Browsing by Author "Muhammad Naveed"

Now showing 1 - 17 of 17

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
(Elsevier Ltd, 2022) Emma Nichols; Jaimie D. Steinmetz; Stein Emil Vollset; Kai Fukutaki; Julian Chalek; Foad Abd-Allah; Amir Abdoli; Ahmed Abualhasan; Eman Abu-Gharbieh; Tayyaba Tayyaba Akram; Hanadi Al Hamad; Fares Alahdab; Fahad Mashhour Alanezi; Vahid Alipour; Sami Almustanyir; Hubert Amu; Iman Ansari; Jalal Arabloo; Tahira Ashraf; Thomas Astell-Burt; Getinet Ayano; Jose L. Ayuso-Mateos; Atif Amin Baig; Anthony Barnett; Amadou Barrow; Bernhard T. Baune; Yannick Béjot; Woldesellassie M. Mequanint Bezabhe; Yihienew Mequanint Bezabih; Akshaya Srikanth Bhagavathula; Sonu Bhaskar; Krittika Bhattacharyya; Ali Bijani; Atanu Biswas; Srinivasa Rao Bolla; Archith Boloor; Carol Brayne; Hermann Brenner; Katrin Burkart; Richard A. Burns; Luis Alberto Cámera; Chao Cao; Felix Carvalho; Luis F.S. Castro-De-Araujo; Ferrán Catalá-López; Ester Cerin; Prachi P. Chavan; Nicolas Cherbuin; Dinh-Toi Chu; Vera Marisa Costa; Rosa A.S. Couto; Omid Dadras; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Vanessa De la Cruz-Góngora; Deepak Dhamnetiya; Diana Dias da Silva; Daniel Diaz; Abdel Douiri; David Edvardsson; Michael Ekholuenetale; Iman El Sayed; Shaimaa I. El-Jaafary; Khalil Eskandari; Sharareh Eskandarieh; Saman Esmaeilnejad; Jawad Fares; Andre Faro; Umar Farooque; Valery L. Feigin; Xiaoqi Feng; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Irina Filip; Howard Fillit; Florian Fischer; Shilpa Gaidhane; Lucia Galluzzo; Ahmad Ghashghaee; Nermin Ghith; Alessandro Gialluisi; Syed Amir Gilani; Ionela-Roxana Glavan; Elena V. Gnedovskaya; Mahaveer Golechha; Rajeev Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Mohammad Rifat Haider; Brian J. Hall; Samer Hamidi; Asif Hanif; Graeme J. Hankey; Shafiul Haque; Risky Kusuma Hartono; Ahmed I. Hasaballah; M. Tasdik Hasan; Amr Hassan; Simon I. Hay; Khezar Hayat; Mohamed I. Hegazy; Golnaz Heidari; Reza Heidari-Soureshjani; Claudiu Herteliu; Mowafa Househ; Rabia Hussain; Bing-Fang Hwang; Licia Iacoviello; Ivo Iavicoli; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Seyed Sina Naghibi Irvani; Hiroyasu Iso; Masao Iwagami; Roxana Jabbarinejad; Louis Jacob; Vardhmaan Jain; Sathish Kumar Jayapal; Ranil Jayawardena; Ravi Prakash Jha; Jost B. Jonas; Nitin Joseph; Rizwan Kalani; Amit Kandel; Himal Kandel; André Karch; Ayele Semachew Kasa; Gizat M. Kassie; Pedram Keshavarz; Moien A.B. Khan; Mahalaqua Nazli Khatib; Tawfik Ahmed Muthafer Khoja; Jagdish Khubchandani; Min Seo Kim; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Mika Kivimäki; Walter J. Koroshetz; Ai Koyanagi; G. Anil Kumar; Manasi Kumar; Hassan Mehmood Lak; Matilde Leonardi; Bingyu Li; Stephen S. Lim; Xuefeng Liu; Yuewei Liu; Giancarlo Logroscino; Stefan Lorkowski; Giancarlo Lucchetti; Ricardo Lutzky Saute; Francesca Giulia Magnani; Ahmad Azam Malik; João Massano; Man Mohan Mehndiratta; Ritesh G. Menezes; Atte Meretoja; Bahram Mohajer; Norlinah Mohamed Ibrahim; Yousef Mohammad; Arif Mohammed; Ali H. Mokdad; Stefania Mondello; Mohammad Ali Moni; Md Moniruzzaman; Tilahun Belete Mossie; Gabriele Nagel; Muhammad Naveed; Vinod C. Nayak; Sandhya Neupane Kandel; Trang Huyen Nguyen; Bogdan Oancea; Nikita Otstavnov; Stanislav S. Otstavnov; Mayowa O. Owolabi; Songhomitra Panda-Jonas; Fatemeh Pashazadeh Kan; Maja Pasovic; Urvish K. Patel; Mona Pathak; Mario F.P. Peres; Arokiasamy Perianayagam; Carrie B. Peterson; Michael R. Phillips; Marina Pinheiro; Michael A. Piradov; Constance Dimity Pond; Michele H. Potashman; Faheem Hyder Pottoo; Sergio I. Prada; Amir Radfar; Alberto Raggi; Fakher Rahim; Mosiur Rahman; Pradhum Ram; Priyanga Ranasinghe; David Laith Rawaf; Salman Rawaf; Nima Rezaei; Aziz Rezapour; Stephen R. Robinson; Michele Romoli; Gholamreza Roshandel; Ramesh Sahathevan; Amirhossein Sahebkar; Mohammad Ali Sahraian; Brijesh Sathian; Davide Sattin; Monika Sawhney; Mete Saylan; Silvia Schiavolin; Allen Seylani; Feng Sha; Masood Ali Shaikh; K.S. Shaji; Mohammed Shannawaz; Jeevan K. Shetty; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Diego Augusto Santos Silva; Joao Pedro Silva; Renata Silva; Jasvinder A. Singh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Amanda E. Smith; Sergey Soshnikov; Emma Elizabeth Spurlock; Dan J. Stein; Jing Sun; Rafael Tabarés-Seisdedos; Bhaskar Thakur; Binod Timalsina; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Gebiyaw Wudie Tsegaye; Sahel Valadan Tahbaz; Pascual R. Valdez; Narayanaswamy Venketasubramanian; Vasily Vlassov; Giang Thu Vu; Linh Gia Vu; Yuan-Pang Wang; Anders Wimo; Andrea Sylvia Winkler; Lalit Yadav; Seyed Hossein Yahyazadeh Jabbari; Kazumasa Yamagishi; Lin Yang; Yuichiro Yano; Naohiro Yonemoto; Chuanhua Yu; Ismaeel Yunusa; Siddhesh Zadey; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Zhi-Jiang Zhang; Christopher J.L. Murray; Theo Vos
Background: Given the projected trends in population ageing and population growth, the number of people with dementia is expected to increase. In addition, strong evidence has emerged supporting the importance of potentially modifiable risk factors for dementia. Characterising the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritisation. This study aimed to improve on previous forecasts of dementia prevalence by producing country-level estimates and incorporating information on selected risk factors. Methods: We forecasted the prevalence of dementia attributable to the three dementia risk factors included in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 (high body-mass index, high fasting plasma glucose, and smoking) from 2019 to 2050, using relative risks and forecasted risk factor prevalence to predict GBD risk-attributable prevalence in 2050 globally and by world region and country. Using linear regression models with education included as an additional predictor, we then forecasted the prevalence of dementia not attributable to GBD risks. To assess the relative contribution of future trends in GBD risk factors, education, population growth, and population ageing, we did a decomposition analysis. Findings: We estimated that the number of people with dementia would increase from 57·4 (95% uncertainty interval 50·4–65·1) million cases globally in 2019 to 152·8 (130·8–175·9) million cases in 2050. Despite large increases in the projected number of people living with dementia, age-standardised both-sex prevalence remained stable between 2019 and 2050 (global percentage change of 0·1% [–7·5 to 10·8]). We estimated that there were more women with dementia than men with dementia globally in 2019 (female-to-male ratio of 1·69 [1·64–1·73]), and we expect this pattern to continue to 2050 (female-to-male ratio of 1·67 [1·52–1·85]). There was geographical heterogeneity in the projected increases across countries and regions, with the smallest percentage changes in the number of projected dementia cases in high-income Asia Pacific (53% [41–67]) and western Europe (74% [58–90]), and the largest in north Africa and the Middle East (367% [329–403]) and eastern sub-Saharan Africa (357% [323–395]). Projected increases in cases could largely be attributed to population growth and population ageing, although their relative importance varied by world region, with population growth contributing most to the increases in sub-Saharan Africa and population ageing contributing most to the increases in east Asia. Interpretation: Growth in the number of individuals living with dementia underscores the need for public health planning efforts and policy to address the needs of this group. Country-level estimates can be used to inform national planning efforts and decisions. Multifaceted approaches, including scaling up interventions to address modifiable risk factors and investing in research on biological mechanisms, will be key in addressing the expected increases in the number of individuals affected by dementia. Funding: Bill & Melinda Gates Foundation and Gates Ventures. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global Burden of Cardiovascular Diseases and Risks, 1990-2022
(Elsevier Inc., 2023) George A. Mensah; Valentin Fuster; Christopher J.L. Murray; Gregory A. Roth; George A. Mensah; Yohannes Habtegiorgis Abate; Mohammadreza Abbasian; Foad Abd-Allah; Ashkan Abdollahi; Mohammad Abdollahi; Deldar Morad Abdulah; Auwal Abdullahi; Ayele Mamo Abebe; Aidin Abedi; Armita Abedi; Olugbenga Olusola Abiodun; Hiwa Abubaker Ali; Eman Abu-Gharbieh; Niveen M.E. Abu-Rmeileh; Salahdein Aburuz; Abdelrahman I. Abushouk; Ahmed Abu-Zaid; Tigist Demssew Adane; Nicola J. Adderley; Oladimeji M. Adebayo; Bashir Aden; Temitayo Esther Adeyeoluwa; Olorunsola Israel Adeyomoye; Qorinah Estiningtyas Sakilah Adnani; Fatemeh Afrashteh; Shadi Afyouni; Saira Afzal; Pradyumna Agasthi; Antonella Agodi; Constanza Elizabeth Aguilera Arriagada; Williams Agyemang-Duah; Bright Opoku Ahinkorah; Aqeel Ahmad; Danish Ahmad; Firdos Ahmad; Muayyad M. Ahmad; Ayman Ahmed; Haroon Ahmed; Muktar Beshir Ahmed; Syed Anees Ahmed; Marjan Ajami; Karolina Akinosoglou; Moein Ala; Tareq Mohammed Ali AL-Ahdal; Samer O. Alalalmeh; Ziyad Al-Aly; Nazmul Alam; Rasmieh Mustafa Al-Amer; Alaa Alashi; Mohammed Albashtawy; Mohammad T. AlBataineh; Haileselasie Berhane Alema; Sharifullah Alemi; Yihun Mulugeta Alemu; Adel Ali Saeed Al-Gheethi; Khalid F. Alhabib; Fadwa Alhalaiqa Naji Alhalaiqa; Mohammed Usman Ali; Rafat Ali; Syed Shujait Shujait Ali; Gianfranco Alicandro; Reyhaneh Alikhani; Syed Mohamed Aljunid; François Alla; Wael Almahmeed; Sabah Al-Marwani; Jordi Alonso; Rajaa M. Al-Raddadi; Farrukh Jawad Alvi; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Hassan Alwafi; Hany Aly; Prince M. Amegbor; Tarek Tawfik Amin; Alireza Amindarolzarbi; Mostafa Amini-Rarani; Sohrab Amiri; Enrico Ammirati; Tanu Anand; Robert Ancuceanu; Deanna Anderlini; Abhishek Anil; Golnoosh Ansari; Philip Emeka Anyanwu; Anayochukwu Edward Anyasodor; Geminn Louis Carace Apostol; Jalal Arabloo; Mosab Arafat; Aleksandr Y. Aravkin; Olatunde Aremu; Benedetta Armocida; Johan Ärnlöv; Oluwaseyi Olalekan Arowosegbe; Anton A. Artamonov; Kurnia Dwi Artanti; Judie Arulappan; Idowu Thomas Aruleba; Ashokan Arumugam; Zahra Aryan; Mohammad Asghari-Jafarabadi; Thomas Astell-Burt; Mahshid Ataei; Mohammad Athar; Alok Atreya; Avinash Aujayeb; Adedapo Wasiu Awotidebe; Amdehiwot A. Aynalem; Zahra Azizi; Ahmed Y. Azzam; Abraham Samuel Babu; Muhammad Badar; Feras Bader; Ashish D. Badiye; Arvind Bagga; Sara Bagherieh; Farshad Bahrami Asl; Ruhai Bai; Jennifer L. Baker; Shankar M. Bakkannavar; Abdulaziz T. Bako; Ravleen Kaur Bakshi; Saliu A. Balogun; Ovidiu Constantin Baltatu; Kiran Bam; MacIej Banach; Soham Bandyopadhyay; Biswajit Banik; Palash Chandra Banik; Kannu Bansal; Hamid Reza Baradaran; Franca Barbic; Martina Barchitta; Mainak Bardhan; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Francesco Barone-Adesi; Sandra Barteit; Lingkan Barua; Azadeh Bashiri; Mohsen Bayati; Nebiyou Simegnew Bayileyegn; Emad Behboudi; Amir Hossein Behnoush; Yannick Béjot; Sefealem Assefa Belay; Melaku Ashagrie Belete; Uzma Iqbal Belgaumi; Michelle L. Bell; Luis Belo; Salaheddine Bendak; Bright Benfor; Derrick A. Bennett; Isabela M. Bensenor; Catherine P. Benziger; Azizullah Beran; Adam E. Berman; Amiel Nazer C. Bermudez; Gregory J. Bertolacci; Habtamu B. Beyene; Kebede A. Beyene; Akshaya Srikanth Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Prarthna V. Bhardwaj; Vivek Bhat; Gurjit Kaur Bhatti; Jasvinder Singh Bhatti; Boris Bikbov; Andras Bikov; Marina G. Birck; Bijit Biswas; Saeid Bitaraf; Aadam Olalekan Bodunrin; Eyob Ketema Bogale; Kassawmar Angaw Bogale; Archith Boloor; Milad Bonakdar Hashemi; Hamed Borhany; Edward J. Boyko; Dejana Braithwaite; Luisa C. Brant; Michael Brauer; Susanne Breitner; Andrey Briko; Lemma N. Bulto; Yasser Bustanji; Zahid A. Butt; Daniela Calina; Fan Cao; Rosario Cárdenas; Sinclair Carr; Giulia Carreras; Juan J. Carrero; Márcia Carvalho; Joao Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Maria Sofia Cattaruzza; Luca Cegolon; Ester Cerin; Yaacoub Chahine; Jeffrey Shi Kai Chan; Mei Yen Chan; Raymond N.C. Chan; Periklis Charalampous; Jaykaran Charan; Vijay Kumar Chattu; An-Tian Chen; Catherine S. Chen; Haowei Chen; Suma Sri Chennapragada; Derek S. Chew; Gerald Chi; Patrick R. Ching; Abdulaal Chitheer; So Mi Jemma Cho; William C.S. Cho; Bryan Chong; Hitesh Chopra; Rahul Choudhary; Enayet Karim Chowdhury; Rajiv Chowdhury; Dinh-Toi Chu; Isaac Sunday Chukwu; Arrigo Francesco Giuseppe Cicero; Zinhle Cindi; Iolanda Cioffi; Kaleb Coberly; Sean Coffey; Alyssa Columbus; Joao Conde; Sara Conti; Barbara Corso; Sandra Cortés; Paolo Angelo Cortesi; Vera Marisa Costa; Rosa A.S. Couto; Emma Johnson Cowart; Michael H. Criqui; Jessica A. Cruz; Sriharsha Dadana; Omid Dadras; Xiaochen Dai; Zhaoli Dai; Maxwell Ayindenaba Dalaba; Albertino Antonio Moura Damasceno; Giovanni Damiani; Emanuele D'Amico; Saswati Das; Subasish Das; Mohsen Dashti; Mohammad Dashtkoohi; Maedeh Dastmardi; Kairat Davletov; Aklilu Tamire Debele; Shayom Debopadhaya; Nicole K. DeCleene; Ivan Delgado-Enciso; Juana Maria Delgado-Saborit; Berecha Hundessa Demessa; Andreas K. Demetriades; Xinlei Deng; Edgar Denova-Gutiérrez; Nebiyu Dereje Dereje; Awoke Masrie Asrat Derese; Hardik Dineshbhai Desai; Rupak Desai; Vinoth Gnana Chellaiyan Devanbu; Syed Masudur Rahman Dewan; Sourav Dey; Vishal R. Dhulipala; Daniel Diaz; Michael J. Diaz; Delaney D. Ding; Ricardo Jorge Dinis-Oliveira; Thanh Chi Do; Thao Huynh Phuong Do; Saeid Doaei; Sushil Dohare; Wanyue Dong; Mario D'Oria; Wendel Mombaque Dos Santos; Abdel Douiri; Robert Kokou Dowou; Ashel Chelsea Dsouza; Haneil Larson Dsouza; Viola Dsouza; Mi Du; Andre Rodrigues Duraes; Oyewole Christopher Durojaiye; Sulagna Dutta; Arkadiusz Marian Dziedzic; Alireza Ebrahimi; Defi Efendi; Ferry Efendi; Diyan Ermawan Effendi; Ebrahim Eini; Michael Ekholuenetale; Temitope Cyrus Ekundayo; Iman El Sayed; Maha El Tantawi; Iffat Elbarazi; Frank J. Elgar; Islam Y. Elgendy; Muhammed Elhadi; Waseem El-Huneidi; Mehdi Emamverdi; Theophilus I. Emeto; Ryenchindorj Erkhembayar; Tesfahun C. Eshetie; Juan Espinosa-Montero; Farshid Etaee; Natalia Fabin; Ibtihal Fadhil; Adeniyi Francis Fagbamigbe; Luca Falzone; Carla Sofia E Sá Farinha; MoezAlIslam Ezzat Mahmoud Faris; Andre Faro; Mithila Faruque; Medhat Farwati; Abidemi Omolara Fasanmi; Ali Fatehizadeh; Pooria Fazeli; Valery L. Feigin; Xiaoqi Feng; Seyed-Mohammad Fereshtehnejad; Abdullah Hamid Feroze; Pietro Ferrara; Nuno Ferreira; Irina Filip; Laura Fleszar; David Flood; Morenike Oluwatoyin Folayan; Artem Alekseevich Fomenkov; Diogo A. Fonseca; Carla Fornari; Matteo Foschi; Richard Charles Franklin; Takeshi Fukumoto; Blima Fux; Peter Andras Gaal; Muktar A. Gadanya; Shilpa Gaidhane; Abduzhappar Gaipov; Emmanuela Gakidou; Yaseen Galali; Silvano Gallus; Aravind P. Gandhi; Balasankar Ganesan; Rupesh K. Gautam; Miglas W.W. Gebregergis; Kahsu Gebrekirstos Gebrekidan; Johanna M. Geleijnse; Urge Gerema; Alireza Ghajar; Seyyed-Hadi Ghamari; Mohammad Reza Ghasemi; Ghazal Ghasempour Dabaghi; Afsaneh Ghasemzadeh; Ramy Mohamed Ghazy; Maryam Gholamalizadeh; Arun Digambarrao Ghuge; Paramjit Singh Gill; Tiffany K. Gill; Richard F. Gillum; Elena V. Gnedovskaya; Ali Golchin; Pouya Goleij; Giuseppe Gorini; Alessandra C. Goulart; Anmol Goyal; Kashish Goyal; Shi-Yang Guan; Giovanni Guarducci; Mesay Dechasa Gudeta; Avirup Guha; Stefano Guicciardi; David Gulisashvili; Damitha Asanga Gunawardane; Cui Guo; Anish Kumar Gupta; Bhawna Gupta; Indarchand Ratanlal Gupta; Kartik Gupta; Mohak Gupta; Rajat Das Gupta; Rajeev Gupta; Renu Gupta; Sapna Gupta; Veer Bala Gupta; Vijai Kumar Gupta; Vivek Kumar Gupta; Lami Gurmessa; Reyna Alma Gutiérrez; Farrokh Habibzadeh; Mostafa Hadei; Helia Sadat Haeri Boroojeni; Aram Halimi; Sebastian Haller; Rabih Halwani; Randah R. Hamadeh; Nadia M. Hamdy; Samer Hamidi; Chieh Han; Qiuxia Han; Graeme J. Hankey; Md. Abdul Hannan; Arief Hargono; Josep Maria Haro; Faizul Hasan; Ikramul Hasan; Hamidreza Hasani; Maryam Hashemian; Md Saquib Hasnain; Amr Hassan; Ikrama Hassan; Johannes Haubold; Rasmus J. Havmoeller; Simon I. Hay; Khezar Hayat; Youssef Hbid; Omar E. Hegazi; Tadele Yohannes Hegena; Mohammad Heidari; Bartosz Helfer; Brenda Yuliana Herrera-Serna; Claudiu Herteliu; Hamed Hesami; Kamran Hessami; Keyvan Heydari; Kamal Hezam; Yuta Hiraike; Nguyen Quoc Hoan; Ramesh Holla; Md Mahbub Hossain; Md. Belal Hossain; Hassan Hosseinzadeh; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mohamed Hsairi; Junjie Huang; Michael Hultström; Hong-Han Huynh; Bing-Fang Hwang; Khalid S. Ibrahim; Oluwatope Olaniyi Idowu; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Mustapha Immurana; Leeberk Raja Inbaraj; Muhammad Iqhrammullah; Sheikh Mohammed Shariful Islam; Faisal Ismail; Nahlah Elkudssiah Ismail; Gaetano Isola; Masao Iwagami; J. Linda Merin; Jalil Jaafari; Louis Jacob; Abdollah Jafarzadeh; Khushleen Jaggi; Haitham Jahrami; Akhil Jain; Nityanand Jain; Ammar Abdulrahman Jairoun; Mihajlo Jakovljevic; Roland Dominic G. Jamora; Nilofer Javadi; Sathish Kumar Jayapal; Shubha Jayaram; Rime Jebai; Rebuma Sorsa Jeben; Sun Ha Jee; Anil K. Jha; Ravi Prakash Jha; Vivekanand Jha; Heng Jiang; Yinzi Jin; Yash B. Jobanputra; Catherine Owens Johnson; Mohammad Jokar; Tamas Joo; Abel Joseph; Nitin Joseph; Charity Ehimwenma Joshua; Jacek Jerzy Jozwiak; Mikk Jürisson; Ali Kabir; Zubair Kabir; Vidya Kadashetti; Farima Kahe; Rizwan Kalani; Laleh R. Kalankesh; Farnaz Kalantar; Yogeshwar Kalkonde; Sanjay Kalra; Ashwin Kamath; Sagarika Kamath; Arun Kamireddy; Tanuj Kanchan; Himal Kandel; Arun R. Kanmanthareddy; Kehinde Kazeem Kanmodi; Sushil Kumar Kansal; Daniel John Kapner; Sitanshu Sekhar Kar; Paschalis Karakasis; Prabin Karki; Faizan Zaffar Kashoo; Hengameh Kasraei; Eskeziaw Abebe Kassahun; Nicholas J. Kassebaum; Patrick D.M.C. Katoto; Neda Kaydi; Foad Kazemi; Sina Kazemian; Sara Kazeminia; Jessica A. Kerr; Emmanuelle Kesse-Guyot; Mohammad Keykhaei; Mohamad Mehdi Khadembashiri; Mohammad Amin Khadembashiri; Morteza Abdullatif Khafaie; Himanshu Khajuria; Amirmohammad Khalaji; Nauman Khalid; Alireza Khalilian; Rovshan Khalilov; Asaduzzaman Khan; Ejaz Ahmad Khan; Junaid Khan; M. Nuruzzaman Khan; Maseer Khan; Mohammad Jobair Khan; Muhammad Shahzeb Khan; Yusra H. Khan; Mahammed Ziauddin Khan Suheb; Shaghayegh Khanmohammadi; Khaled Khatab; Sorour Khateri; Hamid Reza Khayat Kashani; Khalid A. Kheirallah; Feriha Fatima Khidri; Saeid Kian; Zemene Demelash Kifle; Ruth W. Kimokoti; Adnan Kisa; Sezer Kisa; Ali-Asghar Kolahi; Farzad Kompani; Gerbrand Koren; Ashwin Laxmikant Kotnis; Parvaiz A. Koul; Ai Koyanagi; Kewal Krishan; Hare Krishna; Vijay Krishnamoorthy; Yuvaraj Krishnamoorthy; Md Abdul Kuddus; Mohammed Kuddus; Mukhtar Kulimbet; Vishnutheertha Kulkarni; Akshay Kumar; Ashish Kumar; Naveen Kumar; Nithin Kumar; Rahul Kumar; Netsanet Bogale Kumsa; Kunle Rotimi Kunle; Dian Kusuma; Ilias Kyriopoulos; Carlo La Vecchia; Ben Lacey; Muhammad Awwal Ladan; Lucie Laflamme; Chandrakant Lahariya; Arista Lahiri; Daphne Teck Ching Lai; Tea Lallukka; Qing Lan; Iván Landires; Francesco Lanfranchi; Bagher Larijani; Anders O. Larsson; Savita Lasrado; Kamaluddin Latief; Kaveh Latifinaibin; Jerrald Lau; Paolo Lauriola; Khuong Le; Long Khanh Dao Le; Nhi Huu Hanh Le; Thao Thi Thu Le; Trang Diep Thanh Le; Trang Thi Bich Le; Caterina Ledda; Munjae Lee; Paul H. Lee; Seung Won Lee; Wei-Chen Lee; Yo Han Lee; Kate E. LeGrand; Mall Leinsalu; Matilde Leonardi; Temesgen L. Lerango; An Li; Ming-Chieh Li; Wei Li; Xiaopan Li; Yichong Li; Lee-Ling Lim; Stephen S. Lim; Ro-Ting Lin; Megan Lindstrom; Shai Linn; Gang Liu; Simin Liu; Xiaofeng Liu; Xuefeng Liu; Katherine M. Livingstone; Erand Llanaj; Platon D. Lopukhov; Arianna Maever Loreche; László Lorenzovici; Stefan Lorkowski; Paulo A. Lotufo; Giancarlo Lucchetti; Alessandra Lugo; Zheng Feei Ma; Farzan Madadizadeh; Ralph Maddison; Javier A. Magaña Gómez; Julien Magne; D.R. Mahadeshwara Prasad; Mehrdad Mahalleh; Mansour Adam Mahmoud; Elham Mahmoudi; Behnaz Mahmoudvand; Omar Mohamed Makram; Elaheh Malakan Rad; Reza Malekzadeh; Kashish Malhotra; Iram Malik; Muhammad Sajeel Ahmed Malik; Tauqeer Hussain Mallhi; Deborah Carvalho Malta; Aseer Manilal; Yosef Manla; Yasaman Mansoori; Borhan Mansouri; Pejman Mansouri; Mohammad Ali Mansournia; Hamid Reza Marateb; Mirko Marino; Daniela Martini; Santi Martini; Sharmeen Maryam; Roy Rillera Marzo; Alireza Masoudi; Sahar Masoudi; Clara N. Matei; Yasith Mathangasinghe; Elezebeth Mathews; Manu Raj Mathur; Jishanth Mattumpuram; Richard James Maude; Andrea Maugeri; Mahsa Mayeli; Mohsen Mazidi; John J. McGrath; Steven M. McPhail; Enkeleint A. Mechili; John Robert Carabeo Medina; Jitendra Kumar Meena; Kamran Mehrabani-Zeinabad; Max Alberto Mendez Mendez-Lopez; Walter Mendoza; Ritesh G. Menezes; Belayneh Mengist; Sultan Ayoub Meo; Haftu Asmerom Meresa; Atte Meretoja; Tuomo J. Meretoja; Tomislav Mestrovic; Kukulege Chamila Dinushi Mettananda; Sachith Mettananda; Laurette Mhlanga; Tianyue Mi; Junmei Miao Jonasson; Tomasz Miazgowski; Irmina Maria Michalek; Ted R. Miller; Le Huu Nhat Minh; Neema W. Minja; Pouya Mir Mohammad Sadeghi; Niloofar Mirdamadi; Andreea Mirica; Erkin M. Mirrakhimov; Moonis Mirza; Mohammad Mirza-Aghazadeh-Attari; Prasanna Mithra; Zahra Moghimi; Jama Mohamed; Mouhand F.H. Mohamed; Nouh Saad Mohamed; Soheil Mohammadi; Hussen Mohammed; Mustapha Mohammed; Salahuddin Mohammed; Shafiu Mohammed; Nagabhishek Moka; Ali H. Mokdad; Hossein Molavi Vardanjani; Sara Momtazmanesh; Lorenzo Monasta; Fateme Montazeri; AmirAli Moodi