil Kumar; Nithin Kumar; Alexander Kwarteng; Carlo La Vecchia; Qing Lan; Iván Landires; Savita Lasrado; Paolo Lauriola; Caterina Ledda; Sang-Woong Lee; Wei-Chen Lee; Yeong Yeh Lee; Yo Han Lee; James Leigh; Elvynna Leong; Bingyu Li; Jiarui Li; Ming-Chieh Li; Stephen S. Lim; Xuefeng Liu; Stany W. Lobo; Joana A. Loureiro; Alessandra Lugo; Raimundas Lunevicius; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; Morteza Mahmoudi; Azeem Majeed; Alaa Makki; Shilpa Male; Mohammad-Reza Malekpour; Reza Malekzadeh; Ahmad Azam Malik; Mohammed A. Mamun; Navid Manafi; Fariborz Mansour-Ghanaei; Borhan Mansouri; Mohammad Ali Mansournia; Santi Martini; Seyedeh Zahra Masoumi; Clara N. Matei; Manu Raj Mathur; Colm McAlinden; Ravi Mehrotra; Walter Mendoza; Ritesh G. Menezes; Alexios-Fotios A. Mentis; Tuomo J. Meretoja; Amanual Getnet Mersha; Mohamed Kamal Mesregah; Tomislav Mestrovic; Junmei Miao Jonasson; Bartosz Miazgowski; Irmina Maria Michalek; Ted R. Miller; Alemu Basazin Mingude; Seyyedmohammadsadeq Mirmoeeni; Hamed Mirzaei; Sanjeev Misra; Prasanna Mithra; Karzan Abdulmuhsin Mohammad; Mokhtar Mohammadi; Seyyede Momeneh Mohammadi; Abdollah Mohammadian-Hafshejani; Reza Mohammadpourhodki; Arif Mohammed; Shafiu Mohammed; Teroj Abdulrahman Mohammed; Nagabhishek Moka; Ali H. Mokdad; Mariam Molokhia; Sara Momtazmanesh; Lorenzo Monasta; Mohammad Ali Moni; Ghobad Moradi; Yousef Moradi; Maliheh Moradzadeh; Rahmatollah Moradzadeh; Paula Moraga; Shane Douglas Morrison; Ebrahim Mostafavi; Amin Mousavi Khaneghah; Christine Mpundu-Kaambwa; Sumaira Mubarik; Lillian Mwanri; Ashraf F. Nabhan; Shankar Prasad Nagaraju; Chie Nagata; Mohsen Naghavi; Mukhammad David Naimzada; Luigi Naldi; Vinay Nangia; Atta Abbas Naqvi; Sreenivas Narasimha Swamy; Aparna Ichalangod Narayana; Biswa Prakash Nayak; Vinod C. Nayak; Javad Nazari; Sabina Onyinye Nduaguba; Ionut Negoi; Serban Mircea Negru; Seyed Aria Nejadghaderi; Samata Nepal; Sandhya Neupane Kandel; Haruna Asura Nggada; Cuong Tat Nguyen; Chukwudi A. Nnaji; Hamed Nosrati; Hasti Nouraei; Ali Nowroozi; Virginia Nuñez-Samudio; Vincent Ebuka Nwatah; Chimezie Igwegbe Nzoputam; Bogdan Oancea; Oluwakemi Ololade Odukoya; Ayodipupo Sikiru Oguntade; In-Hwan Oh; Andrew T. Olagunju; Tinuke O. Olagunju; Babayemi Oluwaseun Olakunde; Mojisola Morenike Oluwasanu; Emad Omar; Ahmed Omar Bali; Sokking Ong; Obinna E. Onwujekwe; Doris V. Ortega-Altamirano; Nikita Otstavnov; Stanislav S. Otstavnov; Bilcha Oumer; Mayowa O. Owolabi; P.A. Mahesh; Alicia Padron-Monedero; Jagadish Rao Padubidri; Keyvan Pakshir; Adrian Pana; Anamika Pandey; Shahina Pardhan; Fatemeh Pashazadeh; Maja Pasovic; Jenil R. Patel; Siddhartha Pati; Sanjay M. Pattanshetty; Uttam Paudel; Renato B. Pereira; Mario F. P. Peres; Arokiasamy Perianayagam; Maarten J. Postma; Hadi Pourjafar; Akram Pourshams; Akila Prashant; Thejodhar Pulakunta; Mirza Muhammad Fahd Fahd Qadir; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Raghu Anekal Radhakrishnan; Ata Rafiee; Alireza Rafiei; Sima Rafiei; Fakher Rahim; Shadi Rahimzadeh; Mosiur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Aashish Rajesh; Vajiheh Ramezani-Doroh; Kamal Ranabhat; Priyanga Ranasinghe; Chythra R. Rao; Sowmya J. Rao; Sina Rashedi; Mahsa Rashidi; Mohammad-Mahdi Rashidi; Goura Kishor Rath; David Laith Rawaf; Salman Rawaf; Lal Rawal; Reza Rawassizadeh; Mohammad Sadegh Razeghinia; Misganu Teshoma Regasa; Andre M. N. Renzaho; Maryam Rezaei; Negar Rezaei; Nima Rezaei; Mohsen Rezaeian; Aziz Rezapour; Sahba Rezazadeh-Khadem; Abanoub Riad; Ligia Estefania Rios Lopez; Jefferson Antonio Buendia Rodriguez; Luca Ronfani; Gholamreza Roshandel; Godfrey M. Rwegerera; Maha Mohamed Saber-Ayad; Siamak Sabour; Basema Saddik; Erfan Sadeghi; Saeid Sadeghian; Umar Saeed; Amirhossein Sahebkar; K.M. Saif-Ur-Rahman; S. Mohammad Sajadi; Sarvenaz Salahi; Sana Salehi; Marwa Rashad Salem; Hamideh Salimzadeh; Abdallah M. Samy; Juan