Browsing by Author "Mohammed S. Mustak"

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Correction to: Genetic evidence for a single founding population of the Lakshadweep Islands (Molecular Genetics and Genomics, (2024), 299, 1, (8), 10.1007/s00438-024-02110-z)
(Springer Science and Business Media Deutschland GmbH, 2024) Sachin Kumar; Prajjval Pratap Singh; Nagarjuna Pasupuleti; Shivanand S. Shendre; Jaison Jeevan Sequeira; Idrees Babu; Mohammed S. Mustak; Niraj Rai; Gyaneshwer Chaubey
In this article the author name Mohammed S. Mustak was incorrectly written as Mohammed S. Mutak. The original article has been corrected. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
Exploring the genetic implications of demographic dynamics in Jammu and Kashmir using autosomal STRs
(Springer Science and Business Media Deutschland GmbH, 2024) Nadeem Mubarik; Masroor Ahmad Ganei; Shivani Dixit; R.K. Kumawat; Jaison Jeevan Sequeira; Naseer Ahmad Ahangar; Shahul Ahmad Kanth; Imtiyaz Ahmad Dar; Ishrat Mushtaq; Mohammad Mohsin; Mohammed S. Mustak; Gyaneshwer Chaubey; Sania Hamid; Pankaj Shrivastava
The Union Territory of Jammu and Kashmir has always been a point of contention among India, Pakistan, and China for various reasons. This region has great significance historically due to its geography and ethnic diversity. However, a comprehensive genetic study providing the genetic landscape of Jammu and Kashmir was lacking until now. In this study, we analysed 21 hyper-variable autosomal STR loci of 694 individuals from Jammu and Kashmir and compared them with neighbouring populations to explore the genetic implications of demographic dynamics that have taken place in this region. Our findings suggest that the population of Jammu and Kashmir is a genetic mixture of two major clines, northern and southern, that correspond with the variation in geography, linguistics, and demography of the region. Broadly, the gene flow into the southern cline appears to be in historical times perhaps as a result of the spread of Gurjars, Dogri language and invasions of Mongols. However, the arrival of ancient nomadic tribes into this region may belong to the time depth of the arrival of pastoralist communities in this region. As a future perspective, a comprehensive study including samples from individual tribes will provide fine-scale structure of the gene pool of Jammu and Kashmir. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
Forensic Characterization, Genomic Variability and Ancestry Analysis of Six Populations from Odisha Using mtDNA SNPs and Autosomal STRs
(Springer, 2024) Jaison Jeevan Sequeira; Muktikanta Panda; Shivani Dixit; Ramkishan Kumawat; Mohammed S. Mustak; Awdhesh Narayan Sharma; Gyaneshwer Chaubey; Pankaj Shrivastava
Located on India's eastern coast, Odisha is known for its diverse tribes and castes. In the early days of genome sequencing technology, researchers primarily studied the Austroasiatic communities inhabiting this region to reconstruct the ancient origins and dispersal of this broad linguistic group. However, current research has shifted towards identifying population and individual-specific genome variation for forensic applications. This study aims to analyze the forensic efficiency and ancestry of six populations from Odisha. We assessed the SF mtDNA-SNP60™ PCR Amplification Kit by comparing it with PowerPlex® Fusion 6C System, a widely used autosomal STR (aSTR) kit, in an Indian cohort. Although the mtDNA SNP kit showed low discriminating power for individuals of a diverse population, it could identify deep lineage divergence. Also, we utilized mitochondrial and autosomal variation information to analyze the ancestry of six endogamous ethnic groups in Odisha. We observe two extremities—populations with higher West Asian affinity and those with East Asian affinity. This observation is in congruence with the existing information of their tribal and non-tribal affiliation. When compared with neighbouring populations from Central and Eastern India, multivariate analysis showed that the Brahmins clustered separately or with the Gopala, Kaibarta appeared as an intermediate, Pana and Kandha clustered with the Gonds, and Savara with the Munda tribes. Our findings indicate significant deep lineage stratification in the ethnic populations of Odisha and a gene flow from West and East Asia. The artefacts of unique deep lineage in such a diverse population will help in improving forensic identification. In addition, we conclude that the SF mtDNA-SNP60 PCR Amplification Kit may be used only as a supplementary tool for forensic analysis. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
The peopling of Lakshadweep Archipelago
(Nature Publishing Group, 2019) Mohammed S. Mustak; Niraj Rai; Mohan Rao Naveen; Satya Prakash; S. Justin Carlus; Nagarjuna Pasupuleti; Anshika Srivastava; Prajjval Pratap Singh; Idrees Babu; Pavan Kumar Dubey; Gyaneshwer Chaubey; Kumarasamy Thangaraj
The archipelago of Lakshadweep is considered as a stopover to the maritime route since ancient time. It is not very clear when the human first occupied these islands, however in the long history of the islands, the local legends suggest that Lakshadweep has been ruled by different kingdoms. To have a better understanding of peopling of Lakshadweep, we have analysed 557 individuals from eight major islands for mitochondrial DNA and 166 individuals for Y chromosome markers. We found a strong founder effect for both paternal and maternal lineages. Moreover, we report a close genetic link of Lakshadweep islanders with the Maldives, Sri Lanka and India. Most of the Lakshadweep islands share the haplogroups specific to South Asia and West Eurasia, except Minicoy Island that also shares haplogroups of East Eurasia. The paternal and maternal ancestries of the majority of island populations suggest their arrival from distinct sources. We found that the maternal ancestry was closer to South Indian populations, whereas the paternal ancestry was overwhelmed with the haplogroups, more common in the Maldives and North of India. In conclusion, our first genetic data suggest that the majority of human ancestry in Lakshadweep is largely derived from South Asia with minor influences from East and West Eurasia. © 2019, The Author(s).