Ghalibaf; Yousef Moradi; Paula Moraga; Lidia Morawska; Negar Morovatdar; Shane Douglas Morrison; Jakub Morze; Ebrahim Mostafavi; Amirmahdi Mostofinejad; Vincent Mougin; Parsa Mousavi; Seyed Ehsan Mousavi; Dariush Mozaffarian; Ahmed Msherghi; Lorenzo Muccioli; Ulrich Otto Mueller; Sumoni Mukherjee; Kavita Munjal; Efrén Murillo-Zamora; Ghulam Mustafa; Sathish Muthu; Julius C. Mwita; Woojae Myung; Ahamarshan Jayaraman Nagarajan; Shankar Prasad Nagaraju; Ganesh R. Naik; Gurudatta Naik; Tapas Sadasivan Nair; Mohammad Sadeq Najafi; Noureddin Nakhostin Ansari; Vinay Nangia; Sreenivas Narasimha Swamy; Shumaila Nargus; Bruno Ramos Nascimento; Gustavo G. Nascimento; Hadis Nasoori; Zuhair S. Natto; Javaid Nauman; Muhammad Naveed; Biswa Prakash Nayak; Vinod C. Nayak; Hadush Negash; Ionut Negoi; Ruxandra Irina Negoi; Reza Nejad Shahrokh Abadi; Seyed Aria Nejadghaderi; Chakib Nejjari; Mohammad Hadi Nematollahi; Samata Nepal; Nawi Ng; Dang H. Nguyen; Phat Tuan Nguyen; Van Thanh Nguyen; Robina Khan Niazi; Shawn S. Nijjar; Muhammad A. Nizam; Efaq Ali Noman; Shuhei Nomura; Mamoona Noreen; Bo Norrving; Jean Jacques Noubiap; Chisom Adaobi Nri-Ezedi; Mpiko Ntsekhe; Dieta Nurrika; Chimezie Igwegbe Nzoputam; Ogochukwu Janet Nzoputam; Kehinde O. Obamiro; Martin James O'Donnell; Onome Bright Oghenetega; Ayodipupo Sikiru Oguntade; James Odhiambo Oguta; Sylvester Reuben Okeke; Akinkunmi Paul Okekunle; Lawrence Okidi; Osaretin Christabel Okonji; Patrick Godwin Okwute; Andrew T. Olagunju; Muideen Tunbosun Olaiya; Matifan Dereje Olana; Matthew Idowu Olatubi; Gláucia Maria Moraes Oliveira; Abdulhakeem Abayomi Olorukooba; Isaac Iyinoluwa Olufadewa; Yinka Doris Oluwafemi; Gideon Olamilekan Oluwatunase; Goran Latif Omer; Mohammad Mehdi Ommati; Kanyin Liane Ong; Sokking Ong; Kenneth Ikenna Onyedibe; Michal Ordak; Doris V. Ortega-Altamirano; Alberto Ortiz; Esteban Ortiz-Prado; Wael M.S. Osman; Uchechukwu Levi Osuagwu; Adrian Otoiu; Stanislav S. Otstavnov; Mayowa O. Owolabi; P.A. Mahesh Padukudru; Alicia Padron-Monedero; Jagadish Rao Padubidri; Mahsa Pahlavikhah Varnosfaderani; Tamás Palicz; Raffaele Palladino; Feng Pan; Hai-Feng Pan; Seithikurippu R. Pandi-Perumal; Paraskevi Papadopoulou; Seoyeon Park; Roberto Passera; Jay Patel; Shankargouda Patil; Dimitrios Patoulias; Venkata Suresh Patthipati; Shrikant Pawar; Amy E. Peden; Paolo Pedersini; Minjin Peng; Veincent Christian Filipino Pepito; Emmanuel K. Peprah; Marcos Pereira; Maria Odete Pereira; Mario F.P. Peres; Arokiasamy Perianayagam; Norberto Perico; Fanny Emily Petermann-Rocha; Hoang Tran Pham; Anil K. Philip; David M. Pigott; Thomas Pilgrim; Michael A. Piradov; Evgenii Plotnikov; Dimitri Poddighe; Roman V. Polibin; Ramesh Poluru; Ghazaleh Pourali; Akram Pourshams; Pranil Man Singh Pradhan; Manya Prasad; Elton Junio Sady Prates; Bharathi M. Purohit; Jagadeesh Puvvula; Ibrahim Qattea; Gangzhen Qian; Maryam Faiz Qureshi; Mehrdad Rabiee Rad; Amir Radfar; Seyedeh Niloufar Rafiei Alavi; Ibrar Rafique; Alberto Raggi; Fakher Rahim; Md Jillur Rahim; Mehran Rahimi; Mosiur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Bita Rahmani; Shayan Rahmani; Vahid Rahmanian; Pramila Rai; Sathish Rajaa; Ali Rajabpour-Sanati; Prashant Rajput; Pradhum Ram; Prasanna Ram; Sudha Ramalingam; Shakthi Kumaran Ramasamy; Sheena Ramazanu; Pushkal Sinduvadi Ramesh; Juwel Rana; Kritika Rana; Chhabi Lal Ranabhat; Nemanja Rancic; Amey Rane; Shubham Ranjan; Annemarei Ranta; Indu Ramachandra Rao; Mithun Rao; Sowmya J. Rao; Sina Rashedi; Vahid Rashedi; Ahmed Mustafa Rashid; Azad Rasul; Zubair Ahmed Ratan; Giridhara Rathnaiah Babu; Nakul Ravikumar; Salman Rawaf; Iman Razeghian-Jahromi; Christian Razo; Murali Mohan Rama Krishna Reddy; Elrashdy Moustafa Mohamed Redwan; Giuseppe Remuzzi; Luis Felipe Reyes; Nazila Rezaei; Mohsen Rezaeian; Antonio Luiz P. Ribeiro; Daniela Ribeiro; Reza Rikhtegar; Leonardo Roever; Debby Syahru Romadlon; Luca Ronfani; Himanshu Sehar Sekhar Rout; Nitai Roy; Priyanka Roy; Andrzej Rynkiewicz; Aly M.A. Saad; Zahra Saadatian; Siamak Sabour; Simona Sacco; Rajesh Sachdeva; Basema Saddik; Erfan Sadeghi; Umar Saeed; Fahimeh Safaeinejad; Fatemeh Saheb Sharif-Askari; Narjes Saheb Sharif-Askari; Amirhossein Sahebkar; Soumya Swaroop Sahoo; Seyed Aidin Sajedi; Mirza Rizwan Sajid; Joseph W. Sakshaug; Nasir Salam; Afeez Abolarinwa Salami; Mohamed A. Saleh; Sana Salehi; Marwa Rashad Salem; Mohammed Z.Y. Salem; Sara Samadzadeh; Saad Samargandy; Vijaya Paul Samuel; Abdallah M. Samy; Juan Sanabria; Rama Krishna Sanjeev; Milena M. Santric-Milicevic; Muhammad Arif Nadeem Saqib; Made Ary Sarasmita; Aswini Saravanan; Yaser Sarikhani; Tanmay Sarkar; Rodrigo Sarmiento-Suárez; Gargi Sachin Sarode; Sachin C. Sarode; Thirunavukkarasu Sathish; Anudeep Sathyanarayan; Monika Sawhney; Mehdi Sayyah; Benedikt Michael Schaarschmidt
[No abstract available]
Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
(Elsevier B.V., 2024) Natalia V. Bhattacharjee; Austin E. Schumacher; Amirali Aali; Yohannes Habtegiorgis Abate; Rouzbeh Abbasgholizadeh; Mohammadreza Abbasian; Mohsen Abbasi-Kangevari; Hedayat Abbastabar; Samar Abd ElHafeez; Sherief Abd-Elsalam; Mohammad Abdollahi; Mohammad-Amin Abdollahifar; Meriem Abdoun; Auwal Abdullahi; Mesfin Abebe; Samrawit Shawel Abebe; Olumide Abiodun; Hassan Abolhassani; Meysam Abolmaali; Mohamed Abouzid; Girma Beressa Aboye; Lucas Guimarães Abreu; Woldu Aberhe Abrha; Michael R.M. Abrigo; Dariush Abtahi; Hasan Abualruz; Bilyaminu Abubakar; Eman Abu-Gharbieh; Niveen M.E. Abu-Rmeileh; Tadele Girum Girum Adal; Mesafint Molla Adane; Oluwafemi Atanda Adeagbo Adeagbo; Rufus Adesoji Adedoyin; Victor Adekanmbi; Bashir Aden; Abiola Victor Adepoju; Olatunji O. Adetokunboh; Juliana Bunmi Adetunji; Daniel Adedayo Adeyinka; Olorunsola Israel Adeyomoye; Qorinah Estiningtyas Sakilah Adnani; Saryia Adra; Rotimi Felix Afolabi; Shadi Afyouni; Muhammad Sohail Afzal; Saira Afzal; Shahin Aghamiri; Antonella Agodi; Williams Agyemang-Duah; Bright Opoku Ahinkorah; Austin J. Ahlstrom; Aqeel Ahmad; Danish Ahmad; Firdos Ahmad; Muayyad M. Ahmad; Sajjad Ahmad; Tauseef Ahmad; Ali Ahmed; Ayman Ahmed; Haroon Ahmed; Luai A. Ahmed; Meqdad Saleh Ahmed; Syed Anees Ahmed; Marjan Ajami; Budi Aji; Gizachew Taddesse Akalu; Hossein Akbarialiabad; Rufus Olusola Akinyemi; Mohammed Ahmed Akkaif; Sreelatha Akkala; Hanadi Al Hamad; Syed Mahfuz Al Hasan; Mohammad Al Qadire; Tareq Mohammed Ali AL-Ahdal; Samer O. Alalalmeh; Tariq A. Alalwan; Ziyad Al-Aly; Khurshid Alam; Rasmieh Mustafa Al-Amer; Fahad Mashhour Alanezi; Turki M. Alanzi; Almaza Albakri; Mohammed Albashtawy; Mohammad T. AlBataineh; Hediyeh Alemi; Sharifullah Alemi; Yihun Mulugeta Alemu; Ayman Al-Eyadhy; Adel Ali Saeed Al-Gheethi; Khalid F. Alhabib; Noora Alhajri; Fadwa Alhalaiqa Naji Alhalaiqa; Robert Kaba Alhassan; Abid Ali; Beriwan Abdulqadir Ali; Liaqat Ali; Mohammed Usman Ali; Rafat Ali; Syed Shujait Shujait Ali; Sheikh Mohammad Alif; Mohammad Aligol; Mehran Alijanzadeh; Mohammad A.M. Aljasir; Syed Mohamed Aljunid; Sabah Al-Marwani; Joseph Uy Almazan; Hesham M. Al-Mekhlafi; Omar Almidani; Mahmoud A. Alomari; Basem Al-Omari; Jaber S. Alqahtani; Ahmed Yaseen Alqutaibi; Rajaa M. Al-Raddadi; Salman Khalifah Al-Sabah; Awais Altaf; Jaffar A. Al-Tawfiq; Khalid A. Altirkawi; Deborah Oyine Aluh; Farrukh Jawad Alvi; Nelson Alvis-Guzman; Hassan Alwafi; Yaser Mohammed Al-Worafi; Hany Aly; Safwat Aly; Karem H. Alzoubi; Edward Kwabena Ameyaw; Tarek Tawfik Amin; Alireza Amindarolzarbi; Mostafa Amini-Rarani; Sohrab Amiri; Irene Gyamfuah Ampomah; Dickson A. Amugsi; Ganiyu Adeniyi Amusa; Robert Ancuceanu; Deanna Anderlini; Pedro Prata Andrade; Catalina Liliana Andrei; Tudorel Andrei; Abhishek Anil; Sneha Anil; Adnan Ansar; Alireza Ansari-Moghaddam; Catherine M. Antony; Ernoiz Antriyandarti; Saeid Anvari; Saleha Anwar; Razique Anwer; Anayochukwu Edward Anyasodor; Jalal Arabloo; Razman Arabzadeh Bahri; Elshaimaa A. Arafa; Mosab Arafat; Ana Margarida Araujo; Aleksandr Y. Aravkin; Abdulfatai Aremu; Timur Aripov; Mesay Arkew; Benedetta Armocida; Johan Ärnlöv; Mahwish Arooj; Anton A. Artamonov; Judie Arulappan; Raphael Taiwo Aruleba; Ashokan Arumugam; Mohsen Asadi-Lari; Zatollah Asemi; Saeed Asgary; Mona Asghariahmadabad; Mohammad Asghari-Jafarabadi; Mubarek Yesse Ashemo; Muhammad Ashraf; Tahira Ashraf; Marvellous O. Asika; Seyyed Shamsadin Athari; Maha Moh'd Wahbi Atout; Alok Atreya; Avinash Aujayeb; Marcel Ausloos; Abolfazl Avan; Amlaku Mulat Aweke; Getnet Melaku Ayele; Seyed Mohammad Ayyoubzadeh; Sina Azadnajafabad; Rui M.S. Azevedo; Ahmed Y. Azzam; Muhammad Badar; Ashish D. Badiye; Soroush Baghdadi; Nasser Bagheri; Sara Bagherieh; Najmeh Bahmanziari; Ruhai Bai; Atif Amin Baig; Jennifer L. Baker; Abdulaziz T. Bako; Ravleen Kaur Bakshi; Madhan Balasubramanian; Ovidiu Constantin Baltatu; Kiran Bam; MacIej Banach; Soham Bandyopadhyay; Biswajit Banik; Palash Chandra Banik; Hansi Bansal; Mehmet Firat Baran; Martina Barchitta; Mainak Bardhan; Erfan Bardideh; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Francesco Barone-Adesi; Hiba Jawdat Barqawi; Amadou Barrow; Sandra Barteit; Zarrin Basharat; Asma'u I.J. Bashir; Hameed Akande Bashiru; Afisu Basiru; Joao Diogo Basso; Sanjay Basu; Abdul-Monim Mohammad Batiha; Kavita Batra; Bernhard T. Baune; Mohsen Bayati; Tahmina Begum; Emad Behboudi; Amir Hossein Behnoush; Maryam Beiranvand; Diana Fernanda Bejarano Ramirez; Alehegn Bekele; Sefealem Assefa Belay; Uzma Iqbal Belgaumi; Michelle L. Bell; Olorunjuwon Omolaja Bello; Apostolos Beloukas; Isabela M. Bensenor; Zombor Berezvai; Alemshet Yirga Berhie; Amiel Nazer C. Bermudez; Paulo J.G. Bettencourt; Akshaya Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Prarthna V. Bhardwaj; Sonu Bhaskar; Vivek Bhat; Gurjit Kaur Bhatti; Jasvinder Singh Bhatti; Manpreet S. Bhatti; Rajbir Bhatti; Antonio Biondi; Catherine Bisignano; Atanu Biswas; Raaj Kishore Biswas; Veera R. Bitra; Tone Bjørge; Elye Bliss; Micheal Kofi Boachie; Anca Vasilica Bobirca; Virginia Bodolica; Aadam Olalekan Bodunrin; Eyob Ketema Bogale; Kassawmar Angaw Bogale; Milad Bonakdar Hashemi; Berrak Bora Basara; Souad Bouaoud; Dejana Braithwaite; Michael Brauer; Nicholas J.K. Breitborde; Dana Bryazka; Norma B. Bulamu; Danilo Buonsenso; Katrin Burkart; Richard A. Burns; Yasser Bustanji; Nadeem Shafique Butt; Zahid A. Butt; Florentino Luciano Caetano Dos Santos; Daniela Calina; Ismael R. Campos-Nonato; Fan Cao; Shujin Cao; Angelo Capodici; Giulia Carreras; Andrea Carugno; Carlos A. Castañeda-Orjuela; Giulio Castelpietra; Maria Sofia Cattaruzza; Arthur Caye; Luca Cegolon; Francieli Cembranel; Ester Cerin; Joshua Chadwick; Yaacoub Chahine; Chiranjib Chakraborty; Julian Chalek; Jeffrey Shi Kai Chan; Periklis Charalampous; Vijay Kumar Chattu; Sarika Chaturvedi; Malizgani Paul Chavula; An-Tian Chen; Haowei Chen; Simiao Chen; Gerald Chi; Fatemeh Chichagi; Ju-Huei Chien; Patrick R. Ching; William C.S. Cho; Sungchul Choi; Bryan Chong; Hitesh Chopra; Sonali Gajanan Choudhari; Devasahayam J. Christopher; Dinh-Toi Chu; Isaac Sunday Chukwu; Eric Chung; Sheng-Chia Chung; Zinhle Cindi; Iolanda Cioffi; Raffaela Ciuffreda; Rafael M. Claro; Kaleb Coberly; Alyssa Columbus; Haley Comfort; Joao Conde; Michael H. Criqui; Natalia Cruz-Martins; Silvia Magali Cuadra-Hernández; Sriharsha Dadana; Omid Dadras; Tukur Dahiru; Zhaoli Dai; Bronte Dalton; Giovanni Damiani; Aso Mohammad Darwesh; Jai K. Das; Saswati Das; Mohsen Dashti; Anna Dastiridou; Claudio Alberto Dávila-Cervantes; Kairat Davletov; Aklilu Tamire Debele; Shayom Debopadhaya; Somayeh Delavari; Ivan Delgado-Enciso; Dessalegn Demeke; Berecha Hundessa Demessa; Xinlei Deng; Edgar Denova-Gutiérrez; Kebede Deribe; Nikolaos Dervenis; Hardik Dineshbhai Desai; Rupak Desai; Vinoth Gnana Chellaiyan Devanbu; Arkadeep Dhali; Kuldeep Dhama; Meghnath Dhimal; Vishal R. Dhulipala; Diana Dias Da Silva; Daniel Diaz; Michael J. Diaz; Adriana Dima; Delaney D. Ding; M. Ashworth Dirac; Thanh Chi Do; Thao Huynh Phuong Do; Camila Bruneli Do Prado; Sushil Dohare; Wanyue Dong; Mario D'Oria; Wendel Mombaque Dos Santos; Leila Doshmangir; Robert Kokou Dowou; Ashel Chelsea Dsouza; Haneil Larson Dsouza; Viola Dsouza; John Dube; Joe Duprey; Andre Rodrigues Duraes; Senbagam Duraisamy; Oyewole Christopher Durojaiye; Sulagna Dutta; Laura Dwyer-Lindgren; Paulina Agnieszka Dzianach; Arkadiusz Marian Dziedzic; Alireza Ebrahimi; Hisham Atan Edinur; Kristina Edvardsson; Ferry Efendi; Terje Andreas Eikemo; Michael Ekholuenetale; Maha El Tantawi; Noha Mousaad Elemam; Ghada Metwally Tawfik ElGohary; Muhammed Elhadi; Legesse Tesfaye Elilo; Omar Abdelsadek Abdou Elmeligy; Mohamed A. Elmonem; Mohammed Elshaer; Ibrahim Elsohaby; Amir Emami Zeydi; Luchuo Engelbert Bain; Sharareh Eskandarieh; Francesco Esposito; Kara Estep; Farshid Etaee; Natalia Fabin; Adeniyi Francis Fagbamigbe; Saman Fahimi; Aliasghar Fakhri-Demeshghieh; Luca Falzone; Ali Faramarzi; MoezAlIslam Ezzat Mahmoud Faris; Sam Farmer; Andre Faro; Abidemi Omolara Fasanmi; Ali Fatehizadeh; Nelsensius Klau Fauk; Pooria Fazeli; Valery L. Feigin; Seyed-Mohammad Fereshtehnejad; Abdullah Hamid Feroze; Pietro Ferrara; Nuno Ferreira; Getahun Fetensa; Irina Filip; Florian Fischer; Joanne Flavel; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Artem Alekseevich Fomenkov; Behzad Foroutan; Matteo Foschi; Kayode Raphael Fowobaje; Kate Louise Francis; Alberto Freitas; Takeshi Fukumoto; John E. Fuller; Blima Fux; Peter Andras Gaal; Muktar A. Gadanya; Abhay Motiramji Gaidhane; Yaseen Galali; Silvano Gallus; Aravind P. Gandhi; Balasankar Ganesan; Mohammad Arfat Ganiyani; M.A. Garcia-Gordillo; Naval Garg; Rupesh K. Gautam; Federica Gazzelloni; Semiu Olatunde Gbadamosi; Miglas W. Gebregergis; Mesfin Gebrehiwot; Tesfay Brhane Gebremariam; Teferi Gebru Gebremeskel; Yohannes Fikadu Geda; Simona Roxana Georgescu; Urge Gerema; Habtamu Geremew; Motuma Erena Getachew; Peter W. Gething; MohammadReza Ghasemi; Ghazal Ghasempour Dabaghi; Afsaneh Ghasemzadeh; Fariba Ghassemi; Ramy Mohamed Ghazy; Sailaja Ghimire; Asadollah Gholamian; Ali Gholamrezanezhad; Mahsa Ghorbani; Aloke Gopal Ghoshal; Arun Digambarrao Ghuge; Artyom Urievich Gil; Tiffany K. Gill; Matteo Giorgi; Alem Girmay; James C. Glasbey; Laszlo Göbölös; Amit Goel; Ali Golchin; Mahaveer Golechha; Pouya Goleij; Sameer Vali Gopalani; Houman Goudarzi; Alessandra C. Goulart; Anmol Goyal; Simon Matthew Graham; Michal Grivna; Shi-Yang Guan; Giovanni Guarducci; Mohammed Ibrahim Mohialdeen Gubari; Mesay Dechasa Gudeta; Stefano Guicciardi; Snigdha Gulati; David Gulisashvili; Damitha Asanga Gunawardane; Cui Guo; Anish Kumar Gupta; Bhawna Gupta; Manoj Kumar Gupta; Mohak Gupta; Sapna Gupta; Veer Bala Gupta; Vijai Kumar Gupta; Vivek Kumar Gupta; Annie Haakenstad; Farrokh Habibzadeh; Najah R. Hadi; Nils Haep; Ramtin Hajibeygi; Sebastian Haller; Rabih Halwani; Randah R. Hamadeh; Nadia M. Hamdy; Sajid Hameed; Samer Hamidi; Qiuxia Han; Alexis J. Handal; Graeme J. Hankey; Md Nuruzzaman Haque; Josep Maria Haro; Ahmed I. Hasaballah; Ikramul Hasan; Mohammad Jahid Hasan; S.M. Mahmudul Hasan; Hamidreza Hasani; Md Saquib Hasnain; Amr Hassan; Ikrama Hassan; Soheil Hassanipour; Hadi Hassankhani; Simon I. Hay; Jeffrey J. Hebert; Omar E. Hegazi; Mohammad Heidari; Bartosz Helfer; Mehdi Hemmati; Brenda Yuliana Herrera-Serna; Claudiu Herteliu; Kamran Hessami; Kamal Hezam; Yuta Hiraike; Nguyen Quoc Hoan; Ramesh Holla; Nobuyuki Horita; Md Mahbub Hossain; Mohammad Bellal Hossain Hossain; Hassan Hosseinzadeh; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mohamed Hsairi; Vivian Chia-Rong Hsieh; Chengxi Hu; Junjie Huang; M. Mamun Huda; Ayesha Humayun; Javid Hussain; Nawfal R. Hussein; Hong-Han Huynh; Bing-Fang Hwang; Segun Emmanuel Ibitoye; Pulwasha Maria Iftikhar; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Mustapha Immurana; Leeberk Raja Inbaraj; Afrin Iqbal; Md. Rabiul Islam; Nahlah Elkudssiah Ismail; Hiroyasu Iso; Gaetano Isola; Masao Iwagami; Mahalaxmi Iyer; J. Linda Merin; Jalil Jaafari; Louis Jacob; Farhad Jadidi-Niaragh; Khushleen Jaggi; Kasra Jahankhani; Nader Jahanmehr; Haitham Jahrami; Akhil Jain; Nityanand Jain; Ammar Abdulrahman Jairoun; Mihajlo Jakovljevic; Elham Jamshidi; Sabzali Javadov; Tahereh Javaheri; Sathish Kumar Jayapal; Shubha Jayaram; Sun Ha Jee; Jayakumar Jeganathan; Anil K. Jha; Ravi Prakash Jha; Heng Jiang; Mohammad Jokar; Jost B. Jonas; Tamas Joo; Nitin Joseph; Charity Ehimwenma Joshua; Farahnaz Joukar; Jacek Jerzy Jozwiak; Mikk Jürisson; K. Vaishali; Billingsley Kaambwa; Abdulkareem Kabir; Ali Kabir; Hannaneh Kabir; Zubair Kabir; Rizwan Kalani; Leila R. Kalankesh; Feroze Kaliyadan; Sanjay Kalra; Rajesh Kamath; Sagarika Kamath; Tanuj Kanchan; Edmund Wedam Kanmiki; Kehinde Kazeem Kanmodi; S. Suthanthira Kannan; Sushil Kumar Kansal; Rami S. Kantar; Neeti Kapoor; Mehrdad Karajizadeh; Manoochehr Karami; Ibraheem M. Karaye; Faizan Zaffar Kashoo; Hengameh Kasraei; Nicholas J. Kassebaum; Molly B. Kassel; Joonas H. Kauppila; Foad Kazemi; Sara Kazeminia; John H. Kempen; Evie Shoshannah Kendal; Kamyab Keshtkar; Mohammad Keykhaei; Himanshu Khajuria; Amirmohammad Khalaji; Nauman Khalid; Anees Ahmed Khalil; Alireza Khalilian; Faham Khamesipour; Ajmal Khan; Asaduzzaman Khan; Ikramullah Khan; M. Nuruzzaman Khan; Maseer Khan; Mohammad Jobair Khan; Moien A.B. Khan; Young-Ho Khang; Shaghayegh Khanmohammadi; Khaled Khatab; Armin Khavandegar; Hamid Reza Khayat Kashani; Feriha Fatima Khidri; Moein Khormali; Mohammad Ali Khosravi; Mahmood Khosrowjerdi; Wondwosen Teklesilasie Kidane; Zemene Demelash Kifle; Julie Sojin Kim; Min Seo Kim; Ruth W. Kimokoti; Kasey E. Kinzel; Girmay Tsegay Kiross; Adnan Kisa; Sezer Kisa; Ali-Asghar Kolahi; Farzad Kompani; Gerbrand Koren; Oleksii Korzh; Soewarta Kosen; Sindhura Lakshmi Koulmane Laxminarayana; Kewal Krishan; Varun Krishna; Vijay Krishnamoorthy; Barthelemy Kuate Defo; Connor M. Kubeisy; Burcu Kucuk Bicer; Md Abdul Kuddus; Mohammed Kuddus; Ilari Kuitunen; Mukhtar Kulimbet; Harish Kumar; Satyajit Kundu; Kunle Rotimi Kunle; Om P. Kurmi; Asep Kusnali; Dian Kusuma; Evans F. Kyei; Ilias Kyriopoulos; Carlo La Vecchia; Ben Lacey; Muhammad Awwal Ladan; Lucie Laflamme; Chandrakant Lahariya; Daphne Teck Ching Lai; Dharmesh Kumar Lal; Ratilal Lalloo; Judit Lám; Demetris Lamnisos; Ivan Landires; Francesco Lanfranchi; Berthold Langguth; Ariane Laplante-Lévesque; Heidi Jane Larson; Anders O. Larsson; Savita Lasrado; Kamaluddin Latief; Kaveh Latifinaibin; Long Khanh Dao Le; Nhi Huu Hanh Le; Trang Diep Thanh Le; Caterina Ledda; Munjae Lee; Paul H. Lee; Seung Won Lee; Yo Han Lee; Gebretsadik Kiros Lema; Elvynna Leong; Temesgen L. Lerango; An Li; Ming-Chieh Li; Shanshan Li; Wei Li; Xiaopan Li; Virendra S. Ligade; Stephen S. Lim; Ro-Ting Lin; Paulina A. Lindstedt; Stefan Listl; Gang Liu; Jue Liu; Xiaofeng Liu; Xuefeng Liu; Yuewei Liu; Erand Llanaj; Ruben López-Bueno; Platon D. Lopukhov; Laszlo Lorenzovici; Paulo A. Lotufo; Jailos Lubinda; Giancarlo Lucchetti; Alessandra Lugo; Raimundas Lunevicius; Hengliang Lv; Zheng Feei Ma; Kelsey Lynn Maass; Monika MacHoy; Áurea M. Madureira-Carvalho; Mohammed Magdy Abd El Razek; Azzam A. Maghazachi; Soleiman Mahjoub; Mansour Adam Mahmoud; Azeem Majeed; Jeadran N. Malagón-Rojas; Elaheh Malakan Rad; Kashish Malhotra; Ahmad Azam Malik; Iram Malik; Deborah Carvalho Malta; Abdullah A. Mamun; Yosef Manla; Yasaman Mansoori; Ali Mansour; Borhan Mansouri; Zeinab Mansouri; Mohammad Ali Mansournia; Joemer C. Maravilla; Mirko Marino; Abdoljalal Marjani; Gabriel Martinez; Ramon Martinez-Piedra; Francisco Rogerlandio Martins-Melo; Miquel Martorell; Sharmeen Maryam; Roy Rillera Marzo; Alireza Masoudi; Jishanth Mattumpuram; Richard James Maude; Andrea Maugeri; Erin A. May; Mahsa Mayeli; Maryam Mazaheri; John J. McGrath; Martin McKee; Anna Laura Wensel McKowen; Susan A. McLaughlin; Steven M. McPhail; Rahul Mehra; Kamran Mehrabani-Zeinabad; Entezar Mehrabi Nasab; Tesfahun Mekene Meto; Max Alberto Mendez Mendez-Lopez; Walter Mendoza; Ritesh G. Menezes; George A. Mensah; Alexios-Fotios A. Mentis; Sultan Ayoub Meo; Mohsen Merati; Atte Meretoja; Tuomo J. Meretoja; Abera M. Mersha; Tomislav Mestrovic; Pouya Metanat; Kukulege Chamila Dinushi Mettananda; Sachith Mettananda; Adquate Mhlanga; Laurette Mhlanga; Tianyue Mi; Tomasz Miazgowski; Georgia Micha; Irmina Maria Michalek; Ted R. Miller; Le Huu Nhat Minh; Mojgan Mirghafourvand; Erkin M. Mirrakhimov; Mizan Kiros Mirutse; Moonis Mirza; Roya Mirzaei; Ashim Mishra; Sanjeev Misra; Philip B. Mitchell; Chaitanya Mittal; Babak Moazen; Abdalla Z. Mohamed; Ahmed Ismail Mohamed; Jama Mohamed; Mouhand F.H. Mohamed; Nouh Saad Mohamed; Sakineh Mohammad-Alizadeh-Charandabi; Soheil Mohammadi; Abdollah Mohammadian-Hafshejani; Mustapha Mohammed; Salahuddin Mohammed; Shafiu Mohammed; Ali H. Mokdad; Peyman Mokhtarzadehazar; Hossein Molavi Vardanjani; Sabrina Molinaro; Lorenzo Monasta; Mohammad Ali Moni; Maryam Moradi; Yousef Moradi; Paula Moraga; Rafael Silveira Moreira; Negar Morovatdar; Shane Douglas Morrison; Jakub Morze; Abbas Mosapour; Elias Mossialos; Rohith Motappa; Parsa Mousavi; Amin Mousavi Khaneghah; Christine Mpundu-Kaambwa; Sumaira Mubarik; Lorenzo Muccioli; Francesk Mulita; Kavita Munjal; Efren Murillo-Zamora; Jonah Musa; Fungai Musaigwa; Ana-Maria Musina; Sathish Muthu; Saravanan Muthupandian; Muhammad Muzaffar; Woojae Myung; Ahamarshan Jayaraman Nagarajan; Gabriele Nagel; Pirouz Naghavi; Ganesh R. Naik; Gurudatta Naik; Mukhammad David Naimzada; Firzan Nainu; Vinay Nangia; Sreenivas Narasimha Swamy; Bruno Ramos Nascimento; Gustavo G. Nascimento; Abdallah Y. Naser; Mohammad Javad Nasiri; Zuhair S. Natto; Javaid Nauman; Muhammad Naveed; Biswa Prakash Nayak; Vinod C. Nayak; Rawlance Ndejjo; Sabina Onyinye Nduaguba; Hadush Negash; Chernet Tafere Negesse; Ionut Negoi; Ruxandra Irina Negoi; Seyed Aria Nejadghaderi; Chakib Nejjari; Samata Nepal; Henok Biresaw Netsere; Georges Nguefack-Tsague; Josephine W. Ngunjiri; Dang H. Nguyen; Hau Thi Hien Nguyen; Phuong The Nguyen; QuynhAnh P. Nguyen; Van Thanh Nguyen; Robina Khan Niazi; Yeshambel T. Nigatu; Taxiarchis Konstantinos Nikolouzakis; Ali Nikoobar; Amin Reza Nikpoor; Chukwudi A. Nnaji; Lawrence Achilles Nnyanzi; Efaq Ali Noman; Shuhei Nomura; Mamoona Noreen; Nafise Noroozi; Chisom Adaobi Nri-Ezedi; Mengistu H. Nunemo; Virginia Nuñez-Samudio; Dieta Nurrika; Jerry John Nutor; Bogdan Oancea; Kehinde O. Obamiro; Ismail A. Odetokun; Nkechi Martina Odogwu; Martin James O'Donnell; Oluwakemi Ololade Odukoya; Ayodipupo Sikiru Oguntade; James Odhiambo Oguta; In-Hwan Oh; Sylvester Reuben Okeke; Akinkunmi Paul Okekunle; Osaretin Christabel Okonji; Patrick Godwin Okwute; Andrew T. Olagunju; Omotola O. Olasupo; Matthew Idowu Olatubi; Glaucia Maria Moraes Oliveira; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Gideon Olamilekan Oluwatunase; Hany A. Omar; Goran Latif Omer; Obinna E. Onwujekwe; Michal Ordak; Orish Ebere Orisakwe; Verner N. Orish; Doris V. Ortega-Altamirano; Alberto Ortiz; Esteban Ortiz-Prado; Wael M.S. Osman; Uchechukwu Levi Osuagwu; Olayinka Osuolale; Adrian Otoiu; Stanislav S. Otstavnov; Amel Ouyahia; Guoqing Ouyang; Mayowa O. Owolabi; Yaz Ozten; P.A. Mahesh Padukudru; Mohammad Taha Pahlevan Fallahy; Feng Pan; Hai-Feng Pan; Adrian Pana; Paramjot Panda; Songhomitra Panda-Jonas