Sanabria; Francesco Sanmarchi; Arash Sarveazad; Brijesh Sathian; Monika Sawhney; Susan M. Sawyer; Mete Saylan; Ione Jayce Ceola Schneider; Abdul-Aziz Seidu; Mario Šekerija; Endalew Gemechu Sendo; Sadaf G. Sepanlou; Allen Seylani; Kenbon Seyoum; Feng Sha; Omid Shafaat; Masood Ali Shaikh; Erfan Shamsoddin; Mohammed Shannawaz; Rajesh Sharma; Sara Sheikhbahaei; Adithi Shetty; B. Suresh Kumar Shetty; Pavanchand H. Shetty; Jae Il Shin; Reza Shirkoohi; K.M. Shivakumar; Parnian Shobeiri; Soraya Siabani; Migbar Mekonnen Sibhat; Sudeep K. Siddappa Malleshappa; Negussie Boti Sidemo; Diego Augusto Santos Silva; Guilherme Silva Julian; Achintya Dinesh Singh; Jasvinder A. Singh; Jitendra Kumar Singh; Surjit Singh; Abiy H. Sinke; Yitagesu Sintayehu; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Lee Smith; Ahmad Sofi-Mahmudi; Mohammad Sadegh Soltani-Zangbar; Suhang Song; Emma Elizabeth Spurlock; Paschalis Steiropoulos; Kurt Straif; Ranjeeta Subedi; Mu'Awiyyah Babale Sufiyan; Rizwan Suliankatchi Abdulkader; Saima Sultana; Viktória Szerencsés; Miklós Szócska; Seidamir Pasha Tabaeian; Rafael Tabarés-Seisdedos; Mohammadreza Tabary; Takahiro Tabuchi; Hooman Tadbiri; Majid Taheri; Amir Taherkhani; Ken Takahashi; Mircea Tampa; Ker-Kan Tan; Vivian Y. Tat; Ahmad Tavakoli; Abdelghani Tbakhi; Arash Tehrani-Banihashemi; Mohamad-Hani Temsah; Fisaha Haile Tesfay; Bekele Tesfaye; Jarnail Singh Thakur; Rekha Thapar; Aravind Thavamani; Arulmani Thiyagarajan; Nihal Thomas; Ruoyan Tobe-Gai; Munkhsaikhan Togtmol; Seyed Abolfazl Tohidast; Hamid Reza Tohidinik; Musliu Adetola Tolani; Daniel Nigusse Tollosa; Mathilde Touvier; Marcos Roberto Tovani-Palone; Eugenio Traini; Bach Xuan Tran; Mai Thi Ngoc Tran; Jaya Prasad Tripathy; Biruk Shalmeno Tusa; Gebresilasea Gendisha Ukke; Irfan Ullah; Saif Ullah; Krishna Kishore Umapathi; Bhaskaran Unnikrishnan; Era Upadhyay; Tolassa Wakayo Ushula; Marco Vacante; Sahel Valadan Tahbaz; Shoban Babu Varthya; Massimiliano Veroux; Paul J. Villeneuve; Francesco S. Violante; Vasily Vlassov; Giang Thu Vu; Yasir Waheed; Ning Wang; Paul Ward; Adisu Birhanu Weldesenbet; Yi Feng Wen; Ronny Westerman; Andrea Sylvia Winkler; Befikadu Legesse Wubishet; Suowen Xu; Seyed Hossein Yahyazadeh Jabbari; Lin Yang; Sanni Yaya; Vahid Yazdi-Feyzabadi; Taklo Simeneh Yazie; Sisay Shewasinad Yehualashet; Alex Yeshaneh; Yigizie Yeshaw; Birhanu Wubale Yirdaw; Naohiro Yonemoto; Mustafa Z. Younis; Zabihollah Yousefi; Chuanhua Yu; Ismaeel Yunusa; Vesna Zadnik; Mazyar Zahir; Telma Zahirian Moghadam; Mohammad Zamani; Maryam Zamanian; Hamed Zandian; Fariba Zare; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Jianrong Zhang; Zhi-Jiang Zhang; Arash Ziapour; Mohammad Zoladl; Christopher J. L. Murray; Christina Fitzmaurice; Archie Bleyer; Nickhill Bhakta
Background: In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15–39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods: Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15–39 years to define adolescents and young adults. Findings: There were 1·19 million (95% UI 1·11–1·28) incident cancer cases and 396 000 (370 000–425 000) deaths due to cancer among people aged 15–39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59·6 [54·5–65·7] per 100 000 person-years) and high-middle SDI countries (53·2 [48·8–57·9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14·2 [12·9–15·6] per 100 000 person-years) and middle SDI (13·6 [12·6–14·8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23·5 million (21·9–25·2) DALYs to the global burden of disease, of which 2·7% (1·9–3·6) came from YLDs and 97·3% (96·4–98·1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation: Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Funding: Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities, St Baldrick's Foundation, and the National Cancer Institute. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license