Background: Accurate assessments of current and future fertility—including overall trends and changing population age structures across countries and regions—are essential to help plan for the profound social, economic, environmental, and geopolitical challenges that these changes will bring. Estimates and projections of fertility are necessary to inform policies involving resource and health-care needs, labour supply, education, gender equality, and family planning and support. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 produced up-to-date and comprehensive demographic assessments of key fertility indicators at global, regional, and national levels from 1950 to 2021 and forecast fertility metrics to 2100 based on a reference scenario and key policy-dependent alternative scenarios. Methods: To estimate fertility indicators from 1950 to 2021, mixed-effects regression models and spatiotemporal Gaussian process regression were used to synthesise data from 8709 country-years of vital and sample registrations, 1455 surveys and censuses, and 150 other sources, and to generate age-specific fertility rates (ASFRs) for 5-year age groups from age 10 years to 54 years. ASFRs were summed across age groups to produce estimates of total fertility rate (TFR). Livebirths were calculated by multiplying ASFR and age-specific female population, then summing across ages 10–54 years. To forecast future fertility up to 2100, our Institute for Health Metrics and Evaluation (IHME) forecasting model was based on projections of completed cohort fertility at age 50 years (CCF50; the average number of children born over time to females from a specified birth cohort), which yields more stable and accurate measures of fertility than directly modelling TFR. CCF50 was modelled using an ensemble approach in which three sub-models (with two, three, and four covariates variously consisting of female educational attainment, contraceptive met need, population density in habitable areas, and under-5 mortality) were given equal weights, and analyses were conducted utilising the MR-BRT (meta-regression—Bayesian, regularised, trimmed) tool. To capture time-series trends in CCF50 not explained by these covariates, we used a first-order autoregressive model on the residual term. CCF50 as a proportion of each 5-year ASFR was predicted using a linear mixed-effects model with fixed-effects covariates (female educational attainment and contraceptive met need) and random intercepts for geographical regions. Projected TFRs were then computed for each calendar year as the sum of single-year ASFRs across age groups. The reference forecast is our estimate of the most likely fertility future given the model, past fertility, forecasts of covariates, and historical relationships between covariates and fertility. We additionally produced forecasts for multiple alternative scenarios in each location: the UN Sustainable Development Goal (SDG) for education is achieved by 2030; the contraceptive met need SDG is achieved by 2030; pro-natal policies are enacted to create supportive environments for those who give birth; and the previous three scenarios combined. Uncertainty from past data inputs and model estimation was propagated throughout analyses by taking 1000 draws for past and present fertility estimates and 500 draws for future forecasts from the estimated distribution for each metric, with 95% uncertainty intervals (UIs) given as the 2·5 and 97·5 percentiles of the draws. To evaluate the forecasting performance of our model and others, we computed skill values—a metric assessing gain in forecasting accuracy—by comparing predicted versus observed ASFRs from the past 15 years (2007–21). A positive skill metric indicates that the model being evaluated performs better than the baseline model (here, a simplified model holding 2007 values constant in the future), and a negative metric indicates that the evaluated model performs worse than baseline. Findings: During the period from 1950 to 2021, global TFR more than halved, from 4·84 (95% UI 4·63–5·06) to 2·23 (2·09–2·38). Global annual livebirths peaked in 2016 at 142 million (95% UI 137–147), declining to 129 million (121–138) in 2021. Fertility rates declined in all countries and territories since 1950, with TFR remaining above 2·1—canonically considered replacement-level fertility—in 94 (46·1%) countries and territories in 2021. This included 44 of 46 countries in sub-Saharan Africa, which was the super-region with the largest share of livebirths in 2021 (29·2% [28·7–29·6]). 47 countries and territories in which lowest estimated fertility between 1950 and 2021 was below replacement experienced one or more subsequent years with higher fertility; only three of these locations rebounded above replacement levels. Future fertility rates were projected to continue to decline worldwide, reaching a global TFR of 1·83 (1·59–2·08) in 2050 and 1·59 (1·25–1·96) in 2100 under the reference scenario. The number of countries and territories with fertility rates remaining above replacement was forecast to be 49 (24·0%) in 2050 and only six (2·9%) in 2100, with three of these six countries included in the 2021 World Bank-defined low-income group, all located in the GBD super-region of sub-Saharan Africa. The proportion of livebirths occurring in sub-Saharan Africa was forecast to increase to more than half of the world's livebirths in 2100, to 41·3% (39·6–43·1) in 2050 and 54·3% (47·1–59·5) in 2100. The share of livebirths was projected to decline between 2021 and 2100 in most of the six other super-regions—decreasing, for example, in south Asia from 24·8% (23·7–25·8) in 2021 to 16·7% (14·3–19·1) in 2050 and 7·1% (4·4–10·1) in 2100—but was forecast to increase modestly in the north Africa and Middle East and high-income super-regions. Forecast estimates for the alternative combined scenario suggest that meeting SDG targets for education and contraceptive met need, as well as implementing pro-natal policies, would result in global TFRs of 1·65 (1·40–1·92) in 2050 and 1·62 (1·35–1·95) in 2100. The forecasting skill metric values for the IHME model were positive across all age groups, indicating that the model is better than the constant prediction. Interpretation: Fertility is declining globally, with rates in more than half of all countries and territories in 2021 below replacement level. Trends since 2000 show considerable heterogeneity in the steepness of declines, and only a small number of countries experienced even a slight fertility rebound after their lowest observed rate, with none reaching replacement level. Additionally, the distribution of livebirths across the globe is shifting, with a greater proportion occurring in the lowest-income countries. Future fertility rates will continue to decline worldwide and will remain low even under successful implementation of pro-natal policies. These changes will have far-reaching economic and societal consequences due to ageing populations and declining workforces in higher-income countries, combined with an increasing share of livebirths among the already poorest regions of the world. Funding: Bill & Melinda Gates Foundation. © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019
(Elsevier B.V., 2022) Kevin S Ikuta; Lucien R Swetschinski; Gisela Robles Aguilar; Fablina Sharara; Tomislav Mestrovic; Authia P Gray; Nicole Davis Weaver; Eve E Wool; Chieh Han; Anna Gershberg Hayoon; Amirali Aali; Semagn Mekonnen Abate; Mohsen Abbasi-Kangevari; Zeinab Abbasi-Kangevari; Sherief Abd-Elsalam; Getachew Abebe; Aidin Abedi; Amir Parsa Abhari; Hassan Abidi; Richard Gyan Aboagye; Abdorrahim Absalan; Hiwa Abubaker Ali; Juan Manuel Acuna; Tigist Demssew Adane; Isaac Yeboah Addo; Oyelola A Adegboye; Mohammad Adnan; Qorinah Estiningtyas Sakilah Adnani; Muhammad Sohail Afzal; Saira Afzal; Zahra Babaei Aghdam; Bright Opoku Ahinkorah; Aqeel Ahmad; Araz Ramazan Ahmad; Rizwan Ahmad; Sajjad Ahmad; Sohail Ahmad; Sepideh Ahmadi; Ali Ahmed; Haroon Ahmed; Jivan Qasim Ahmed; Tarik Ahmed Rashid; Marjan Ajami; Budi Aji; Mostafa Akbarzadeh-Khiavi; Chisom Joyqueenet Akunna; Hanadi Al Hamad; Fares Alahdab; Ziyad Al-Aly; Mamoon A Aldeyab; Alicia V Aleman; Fadwa Alhalaiqa Naji Alhalaiqa; Robert Kaba Alhassan; Beriwan Abdulqadir Ali; Liaqat Ali; Syed Shujait Ali; Yousef Alimohamadi; Vahid Alipour; Atiyeh Alizadeh; Syed Mohamed Aljunid; Kasim Allel; Sami Almustanyir; Edward Kwabena Ameyaw; Arianna Maever L Amit; Nivedita Anandavelane; Robert Ancuceanu; Catalina Liliana Andrei; Tudorel Andrei; Dewi Anggraini; Adnan Ansar; Anayochukwu Edward Anyasodor; Jalal Arabloo; Aleksandr Y Aravkin; Demelash Areda; Timur Aripov; Anton A Artamonov; Judie Arulappan; Raphael Taiwo Aruleba; Muhammad Asaduzzaman; Tahira Ashraf; Seyyed Shamsadin Athari; Daniel Atlaw; Sameh Attia; Marcel Ausloos; Tewachew Awoke; Beatriz Paulina Ayala Quintanilla; Tegegn Mulatu Ayana; Sina Azadnajafabad; Amirhossein Azari Jafari; B. Darshan; Muhammad Badar; Ashish D Badiye; Nayereh Baghcheghi; Sara Bagherieh; Atif Amin Baig; Indrajit Banerjee; Aleksandra Barac; Mainak Bardhan; Francesco Barone-Adesi; Hiba Jawdat Barqawi; Amadou Barrow; Pritish Baskaran; Saurav Basu; Abdul-Monim Mohammad Batiha; Neeraj Bedi; Melaku Ashagrie Belete; Uzma Iqbal Belgaumi; Rose G Bender; Bharti Bhandari; Dinesh Bhandari; Pankaj Bhardwaj; Sonu Bhaskar; Krittika Bhattacharyya; Suraj Bhattarai; Saeid Bitaraf; Danilo Buonsenso; Zahid A Butt; Florentino Luciano Caetano Dos Santos; Jiao Cai; Daniela Calina; Paulo Camargos; Luis Alberto Cámera; Rosario Cárdenas; Muge Cevik; Joshua Chadwick; Jaykaran Charan; Akhilanand Chaurasia; Patrick R Ching; Sonali Gajanan Choudhari; Enayet Karim Chowdhury; Fazle Rabbi Chowdhury; Dinh-Toi Chu; Isaac Sunday Chukwu; Omid Dadras; Fentaw Teshome Dagnaw; Xiaochen Dai; Saswati Das; Anna Dastiridou; Sisay Abebe Debela; Fitsum Wolde Demisse; Solomon Demissie; Diriba Dereje; Msganaw Derese; Hardik Dineshbhai Desai; Fikadu Nugusu Dessalegn; Samuel Abebe A Dessalegni; Belay Desye; Kartik Dhaduk; Meghnath Dhimal; Sameer Dhingra; Nancy Diao; Daniel Diaz; Shirin Djalalinia; Milad Dodangeh; Deepa Dongarwar; Bezabih Terefe Dora; Fariba Dorostkar; Haneil Larson Dsouza; Eleonora Dubljanin; Susanna J Dunachie; Oyewole Christopher Durojaiye; Hisham Atan Edinur; Habtamu Bekele Ejigu; Michael Ekholuenetale; Temitope Cyrus Ekundayo; Hassan El-Abid; Muhammed Elhadi; Mohamed A Elmonem; Amir Emami; Luchuo Engelbert Bain; Daniel Berhanie Enyew; Ryenchindorj Erkhembayar; Babak Eshrati; Farshid Etaee; Adeniyi Francis Fagbamigbe; Shahab Falahi; Aida Fallahzadeh; Emerito Jose A Faraon; Ali Fatehizadeh; Ginenus Fekadu; João C Fernandes; Allegra Ferrari; Getahun Fetensa; Irina Filip; Florian Fischer; Masoud Foroutan; Peter Andras Gaal; Muktar A Gadanya; Abhay Motiramji Gaidhane; Balasankar Ganesan; Mesfin Gebrehiwot; Reza Ghanbari; Mohammad Ghasemi Nour; Ahmad Ghashghaee; Ali Gholamrezanezhad; Abdolmajid Gholizadeh; Mahaveer Golechha; Pouya Goleij; Davide Golinelli; Amador Goodridge; Damitha Asanga Gunawardane; Yuming Guo; Rajat Das Gupta; Sapna Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Alemu Guta; Parham Habibzadeh; Atlas Haddadi Avval; Rabih Halwani; Asif Hanif; Md Abdul Hannan; Harapan Harapan; Shoaib Hassan; Hadi Hassankhani; Khezar Hayat; Behzad Heibati; Golnaz Heidari; Mohammad Heidari; Reza Heidari-Soureshjani; Claudiu Herteliu; Demisu Zenbaba Heyi; Kamal Hezam; Praveen Hoogar; Nobuyuki Horita; Md Mahbub Hossain; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Soodabeh Hoveidamanesh; Junjie Huang; Salman Hussain; Nawfal R Hussein; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena M Ilic; Milena D Ilic; Mohammad Tarique Imam; Mustapha Immurana; Leeberk Raja Inbaraj; Arnaud Iradukunda; Nahlah Elkudssiah Ismail; Chidozie C D Iwu; Chinwe Juliana Iwu; Merin J. Linda; Mihajlo Jakovljevic; Elham Jamshidi; Tahereh Javaheri; Fatemeh Javanmardi; Javad Javidnia; Sathish Kumar Jayapal; Umesh Jayarajah; Rime Jebai; Ravi Prakash Jha; Tamas Joo; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; Salah Eddine Oussama Kacimi; Vidya Kadashetti; Laleh R Kalankesh; Rohollah Kalhor; Vineet Kumar Kamal; Himal Kandel; Neeti Kapoor; Samad Karkhah; Bekalu Getnet Kassa; Nicholas J Kassebaum; Patrick D.M.C. Katoto; Mohammad Keykhaei; Himanshu Khajuria; Abbas Khan; Imteyaz A. Khan; Maseer Khan; Md Nuruzzaman Khan; Moien A.B. Khan; Moawiah Mohammad Khatatbeh; Mona M Khater; Hamid Reza Khayat Kashani; Jagdish Khubchandani; Hanna Kim; Min Seo Kim; Ruth W Kimokoti; Niranjan Kissoon; Sonali Kochhar; Farzad Kompani; Soewarta Kosen; Parvaiz A Koul; Sindhura Lakshmi Koulmane Laxminarayana; Fiorella Krapp Lopez; Kewal Krishan; Vijay Krishnamoorthy; Vishnutheertha Kulkarni; Naveen Kumar; Om P Kurmi; Ambily Kuttikkattu; Hmwe Hmwe Kyu; Dharmesh Kumar Lal; Judit Lám; Iván Landires; Savita Lasrado; Sang-Woong Lee; Jacopo Lenzi; Sonia Lewycka; Shanshan Li; Stephen S Lim; Wei Liu; Rakesh Lodha; Michael J Loftus; Ayush Lohiya; Lászl Lorenzovici; Mojgan Lotfi; Ata Mahmoodpoor; Mansour Adam Mahmoud; Razzagh Mahmoudi; Azeem Majeed; Jamal Majidpoor; Alaa Makki; Galana Ayana Mamo; Yosef Manla; Miquel Martorell; Clara N Matei; Barney Mcmanigal; Entezar Mehrabi Nasab; Ravi Mehrotra; Addisu Melese; Oliver Mendoza-Cano; Ritesh G Menezes; Alexios-Fotios A Mentis; Georgia Micha; Irmina Maria Michalek; Ana Carolina Micheletti Gomide Nogueira Des; Neda Milevska Kostova; Shabir Ahmad Mir; Mojgan Mirghafourvand; Seyyedmohammadsadeq Mirmoeeni; Erkin M Mirrakhimov; Mohammad Mirza-Aghazadeh-attari; Abay Sisay Misganaw; Awoke Misganaw; Sanjeev Misra; Esmaeil Mohammadi; Mokhtar Mohammadi; Abdollah Mohammadian-Hafshejani; Shafiu Mohammed; Syam Mohan; Mohammad Mohseni; Ali H Mokdad; Sara Momtazmanesh; Lorenzo Monasta; Catrin E Moore; Maryam Moradi; Mostafa Moradi Sarabi; Shane Douglas Morrison; Majid Motaghinejad; Haleh Mousavi Isfahani; Amin Mousavi Khaneghah; Seyed Ali Mousavi-Aghdas; Sumaira Mubarik; Francesk Mulita; Getaneh Baye B Mulu; Sandra B Munro; Saravanan Muthupandian; Tapas Sadasivan Nair; Atta Abbas Naqvi; Himanshi Narang; Zuhair S Natto; Muhammad Naveed; Biswa Prakash Nayak; Shumaila Naz; Ionut Negoi; Seyed Aria Nejadghaderi; Sandhya Neupane Kandel; Che Henry Ngwa; Robina Khan Niazi; Antonio Tolentino Nogueira Des; Nafise Noroozi; Hasti Nouraei; Ali Nowroozi; Virginia Nuñez-Samudio; Jerry John Nutor; Chimezie Igwegbe Nzoputam; Ogochukwu Janet Nzoputam; Bogdan Oancea; Rahman Md Obaidur; Vivek Anand Ojha; Akinkunmi Paul Okekunle; Osaretin Christabel Okonji; Andrew T Olagunju; Bolajoko Olubukunola Olusanya; Ahmed Omar Bali; Emad Omer; Nikita Otstavnov; Bilcha Oumer; Jagadish Rao Padubidri; Keyvan Pakshir; Tamás Palicz; Adrian Pana; Shahina Pardhan; Jose L Paredes; Utsav Parekh; Eun-Cheol Park; Seoyeon Park; Ashish Pathak; Rajan Paudel; Uttam Paudel; Shrikant Pawar; Hamidreza Pazoki Toroudi; Minjin Peng; Umberto Pensato; Veincent Christian Filipino Pepito; Marcos Pereira; Mario F P Peres; Norberto Perico; Ionela-Roxana Petcu; Zahra Zahid Piracha; Indrashis Podder; Nayanum Pokhrel; Ramesh Poluru; Maarten J Postma; Naeimeh Pourtaheri; Akila Prashant; Ibrahim Qattea; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Saber Raeghi; Sima Rafiei; Pankaja Raghav Raghav; Leila Rahbarnia; Vafa Rahimi-Movaghar; Mosiur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Vahid Rahmanian; Pradhum Ram; Muhammad Modassar Ali Nawaz Ranjha; Sowmya J Rao; Mohammad-Mahdi Rashidi; Azad Rasul; Zubair Ahmed Ratan; Salman Rawaf; Reza Rawassizadeh; Mohammad Sadegh Razeghinia; Elrashdy Moustafa Mohamed Redwan; Misganu Teshoma Regasa; Giuseppe Remuzzi; Melese Abate Reta; Nazila Rezaei; Aziz Rezapour; Abanoub Riad; Rezaul Karim Ripon; Kristina E Rudd; Basema Saddik; Saeid Sadeghian; Umar Saeed; Mohsen Safaei; Azam Safary; Sher Zaman Safi; Maryam Sahebazzamani; Amirhossein Sahebkar; Harihar Sahoo; Saina Salahi; Sarvenaz Salahi; Hedayat Salari; Sana Salehi; Hossein Samadi Kafil; Abdallah M Samy; Nima Sanadgol; Senthilkumar Sankararaman; Francesco Sanmarchi; Brijesh Sathian; Monika Sawhney; Ganesh Kumar Saya; Subramanian Senthilkumaran; Allen Seylani; Pritik A Shah; Masood Ali Shaikh; Elaheh Shaker; Murad Ziyaudinovich Shakhmardanov; Mequannent Melaku Sharew; Athena Sharifi-Razavi; Purva Sharma; Rahim Ali Sheikhi; Ali Sheikhy; Pavanchand H Shetty; Mika Shigematsu; Jae Il Shin; Hesamaddin Shirzad-Aski; K.M. Shivakumar; Parnian Shobeiri; Seyed Afshin Shorofi; Sunil Shrestha; Migbar Mekonnen Sibhat; Negussie Boti Sidemo; Mustafa Kamal Sikder; Luís Manuel Lopes Rodrigues Silva; Jasvinder A Singh; Paramdeep Singh; Surjit Singh; Md Shahjahan Siraj; Samarjeet Singh Siwal; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Bogdan Socea; Damtew Damtew Solomon; Yimeng Song; Chandrashekhar T Sreeramareddy; Muhammad Suleman; Rizwan Suliankatchi Abdulkader; Saima Sultana; Miklós Szócska; Seyed-Amir Tabatabaeizadeh; Mohammad Tabish; Majid Taheri; Elahe Taki; Ker-Kan Tan; Sarmila Tandukar; Nathan Y Tat; Vivian Y Tat; Belay Negash Tefera; Yibekal Manaye Tefera; Gebremaryam Temesgen; Mohamad-Hani Temsah; Samar Tharwat; Arulmani Thiyagarajan; Imad I Tleyjeh; Christopher E Troeger; Krishna Kishore Umapathi; Era Upadhyay; Sahel Valadan Tahbaz; Pascual R Valdez; Jef Van Den Eynde; H Rogier Van Doorn; Siavash Vaziri; Georgios-Ioannis Verras; Harimadhav Viswanathan; Bay Vo; Abdul Waris; Gizachew Tadesse Wassie; Nuwan Darshana Wickramasinghe; Sajad Yaghoubi; Gahin Abdulraheem Tayib Yahya Yahya; Seyed Hossein Yahyazadeh Jabbari; Arzu Yigit; Vahit Yigit; Dong Keon Yon; Naohiro Yonemoto; Mazyar Zahir; Burhan Abdullah Zaman; Sojib Bin Zaman; Moein Zangiabadian; Iman Zare; Mikhail Sergeevich Zastrozhin; Zhi-Jiang Zhang; Peng Zheng; Chenwen Zhong; Mohammad Zoladl; Alimuddin Zumla; Simon I Hay; Christiane Dolecek; Benn Sartorius; Christopher J L Murray; Mohsen Naghavi
Background: Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated the number of deaths associated with drug-resistant infections and sepsis and found that infections remain a leading cause of death globally. Understanding the global burden of common bacterial pathogens (both susceptible and resistant to antimicrobials) is essential to identify the greatest threats to public health. To our knowledge, this is the first study to present global comprehensive estimates of deaths associated with 33 bacterial pathogens across 11 major infectious syndromes. Methods: We estimated deaths associated with 33 bacterial genera or species across 11 infectious syndromes in 2019 using methods from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, in addition to a subset of the input data described in the Global Burden of Antimicrobial Resistance 2019 study. This study included 343 million individual records or isolates covering 11 361 study-location-years. We used three modelling steps to estimate the number of deaths associated with each pathogen: deaths in which infection had a role, the fraction of deaths due to infection that are attributable to a given infectious syndrome, and the fraction of deaths due to an infectious syndrome that are attributable to a given pathogen. Estimates were produced for all ages and for males and females across 204 countries and territories in 2019. 95% uncertainty intervals (UIs) were calculated for final estimates of deaths and infections associated with the 33 bacterial pathogens following standard GBD methods by taking the 2·5th and 97·5th percentiles across 1000 posterior draws for each quantity of interest. Findings: From an estimated 13·7 million (95% UI 10·9–17·1) infection-related deaths in 2019, there were 7·7 million deaths (5·7–10·2) associated with the 33 bacterial pathogens (both resistant and susceptible to antimicrobials) across the 11 infectious syndromes estimated in this study. We estimated deaths associated with the 33 bacterial pathogens to comprise 13·6% (10·2–18·1) of all global deaths and 56·2% (52·1–60·1) of all sepsis-related deaths in 2019. Five leading pathogens—Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa—were responsible for 54·9% (52·9–56·9) of deaths among the investigated bacteria. The deadliest infectious syndromes and pathogens varied by location and age. The age-standardised mortality rate associated with these bacterial pathogens was highest in the sub-Saharan Africa super-region, with 230 deaths (185–285) per 100 000 population, and lowest in the high-income super-region, with 52·2 deaths (37·4–71·5) per 100 000 population. S aureus was the leading bacterial cause of death in 135 countries and was also associated with the most deaths in individuals older than 15 years, globally. Among children younger than 5 years, S pneumoniae was the pathogen associated with the most deaths. In 2019, more than 6 million deaths occurred as a result of three bacterial infectious syndromes, with lower respiratory infections and bloodstream infections each causing more than 2 million deaths and peritoneal and intra-abdominal infections causing more than 1 million deaths. Interpretation: The 33 bacterial pathogens that we investigated in this study are a substantial source of health loss globally, with considerable variation in their distribution across infectious syndromes and locations. Compared with GBD Level 3 underlying causes of death, deaths associated with these bacteria would rank as the second leading cause of death globally in 2019; hence, they should be considered an urgent priority for intervention within the global health community. Strategies to address the burden of bacterial infections include infection prevention, optimised use of antibiotics, improved capacity for microbiological analysis, vaccine development, and improved and more pervasive use of available vaccines. These estimates can be used to help set priorities for vaccine need, demand, and development. Funding: Bill & Melinda Gates Foundation, Wellcome Trust, and Department of Health and Social Care, using UK aid funding managed by the Fleming Fund. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019
(John Wiley and Sons Inc, 2021) Emma Nichols; Foad Abd-Allah; Amir Abdoli; Akine Eshete Abosetugn; Woldu Aberhe Abrha; Ahmed Abualhasan; Eman Abu-Gharbieh; Rufus Olusola Akinyemi; Fares Alahdab; Fahad Mashhour Alanezi; Vahid Alipour; Iman Ansari; Jalal Arabloo; Amir Ashraf-Ganjouei; Abolfazl Avan; Getinet Ayano; Zaheer-Ud-Din Babar; Atif Amin Baig; Maciej Banach; Miguel A. Barboza; Suzanne Lyn Barker-Collo; Bernhard T. Baune; Akshaya Srikanth Bhagavathula; Krittika Bhattacharyya; Ali Bijani; Antonio Biondi; Tsegaye Adane Birhan; Atanu Biswas; Srinivasa Rao Bolla; Archith Boloor; Carol Brayne; Hermann Brenner; Katrin Burkart; Richard A. Burns; Sharath Burugina Nagaraja; Felix Carvalho; Luis F. S. Castro-De-araujo; Ferrán Catalá-López; Ester Cerin; Achille Cernigliaro; Nicolas Cherbuin; Jee-Young Jasmine Choi; Dinh-Toi Chu; Baye Dagnew; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Daniel Diaz; Zahra Sadat Dibaji Forooshani; Abdel Douiri; Bruce B. Duncan; David Edvardsson; Shaimaa I. El-Jaafary; Khalil Eskandari; Sharareh Eskandarieh; Valery L. Feigin; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Irina Filip; Florian Fischer; Shilpa Gaidhane; Kidane Zereabruk Gebregzabiher; Ahmad Ghashghaee; Asadollah Gholamian; Elena V. Gnedovskaya; Mahaveer Golechha; Rajeev Gupta; Vladimir Hachinski; Samer Hamidi; Graeme J. Hankey; Josep Maria Haro; Amr Hassan; Simon I. Hay; Golnaz Heidari; Reza Heidari-Soureshjani; Mowafa Househ; Rabia Hussain; Bing-Fang Hwang; Irena M. Ilic; Milena D. Ilic; Seyed Sina Naghibi Irvani; Hiroyasu Iso; Masao Iwagami; Ravi Prakash Jha; Rizwan Kalani; Himal Kandel; André Karch; Ayele Semachew Kasa; Andre Pascal Kengne; Young-Eun Kim; Yun Jin Kim; Sezer Kisa; Adnan Kisa; Mika Kivimäki; Hamidreza Komaki; Aikoyanagi; Walter A. Kukull; G. Anil Kumar; Manasi Kumar; Iván Landires; Matilde Leonardi; Stephen S. Lim; Xuefeng Liu; Giancarlo Logroscino; Alan D. Lopez; Stefan Lorkowski; Clement T. Loy; Hawraz Ibrahim M. Amin; Navid Manafi; Narayana Manjunatha; Man Mohan Mehndiratta; Ritesh G. Menezes; Atte Meretoja; Alexander Merkin; Workua Mekonnen Metekiya; Awoke Temesgen Misganaw; Bahram Mohajer; Norlinah Mohamed Ibrahim; Yousef Mohammad; Archisman Mohapatra; Farnam Mohebi; Ali H. Mokdad; Stefania Mondello; Tilahun Belete Mossie; Anwar Mulugeta; Gabriele Nagel; Muhammad Naveed; Vinod C. Nayak; Sandhya Neupane Kandel; Son Hoang Nguyen; Huong Lan Thi Nguyen; Virginia Nuñez-Samudio; Felix Akpojene Ogbo; Andrew T. Olagunju; Hans Orru; Sergej M. Ostojic; Samuel M. Ostroff; Nikita Otstavnov; Stanislav S. Otstavnov; Mayowa O. Owolabi; Mona Pathak; Hamidreza Pazoki Toroudi; Carrie B. Peterson; Hai Quang Pham; Michael R. Phillips; Michael A. Piradov; Faheem Hyder Pottoo; Sergio I. Prada; Dimas Ria Angga Pribadi; Amir Radfar; Alberto Raggi; Fakher Rahim; Pradhum Ram; Juwel Rana; Vahid Rashedi; Salman Rawaf; David Laith Rawaf; Nickolas Reinig; Nima Rezaei; Stephen R Robinson; Michele Romoli; Perminder S. Sachdev; Ramesh Sahathevan; Amirhossein Sahebkar; Mohammad Ali Sahraian; Davide Sattin; Mete Saylan; Mehdi Sayyah; Silvia Schiavolin; Maria Inês Schmidt; Izza Shahid; Masood Ali Shaikh; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Tariq Jamal Siddiqi; João Pedro Silva; Jasvinder A. Singh; Amin Soheili; Emma Elizabeth Spurlock; Cassandra E. I. Szoeke; Rafael Tabarés-Seisdedos; Biruk Wogayehu Taddele; Bhaskar Thakur; Akhil Soman Thekke Purakkal; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Ravensara S. Travillian; Manjari Tripathi; Gebiyaw Wudie Tsegaye; Muhammad Shariq Usman; Marco Vacante; Diana Zuleika Velazquez; Narayanaswamy Venketasubramanian; Simone Vidale; Vasily Vlassov; Yuan-Pang Wang; Jingkai Wei; Jordan Weiss; Abrha Hailay Weldemariam; Anders Wimo; Chenkai Wu; Ali Yadollahpour; Kazumasa Yamagishi; Yordanos Gizachew Yeshitila; Naohiro Yonemoto; Siddhesh Zadey; Zhi-Jiang Zhang; Christopher J. L. Murray; Theo Vos
Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally. © 2021 The Authors.
Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021
(Elsevier Ltd, 2023) Azalea M. Thomson; Theresa A. McHugh; Assaf P. Oron; Corey Teply; Nikhil Lonberg; Victor M. Vilchis Tella; Lauren B. Wilner; Kia Fuller; Hailey Hagins; Richard Gyan Aboagye; Melka Biratu Aboye; Eman Abu-Gharbieh; Ahmed Abu-Zaid; Isaac Yeboah Addo; Bright Opoku Ahinkorah; Aqeel Ahmad; Saif Aldeen S. AlRyalat; Hubert Amu; Aleksandr Y. Aravkin; Judie Arulappan; Maha Moh'd Wahbi Atout; Ashish D. Badiye; Sara Bagherieh; MacIej Banach; Morteza Banakar; Mainak Bardhan; Amadou Barrow; Deriba Abera Bedane; Isabela M. Bensenor; Akshaya Srikanth Bhagavathula; Pankaj Bhardwaj; Prarthna V. Bhardwaj; Ajay Nagesh Bhat; Zulfiqar A. Bhutta; Mariah Malak Bilalaga; Jessica Devin Bishai; Saeid Bitaraf; Archith Boloor; Muhammad Hammad Butt; Vijay Kumar Chattu; Dinh-Toi Chu; Omid Dadras; Xiaochen Dai; Bardia Danaei; Anh Kim Dang; Fitsum Wolde Demisse; Meghnath Dhimal; Daniel Diaz; Shirin Djalalinia; Deepa Dongarwar; Muhammed Elhadi; Mohamed A. Elmonem; Christopher Imokhuede Esezobor; Farshid Etaee; Oghenowede Eyawo; Adeniyi Francis Fagbamigbe; Ali Fatehizadeh; Lisa M. Force; William M. Gardner; Kazem Ghaffari; Paramjit Singh Gill; Mahaveer Golechha; Pouya Goleij; Vivek Kumar Gupta; Hamidreza Hasani; Treska S. Hassan; Mohammed Bheser Hassen; Segun Emmanuel Ibitoye; Adalia I. Ikiroma; Chidozie C.D. Iwu; Peter Bai James; Shubha Jayaram; Rime Jebai; Ravi Prakash Jha; Nitin Joseph; Farnaz Kalantar; Himal Kandel; Ibraheem M. Karaye; Woldeteklehaymanot Dagne Kassahun; Imteyaz A. Khan; Shaghayegh Khanmohammadi; Adnan Kisa; Farzad Kompani; Kewal Krishan; Iván Landires; Stephen S. Lim; Preetam Bhalchandra Mahajan; Soleiman Mahjoub; Azeem Majeed; Bishnu P. Marasini; Haftu Asmerom Meresa; Tomislav Mestrovic; Sonica Minhas; Awoke Misganaw; Ali H. Mokdad; Lorenzo Monasta; Ghulam Mustafa; Tapas Sadasivan Nair; Sreenivas Narasimha Swamy; Hasan Nassereldine; Zuhair S. Natto; Muhammad Naveed; Biswa Prakash Nayak; Jean Jacques Noubiap; Taylor Noyes; Chisom Adaobi Nri-Ezedi; Vincent Ebuka Nwatah; Chimezie Igwegbe Nzoputam; Ogochukwu Janet Nzoputam; Osaretin Christabel Okonji; Adeyinka Omoniyi Onikan; Mayowa O. Owolabi; Jay Patel; Siddhartha Pati; Shrikant Pawar; Ionela-Roxana Petcu; Frédéric B. Piel; Ibrahim Qattea; Mehran Rahimi; Mosiur Rahman; Salman Rawaf; Elrashdy Moustafa Mohamed Redwan; Nazila Rezaei; Basema Saddik; Umar Saeed; Fatemeh Saheb Sharif-Askari; Abdallah M. Samy; Austin E. Schumacher; Elaheh Shaker; Adithi Shetty; Migbar Mekonnen Sibhat; Jasvinder A. Singh; Muhammad Suleman; Dev Ram Sunuwar; Mindy D. Szeto; Jacques J.L. Lukenze Tamuzi; Nathan Y. Tat; Birhan Tsegaw Taye; Mohamad-Hani Temsah; Muhammad Umair; Sahel Valadan Tahbaz; Cong Wang; Nuwan Darshana Wickramasinghe; Arzu Yigit; Vahit Yigit; Ismaeel Yunusa; Burhan Abdullah Zaman; Moein Zangiabadian; Peng Zheng; Simon I. Hay; Mohsen Naghavi; Christopher J.L. Murray; Nicholas J. Kassebaum
Background: Previous global analyses, with known underdiagnosis and single cause per death attribution systems, provide only a small insight into the suspected high population health effect of sickle cell disease. Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, this study delivers a comprehensive global assessment of prevalence of sickle cell disease and mortality burden by age and sex for 204 countries and territories from 2000 to 2021. Methods: We estimated cause-specific sickle cell disease mortality using standardised GBD approaches, in which each death is assigned to a single underlying cause, to estimate mortality rates from the International Classification of Diseases (ICD)-coded vital registration, surveillance, and verbal autopsy data. In parallel, our goal was to estimate a more accurate account of sickle cell disease health burden using four types of epidemiological data on sickle cell disease: birth incidence, age-specific prevalence, with-condition mortality (total deaths), and excess mortality (excess deaths). Systematic reviews, supplemented with ICD-coded hospital discharge and insurance claims data, informed this modelling approach. We employed DisMod-MR 2.1 to triangulate between these measures—borrowing strength from predictive covariates and across age, time, and geography—and generated internally consistent estimates of incidence, prevalence, and mortality for three distinct genotypes of sickle cell disease: homozygous sickle cell disease and severe sickle cell β-thalassaemia, sickle-haemoglobin C disease, and mild sickle cell β-thalassaemia. Summing the three models yielded final estimates of incidence at birth, prevalence by age and sex, and total sickle cell disease mortality, the latter of which was compared directly against cause-specific mortality estimates to evaluate differences in mortality burden assessment and implications for the Sustainable Development Goals (SDGs). Findings: Between 2000 and 2021, national incidence rates of sickle cell disease were relatively stable, but total births of babies with sickle cell disease increased globally by 13·7% (95% uncertainty interval 11·1–16·5), to 515 000 (425 000–614 000), primarily due to population growth in the Caribbean and western and central sub-Saharan Africa. The number of people living with sickle cell disease globally increased by 41·4% (38·3–44·9), from 5·46 million (4·62–6·45) in 2000 to 7·74 million (6·51–9·2) in 2021. We estimated 34 400 (25 000–45 200) cause-specific all-age deaths globally in 2021, but total sickle cell disease mortality burden was nearly 11-times higher at 376 000 (303 000–467 000). In children younger than 5 years, there were 81 100 (58 800–108 000) deaths, ranking total sickle cell disease mortality as 12th (compared to 40th for cause-specific sickle cell disease mortality) across all causes estimated by the GBD in 2021. Interpretation: Our findings show a strikingly high contribution of sickle cell disease to all-cause mortality that is not apparent when each death is assigned to only a single cause. Sickle cell disease mortality burden is highest in children, especially in countries with the greatest under-5 mortality rates. Without comprehensive strategies to address morbidity and mortality associated with sickle cell disease, attainment of SDG 3.1, 3.2, and 3.4 is uncertain. Widespread data gaps and correspondingly high uncertainty in the estimates highlight the urgent need for routine and sustained surveillance efforts, further research to assess the contribution of conditions associated with sickle cell disease, and widespread deployment of evidence-based prevention and treatment for those with sickle cell disease. Funding: Bill & Melinda Gates Foundation. © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019
(Elsevier B.V., 2021) Katherine R. Paulson; Aruna M. Kamath; Tahiya Alam; Kelly Bienhoff; Gdiom Gebreheat Abady; Jaffar Abbas; Mohsen Abbasi-Kangevari; Hedayat Abbastabar; Foad Abd-Allah; Sherief M. Abd-Elsalam; Amir Abdoli; Aidin Abedi; Hassan Abolhassani; Lucas Guimarães Abreu; Eman Abu-Gharbieh; Niveen M. E. Abu-Rmeileh; Abdelrahman I. Abushouk; Aishatu L. Adamu; Oladimeji M. Adebayo; Adeyinka Emmanuel Adegbosin; Victor Adekanmbi; Olatunji O. Adetokunboh; Daniel Adedayo Adeyinka; Jose C. Adsuar; Khashayar Afshari; Mohammad Aghaali; Marcela Agudelo-Botero; Bright Opoku Ahinkorah; Tauseef Ahmad; Keivan Ahmadi; Muktar Beshir Ahmed; Budi Aji; Yonas Akalu; Oluwaseun Oladapo Akinyemi; Addis Aklilu; Ziyad Al-Aly; Khurshid Alam; Fahad Mashhour Alanezi; Turki M. Alanzi; Jacqueline Elizabeth Alcalde-Rabanal; Ayman Al-Eyadhy; Tilahun Ali; Gianfranco Alicandro; Sheikh Mohammad Alif; Vahid Alipour; Hesam Alizade; Syed Mohamed Aljunid; Amir Almasi-Hashiani; Nihad A. Almasri; Hesham M. Al-Mekhlafi; Jordi Alonso; Rajaa M. Al-Raddadi; Khalid A. Altirkawi; Arwa Khalid Alumran; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Edward Kwabena Ameyaw; Saeed Amini; Mostafa Amini-Rarani; Arianna Maever L. Amit; Dickson A. Amugsi; Robert Ancuceanu; Deanna Anderlini; Catalina Liliana Andrei; Fereshteh Ansari; Alireza Ansari-Moghaddam; Carl Abelardo T. Antonio; Ernoiz Antriyandarti; Davood Anvari; Razique Anwer; Muhammad Aqeel; Jalal Arabloo; Morteza Arab-Zozani; Timur Aripov; Johan Ärnlöv; Kurnia Dwi Artanti; Afsaneh Arzani; Malke Asaad; Mehran Asadi-Aliabadi; Ali A. Asadi-Pooya; Mohammad Asghari Jafarabadi; Seyyed Shamsadin Athari; Seyyede Masoume Athari; Desta Debalkie Atnafu; Alok Atreya; Madhu Sudhan Atteraya; Marcel Ausloos; Asma Tahir Awan; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Yared Asmare Aynalem; Samad Azari; Ghasem Azarian; Zelalem Nigussie Azene; B.B. Darshan; Ebrahim Babaee; Ashish D. Badiye; Atif Amin Baig; Maciej Banach; Palash Chandra Banik; Suzanne Lyn Barker-Collo; Hiba Jawdat Barqawi; Quique Bassat; Sanjay Basu; Bernhard T. Baune; Mohsen Bayati; Neeraj Bedi; Ettore Beghi; Massimiliano Beghi; Michelle L. Bell; Salaheddine Bendak; Derrick A. Bennett; Isabela M. Bensenor; Kidanemaryam Berhe; Adam E. Berman; Yihienew Mequanint Bezabih; Akshaya Srikanth Bhagavathula; Dinesh Bhandari; Nikha Bhardwaj; Pankaj Bhardwaj; Krittika Bhattacharyya; Suraj Bhattarai; Zulfiqar A. Bhutta; Boris Bikbov; Antonio Biondi; Binyam Minuye Birihane; Raaj Kishore Biswas; Somayeh Bohlouli; Nicola Luigi Bragazzi; Alexey V. Breusov; Andre R. Brunoni; Katrin Burkart; Sharath Burugina Nagaraja; Reinhard Busse; Zahid A. Butt; Florentino Luciano Caetano dos Santos; Lucero Cahuana-Hurtado; Paulo Camargos; Luis Alberto Cámera; Rosario Cárdenas; Giulia Carreras; Juan J. Carrero; Felix Carvalho; Joao Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Giulio Castelpietra; Ester Cerin; Jung-Chen Chang; Wagaye Fentahun Chanie; Jaykaran Charan; Souranshu Chatterjee; Soosanna Kumary Chattu; Vijay Kumar Chattu; Sarika Chaturvedi; Simiao Chen; Daniel Youngwhan Cho; Jee-Young Jasmine Choi; Dinh-Toi Chu; Liliana G. Ciobanu; Massimo Cirillo; Joao Conde; Vera Marisa Costa; Rosa A. S. Couto; Berihun Assefa Dachew; Saad M. A. Dahlawi; Hancheng Dai; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Parnaz Daneshpajouhnejad; Gary L. Darmstadt; Jai K. Das; Claudio Alberto Dávila-Cervantes; Adrian C. Davis; Kairat Davletov; Fernando Pio De la Hoz; Diego De Leo; Farah Deeba; Edgar Denova-Gutiérrez; Nikolaos Dervenis; Assefa Desalew; Keshab Deuba; Sagnik Dey; Samath Dhamminda Dharmaratne; Sameer Dhingra; Govinda Prasad Dhungana; Diana Dias da Silva; Daniel Diaz; Fariba Dorostkar; Leila Doshmangir; Eleonora Dubljanin; Andre Rodrigues Duraes; Arielle Wilder Eagan; Hisham Atan Edinur; Ferry Efendi; Sahar Eftekharzadeh; Iman El Sayed; Maha El Tantawi; Iffat Elbarazi; Islam Y. Elgendy; Shaimaa I. El-Jaafary; Amir Emami; Shymaa Enany; Oghenowede Eyawo; Sayeh Ezzikouri; Pawan Sirwan Faris; Farshad Farzadfar; Nazir Fattahi; Nelsensius Klau Fauk; Mehdi Fazlzadeh; Valery L. Feigin; Tomas Y. Ferede; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Irina Filip; Florian Fischer; James L. Fisher; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Masoud Foroutan; Richard Charles Franklin; Marisa Freitas; Sara D. Friedman; Takeshi Fukumoto; Mohamed M. Gad; Abhay Motiramji Gaidhane; Shilpa Gaidhane; Santosh Gaihre; Silvano Gallus; Alberto L. Garcia-Basteiro; M.A. Garcia-Gordillo; William M. Gardner; Mariana Gaspar Fonseca; Ketema Bizuwork Gebremedhin; Lemma Getacher; Ahmad Ghashghaee; Asadollah Gholamian; Syed Amir Gilani; Tiffany K. Gill; Giorgia Giussani; Elena V. Gnedovskaya; Myron Anthony Godinho; Amit Goel; Mahaveer Golechha; Philimon N. Gona; Sameer Vali Gopalani; Houman Goudarzi; Michal Grivna; Harish Chander Gugnani; Davide Guido; Rafael Alves Guimarães; Rajat Das Gupta; Rajeev Gupta; Nima Hafezi-Nejad; Mohammad Rifat Haider; Arvin Haj-Mirzaian; Samer Hamidi; Asif Hanif; Graeme J. Hankey; Arief Hargono; Ahmed I. Hasaballah; Md Mehedi Hasan; Syed Shahzad Hasan; Amr Hassan; Soheil Hassanipour; Hadi Hassankhani; Rasmus J. Havmoeller; Khezar Hayat; Reza Heidari-Soureshjani; Nathaniel J. Henry; Claudiu Herteliu; Michael K. Hole; Ramesh Holla; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mowafa Househ; Junjie Huang; Ayesha Humayun; Bing-Fang Hwang; Ivo Iavicoli; Segun Emmanuel Ibitoye; Kevin S. Ikuta; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Sumant Inamdar; Leeberk Raja Inbaraj; Khalid Iqbal; Usman Iqbal; M. Mofizul Islam; Sheikh Mohammed Shariful Islam; Hiroyasu Iso; Masao Iwagami; Chidozie C.D. Iwu; Jalil Jaafari; Kathryn H. Jacobsen; Jagnoor Jagnoor; Vardhmaan Jain; Manthan Dilipkumar Janodia; Tahereh Javaheri; Fatemeh Javanmardi; Shubha Jayaram; Achala Upendra Jayatilleke; Ensiyeh Jenabi; Ravi Prakash Jha; John S. Ji; Oommen John; Jost B. Jonas; Tamas Joo; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; Mikk Jürisson; Ali Kabir; Zubair Kabir; Leila R. Kalankesh; Naser Kamyari; Tanuj Kanchan; Neeti Kapoor; Behzad Karami Matin; André Karch; Salah Eddin Karimi; Getinet Kassahun; Gbenga A. Kayode; Ali Kazemi Karyani; Laura Kemmer; Nauman Khalid; Rovshan Khalilov; Mohammad Khammarnia; Ejaz Ahmad Khan; Gulfaraz Khan; Maseer Khan; Md Nuruzzaman Khan; Young-Ho Khang; Khaled Khatab; Amir M. Khater; Mona M. Khater; Maryam Khayamzadeh; Ardeshir Khosravi; Daniel Kim; Young-Eun Kim; Yun Jin Kim; Ruth W. Kimokoti; Adnan Kisa; Sezer Kisa; Niranjan Kissoon; Jacek A. Kopec; Soewarta Kosen; Parvaiz A. Koul; Sindhura Lakshmi Koulmane Laxminarayana; Ai Koyanagi; Kewal Krishan; Vijay Krishnamoorthy; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Vaman Kulkarni; G. Anil Kumar; Manasi Kumar; Nithin Kumar; Om P. Kurmi; Dian Kusuma; Carlo La Vecchia; Ben Lacey; Ratilal Lalloo; Faris Hasan Lami; Iván Landires; Anders O. Larsson; Savita Lasrado; Zohra S. Lassi; Paolo Lauriola; Paul H. Lee; Shaun Wen Huey Lee; Yo Han Lee; James Leigh; Matilde Leonardi; Sonia Lewycka; Bingyu Li; Shanshan Li; Juan Liang; Lee-Ling Lim; Miteku Andualem Limenih; Ro-Ting Lin; Xuefeng Liu; Rakesh Lodha; Alan D. Lopez; Rafael Lozano; Alessandra Lugo; Raimundas Lunevicius; Mark T. Mackay; Shilpashree Madhava Kunjathur; Francesca Giulia Magnani; D. R. Mahadeshwara Prasad; Mina Maheri; Morteza Mahmoudi; Azeem Majeed; Venkatesh Maled; Afshin Maleki; Shokofeh Maleki; Reza Malekzadeh; Ahmad Azam Malik; Deborah Carvalho Malta; Abdullah A. Mamun; Borhan Mansouri; Mohammad Ali Mansournia; Gabriel Martinez; Santi Martini; Francisco Rogerlândio Martins-Melo; Seyedeh Zahra Masoumi; Pallab K. Maulik; Colm Mcalinden; John J. Mcgrath; Carlo Eduardo Medina-Solís; Entezar Mehrabi Nasab; Fabiola Mejia-Rodriguez; Ziad A. Memish; Walter Mendoza; Ritesh G. Menezes; Endalkachew Worku Mengesha; George A. Mensah; Atte Meretoja; Tuomo J. Meretoja; Abera M. Mersha; Tomislav Mestrovic; Bartosz Miazgowski; Tomasz Miazgowski; Irmina Maria Michalek; Ted R. Miller; G.K. Mini; Mohammad Miri; Andreea Mirica; Erkin M. Mirrakhimov; Hamed Mirzaei; Maryam Mirzaei; Babak Moazen; Masoud Moghadaszadeh; Bahram Mohajer; Osama Mohamad; Yousef Mohammad; Seyyede Momeneh Mohammadi; Abdollah Mohammadian-Hafshejani; Shafiu Mohammed; Ali H. Mokdad; Mariam Molokhia; Lorenzo Monasta; Stefania Mondello; Mohammad Ali Moni; Catrin E. Moore; Ghobad Moradi; Masoud Moradi; Rahmatollah Moradzadeh; Paula Moraga; Lidia Morawska; Shane Douglas Morrison; Jonathan F. Mosser; Amin Mousavi Khaneghah; Ghulam Mustafa; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Shankar Prasad Nagaraju; Mohsen Naghavi; Behshad Naghshtabrizi; Mukhammad David Naimzada; Vinay Nangia; Sreenivas Narasimha Swamy; Bruno Ramos Nascimento; Muhammad Naveed; Javad Nazari; Rawlance Ndejjo; Ionut Negoi; Ruxandra Irina Negoi; Evangelia Nena; Samata Nepal; Henok Biresaw Netsere; Georges Nguefack-Tsague; Josephine W. Ngunjiri; Chi Thi Yen Nguyen; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Yeshambel T. Nigatu; Samuel Negash Nigussie; Molly R. Nixon; Chukwudi A. Nnaji; Shuhei Nomura; Nurulamin M. Noor; Jean Jacques Noubiap; Virginia Nuñez-Samudio; Vincent Ebuka Nwatah; Bogdan Oancea; Oluwakemi Ololade Odukoya; Felix Akpojene Ogbo; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Ahmed Omar Bali; Obinna E. Onwujekwe; Alberto Ortiz; Adrian Otoiu; Nikita Otstavnov; Stanislav S. Otstavnov; Mayowa O. Owolabi; P.A. Mahesh; Jagadish Rao Padubidri; Smita Pakhale; Keyvan Pakshir; Pramod Kumar Pal; Raffaele Palladino; Adrian Pana; Songhomitra Panda-Jonas; Anamika Pandey; Ashok Pandey; Seithikurippu R. Pandi-Perumal; Helena Ullyartha Pangaribuan; Ana Melisa Pardo-Montaño; Eun-Kee Park; Sangram Kishor Patel; George C. Patton; Shrikant Pawar; Hamidreza Pazoki Toroudi; Amy E. Peden; Veincent Christian Filipino Pepito; Emmanuel K. Peprah; Jeevan Pereira; Jorge Pérez-Gómez; Norberto Perico; Konrad Pesudovs; Thomas Pilgrim; Marina Pinheiro; Michael A. Piradov; Meghdad Pirsaheb; James A. Platts-Mills; Khem Narayan Pokhrel; Maarten J. Postma; Hadi Pourjafar; Sergio I. Prada; Sanjay Prakash; Elisabetta Pupillo; Zahiruddin Quazi Syed; Navid Rabiee; Amir Radfar; Ata Rafiee; Alireza Rafiei; Alberto Raggi; Shadi Rahimzadeh; Mohammad Hifz Ur Rahman; Amir Masoud Rahmani; Kiana Ramezanzadeh; Juwel Rana; Chhabi Lal Ranabhat; Sowmya J. Rao; Davide Rasella; Prateek Rastogi; Priya Rathi; David Laith Rawaf; Salman Rawaf; Wasiq Faraz Rawasia; Reza Rawassizadeh; Robert C. Reiner; Giuseppe Remuzzi; Andre M.N. Renzaho; Bhageerathy Reshmi; Serge Resnikoff; Negar Rezaei; Nima Rezaei; Aziz Rezapour; Seyed Mohammad Riahi; Daniela Ribeiro; Jennifer Rickard; Leonardo Roever; Luca Ronfani; Dietrich Rothenbacher; Enrico Rubagotti; Susan Fred Rumisha; Paul Macdaragh Ryan; Basema Saddik; Ehsan Sadeghi; Sahar Saeedi Moghaddam; Rajesh Sagar; Amirhossein Sahebkar; Mohammad Reza Salahshoor; Sana Salehi; Marwa Rashad Salem; Hamideh Salimzadeh; Joshua A. Salomon; Yoseph Leonardo Samodra; Abdallah M. Samy; Juan Sanabria; Milena M. Santric-Milicevic; Sivan Yegnanarayana Iyer Saraswathy; Abdur Razzaque Sarker; Nizal Sarrafzadegan; Arash Sarveazad; Brijesh Sathian; Thirunavukkarasu Sathish; Davide Sattin; Sonia Saxena; Ganesh Kumar Saya; Mete Saylan; Silvia Schiavolin; Markus P. Schlaich; David C. Schwebel; Falk Schwendicke; Subramanian Senthilkumaran; Sadaf G. Sepanlou; Edson Serván-Mori; Feng Sha; Omid Shafaat; Saeed Shahabi; Mohammad Shahbaz; Amira A. Shaheen; Izza Shahid; Masood Ali Shaikh; Saeed Shakiba; Ali S. Shalash; Mehran Shams-Beyranvand; Mohammed Shannawaz; Kiomars Sharafi; Aziz Sheikh; Sara Sheikhbahaei; Wondimeneh Shibabaw Shiferaw; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Ivy Shiue; Kerem Shuval; Tariq Jamal Siddiqi; Negussie Boti Sidemo; Inga Dora Sigfusdottir; Rannveig Sigurvinsdottir; João Pedro Silva; Jonathan I.S. Silverberg; Biagio Simonetti; Balbir Bagicha Singh; Jasvinder A. Singh; Deepika Singhal; Dhirendra Narain Sinha; Eirini Skiadaresi; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; David A. Sleet; Badr Hasan Sobaih; Mohammad Reza Sobhiyeh; Shahin Soltani; Joan B. Soriano; Emma Elizabeth Spurlock; Chandrashekhar T. Sreeramareddy; Paschalis Steiropoulos; Mark A. Stokes; Stefan Stortecky; Mu'awiyyah Babale Sufiyan; Rizwan Suliankatchi Abdulkader; Gerhard Sulo; Carolyn B. Swope; Bryan L. Sykes; Mindy D. Szeto; Miklós Szócska; Rafael Tabarés-Seisdedos; Eyayou Girma Tadesse; Amir Taherkhani; Animut Tagele Tamiru; Md Ismail Tareque; Arash Tehrani-Banihashemi; Mohamad-Hani Temsah; Fisaha Haile Tesfay; Gizachew Assefa Tessema; Zemenu Tadesse Tessema; Kavumpurathu Raman Thankappan; Rekha Thapar; Musliu Adetola Tolani; Marcos Roberto Tovani-Palone; Eugenio Traini; Bach Xuan Tran; Jaya Prasad Tripathy; Giorgos Tsapparellas; Aristidis Tsatsakis; Lorainne Tudor Car; Riaz Uddin; Anayat Ullah; Chukwuma David Umeokonkwo; Brigid Unim; Bhaskaran Unnikrishnan; Era Upadhyay; Muhammad Shariq Usman; Marco Vacante; Maryam Vaezi; Sahel Valadan Tahbaz; Pascual R. Valdez; Tommi Juhani Vasankari; Narayanaswamy Venketasubramanian; Madhur Verma; Francesco S. Violante; Vasily Vlassov; Bay Vo; Giang Thu Vu; Yohannes Dibaba Wado; Yasir Waheed; Richard G. Wamai; Yanping Wang; Yanzhong Wang; Yuan-Pang Wang; Paul Ward; Andrea Werdecker; Ronny Westerman; Nuwan Darshana Wickramasinghe; Lauren B. Wilner; Charles Shey Wiysonge; Ai-Min Wu; Chenkai Wu; Yang Xie; Seyed Hossein Yahyazadeh Jabbari; Kazumasa Yamagishi; Srikanth Yandrapalli; Sanni Yaya; Vahid Yazdi-Feyzabadi; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Mustafa Z. Younis; Zabihollah Yousefi; Taraneh Yousefinezhadi; Chuanhua Yu; Sifat Shahana Yusuf; Syed Saoud Zaidi; Sojib Bin Zaman; Mohammad Zamani; Maryam Zamanian; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Yunquan Zhang; Zhi-Jiang Zhang; Xiu-Ju George Zhao; Arash Ziapour; Simon I. Hay; Christopher J.L. Murray; Haidong Wang; Nicholas J. Kassebaum
Background: Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 findings for all-cause mortality and cause-specific mortality in children younger than 5 years of age, with multiple scenarios for child mortality in 2030 that include the consideration of potential effects of COVID-19, and a novel framework for quantifying optimal child survival. Methods: We completed all-cause mortality and cause-specific mortality analyses from 204 countries and territories for detailed age groups separately, with aggregated mortality probabilities per 1000 livebirths computed for neonatal mortality rate (NMR) and under-5 mortality rate (U5MR). Scenarios for 2030 represent different potential trajectories, notably including potential effects of the COVID-19 pandemic and the potential impact of improvements preferentially targeting neonatal survival. Optimal child survival metrics were developed by age, sex, and cause of death across all GBD location-years. The first metric is a global optimum and is based on the lowest observed mortality, and the second is a survival potential frontier that is based on stochastic frontier analysis of observed mortality and Healthcare Access and Quality Index. Findings: Global U5MR decreased from 71·2 deaths per 1000 livebirths (95% uncertainty interval [UI] 68·3–74·0) in 2000 to 37·1 (33·2–41·7) in 2019 while global NMR correspondingly declined more slowly from 28·0 deaths per 1000 live births (26·8–29·5) in 2000 to 17·9 (16·3–19·8) in 2019. In 2019, 136 (67%) of 204 countries had a U5MR at or below the SDG 3.2 threshold and 133 (65%) had an NMR at or below the SDG 3.2 threshold, and the reference scenario suggests that by 2030, 154 (75%) of all countries could meet the U5MR targets, and 139 (68%) could meet the NMR targets. Deaths of children younger than 5 years totalled 9·65 million (95% UI 9·05–10·30) in 2000 and 5·05 million (4·27–6·02) in 2019, with the neonatal fraction of these deaths increasing from 39% (3·76 million [95% UI 3·53–4·02]) in 2000 to 48% (2·42 million; 2·06–2·86) in 2019. NMR and U5MR were generally higher in males than in females, although there was no statistically significant difference at the global level. Neonatal disorders remained the leading cause of death in children younger than 5 years in 2019, followed by lower respiratory infections, diarrhoeal diseases, congenital birth defects, and malaria. The global optimum analysis suggests NMR could be reduced to as low as 0·80 (95% UI 0·71–0·86) deaths per 1000 livebirths and U5MR to 1·44 (95% UI 1·27–1·58) deaths per 1000 livebirths, and in 2019, there were as many as 1·87 million (95% UI 1·35–2·58; 37% [95% UI 32–43]) of 5·05 million more deaths of children younger than 5 years than the survival potential frontier. Interpretation: Global child mortality declined by almost half between 2000 and 2019, but progress remains slower in neonates and 65 (32%) of 204 countries, mostly in sub-Saharan Africa and south Asia, are not on track to meet either SDG 3.2 target by 2030. Focused improvements in perinatal and newborn care, continued and expanded delivery of essential interventions such as vaccination and infection prevention, an enhanced focus on equity, continued focus on poverty reduction and education, and investment in strengthening health systems across the development spectrum have the potential to substantially improve U5MR. Given the widespread effects of COVID-19, considerable effort will be required to maintain and accelerate progress. Funding: Bill & Melinda Gates Foundation. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the Global Burden of Diseases Study 2019
(Elsevier Ltd, 2021) Deepa Jahagirdar; Magdalene K. Walters; Amanda Novotney; Edmond D. Brewer; Tahvi D. Frank; Austin Carter; Molly H. Biehl; Hedayat Abbastabar; E.S. Abhilash; Eman Abu-Gharbieh; Laith Jamal Abu-Raddad; Victor Adekanmbi; Daniel Adedayo Adeyinka; Qorinah Estiningtyas Sakilah Adnani; Saira Afzal; Soodabeh Aghababaei; Bright Opoku Ahinkorah; Sajjad Ahmad; Keivan Ahmadi; Sepideh Ahmadi; Ehsan Ahmadpour; Muktar Beshir Ahmed; Tarik Ahmed Rashid; Yusra Ahmed Salih; Addis Aklilu; Tayyaba Akram; Chisom Joyqueenet Akunna; Hanadi Al Hamad; Fares Alahdab; Fahad Mashhour Alanezi; Ekaterina A. Aleksandrova; Kefyalew Addis Alene; Liaqat Ali; Vahid Alipour; Sami Almustanyir; Nelson Alvis-Guzman; Edward Kwabena Ameyaw; Hubert Amu; Catalina Liliana Andrei; Tudorel Andrei; Davood Anvari; Jalal Arabloo; Olatunde Aremu; Judie Arulappan; Desta Debalkie Atnafu; Beatriz Paulina Ayala Quintanilla; Muluken Altaye Ayza; Samad Azari; B.B. Darshan; Maciej Banach; Till Winfried Bärnighausen; Fabio Barra; Amadou Barrow; Sanjay Basu; Shahrzad Bazargan-Hejazi; Habtamu Gebrehana Belay; Tezera Moshago Berheto; Woldesellassie Mequanint Bezabhe; Yihienew Mequanint Bezabih; Akshaya Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Krittika Bhattacharyya; Sadia Bibi; Ali Bijani; Catherine Bisignano; Obasanjo Afolabi Bolarinwa; Archith Boloor; Azizbek A. Boltaev; Nikolay Ivanovich Briko; Danilo Buonsenso; Katrin Burkart; Zahid A. Butt; Chao Cao; Jaykaran Charan; Souranshu Chatterjee; Soosanna Kumary Chattu; Vijay Kumar Chattu; Sonali Gajanan Choudhari; Dinh-Toi Chu; Rosa A.S. Couto; Richard G. Cowden; Berihun Assefa Dachew; Omid Dadras; Amare Belachew Dagnew; Saad M.A. Dahlawi; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; José das Neves; Louisa Degenhardt; Feleke Mekonnen Demeke; Abebaw Alemayehu Desta; Keshab Deuba; Deepak Dhamnetiya; Govinda Prasad Dhungana; Mostafa Dianatinasab; Daniel Diaz; Shirin Djalalinia; Linh Phuong Doan; Fariba Dorostkar; Hisham Atan Edinur; Andem Effiong; Sahar Eftekharzadeh; Maysaa El Sayed Zaki; Rajesh Elayedath; Muhammed Elhadi; Shaimaa I. El-Jaafary; Ziad El-Khatib; Aisha Elsharkawy; Aklilu Endalamaw; Aman Yesuf Endries; Sharareh Eskandarieh; Ifeanyi Jude Ezeonwumelu; Sayeh Ezzikouri; Mohammad Farahmand; Emerito Jose A. Faraon; Abidemi Omolara Fasanmi; Simone Ferrero; Lorenzo Ferro Desideri; Irina Filip; Florian Fischer; Morenike Oluwatoyin Folayan; Masoud Foroutan; Takeshi Fukumoto; Mohamed M. Gad; Muktar A. Gadanya; Abhay Motiramji Gaidhane; Tushar Garg; Reta Tsegaye Gayesa; Eyob Alemayehu Gebreyohannes; Hailay Abrha Gesesew; Abera Getachew Obsa; Keyghobad Ghadiri; Ahmad Ghashghaee; Syed Amir Gilani; Themba G. Ginindza; Ionela-Roxana Glăvan; Ekaterina Vladimirovna Glushkova; Mahaveer Golechha; Harish Chander Gugnani; Bhawna Gupta; Sapna Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Samer Hamidi; Senad Handanagic; Shafiul Haque; Harapan Harapan; Arief Hargono; Ahmed I. Hasaballah; Abdiwahab Hashi; Shoaib Hassan; Soheil Hassanipour; Khezar Hayat; Ileana Heredia-Pi; Kamal Hezam; Ramesh Holla; Praveen Hoogar; Mohammad Enamul Hoque; Mostafa Hosseini; Mehdi Hosseinzadeh; Mohamed Hsairi; Rabia Hussain; Segun Emmanuel Ibitoye; Bulat Idrisov; Kevin S. Ikuta; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Seyed Sina Naghibi Irvani; M. Mofizul Islam; Nahlah Elkudssiah Ismail; Ramaiah Itumalla; Ihoghosa Osamuyi Iyamu; Roxana Jabbarinejad; Vardhmaan Jain; Ranil Jayawardena; Ravi Prakash Jha; Nitin Joseph; Ali Kabir; Zubair Kabir; Rohollah Kalhor; Feroze Kaliyadan; Ashwin Kamath; Tanuj Kanchan; Himal Kandel; Getinet Kassahun; Patrick D.M.C. Katoto; Gbenga A. Kayode; Ermiyas Mulu Kebede; Hafte Kahsay Kebede; Himanshu Khajuria; Nauman Khalid; Ejaz Ahmad Khan; Gulfaraz Khan; Khaled Khatab; Min Seo Kim; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Sonali Kochhar; Vladimir Andreevich Korshunov; Parvaiz A. Koul; Sindhura Lakshmi Koulmane Laxminarayana; Ai Koyanagi; Kewal Krishan; Barthelemy Kuate Defo; G. Anil Kumar; Manasi Kumar; Nithin Kumar; Alexander Kwarteng; Dharmesh Kumar Lal; Iván Landires; Savita Lasrado; Zohra S. Lassi; Jeffrey V. Lazarus; Jane Jean-Hee Lee; Yeong Yeh Lee; Kate E. LeGrand; Christine Lin; Xuefeng Liu; Emilie R. Maddison; Hassan Magdy Abd El Razek; Phetole Walter Mahasha; Azeem Majeed; Alaa Makki; Ahmad Azam Malik; Wondimu Ayele Manamo; Mohammad Ali Mansournia; Francisco Rogerlândio Martins-Melo; Seyedeh Zahra Masoumi; Ziad A. Memish; Ritesh G. Menezes; Endalkachew Worku Mengesha; Hayimro Edemealem Merie; Amanual Getnet Mersha; Tomislav Mestrovic; Peter Meylakhs; Nour Mheidly; Ted R. Miller; Andreea Mirica; Babak Moazen; Yousef Mohammad; Mokhtar Mohammadi; Arif Mohammed; Salahuddin Mohammed; Shafiu Mohammed; Modhurima Moitra; Ali H. Mokdad; Mariam Molokhia; Mohammad Ali Moni; Ghobad Moradi; Yousef Moradi; Christine Mpundu-Kaambwa; Sumaira Mubarik; Sandra B. Munro; Lillian Mwanri; Jean B. Nachega; Ahamarshan Jayaraman Nagarajan; Aparna Ichalangod Narayana; Muhammad Naveed; Biswa Prakash Nayak; Sabina O. Nduaguba; Sandhya Neupane Kandel; Georges Nguefack-Tsague; Trang Huyen Nguyen; Molly R. Nixon; Chukwudi A. Nnaji; Jean Jacques Noubiap; Virginia Nuñez-Samudio; Thomas Elliot Nyirenda; Onome Bright Oghenetega; Andrew T. Olagunju; Babayemi Oluwaseun Olakunde; Oluwatomi Funbi Owopetu; P.A. Mahesh; Jagadish Rao Padubidri; Smita Pakhale; Tarang Parekh; Fatemeh Pashazadeh Kan; Shrikant Pawar; Veincent Christian Filipino Pepito; Emmanuel K. Peprah; Marina Pinheiro; Khem Narayan Pokhrel; Roman V. Polibin; Richard Charles G. Pollok; Maarten J. Postma; Zahiruddin Quazi Syed; Amir Radfar; Raghu Anekal Radhakrishnan; Fakher Rahim; Vafa Rahimi-Movaghar; Shadi Rahimzadeh; Mosiur Rahman; Amir Masoud Rahmani; Pradhum Ram; Chhabi Lal Ranabhat; Priyanga Ranasinghe; Chythra R. Rao; Sowmya J. Rao; Priya Rathi; David Laith Rawaf; Salman Rawaf; Lemma Demissie Regassa; Inayat ur Rehman; Andre M.N. Renzaho; Nima Rezaei; Omid Rezahosseini; Mohammad Sadegh Rezai; Aziz Rezapour; Rezaul Karim Ripon; Voilet Rodrigues; Denis O. Roshchin; Godfrey M. Rwegerera; Umar Saeed; Sahar Saeedi Moghaddam; Rajesh Sagar; K.M. Saif-Ur-Rahman; Marwa Rashad Salem; Mehrnoosh Samaei; Abdallah M. Samy; Milena M. Santric-Milicevic; Satish Saroshe; Brijesh Sathian; Maheswar Satpathy; Monika Sawhney; Aletta Elisabeth Schutte; Allen Seylani; Masood Ali Shaikh; Mohammed Feyisso Shaka; Hina Shamshad; Morteza Shamsizadeh; Mohammed Shannawaz; Adithi Shetty; Jae Il Shin; K.M. Shivakumar; Jasvinder A. Singh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Ranjani Somayaji; Sergey Soshnikov; Emma Elizabeth Spurlock; Dan J. Stein; Mu'awiyyah Babale Sufiyan; Hooman Tadbiri; Birkneh Tilahun Tadesse; Eyayou Girma Tadesse; Animut Tagele Tamiru; Elvis Enowbeyang Tarkang; Nuno Taveira; Yohannes Tekalegn; Fisaha Haile Tesfay; Gizachew Assefa Tessema; Rekha Thapar; Marcos Roberto Tovani-Palone; Eugenio Traini; Bach Xuan Tran; Alexander C. Tsai; Biruk Shalmeno Tusa; Saif Ullah; Chukwuma David Umeokonkwo; Bhaskaran Unnikrishnan; Sahel Valadan Tahbaz; Jorge Hugo Villafañe; Sergey Konstantinovitch Vladimirov; Bay Vo; Avina Vongpradith; Giang Thu Vu; Yasir Waheed; Richard G. Wamai; Guan Wang; Yanzhong Wang; Paul Ward; Ronny Westerman; Andrea Sylvia Winkler; Lalit Yadav; Seyed Hossein Yahyazadeh Jabbari; Taklo Simeneh Yazie; Siyan Yi; Vahit Yiğit; Birhanu Wubale Yirdaw; Naohiro Yonemoto; Chuanhua Yu; Ismaeel Yunusa; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Zhi-Jiang Zhang; Alimuddin Zumla; Joshua A. Salomon; Jeffrey W. Eaton; Mohsen Naghavi; Laura Dwyer-Lindgren; Haidong Wang; Stephen S. Lim; Simon I. Hay; Christopher J.L. Murray; Hmwe H. Kyu
Background: The sustainable development goals (SDGs) aim to end HIV/AIDS as a public health threat by 2030. Understanding the current state of the HIV epidemic and its change over time is essential to this effort. This study assesses the current sex-specific HIV burden in 204 countries and territories and measures progress in the control of the epidemic. Methods: To estimate age-specific and sex-specific trends in 48 of 204 countries, we extended the Estimation and Projection Package Age-Sex Model to also implement the spectrum paediatric model. We used this model in cases where age and sex specific HIV-seroprevalence surveys and antenatal care-clinic sentinel surveillance data were available. For the remaining 156 of 204 locations, we developed a cohort-incidence bias adjustment to derive incidence as a function of cause-of-death data from vital registration systems. The incidence was input to a custom Spectrum model. To assess progress, we measured the percentage change in incident cases and deaths between 2010 and 2019 (threshold >75% decline), the ratio of incident cases to number of people living with HIV (incidence-to-prevalence ratio threshold <0·03), and the ratio of incident cases to deaths (incidence-to-mortality ratio threshold <1·0). Findings: In 2019, there were 36·8 million (95% uncertainty interval [UI] 35·1–38·9) people living with HIV worldwide. There were 0·84 males (95% UI 0·78–0·91) per female living with HIV in 2019, 0·99 male infections (0·91–1·10) for every female infection, and 1·02 male deaths (0·95–1·10) per female death. Global progress in incident cases and deaths between 2010 and 2019 was driven by sub-Saharan Africa (with a 28·52% decrease in incident cases, 95% UI 19·58–35·43, and a 39·66% decrease in deaths, 36·49–42·36). Elsewhere, the incidence remained stable or increased, whereas deaths generally decreased. In 2019, the global incidence-to-prevalence ratio was 0·05 (95% UI 0·05–0·06) and the global incidence-to-mortality ratio was 1·94 (1·76–2·12). No regions met suggested thresholds for progress. Interpretation: Sub-Saharan Africa had both the highest HIV burden and the greatest progress between 1990 and 2019. The number of incident cases and deaths in males and females approached parity in 2019, although there remained more females with HIV than males with HIV. Globally, the HIV epidemic is far from the UNAIDS benchmarks on progress metrics. Funding: The Bill & Melinda Gates Foundation, the National Institute of Mental Health of the US National Institutes of Health (NIH), and the National Institute on Aging of the NIH. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018
(BioMed Central Ltd, 2022) Emily Haeuser; Audrey L. Serfes; Michael A. Cork; Mingyou Yang; Hedayat Abbastabar; E.S. Abhilash; Maryam Adabi; Oladimeji M. Adebayo; Victor Adekanmbi; Daniel Adedayo Adeyinka; Saira Afzal; Bright Opoku Ahinkorah; Keivan Ahmadi; Muktar Beshir Ahmed; Yonas Akalu; Rufus Olusola Akinyemi; Chisom Joyqueenet Akunna; Fares Alahdab; Fahad Mashhour Alanezi; Turki M. Alanzi; Kefyalew Addis Alene; Robert Kaba Alhassan; Vahid Alipour; Amir Almasi-Hashiani; Nelson Alvis-Guzman; Edward Kwabena Ameyaw; Saeed Amini; Dickson A. Amugsi; Robert Ancuceanu; Davood Anvari; Seth Christopher Yaw Appiah; Jalal Arabloo; Olatunde Aremu; Mulusew A. Asemahagn; Mohammad Asghari Jafarabadi; Atalel Fentahun Awedew; Beatriz Paulina Ayala Quintanilla; Martin Amogre Ayanore; Yared Asmare Aynalem; Samad Azari; Zelalem Nigussie Azene; B.B. Darshan; Tesleem Kayode Babalola; Atif Amin Baig; Maciej Banach; Till Winfried Bärnighausen; Arielle Wilder Bell; Akshaya Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Krittika Bhattacharyya; Ali Bijani; Zebenay Workneh Bitew; Somayeh Bohlouli; Obasanjo Afolabi Bolarinwa; Archith Boloor; Ivana Bozicevic; Zahid A. Butt; Rosario Cárdenas; Felix Carvalho; Jaykaran Charan; Vijay Kumar Chattu; Mohiuddin Ahsanul Kabir Chowdhury; Dinh-Toi Chu; Richard G. Cowden; Saad M. A. Dahlawi; Giovanni Damiani; Eugene Kofuor Maafo Darteh; Aso Mohammad Darwesh; José das Neves; Nicole Davis Weaver; Diego De Leo; Jan-Walter De Neve; Kebede Deribe; Keshab Deuba; Samath Dharmaratne; Mostafa Dianatinasab; Daniel Diaz; Alireza Didarloo; Shirin Djalalinia; Fariba Dorostkar; Eleonora Dubljanin; Bereket Duko; Maha El Tantawi; Shaimaa I. El-Jaafary; Babak Eshrati; Sharareh Eskandarieh; Oghenowede Eyawo; Ifeanyi Jude Ezeonwumelu; Sayeh Ezzikouri; Farshad Farzadfar; Nazir Fattahi; Nelsensius Klau Fauk; Eduarda Fernandes; Irina Filip; Florian Fischer; Nataliya A. Foigt; Masoud Foroutan; Takeshi Fukumoto; Mohamed M. Gad; Abhay Motiramji Gaidhane; Birhan Gebresillassie Gebregiorgis; Ketema Bizuwork Gebremedhin; Lemma Getacher; Keyghobad Ghadiri; Ahmad Ghashghaee; Mahaveer Golechha; Mohammed Ibrahim Mohialdeen Gubari; Harish Chander Gugnani; Rafael Alves Guimarães; Mohammad Rifat Haider; Arvin Haj-Mirzaian; Samer Hamidi; Abdiwahab Hashi; Soheil Hassanipour; Hadi Hassankhani; Khezar Hayat; Claudiu Herteliu; Hung Chak Ho; Ramesh Holla; Mostafa Hosseini; Mehdi Hosseinzadeh; Bing-Fang Hwang; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Rakibul M. Islam; Chidozie C. D. Iwu; Mihajlo Jakovljevic; Ravi Prakash Jha; John S. Ji; Kimberly B. Johnson; Nitin Joseph; Vasna Joshua; Farahnaz Joukar; Jacek Jerzy Jozwiak; Leila R. Kalankesh; Rohollah Kalhor; Naser Kamyari; Tanuj Kanchan; Behzad Karami Matin; Salah Eddin Karimi; Gbenga A. Kayode; Ali Kazemi Karyani; Maryam Keramati; Ejaz Ahmad Khan; Gulfaraz Khan; Md Nuruzzaman Khan; Khaled Khatab; Jagdish Khubchandani; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Jacek A. Kopec; Soewarta Kosen; Sindhura Lakshmi Koulmane Laxminarayana; Ai Koyanagi; Kewal Krishan; Barthelemy Kuate Defo; Nuworza Kugbey; Vaman Kulkarni; Manasi Kumar; Nithin Kumar; Dian Kusuma; Carlo La Vecchia; Dharmesh Kumar Lal; Iván Landires; Heidi Jane Larson; Savita Lasrado; Paul H. Lee; Shanshan Li; Xuefeng Liu; Afshin Maleki; Preeti Malik; Mohammad Ali Mansournia; Francisco Rogerlândio Martins-Melo; Walter Mendoza; Ritesh G. Menezes; Endalkachew Worku Mengesha; Tuomo J. Meretoja; Tomislav Mestrovic; Andreea Mirica; Babak Moazen; Osama Mohamad; Yousef Mohammad; Abdollah Mohammadian-Hafshejani; Reza Mohammadpourhodki; Salahuddin Mohammed; Shafiu Mohammed; Ali H. Mokdad; Masoud Moradi; Paula Moraga; Sumaira Mubarik; Getaneh Baye B. Mulu; Lillian Mwanri; Ahamarshan Jayaraman Nagarajan; Mukhammad David Naimzada; Muhammad Naveed; Javad Nazari; Rawlance Ndejjo; Ionut Negoi; Frida N. Ngalesoni; Georges Nguefack-Tsague; Josephine W. Ngunjiri; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Chukwudi A. Nnaji; Jean Jacques Noubiap; Virginia Nuñez-Samudio; Vincent Ebuka Nwatah; Bogdan Oancea; Oluwakemi Ololade Odukoya; Andrew T. Olagunju; Babayemi Oluwaseun Olakunde; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Ahmed Omar Bali; Obinna E. Onwujekwe; Orish Ebere Orisakwe; Nikita Otstavnov; Stanislav S. Otstavnov; Mayowa O. Owolabi; P.A. Mahesh; Jagadish Rao Padubidri; Adrian Pana; Ashok Pandey; Seithikurippu R. Pandi-Perumal; Fatemeh Pashazadeh Kan; George C. Patton; Shrikant Pawar; Emmanuel K. Peprah; Maarten J. Postma; Liliana Preotescu; Zahiruddin Quazi Syed; Navid Rabiee; Amir Radfar; Alireza Rafiei; Fakher Rahim; Vafa Rahimi-Movaghar; Amir Masoud Rahmani; Kiana Ramezanzadeh; Juwel Rana; Chhabi Lal Ranabhat; Sowmya J. Rao; David Laith Rawaf; Salman Rawaf; Reza Rawassizadeh; Lemma Demissie Regassa; Nima Rezaei; Aziz Rezapour; Mavra A. Riaz; Ana Isabel Ribeiro; Jennifer M. Ross; Enrico Rubagotti; Susan Fred Rumisha; Godfrey M. Rwegerera; Sahar Saeedi Moghaddam; Rajesh Sagar; Biniyam Sahiledengle; Maitreyi Sahu; Marwa Rashad Salem; Hossein Samadi Kafil; Abdallah M. Samy; Benn Sartorius; Brijesh Sathian; Abdul-Aziz Seidu; Amira A. Shaheen; Masood Ali Shaikh; Morteza Shamsizadeh; Wondimeneh Shibabaw Shiferaw; Jae Il Shin; Roman Shrestha; Jasvinder A. Singh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Shahin Soltani; Mu’awiyyah Babale Sufiyan; Takahiro Tabuchi; Eyayou Girma Tadesse; Nuno Taveira; Fisaha Haile Tesfay; Rekha Thapar; Marcos Roberto Tovani-Palone; Gebiyaw Wudie Tsegaye; Chukwuma David Umeokonkwo; Bhaskaran Unnikrishnan; Jorge Hugo Villafañe; Francesco S. Violante; Bay Vo; Giang Thu Vu; Yohannes Dibaba Wado; Yasir Waheed; Richard G. Wamai; Yanzhong Wang; Paul Ward; Nuwan Darshana Wickramasinghe; Katherine Wilson; Sanni Yaya; Paul Yip; Naohiro Yonemoto; Chuanhua Yu; Mikhail Sergeevich Zastrozhin; Yunquan Zhang; Zhi-Jiang Zhang; Simon I. Hay; Laura Dwyer-Lindgren
Background: Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to meet targets set for ending the epidemic by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the United Nations Sustainable Development Goals (SDGs). Precise HIV burden information is critical for effective geographic and epidemiological targeting of prevention and treatment interventions. Age- and sex-specific HIV prevalence estimates are widely available at the national level, and region-wide local estimates were recently published for adults overall. We add further dimensionality to previous analyses by estimating HIV prevalence at local scales, stratified into sex-specific 5-year age groups for adults ages 15–59 years across SSA. Methods: We analyzed data from 91 seroprevalence surveys and sentinel surveillance among antenatal care clinic (ANC) attendees using model-based geostatistical methods to produce estimates of HIV prevalence across 43 countries in SSA, from years 2000 to 2018, at a 5 × 5-km resolution and presented among second administrative level (typically districts or counties) units. Results: We found substantial variation in HIV prevalence across localities, ages, and sexes that have been masked in earlier analyses. Within-country variation in prevalence in 2018 was a median 3.5 times greater across ages and sexes, compared to for all adults combined. We note large within-district prevalence differences between age groups: for men, 50% of districts displayed at least a 14-fold difference between age groups with the highest and lowest prevalence, and at least a 9-fold difference for women. Prevalence trends also varied over time; between 2000 and 2018, 70% of all districts saw a reduction in prevalence greater than five percentage points in at least one sex and age group. Meanwhile, over 30% of all districts saw at least a five percentage point prevalence increase in one or more sex and age group. Conclusions: As the HIV epidemic persists and evolves in SSA, geographic and demographic shifts in prevention and treatment efforts are necessary. These estimates offer epidemiologically informative detail to better guide more targeted interventions, vital for combating HIV in SSA. © 2022, The Author(s).
Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1
(Elsevier B.V., 2021) Natalie C Galles; Patrick Y Liu; Rachel L Updike; Nancy Fullman; Jason Nguyen; Sam Rolfe; Alyssa N Sbarra; Megan F Schipp; Ashley Marks; Gdiom Gebreheat Abady; Kaja M Abbas; Sumra Wajid Abbasi; Hedayat Abbastabar; Foad Abd-Allah; Amir Abdoli; Hassan Abolhassani; Akine Eshete Abosetugn; Maryam Adabi; Abdu A Adamu; Olatunji O Adetokunboh; Qorinah Estiningtyas Sakilah Adnani; Shailesh M Advani; Saira Afzal; Seyed Mohammad Kazem Aghamir; Bright Opoku Ahinkorah; Sohail Ahmad; Tauseef Ahmad; Sepideh Ahmadi; Haroon Ahmed; Muktar Beshir Ahmed; Tarik Ahmed Rashid; Yusra Ahmed Salih; Yonas Akalu; Addis Aklilu; Chisom Joyqueenet Akunna; Hanadi Al Hamad; Fares Alahdab; Luciana Albano; Yosef Alemayehu; Kefyalew Addis Alene; Ayman Al-Eyadhy; Robert Kaba Alhassan; Liaqat Ali; Syed Mohamed Aljunid; Sami Almustanyir; Khalid A Altirkawi; Nelson Alvis-Guzman; Hubert Amu; Catalina Liliana Andrei; Tudorel Andrei; Adnan Ansar; Alireza Ansari-Moghaddam; Ippazio Cosimo Antonazzo; Benny Antony; Jalal Arabloo; Morteza Arab-Zozani; Kurnia Dwi Artanti; Judie Arulappan; Asma Tahir Awan; Mamaru Ayenew Awoke; Muluken Altaye Ayza; Ghasem Azarian; Ahmed Y Azzam; Darshan B B; Zaheer-Ud-Din Babar; Senthilkumar Balakrishnan; Maciej Banach; Simachew Animen Bante; Till Winfried Bärnighausen; Hiba Jawdat Barqawi; Amadou Barrow; Quique Bassat; Narantuya Bayarmagnai; Diana Fernanda Bejarano Ramirez; Tariku Tesfaye Bekuma; Habtamu Gebrehana Belay; Uzma Iqbal Belgaumi; Akshaya Srikanth Bhagavathula; Dinesh Bhandari; Nikha Bhardwaj; Pankaj Bhardwaj; Sonu Bhaskar; Krittika Bhattacharyya; Sadia Bibi; Ali Bijani; Antonio Biondi; Archith Boloor; Dejana Braithwaite; Danilo Buonsenso; Zahid A Butt; Paulo Camargos; Giulia Carreras; Felix Carvalho; Carlos A Castañeda-Orjuela; Raja Chandra Chakinala; Jaykaran Charan; Souranshu Chatterjee; Soosanna Kumary Chattu; Vijay Kumar Chattu; Fazle Rabbi Chowdhury; Devasahayam J Christopher; Dinh-Toi Chu; Sheng-Chia Chung; Paolo Angelo Cortesi; Vera Marisa Costa; Rosa A S Couto; Omid Dadras; Amare Belachew Dagnew; Baye Dagnew; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Jan-Walter De Neve; Meseret Derbew Molla; Behailu Tariku Derseh; Rupak Desai; Abebaw Alemayehu Desta; Deepak Dhamnetiya; Mandira Lamichhane Dhimal; Meghnath Dhimal; Mostafa Dianatinasab; Daniel Diaz; Shirin Djalalinia; Fariba Dorostkar; Bassey Edem; Hisham Atan Edinur; Sahar Eftekharzadeh; Iman El Sayed; Maysaa El Sayed Zaki; Muhammed Elhadi; Shaimaa I El-Jaafary; Aisha Elsharkawy; Shymaa Enany; Ryenchindorj Erkhembayar; Christopher Imokhuede Esezobor; Sharareh Eskandarieh; Ifeanyi Jude Ezeonwumelu; Sayeh Ezzikouri; Jawad Fares; Pawan Sirwan Faris; Berhanu Elfu Feleke; Tomas Y Ferede; Eduarda Fernandes; João C Fernandes; Pietro Ferrara; Irina Filip; Florian Fischer; Mark Rohit Francis; Takeshi Fukumoto; Mohamed M Gad; Shilpa Gaidhane; Silvano Gallus; Tushar Garg; Biniyam Sahiledengle Geberemariyam; Teshome Gebre; Birhan Gebresillassie Gebregiorgis; Ketema Bizuwork Gebremedhin; Berhe Gebremichael; Bradford D Gessner; Keyghobad Ghadiri; Mansour Ghafourifard; Ahmad Ghashghaee; Syed Amir Gilani; Ionela-Roxana Glăvan; Ekaterina Vladimirovna Glushkova; Mahaveer Golechha; Kebebe Bekele Gonfa; Sameer Vali Gopalani; Houman Goudarzi; Mohammed Ibrahim Mohialdeen Gubari; Yuming Guo; Veer Bala Gupta; Vivek Kumar Gupta; Reyna Alma Gutiérrez; Emily Haeuser; Rabih Halwani; Samer Hamidi; Asif Hanif; Shafiul Haque; Harapan Harapan; Arief Hargono; Abdiwahab Hashi; Shoaib Hassan; Mohamed H Hassanein; Soheil Hassanipour; Hadi Hassankhani; Simon I Hay; Khezar Hayat; Mohamed I Hegazy; Golnaz Heidari; Kamal Hezam; Ramesh Holla; Mohammad Enamul Hoque; Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Mowafa Househ; Vivian Chia-rong Hsieh; Junjie Huang; Ayesha Humayun; Rabia Hussain; Nawfal R Hussein; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena M Ilic; Milena D Ilic; Sumant Inamdar; Usman Iqbal; Lalu Muhammad Irham; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Nahlah Elkudssiah Ismail; Ramaiah Itumalla; Ravi Prakash Jha; Farahnaz Joukar; Ali Kabir; Zubair Kabir; Rohollah Kalhor; Zul Kamal; Stanley M Kamande; Himal Kandel; André Karch; Getinet Kassahun; Nicholas J Kassebaum; Patrick DMC Katoto; Bayew Kelkay; Andre Pascal Kengne; Yousef Saleh Khader; Himanshu Khajuria; Ibrahim A Khalil; Ejaz Ahmad Khan; Gulfaraz Khan; Junaid Khan; Maseer Adnan Khan; Moien AB Khan; Young-Ho Khang; Abdullah T Khoja; Jagdish Khubchandani; Gyu Ri Kim; Min Seo Kim; Yun Jin Kim; Ruth W Kimokoti; Adnan Kisa; Sezer Kisa; Vladimir Andreevich Korshunov; Soewarta Kosen; Barthelemy Kuate Defo; Vaman Kulkarni; Avinash Kumar; G Anil Kumar; Nithin Kumar; Alexander Kwarteng; Carlo La Vecchia; Faris Hasan Lami; Iván Landires; Savita Lasrado; Zohra S Lassi; Hankil Lee; Yeong Yeh Lee; Miriam Levi; Sonia Lewycka; Shanshan Li; Xuefeng Liu; Stany W Lobo; Platon D Lopukhov; Rafael Lozano; Ricardo Lutzky Saute; Muhammed Magdy Abd El Razek; Alaa Makki; Ahmad Azam Malik; Fariborz Mansour-Ghanaei; Mohammad Ali Mansournia; Lorenzo Giovanni Mantovani; Francisco Rogerlândio Martins-Melo; Philippa C Matthews; John Robert Carabeo Medina; Walter Mendoza; Ritesh G Menezes; Endalkachew Worku Mengesha; Tuomo J Meretoja; Amanual Getnet Mersha; Mohamed Kamal Mesregah; Tomislav Mestrovic; Bartosz Miazgowski; George J Milne; Andreea Mirica; Erkin M Mirrakhimov; Hamid Reza Mirzaei; Sanjeev Misra; Prasanna Mithra; Masoud Moghadaszadeh; Teroj Abdulrahman Mohamed; Karzan Abdulmuhsin Mohammad; Yousef Mohammad; Mokhtar Mohammadi; Abdollah Mohammadian-Hafshejani; Arif Mohammed; Shafiu Mohammed; Archisman Mohapatra; Ali H Mokdad; Mariam Molokhia; Lorenzo Monasta; Mohammad Ali Moni; Ahmed Al Montasir; Catrin E Moore; Ghobad Moradi; Rahmatollah Moradzadeh; Paula Moraga; Ulrich Otto Mueller; Sandra B Munro; Mohsen Naghavi; Mukhammad David Naimzada; Muhammad Naveed; Biswa Prakash Nayak; Ionut Negoi; Sandhya Neupane Kandel; Trang Huyen Nguyen; Rajan Nikbakhsh; Dina Nur Anggraini Ningrum; Molly R Nixon; Chukwudi A Nnaji; Jean Jacques Noubiap; Virginia Nuñez-Samudio; Vincent Ebuka Nwatah; Bogdan Oancea; Chimedsuren Ochir; Felix Akpojene Ogbo; Andrew T Olagunju; Babayemi Oluwaseun Olakunde; Obinna E Onwujekwe; Nikita Otstavnov; Stanislav S Otstavnov; Mayowa O Owolabi; Jagadish Rao Padubidri; Keyvan Pakshir; Eun-Cheol Park; Fatemeh Pashazadeh Kan; Mona Pathak; Rajan Paudel; Shrikant Pawar; Jeevan Pereira; Mario F P Peres; Arokiasamy Perianayagam; Marina Pinheiro; Majid Pirestani; Vivek Podder; Roman V Polibin; Richard Charles G Pollok; Maarten J Postma; Faheem Hyder Pottoo; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Alireza Rafiei; Vafa Rahimi-Movaghar; Mosiur Rahman; Amir Masoud Rahmani; Setyaningrum Rahmawaty; Aashish Rajesh; Rebecca E Ramshaw; Priyanga Ranasinghe; Chythra R Rao; Sowmya J Rao; Priya Rathi; David Laith Rawaf; Salman Rawaf; Andre M N Renzaho; Negar Rezaei; Mohammad Sadegh Rezai; Maria Rios-Blancas; Emma L B Rogowski; Luca Ronfani; Godfrey M Rwegerera; Anas M Saad; Siamak Sabour; Basema Saddik; Mohammad Reza Saeb; Umar Saeed; Amirhossein Sahebkar; Mohammad Ali Sahraian; Nasir Salam; Hamideh Salimzadeh; Mehrnoosh Samaei; A.M. Samy; Juan Sanabria; Francesco Sanmarchi; Milena M Santric-Milicevic; Benn Sartorius; Arash Sarveazad; Brijesh Sathian; Monika Sawhney; Deepak Saxena; Sonia Saxena; Abdul-Aziz Seidu; Allen Seylani; Masood Ali Shaikh; Morteza Shamsizadeh; Pavanchand H Shetty; Mika Shigematsu; Jae Il Shin; Negussie Boti Sidemo; Ambrish Singh; Jasvinder A Singh; Smriti Sinha; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Amin Soheili; Eyayou Girma Tadesse; Animut Tagele Tamiru; Ker-Kan Tan; Yohannes Tekalegn; Mohamad-Hani Temsah; Bhaskar Thakur; Rekha Thapar; Aravind Thavamani; Ruoyan Tobe-Gai; Hamid Reza Tohidinik; Marcos Roberto Tovani-Palone; Eugenio Traini; Bach Xuan Tran; Manjari Tripathi; Berhan Tsegaye; Gebiyaw Wudie Tsegaye; Anayat Ullah; Saif Ullah; Sana Ullah; Brigid Unim; Marco Vacante; Diana Zuleika Velazquez; Bay Vo; Sebastian Vollmer; Giang Thu Vu; Linh Gia Vu; Yasir Waheed; Andrea Sylvia Winkler; Charles Shey Wiysonge; Vahit Yiğit; Birhanu Wubale Yirdaw; Dong Keon Yon; Naohiro Yonemoto; Chuanhua Yu; Deniz Yuce; Ismaeel Yunusa; Mohammad Zamani; Maryam Zamanian; Dejene Tesfaye Zewdie; Zhi-Jiang Zhang; Chenwen Zhong; Alimuddin Zumla; Christopher J L Murray; Stephen S Lim; Jonathan F Mosser; J. Nguyen; A. Marks; C.J.L. Murray; S.S. Lim; R. Dandona; C.J.L. Murray; S.S. Lim; L. Ali; A. Ullah; B.E. Feleke; A. Elsharkawy; H. Abolhassani; S. Ahmad; T. Ahmad; S. Sabour; H. Ahmed; M.B. Ahmed; T. Ahmed Rashid; D. Saxena; B. Dagnew; M. Derbew Molla; A. Aklilu; Y. Alemayehu; L. Albano; A. Al-Eyadhy; M. Temsah; Y. Mohammad; R.K. Alhassan; M. Hostiuc; I. Negoi; I. Glăvan; A. Ansar; I. Antonazzo; P. Ferrara; A. Singh Mtech; J. Arabloo; A. Ghashghaee; A. Ghashghaee; A. Sarveazad; K.D. Artanti; J. Arulappan; M.A. Awoke; P. Rathi; Z. Babar; B. Gebremichael; M. Zamani; A. Barrow; A. Barrow; V. Kulkarni; D. Saxena; J. Shin; S. Misra; K. Bhattacharyya; S. Bibi; S. Ullah; A. Boloor; S. Sinha; D. Braithwaite; D. Braithwaite; D. Buonsenso; D. Buonsenso; G.W. Tsegaye; J. De Neve; P. Camargos; M. Pinheiro; R. Chakinala; S. Chatterjee; V. Chattu; V. Chattu; I. Bill; D. Chu; S. Chung; S. Chung; L. Dandona; R. Dandona; A. Ansar; G. Kumar; R. Desai; M. Dhimal; S. Eftekharzadeh; M. Elhadi; S. Enany; A.T. Olagunju; P.S. Faris; B. Tsegaye; I. Filip; F. Fischer; M.R. Francis; M.R. Francis; T. Fukumoto; X. Liu; A.M. Saad; S. Gaidhane; T. Garg; Y. Tekalegn; S. Mohammed; T. Gebre; K. Ghadiri; K. Ghadiri; M. Ghafourifard; M. Moghadaszadeh; S. Gilani; S. Gilani; P.D. Lopukhov; M. Golechha; S.V. Gopalani; H. Goudarzi; M.B. Ahmed; H. Goudarzi; Y. Guo; S. Li; Y. Guo; V. Gupta; V.K. Gupta; R.A. Gutiérrez; A. Hargono Dr; S. Hassan; S. Hassan; G. Heidari; S. Islam; V. Hsieh; J. Huang; C. Zhong; A. Humayun; R. Hussain; A. Makki; J. Noubiap; U. Iqbal; S.N. Irvani; S. Islam; R. Kalhor; R. Kalhor; Z. Kamal; Z. Kamal; A. Karch; J. Khan; G. Kim; M. Kim; M. Kim; Y. Kim; S. Kosen; A. Kumar; A. Kwarteng; C. La Vecchia; I. Landires; V. Nuñez-Samudio; I. Landires; S. Lasrado; M. Levi; M. Levi; C.E. Moore; X. Liu; J. Sanabria; A. Thavamani; P.C. Matthews; J.C. Medina; J.C. Medina; W. Mendoza; R.G. Menezes; M.K. Mesregah; T. Mestrovic; M. Mohammadi; A. Mohammed; S. Mohammed; A. Mohapatra; M. Molokhia; E. Traini; H. Mirzaei; M. Zamanian; S.B. Munro; N. Otstavnov; M. Naveed; I. Negoi; T.H. Nguyen; T.H. Nguyen; B.O. Olakunde; M. Pathak; S. Pawar; M. Pirestani; M. Rabiee; M. Rahman; S. Rahmawaty; A. Rajesh; S. Rawaf; S. Rawaf; M. Saeb; U. Saeed; U. Saeed; M. Samaei; J. Sanabria; F. Sanmarchi; M. Sawhney; A. Seidu; A. Seidu; M.A. Shaikh; M. Shigematsu; A. Soheili; K. Tan; B. Thakur; A. Thavamani; E. Traini; M. Tripathi; S. Ullah; S. Ullah; B. Vo; G.T. Vu; A.S. Winkler; A.S. Winkler; C. Yu; D. Yuce
Background: Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabilities. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020, Release 1, we did a systematic analysis of global, regional, and national vaccine coverage trends using a statistical framework, by vaccine and over time. Methods: For this analysis we collated 55 326 country-specific, cohort-specific, year-specific, vaccine-specific, and dose-specific observations of routine childhood vaccination coverage between 1980 and 2019. Using spatiotemporal Gaussian process regression, we produced location-specific and year-specific estimates of 11 routine childhood vaccine coverage indicators for 204 countries and territories from 1980 to 2019, adjusting for biases in country-reported data and reflecting reported stockouts and supply disruptions. We analysed global and regional trends in coverage and numbers of zero-dose children (defined as those who never received a diphtheria-tetanus-pertussis [DTP] vaccine dose), progress towards GVAP targets, and the relationship between vaccine coverage and sociodemographic development. Findings: By 2019, global coverage of third-dose DTP (DTP3; 81·6% [95% uncertainty interval 80·4–82·7]) more than doubled from levels estimated in 1980 (39·9% [37·5–42·1]), as did global coverage of the first-dose measles-containing vaccine (MCV1; from 38·5% [35·4–41·3] in 1980 to 83·6% [82·3–84·8] in 2019). Third-dose polio vaccine (Pol3) coverage also increased, from 42·6% (41·4–44·1) in 1980 to 79·8% (78·4–81·1) in 2019, and global coverage of newer vaccines increased rapidly between 2000 and 2019. The global number of zero-dose children fell by nearly 75% between 1980 and 2019, from 56·8 million (52·6–60·9) to 14·5 million (13·4–15·9). However, over the past decade, global vaccine coverage broadly plateaued; 94 countries and territories recorded decreasing DTP3 coverage since 2010. Only 11 countries and territories were estimated to have reached the national GVAP target of at least 90% coverage for all assessed vaccines in 2019. Interpretation: After achieving large gains in childhood vaccine coverage worldwide, in much of the world this progress was stalled or reversed from 2010 to 2019. These findings underscore the importance of revisiting routine immunisation strategies and programmatic approaches, recentring service delivery around equity and underserved populations. Strengthening vaccine data and monitoring systems is crucial to these pursuits, now and through to 2030, to ensure that all children have access to, and can benefit from, lifesaving vaccines. Funding: Bill & Melinda Gates Foundation. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Plant beneficial rhizospheric microorganism (PBRM) strategies to improve nutrients use efficiency: A review
(Elsevier B.V., 2017) Vijay Singh Meena; Sunita Kumari Meena; Jay Prakash Verma; Ashok Kumar; Abhinav Aeron; Pankaj Kumar Mishra; Jaideep Kumar Bisht; Arunava Pattanayak; Muhammad Naveed; M.L. Dotaniya
Plant beneficial rhizospheric microorganisms (PBRMs) are rhizospheric microbes that are able to colonize rhizosphere and to improve plant growth, development and nutrient use efficiency (NUE) by means of a wide variety of mechanisms like organic matter mineralization, biological control against soil-borne pathogens, biological nitrogen (N) fixation, potassium (K), phosphorous (P) and zinc (Zn) solubilization and root growth promotion. Improved grain production to meet the food demand of an increasing population has been highly dependent on chemical fertilizer input based on the traditionally assumed notion of ‘high input, high output’, which results in overuse of fertilizers but ignores the biological potential of roots or rhizosphere for efficient mobilization and acquisition of soil nutrients. A very interesting feature of PBRMs is their ability of enhancing nutrient bioavailability or NUE by ∼ 20-40% with various nutrients. Although chemical fertilization is a quick method, it is not recommendable economically and environmentally, especially if overused. Several PBRMs species have been characterized as biological N-fixer, P, K-solubilizing microorganisms while other species have been shown to increase the solubility of micronutrients, like those that produce siderophores for iron (Fe) chelation. The enhanced amount of soluble macro- and micronutrients in the close proximity of the soil-root interface has indeed a positive effect on plant nutrition. There is a growing body of evidence that demonstrates the potential of various microbes to enhance plant productivity and yield in cropping systems. However, the molecular mechanisms underlying these phenomena, the signals involved as well as the potential applications in a sustainable agriculture approach, and the biotechnological aspects for possible rhizosphere engineering are still matters of discussion. © 2017 Elsevier B.V.
Seed associated bacterial and fungal endophytes: Diversity, life cycle, transmission, and application potential
(Elsevier B.V., 2021) Tayyaba Samreen; Muhammad Naveed; Muhammad Zulqernain Nazir; Hafiz Naeem Asghar; Muhammad Imran Khan; Zahir Ahmad Zahir; Sehrish Kanwal; B. Jeevan; Devender Sharma; Vijay Singh Meena; Sunita Kumari Meena; Deepranjan Sarkar; O. Siva Devika; Manoj Parihar; Mahipal Choudhary
Exponential upsurge in the global population growth rate claims sustainable means to fulfill their food requirements. Therefore, the collaboration of beneficial microorganisms with their host plants have been of interest for years as these associations can be helpful in the development of sustainable agriculture. However, the endophytic microorganisms develop a strong and persistent interaction with the host plants compared to epiphytic microbes. The origin of plant-associated endophytes was supposed to be from seeds as the endophytic microbes were found inside seeds of several plant species although, endophytes do not necessarily come from seeds only but can also enter the roots or other parts during plant growth. In any case, the richness of seed with the microbes and their dynamics can edify innovative research potentials in the field of plant-microbe associations. Yet, the seed microbiome is often underrepresented in plant microbial studies and is least studied up till now compared to phyllospheric or rhizospheric microbial population. The revival of exploring the seed microbiome is stimulating new insights related to the dynamics and diversity of seed microbiome along with their interconnectedness with the soil and plant microbial community as well as the microbes associated with pollinators and dispersers. This review is an effort to acknowledge the research on seed associated microbial community including bacteria and fungi. It focuses on ecology of seed microbiome from sources to diversity, their association with the host plant, and their life cycle including mode of colonization, localization, and transmission. Both the horizontal and vertical means of transmission have been discussed in this paper whereas the significance of vertical transmission for rapid infection of beneficial microbial community to next generations of plants through seeds is emphasized. Moreover, the applications of seed endophytes for growth promotion of plants, as biocontrol agents and in phytoremediation are discussed. Finally, the association of seed endophytes with seed quality is linked. © 2021
Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990-2019: A systematic analysis from the Global Burden of Disease Study 2019
(Elsevier Ltd, 2021) Parkes J. Kendrick; Marissa B. Reitsma; Mohsen Abbasi-Kangevari; Amir Abdoli; Mohammad Abdollahi; Aidin Abedi; E.S. Abhilash; Victor Aboyans; Oladimeji M. Adebayo; Shailesh M. Advani; Bright Opoku Ahinkorah; Sohail Ahmad; Keivan Ahmadi; Haroon Ahmed; Budi Aji; Yonas Akalu; Chisom Joyqueenet Akunna; Fares Alahdab; Ziyad Al-Aly; Fahad Mashhour Alanezi; Turki M. Alanzi; Khalid F. Alhabib; Tilahun Ali; Sheikh Mohammad Alif; Vahid Alipour; Syed Mohamed Aljunid; Mahmoud A. Alomari; Tarek Tawfik Amin; Saeed Amini; Hubert Amu; Robert Ancuceanu; Jason A. Anderson; Catalina Liliana Andrei; Tudorel Andrei; Alireza Ansari-Moghaddam; Benny Antony; Davood Anvari; Jalal Arabloo; Nicholas D. Arian; Monika Arora; Kurnia Dwi Artanti; Wondwossen Niguse Asmare; Desta Debalkie Atnafu; Marcel Ausloos; Asma Tahir Awan; Getinet Ayano; Getie Lake Aynalem; Samad Azari; B.B. Darshan; Ashish D. Badiye; Atif Amin Baig; Maciej Banach; Srikanta K. Banerjee; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Hiba Jawdat Barqawi; Sanjay Basu; Mohsen Bayati; Shahrzad Bazargan-Hejazi; Tariku Tesfaye Bekuma; Derrick A. Bennett; Isabela M. Bensenor; Habib Benzian; Catherine P. Benziger; Adam E. Berman; Akshaya Srikanth Bhagavathula; Neeraj Bhala; Nikha Bhardwaj; Pankaj Bhardwaj; Krittika Bhattacharyya; Sadia Bibi; Ali Bijani; Antonio Biondi; Dejana Braithwaite; Hermann Brenner; Andre R. Brunoni; Katrin Burkart; Sharath Burugina Nagaraja; Zahid A. Butt; Florentino Luciano Caetano Dos Santos; Josip Car; Giulia Carreras; Joao Mauricio Castaldelli-Maia; Maria Sofia Sofia Cattaruzza; Jung-Chen Chang; Pankaj Chaturvedi; Simiao Chen; Onyema Greg Chido-Amajuoyi; Dinh-Toi Chu; Sheng-Chia Chung; Liliana G. Ciobanu; Vera Marisa Costa; Rosa A. S. Couto; Baye Dagnew; Xiaochen Dai; Albertino Antonio Moura Damasceno; Giovanni Damiani; Lalit Dandona; Rakhi Dandona; Parnaz Daneshpajouhnejad; Jiregna Darega Gela; Meseret Derbew Molla; Abebaw Alemayehu Desta; Samath Dhamminda Dharmaratne; Meghnath Dhimal; Arielle Wilder Eagan; Mohammad Ebrahimi Kalan; Kristina Edvardsson; Andem Effiong; Maha El Tantawi; Iffat Elbarazi; Saman Esmaeilnejad; Ibtihal Fadhil; Emerito Jose A. Faraon; Medhat Farwati; Farshad Farzadfar; Mehdi Fazlzadeh; Valery L. Feigin; Rachel Feldman; Irina Filip; Filippos Filippidis; Florian Fischer; Luisa Sorio Flor; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Masoud Foroutan; Mohamed M. Gad; Silvano Gallus; Biniyam Sahiledengle Geberemariyam; Birhan Gebresillassie Gebregiorgis; Lemma Getacher; Abera Getachew Obsa; Mansour Ghafourifard; Reza Ghanei Gheshlagh; Ahmad Ghashghaee; Nermin Ghith; Gabriela Fernanda Gil; Paramjit Singh Gill; Ibrahim Abdelmageed Ginawi; Salime Goharinezhad; Mahaveer Golechha; Sameer Vali Gopalani; Giuseppe Gorini; Michal Grivna; Avirup Guha; Rafael Alves Guimarães; Yuming Guo; Rajat Das Gupta; Rajeev Gupta; Tarun Gupta; Vin Gupta; Nima Hafezi-Nejad; Mohammad Rifat Haider; Randah R. Hamadeh; Graeme J. Hankey; Arief Hargono; Simon I. Hay; Golnaz Heidari; Claudiu Herteliu; Kamal Hezam; Thomas R. Hird; Ramesh Holla; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mowafa Househ; Thomas Hsiao; Junjie Huang; Charles Ugochukwu Ibeneme; Segun Emmanuel Ibitoye; Irena M. Ilic; Milena D. Ilic; Leeberk Raja Inbaraj; Seyed Sina Naghibi Irvani; Jessica Y. Islam; Rakibul M. Islam; Sheikh Mohammed Shariful Islam; Farhad Islami; Hiroyasu Iso; Ramaiah Itumalla; Jalil Jaafari; Vardhmaan Jain; Mihajlo Jakovljevic; Sung-In Jang; Shubha Jayaram; Panniyammakal Jeemon; Ravi Prakas Jha; Jost B. Jonas; Mikk Jürisson; Ali Kabir; Zubair Kabir; Leila R. Kalankesh; Tanuj Kanchan; Himal Kandel; Neeti Kapoor; André Karch; Salah Eddin Karimi; Kindie Mitiku Kebede; Bayew Kelkay; Ryan David Kennedy; Yousef Saleh Khader; Ejaz Ahmad Khan; Maryam Khayamzadeh; Gyu Ri Kim; Ruth W. Kimokoti; Mika Kivimäki; Soewarta Kosen; Sindhura Lakshmi Koulmane Laxminarayana; Ai Koyanagi; Kewal Krishan; Nuworza Kugbey; G. Anil Kumar; Nithin Kumar; Om P. Kurmi; Dian Kusuma; Ben Lacey; Iván Landires; Savita Lasrado; Paolo Lauriola; Doo Woong Lee; Yo Han Lee; Janni Leung; Shanshan Li; Hualiang Lin; Wei Liu; Alessandra Lugo; Shilpashree Madhava Kunjathur; Azeem Majeed; Afshin Maleki; Reza Malekzadeh; Deborah Carvalho Malta; Abdullah A. Mamun; Narayana Manjunatha; Borhan Mansouri; Mohammad Ali Mansournia; Santi Martini; Manu Raj Mathur; Prashant Mathur; Mohsen Mazidi; Martin McKee; Carlo Eduardo Medina-Solís; Suresh Mehata; Walter Mendoza; Ritesh G. Menezes; Bartosz Miazgowski; Irmina Maria Michalek; Ted R. Miller; G.K. Mini; Andreea Mirica; Erkin M. Mirrakhimov; Hamed Mirzaei; Sanjeev Misra; Yousef Mohammad; Abdollah Mohammadian-Hafshejani; Shafiu Mohammed; Ali H. Mokdad; Mariam Molokhia; Lorenzo Monasta; Mohammad Ali Moni; Rahmatollah Moradzadeh; Shane Douglas Morrison; Tilahun Belete Mossie; Sumaira Mubarik; Erin C. Mullany; Christopher J. L. Murray; Shankar Prasad Nagaraju; Mohsen Naghavi; Nitish Naik; Mahdi Nalini; Vinay Nangia; Atta Abbas Naqvi; Sreenivas Narasimha Swamy; Muhammad Naveed; Javad Nazari; Sabina O. Nduaguba; Ruxandra Irina Negoi; Sandhya Neupane Kandel; Huong Lan Thi Nguyen; Yeshambel T. Nigatu; Molly R. Nixon; Chukwudi A. Nnaji; Jean Jacques Noubiap; Christoph Nowak; Virginia Nuñez-Samudio; Felix Akpojene Ogbo; Ayodipupo Sikiru Oguntade; In-Hwan Oh; Andrew T. Olagunju; Mayowa O. Owolabi; P.A. Mahesh; Keyvan Pakshir; Liping Pan; Adrian Pana; Demosthenes Panagiotakos; Songhomitra Panda-Jonas; Ashok Pandey; Utsav Parekh; Eun-Cheol Park; Eun-Kee Park; Fatemeh Pashazadeh Kan; Mona Pathak; Shrikant Pawar; Richard G. Pestell; Hai Quang Pham; Marina Pinheiro; Khem Narayan Pokhrel; Akram Pourshams; Akila Prashant; Amir Radfar; Vafa Rahimi-Movaghar; Mohammad Hifz Ur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Pradhum Ram; Juwel Rana; Chhabi Lal Ranabhat; Priya Rathi; David Laith Rawaf; Salman Rawaf; Reza Rawassizadeh; Andre M. N. Renzaho; Aziz Rezapour; Mavra A. Riaz; Leonardo Roever; Luca Ronfani; Gholamreza Roshandel; Ambuj Roy; Bedanta Roy; Basema Saddik; Amirhossein Sahebkar; Sana Salehi; Hamideh Salimzadeh; Abdallah M. Samy; Juan Sanabria; Milena M. Santric-Milicevic; Bruno Piassi Sao Jose; Brijesh Sathian; Monika Sawhney; Ganesh Kumar Saya; Falk Schwendicke; Abdul-Aziz Seidu; Nachimuthu Senthil Kumar; Sadaf G. Sepanlou; Omid Shafaat; Syed Mahboob Shah; Masood Ali Shaikh; Mohammed Shannawaz; Kiomars Sharafi; Aziz Sheikh; Sara Sheikhbahaei; Mika Shigematsu; Rahman Shiri; Kawkab Shishani; K.M. Shivakumar; Siddharudha Shivalli; Roman Shrestha; Soraya Siabani; Negussie Boti Sidemo; Inga Dora Sigfusdottir; Rannveig Sigurvinsdottir; João Pedro Silva; Ambrish Singh; Jasvinder A. Singh; Virendra Singh; Dhirendra Narain Sinha; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Ali Soroush; Ireneous N. Soyiri; Chandrashekhar T. Sreeramareddy; Dan J. Stein; Paschalis Steiropoulos; Stefan Stortecky; Kurt Straif; Rizwan Suliankatchi Abdulkader; Gerhard Sulo; Johan Sundström; Takahiro Tabuchi; Eyayou Girma Tadesse; Animut Tagele Tamiru; Minale Tareke; Md Ismail Tareque; Ingan Ukur Tarigan; Bhaskar Thakur; Kavumpurathu Raman Thankappan; Rekha Thapar; Musliu Adetola Tolani; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Jaya Prasad Tripathy; Gebiyaw Wudie Tsegaye; Hayley D. Tymeson; Saif Ullah; Brigid Unim; Rachel L. Updike; Olalekan A. Uthman; Marco Vacante; Constantine Vardavas; Narayanaswamy Venketasubramanian; Madhur Verma; Simone Vidale; Bay Vo; Giang Thu Vu; Yasir Waheed; Yanzhong Wang; Kevin Welding; Andrea Werdecker; Joanna L. Whisnant; Nuwan Darshana Wickramasinghe; Befikadu Legesse Wubishet; Kazumasa Yamagishi; Yuichiro Yano; Vahid Yazdi-Feyzabadi; Yigizie Yeshaw; Mohammed Zewdu Yimmer; Naohiro Yonemoto; Zabihollah Yousefi; Chuanhua Yu; Ismaeel Yunusa; Hasan Yusefzadeh; Muhammed Shahriar Zaman; Mohammad Zamani; Maryam Zamanian; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Jianrong Zhang; Zhi-Jiang Zhang; Chenwen Zhong; Yves Miel H. Zuniga; Emmanuela Gakidou
Background: Chewing tobacco and other types of smokeless tobacco use have had less attention from the global health community than smoked tobacco use. However, the practice is popular in many parts of the world and has been linked to several adverse health outcomes. Understanding trends in prevalence with age, over time, and by location and sex is important for policy setting and in relation to monitoring and assessing commitment to the WHO Framework Convention on Tobacco Control. Methods: We estimated prevalence of chewing tobacco use as part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 using a modelling strategy that used information on multiple types of smokeless tobacco products. We generated a time series of prevalence of chewing tobacco use among individuals aged 15 years and older from 1990 to 2019 in 204 countries and territories, including age-sex specific estimates. We also compared these trends to those of smoked tobacco over the same time period. Findings: In 2019, 273·9 million (95% uncertainty interval 258·5 to 290·9) people aged 15 years and older used chewing tobacco, and the global age-standardised prevalence of chewing tobacco use was 4·72% (4·46 to 5·01). 228·2 million (213·6 to 244·7; 83·29% [82·15 to 84·42]) chewing tobacco users lived in the south Asia region. Prevalence among young people aged 15–19 years was over 10% in seven locations in 2019. Although global age-standardised prevalence of smoking tobacco use decreased significantly between 1990 and 2019 (annualised rate of change: –1·21% [–1·26 to –1·16]), similar progress was not observed for chewing tobacco (0·46% [0·13 to 0·79]). Among the 12 highest prevalence countries (Bangladesh, Bhutan, Cambodia, India, Madagascar, Marshall Islands, Myanmar, Nepal, Pakistan, Palau, Sri Lanka, and Yemen), only Yemen had a significant decrease in the prevalence of chewing tobacco use, which was among males between 1990 and 2019 (−0·94% [–1·72 to –0·14]), compared with nine of 12 countries that had significant decreases in the prevalence of smoking tobacco. Among females, none of these 12 countries had significant decreases in prevalence of chewing tobacco use, whereas seven of 12 countries had a significant decrease in the prevalence of tobacco smoking use for the period. Interpretation: Chewing tobacco remains a substantial public health problem in several regions of the world, and predominantly in south Asia. We found little change in the prevalence of chewing tobacco use between 1990 and 2019, and that control efforts have had much larger effects on the prevalence of smoking tobacco use than on chewing tobacco use in some countries. Mitigating the health effects of chewing tobacco requires stronger regulations and policies that specifically target use of chewing tobacco, especially in countries with high prevalence. Funding: Bloomberg Philanthropies and the Bill & Melinda Gates Foundation. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990â€“2019: a systematic analysis from the Global Burden of Disease Study 2019
(Elsevier B.V., 2021) Marissa B Reitsma; Parkes J Kendrick; Emad Ababneh; Cristiana Abbafati; Mohsen Abbasi-Kangevari; Amir Abdoli; Aidin Abedi; E.S. Abhilash; Derrick Bary Abila; Victor Aboyans; Niveen ME Abu-Rmeileh; Oladimeji M Adebayo; Shailesh M Advani; Mohammad Aghaali; Bright Opoku Ahinkorah; Sohail Ahmad; Keivan Ahmadi; Haroon Ahmed; Budi Aji; Chisom Joyqueenet Akunna; Ziyad Al-Aly; Turki M Alanzi; Khalid F Alhabib; Liaqat Ali; Sheikh Mohammad Alif; Vahid Alipour; Syed Mohamed Aljunid; FranÃ§ois Alla; Peter Allebeck; Nelson Alvis-Guzman; Tarek Tawfik Amin; Saeed Amini; Hubert Amu; Gianna Gayle Herrera Amul; Robert Ancuceanu; Jason A Anderson; Alireza Ansari-Moghaddam; Carl Abelardo T Antonio; Benny Antony; Davood Anvari; Jalal Arabloo; Nicholas D Arian; Monika Arora; Malke Asaad; Marcel Ausloos; Asma Tahir Awan; Getinet Ayano; Getie Lake Aynalem; Samad Azari; Darshan B B; Ashish D Badiye; Atif Amin Baig; Mohammad Hossein Bakhshaei; Maciej Banach; Palash Chandra Banik; Suzanne Lyn Barker-Collo; Till Winfried BÃ¤rnighausen; Hiba Jawdat Barqawi; Sanjay Basu; Mohsen Bayati; Shahrzad Bazargan-Hejazi; Masoud Behzadifar; Tariku Tesfaye Bekuma; Derrick A. Bennett; Isabela M Bensenor; Kathleen S Sachiko Berfield; Akshaya Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Krittika Bhattacharyya; Sadia Bibi; Ali Bijani; Bagas Suryo Bintoro; Antonio Biondi; Setognal Birara; Dejana Braithwaite; Hermann Brenner; Andre R Brunoni; Katrin Burkart; Zahid A Butt; Florentino Luciano Caetano dos Santos; Luis Alberto CÃ¡mera; Josip Car; Rosario CÃ¡rdenas; Giulia Carreras; Juan J Carrero; Joao Mauricio Castaldelli-Maia; Maria Sofia Cattaruzza; Jung-Chen Chang; Simiao Chen; Dinh-Toi Chu; Sheng-Chia Chung; Massimo Cirillo; Vera Marisa Costa; Rosa A S Couto; Omid Dadras; Xiaochen Dai; Albertino Antonio Moura Damasceno; Giovanni Damiani; Lalit Dandona; Rakhi Dandona; Parnaz Daneshpajouhnejad; Jiregna Darega Gela; Kairat Davletov; Meseret Derbew Molla; Getenet Ayalew Dessie; Abebaw Alemayehu Desta; Samath Dhamminda Dharmaratne; Mostafa Dianatinasab; Daniel Diaz; Hoa Thi Do; Abdel Douiri; Bruce B Duncan; Andre Rodrigues Duraes; Arielle Wilder Eagan; Mohammad Ebrahimi Kalan; Kristina Edvardsson; Iffat Elbarazi; Maha El Tantawi; Saman Esmaeilnejad; Ibtihal Fadhil; Emerito Jose A Faraon; Carla Sofia e SÃ¡ Farinha; Medhat Farwati; Farshad Farzadfar; Mehdi Fazlzadeh; Valery L Feigin; Rachel Feldman; Carlota Fernandez Prendes; Pietro Ferrara; Irina Filip; Filippos Filippidis; Florian Fischer; Luisa Sorio Flor; Nataliya A Foigt; Morenike Oluwatoyin Folayan; Masoud Foroutan; Mohamed M Gad; Abhay Motiramji Gaidhane; Silvano Gallus; Biniyam Sahiledengle Geberemariyam; Mansour Ghafourifard; Alireza Ghajar; Ahmad Ghashghaee; Simona Giampaoli; Paramjit Singh Gill; Franklin N Glozah; Elena V Gnedovskaya; Mahaveer Golechha; Sameer Vali Gopalani; Giuseppe Gorini; Houman Goudarzi; Alessandra C Goulart; Felix Greaves; Avirup Guha; Yuming Guo; Bhawna Gupta; Rajat Das Gupta; Rajeev Gupta; Tarun Gupta; Vin Gupta; Nima Hafezi-Nejad; Mohammad Rifat Haider; Randah R Hamadeh; Graeme J Hankey; Arief Hargono; Risky Kusuma Hartono; Hadi Hassankhani; Simon I Hay; Golnaz Heidari; Claudiu Herteliu; Kamal Hezam; Thomas R Hird; Michael K Hole; Ramesh Holla; Mehdi Hosseinzadeh; Sorin Hostiuc; Mowafa Househ; Thomas Hsiao; Junjie Huang; Vincent C Iannucci; Segun Emmanuel Ibitoye; Bulat Idrisov; Olayinka Stephen Ilesanmi; Irena M Ilic; Milena D Ilic; Leeberk Raja Inbaraj; Seyed Sina Naghibi Irvani; Jessica Y Islam; Rakibul M Islam; Sheikh Mohammed Shariful Islam; Farhad Islami; Hiroyasu Iso; Ramaiah Itumalla; Masao Iwagami; Jalil Jaafari; Vardhmaan Jain; Mihajlo Jakovljevic; Sung-In Jang; Hosna Janjani; Shubha Jayaram; Panniyammakal Jeemon; Ravi Prakash Jha; Jost B Jonas; Tamas Joo; Mikk JÃ¼risson; Ali Kabir; Zubair Kabir; Leila R Kalankesh; Tanuj Kanchan; Himal Kandel; Neeti Kapoor; Salah Eddin Karimi; Srinivasa Vittal Katikireddi; Hafte Kahsay Kebede; Bayew Kelkay; Ryan David Kennedy; Abdullah T Khoja; Jagdish Khubchandani; Gyu Ri Kim; Young-Eun Kim; Ruth W Kimokoti; Mika KivimÃ¤ki; Soewarta Kosen; Sindhura Lakshmi Koulmane Laxminarayana; Ai Koyanagi; Kewal Krishan; Nuworza Kugbey; G Anil Kumar; Nithin Kumar; Om P Kurmi; Dian Kusuma; Ben Lacey; Jennifer O Lam; IvÃ¡n Landires; Savita Lasrado; Paolo Lauriola; Doo Woong Lee; Yo Han Lee; Janni Leung; Shanshan Li; Hualiang Lin; Shai Linn; Wei Liu; Alan D Lopez; Platon D Lopukhov; Stefan Lorkowski; Alessandra Lugo; Azeem Majeed; Afshin Maleki; Reza Malekzadeh; Deborah Carvalho Malta; Abdullah A Mamun; Narayana Manjunatha; Borhan Mansouri; Mohammad Ali Mansournia; Jose Martinez-Raga; Santi Martini; Manu Raj Mathur; Carlo Eduardo Medina-SolÃs; Suresh Mehata; Walter Mendoza; Ritesh G Menezes; Atte Meretoja; Tuomo J Meretoja; Bartosz Miazgowski; Irmina Maria Michalek; Ted R Miller; Erkin M Mirrakhimov; Hamed Mirzaei; Mehdi Mirzaei-Alavijeh; Sanjeev Misra; Masoud Moghadaszadeh; Yousef Mohammad; Abdollah Mohammadian-Hafshejani; Shafiu Mohammed; Ali H Mokdad; Lorenzo Monasta; Mohammad Ali Moni; Ghobad Moradi; Maziar Moradi-Lakeh; Rahmatollah Moradzadeh; Shane Douglas Morrison; Tilahun Belete Mossie; Sumaira Mubarik; Erin C Mullany; Christopher J L Murray; Mohsen Naghavi; Behshad Naghshtabrizi; Sanjeev Nair; Mahdi Nalini; Vinay Nangia; Atta Abbas Naqvi; Sreenivas Narasimha Swamy; Muhammad Naveed; Smitha Nayak; Vinod C Nayak; Javad Nazari; Sabina O Nduaguba; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Son Hoang Nguyen; Trang Huyen Nguyen; Molly R Nixon; Chukwudi A Nnaji; Bo Norrving; Jean Jacques Noubiap; Christoph Nowak; Felix Akpojene Ogbo; Ayodipupo Sikiru Oguntade; In-Hwan Oh; Andrew T Olagunju; Eyal Oren; Nikita Otstavnov; Stanislav S Otstavnov; Mayowa O. Owolabi; Mahesh P A; Smita Pakhale; Keyvan Pakshir; Raffaele Palladino; Adrian Pana; Songhomitra Panda-Jonas; Ashok Pandey; Utsav Parekh; Eun-Cheol Park; Eun-Kee Park; Fatemeh Pashazadeh Kan; George C Patton; Shrikant Pawar; Richard G Pestell; Marina Pinheiro; Michael A Piradov; Saeed Pirouzpanah; Khem Narayan Pokhrel; Roman V Polibin; Akila Prashant; Dimas Ria Angga Pribadi; Amir Radfar; Vafa Rahimi-Movaghar; Azizur Rahman; Mohammad Hifz Ur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Nazanin Rajai; Pradhum Ram; Chhabi Lal Ranabhat; Priya Rathi; Lal Rawal; Andre M N Renzaho; Luz Myriam Reynales-Shigematsu; Aziz Rezapour; Seyed Mohammad Riahi; Mavra A Riaz; Leonardo Roever; Luca Ronfani; Gholamreza Roshandel; Ambuj Roy; Bedanta Roy; Simona Sacco; Basema Saddik; Amirhossein Sahebkar; Sana Salehi; Hamideh Salimzadeh; Mehrnoosh Samaei; Abdallah M Samy; Itamar S Santos; Milena M Santric-Milicevic; Nizal Sarrafzadegan; Brijesh Sathian; Monika Sawhney; Mete Saylan; Michael P Schaub; Maria InÃªs Schmidt; Ione Jayce Ceola Schneider; Aletta Elisabeth Schutte; Falk Schwendicke; Abdul-Aziz Seidu; Nachimuthu Senthil Kumar; Sadaf Ghajarieh Sepanlou; Allen Seylani; Omid Shafaat; Syed Mahboob Shah; Masood Ali Shaikh; Ali S Shalash; Mohammed Shannawaz; Kiomars Sharafi; Aziz Sheikh; Sara Sheikhbahaei; Mika Shigematsu; Rahman Shiri; Kawkab Shishani; K.M. Shivakumar; Siddharudha Shivalli; Roman Shrestha; Soraya Siabani; Negussie Boti Sidemo; Inga Dora Sigfusdottir; Rannveig Sigurvinsdottir; Diego Augusto Santos Silva; JoÃ£o Pedro Silva; Ambrish Singh; Jasvinder A Singh; Virendra Singh; Dhirendra Narain Sinha; Freddy Sitas; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Matiwos Soboka; Joan B Soriano; Ali Soroush; Sergey Soshnikov; Ireneous N Soyiri; Emma Elizabeth Spurlock; Chandrashekhar T Sreeramareddy; Dan J Stein; Paschalis Steiropoulos; Stefan Stortecky; Kurt Straif; Rizwan Suliankatchi Abdulkader; Gerhard Sulo; Johan SundstrÃ¶m; Takahiro Tabuchi; Santosh Kumar Tadakamadla; Biruk Wogayehu Taddele; Eyayou Girma Tadesse; Animut Tagele Tamiru; Minale Tareke; Md Ismail Tareque; Ingan Ukur Tarigan; Mohamad-Hani Temsah; Kavumpurathu Raman Thankappan; Rekha Thapar; Ales Tichopad; Musliu Adetola Tolani; Fotis Topouzis; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Jaya Prasad Tripathy; Gebiyaw Wudie Tsegaye; Nikolaos Tsilimparis; Hayley D Tymeson; Anayat Ullah; Saif Ullah; Brigid Unim; Rachel L Updike; Marco Vacante; Pascual R Valdez; Constantine Vardavas; Patricia Varona PÃ©rez; Tommi Juhani Vasankari; Narayanaswamy Venketasubramanian; Madhur Verma; Marina V Vetrova; Bay Vo; Giang Thu Vu; Yasir Waheed; Yanzhong Wang; Kevin Welding; Andrea Werdecker; Joanna L Whisnant; Nuwan Darshana Wickramasinghe; Kazumasa Yamagishi; Srikanth Yandrapalli; Hiroshi Yatsuya; Vahid Yazdi-Feyzabadi; Yigizie Yeshaw; Mohammed Zewdu Yimmer; Naohiro Yonemoto; Chuanhua Yu; Ismaeel Yunusa; Hasan Yusefzadeh; Telma Zahirian Moghadam; Muhammed Shahriar Zaman; Maryam Zamanian; Hamed Zandian; Heather J Zar; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Luis Zavala-Arciniega; Jianrong Zhang; Zhi-Jiang Zhang; Chenwen Zhong; Yves Miel H Zuniga; Emmanuela Gakidou; J.A. Anderson; R. Feldman; V. Gupta; C.J.L. Murray; K. Burkart; R. Dandona; V. Gupta; C.J.L. Murray; E. Gakidou; E. Oren; V. Jain; S. Salehi; S. Siabani; R.G. Menezes; S.M. Alif; Y. Guo; S. Li; J. Arabloo; H. Zandian; N. Kumar; A. Ghashghaee; A. Ghashghaee; P. Allebeck; J.J. Carrero; S. Amini; R. Moradzadeh; M. Zamanian; J. Nazari; G.H. Amul; R. Ancuceanu; E.A. Faraon; B. Antony; A. Singh; D. Anvari; M. Arora; M.R. Mathur; G. Kumar; M. Arora; M. Asaad; M. Ausloos; M. Ausloos; C. Herteliu; A. Pana; G.L. Aynalem; M. Derbew Molla; Y. Yeshaw; P. Rathi; M.A. Riaz Mcom; S. Chen; S. Mohammed; S. Basu; J. Car; F. Greaves; D. Kusuma; M. Behzadifar; B. Lacey; I.S. Santos; I.S. Santos; N. Bhardwaj; S. Misra; K. Bhattacharyya; S. Bibi; S. Ullah; S. Birara; D. Braithwaite; S. Basu; D. Braithwaite; J. Car; G. Gorini; D. Chu; S. Chung; S. Chung; M. Cirillo; J.P. Silva; M. Pinheiro; A. Guha; L. Dandona; L. Dandona; G.W. Tsegaye; H.T. Do; H.T. Do; A. Douiri; D. Lee; M.I. Schmidt; A.W. Eagan; I. Fadhil; C.S.E. Farinha; M. Nalini; T. Zahirian Moghadam; H. Zandian; E.V. Gnedovskaya; I. Filip; F. Fischer; A.M. Gaidhane; A. Naqvi; M. Moghadaszadeh; S. Pirouzpanah; A. Ghajar; S. Giampaoli; S. Hostiuc; P.S. Gill; M. Golechha; S.V. Gopalani; H. Goudarzi; H. Goudarzi; F. Greaves; A. Guha; Y. Guo; B. Gupta; R. Gupta; R. Gupta; R. Gupta; T. Gupta; O. Shafaat; S. Sheikhbahaei; K. Welding; M. Haider; A. Hargono Dr; S. Martini; S.N. Irvani; G. Heidari; C. Herteliu; T.R. Hird; S. Hostiuc; J. Huang; C. Zhong; F. Islami; H. Iso; M. Iwagami; M. Iwagami; S. Shivalli; S. Jang; B. Mansouri; M. Nalini; S. Siabani; P. Jeemon; T. Joo; R.D. Kennedy; J. Khubchandani; G. Kim; E. Park; B. Naghshtabrizi; Y. Kim; S. Kosen; A. Koyanagi; O. Shafaat; A. Koyanagi; A.T. Olagunju; D. Kusuma; B. Lacey; J.O. Lam; I. Landires; I. Landires; I. Landires; S. Lasrado; Y. Lee; H. Lin; W. Liu; J. Zhang; P.D. Lopukhov; D.C. Malta; N. Manjunatha; S. Martini; M.R. Mathur; S. Mehata; W. Mendoza; S. Mohammed; A.E. Schutte; S.D. Morrison; S. Mubarik; C. Yu; S. Nair; S. Nair; S. Nair; A. Naqvi; S. Neupane Kandel; C.T. Nguyen; H.L.T. Nguyen; S.H. Nguyen; T.H. Nguyen; H.J. Zar; J. Noubiap; C. Nowak; I. Oh; E. Oren; N. Otstavnov; M P A; A. Pana; A. Pandey; A. Pandey; U. Parekh; S. Pawar; A. Rahman; M. Rahman; M. Rahman; M. Rahman; P. Ram; L. Roever; A. Roy; B. Roy; S. Sacco; M. Samaei; A.S. Shalash; M. Sawhney; M. Saylan; I.J.C. Schneider; F. Schwendicke; A. Seidu Mphil; M. Shigematsu; M. Shigematsu; D.N. Sinha; D.N. Sinha; S. Stortecky; K. Straif; K. Straif; G. Sulo; G. Sulo; J.P. Tripathy; N. Tsilimparis; C. Vardavas; M.V. Vetrova; B. Vo; Y. Waheed; A. Werdecker; S. Yandrapalli; M.S. Zaman; Y.H. Zuniga
Background: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings: Globally in 2019, 1·14 billion (95% uncertainty interval 1·13–1·16) individuals were current smokers, who consumed 7·41 trillion (7·11–7·74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. Globally in 2019, smoking tobacco use accounted for 7·69 million (7·16–8·20) deaths and 200 million (185–214) disability-adjusted life-years, and was the leading risk factor for death among males (20·2% [19·3–21·1] of male deaths). 6·68 million [86·9%] of 7·69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation: In the absence of intervention, the annual toll of 7·69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a clear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens. Funding: Bloomberg Philanthropies and the Bill & Melinda Gates Foundation. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Subnational mapping of HIV incidence and mortality among individuals aged 15–49 years in sub-Saharan Africa, 2000–18: a modelling study
(Elsevier Ltd, 2021) Benn Sartorius; John D. VanderHeide; Mingyou Yang; Erik A. Goosmann; Julia Hon; Emily Haeuser; Michael A. Cork; Samantha Perkins; Deepa Jahagirdar; Lauren E. Schaeffer; Audrey L. Serfes; Kate E. LeGrand; Hedayat Abbastabar; Zeleke Hailemariam Abebo; Akine Eshete Abosetugn; Eman Abu-Gharbieh; Manfred Mario Kokou Accrombessi; Oladimeji M. Adebayo; Adeyinka Emmanuel Adegbosin; Victor Adekanmbi; Olatunji O. Adetokunboh; Daniel Adedayo Adeyinka; Bright Opoku Ahinkorah; Keivan Ahmadi; Muktar Beshir Ahmed; Yonas Akalu; Oluwaseun Oladapo Akinyemi; Rufus Olusola Akinyemi; Addis Aklilu; Chisom Joyqueenet Akunna; Fares Alahdab; Ziyad Al-Aly; Noore Alam; Alehegn Aderaw Alamneh; Turki M. Alanzi; Biresaw Wassihun Alemu; Robert Kaba Alhassan; Tilahun Ali; Vahid Alipour; Saeed Amini; Robert Ancuceanu; Fereshteh Ansari; Zelalem Alamrew Anteneh; Davood Anvari; Razique Anwer; Seth Christopher Yaw Appiah; Jalal Arabloo; Mulusew A. Asemahagn; Mohammad Asghari Jafarabadi; Wondwossen Niguse Asmare; Desta Debalkie Atnafu; Maha Moh'd Wahbi Atout; Alok Atreya; Marcel Ausloos; Atalel Fentahun Awedew; Beatriz Paulina Ayala Quintanilla; Martin Amogre Ayanore; Yared Asmare Aynalem; Muluken Altaye Ayza; Samad Azari; Zelalem Nigussie Azene; Zaheer-Ud-Din Babar; Atif Amin Baig; Senthilkumar Balakrishnan; Maciej Banach; Till Winfried Bärnighausen; Sanjay Basu; Mohsen Bayati; Neeraj Bedi; Tariku Tesfaye Bekuma; Woldesellassie M. Mequanint Bezabhe; Akshaya Srikanth Bhagavathula; Pankaj Bhardwaj; Krittika Bhattacharyya; Zulfiqar A. Bhutta; Sadia Bibi; Boris Bikbov; Tsegaye Adane Birhan; Zebenay Workneh Bitew; Moses John Bockarie; Archith Boloor; Oliver J. Brady; Nicola Luigi Bragazzi; Andrey Nikolaevich Briko; Nikolay Ivanovich Briko; Sharath Burugina Nagaraja; Zahid A. Butt; Rosario Cárdenas; Felix Carvalho; Jaykaran Charan; Souranshu Chatterjee; Soosanna Kumary Chattu; Vijay Kumar Chattu; Mohiuddin Ahsanul Kabir Chowdhury; Dinh-Toi Chu; Aubrey J. Cook; Natalie Maria Cormier; Richard G. Cowden; Carlos Culquichicon; Baye Dagnew; Saad M.A. Dahlawi; Giovanni Damiani; Parnaz Daneshpajouhnejad; Farah Daoud; Ahmad Daryani; José das Neves; Nicole Davis Weaver; Meseret Derbew Molla; Kebede Deribe; Abebaw Alemayehu Desta; Keshab Deuba; Samath Dhamminda Dharmaratne; Govinda Prasad Dhungana; Daniel Diaz; Shirin Djalalinia; Paul Narh Doku; Eleonora Dubljanin; Bereket Duko; Arielle Wilder Eagan; Lucas Earl; Jeffrey W. Eaton; Andem Effiong; Maysaa El Sayed Zaki; Maha El Tantawi; Rajesh Elayedath; Shaimaa I. El-Jaafary; Aisha Elsharkawy; Sharareh Eskandarieh; Oghenowede Eyawo; Sayeh Ezzikouri; Abidemi Omolara Fasanmi; Alebachew Fasil; Nelsensius Klau Fauk; Valery L. Feigin; Tomas Y. Ferede; Eduarda Fernandes; Florian Fischer; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Masoud Foroutan; Joel Msafiri Francis; Takeshi Fukumoto; Mohamed M. Gad; Biniyam Sahiledengle Geberemariyam; Birhan Gebresillassie Gebregiorgis; Berhe Gebremichael; Hailay Abrha Gesesew; Lemma Getacher; Keyghobad Ghadiri; Ahmad Ghashghaee; Syed Amir Gilani; Themba G. Ginindza; Mustefa Glagn; Mahaveer Golechha; Philimon N. Gona; Mohammed Ibrahim Mohialdeen Gubari; Harish Chander Gugnani; Davide Guido; Rashid Abdi Guled; Brian J. Hall; Samer Hamidi; Demelash Woldeyohannes Handiso; Arief Hargono; Abdiwahab Hashi; Soheil Hassanipour; Hadi Hassankhani; Khezar Hayat; Claudiu Herteliu; Hagos Degefa de Hidru; Ramesh Holla; H. Dean Hosgood; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mowafa Househ; Bing-Fang Hwang; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Seyed Sina Naghibi Irvani; Chidozie C.D. Iwu; Chinwe Juliana Iwu; Ihoghosa Osamuyi Iyamu; Vardhmaan Jain; Mihajlo Jakovljevic; Farzad Jalilian; Ravi Prakash Jha; Kimberly B. Johnson; Vasna Joshua; Farahnaz Joukar; Jacek Jerzy Jozwiak; Ali Kabir; Leila R. Kalankesh; Rohollah Kalhor; Ashwin Kamath; Naser Kamyari; Tanuj Kanchan; Behzad Karami Matin; André Karch; Salah Eddin Karimi; Ayele Semachew Kasa; Getinet Kassahun; Gbenga A. Kayode; Ali Kazemi Karyani; Peter Njenga Keiyoro; Bayew Kelkay; Nauman Khalid; Gulfaraz Khan; Junaid Khan; Md Nuruzzaman Khan; Khaled Khatab; Salman Khazaei; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Sonali Kochhar; Jacek A. Kopec; Soewarta Kosen; Sindhura Koulmane Laxminarayana; Ai Koyanagi; Kewal Krishan; Barthelemy Kuate Defo; Nuworza Kugbey; Vaman Kulkarni; Manasi Kumar; Nithin Kumar; Om P. Kurmi; Dian Kusuma; Desmond Kuupiel; Hmwe Hmwe Kyu; Carlo La Vecchia; Dharmesh Kumar Lal; Jennifer O. Lam; Iván Landires; Savita Lasrado; Jeffrey V. Lazarus; Alice Lazzar-Atwood; Paul H. Lee; Cheru Tesema Leshargie; Bingyu Li; Xuefeng Liu; Platon D. Lopukhov; Hawraz Ibrahim M. Amin; Deepak Madi; Phetole Walter Mahasha; Azeem Majeed; Afshin Maleki; Shokofeh Maleki; Abdullah A. Mamun; Navid Manafi; Mohammad Ali Mansournia; Francisco Rogerlândio Martins-Melo; Seyedeh Zahra Masoumi; Benjamin K. Mayala; Birhanu Geta Meharie; Hailemariam Abiy Alemu Meheretu; Hagazi Gebre Meles; Mulugeta Melku; Walter Mendoza; Endalkachew Worku Mengesha; Tuomo J. Meretoja; Abera M. Mersha; Tomislav Mestrovic; Ted R. Miller; Andreea Mirica; Mehdi Mirzaei-Alavijeh; Osama Mohamad; Yousef Mohammad; Abdollah Mohammadian-Hafshejani; Jemal Abdu Mohammed; Salahuddin Mohammed; Shafiu Mohammed; Ali H. Mokdad; Taklu Marama Mokonnon; Mariam Molokhia; Masoud Moradi; Yousef Moradi; Rahmatollah Moradzadeh; Paula Moraga; Jonathan F. Mosser; Sandra B. Munro; Ghulam Mustafa; Saravanan Muthupandian; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Mohsen Naghavi; Muhammad Naveed; Vinod C. Nayak; Javad Nazari; Rawlance Ndejjo; Samata Nepal; Henok Biresaw Netsere; Frida N. Ngalesoni; Georges Nguefack-Tsague; Josephine W. Ngunjiri; Yeshambel T. Nigatu; Samuel Negash Nigussie; Chukwudi A. Nnaji; Jean Jacques Noubiap; Virginia Nuñez-Samudio; Bogdan Oancea; Oluwakemi Ololade Odukoya; Felix Akpojene Ogbo; Olanrewaju Oladimeji; Andrew T. Olagunju; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Muktar Omer Omer; Abidemi E. Emmanuel Omonisi; Obinna E. Onwujekwe; Orish Ebere Orisakwe; Nikita Otstavnov; Mayowa O. Owolabi; P.A. Mahesh; Jagadish Rao Padubidri; Smita Pakhale; Adrian Pana; Seithikurippu R. Pandi-Perumal; Urvish K. Patel; Mona Pathak; George C. Patton; Shrikant Pawar; Emmanuel K. Peprah; Khem Narayan Pokhrel; Maarten J. Postma; Faheem Hyder Pottoo; Hadi Pourjafar; Dimas Ria Angga Pribadi; Zahiruddin Quazi Syed; Alireza Rafiei; Fakher Rahim; Mohammad Hifz Ur Rahman; Amir Masoud Rahmani; Pradhum Ram; Juwel Rana; Chhabi Lal Ranabhat; Satish Rao; Sowmya J. Rao; Priya Rathi; David Laith Rawaf; Salman Rawaf; Reza Rawassizadeh; Vishnu Renjith; Melese Abate Reta; Nima Rezaei; Aziz Rezapour; Ana Isabel Ribeiro; Jennifer M. Ross; Susan Fred Rumisha; Rajesh Sagar; Maitreyi Sahu; S. Mohammad Sajadi; Marwa Rashad Salem; Abdallah M. Samy; Brijesh Sathian; Aletta Elisabeth Schutte; Abdul-Aziz Seidu; Feng Sha; Omid Shafaat; Mohammad Shahbaz; Masood Ali Shaikh; Mohammed Feyisso Shaka; Aziz Sheikh; Kenji Shibuya; Jae Il Shin; K.M. Shivakumar; Negussie Boti Sidemo; Jasvinder A. Singh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Amin Soheili; Shahin Soltani; Oluwaseyi Dolapo Somefun; Muluken Bekele Sorrie; Emma Elizabeth Spurlock; Mu'awiyyah Babale Sufiyan; Biruk Wogayehu Taddele; Eyayou Girma Tadesse; Zemenu Tamir; Animut Tagele Tamiru; Frank C. Tanser; Nuno Taveira; Arash Tehrani-Banihashemi; Yohannes Tekalegn; Fisaha Haile Tesfay; Belay Tessema; Zemenu Tadesse Tessema; Bhaskar Thakur; Musliu Adetola Tolani; Roman Topor-Madry; Marco Torrado; Marcos Roberto Tovani-Palone; Eugenio Traini; Alexander C. Tsai; Gebiyaw Wudie Tsegaye; Irfan Ullah; Saif Ullah; Chukwuma David Umeokonkwo; Bhaskaran Unnikrishnan; Constantine Vardavas; Francesco S. Violante; Bay Vo; Yohannes Dibaba Wado; Yasir Waheed; Richard G. Wamai; Yanzhong Wang; Paul Ward; Andrea Werdecker; Nuwan Darshana Wickramasinghe; Tissa Wijeratne; Charles Shey Wiysonge; Temesgen Gebeyehu Wondmeneh; Tomohide Yamada; Sanni Yaya; Yigizie Yeshaw; Yordanos Gizachew Yeshitila; Mekdes Tigistu Yilma; Paul Yip; Naohiro Yonemoto; Tewodros Yosef; Hasan Yusefzadeh; Syed Saoud Zaidi; Leila Zaki; Maryam Zamanian; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Dejene Tesfaye Zewdie; Yunquan Zhang; Zhi-Jiang Zhang; Arash Ziapour; Simon I. Hay; Laura Dwyer-Lindgren
Background: High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods: In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to estimate HIV prevalence at the second administrative level in 44 countries in sub-Saharan Africa for 2000–18 and sought data on the number of individuals on antiretroviral therapy (ART) by second-level administrative unit. We then modified the Estimation and Projection Package (EPP) to use these HIV prevalence and treatment estimates to estimate HIV incidence and mortality by second-level administrative unit. Findings: The estimates suggest substantial variation in HIV incidence and mortality rates both between and within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater difference in estimated HIV incidence between the second-level administrative units with the lowest and highest estimated incidence levels. Across all 44 countries in 2018, HIV incidence ranged from 2·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and HIV mortality ranged from 0·8 (0·7–0·9) in Mauritania to 676·5 (513·6–888·0) deaths per 100 000 people in Lesotho. Variation in both incidence and mortality was substantially greater at the subnational level than at the national level and the highest estimated rates were accordingly higher. Among second-level administrative units, Guijá District, Gaza Province, Mozambique, had the highest estimated HIV incidence (4661·7 [2544·8–8120·3]) cases per 100 000 people in 2018 and Inhassunge District, Zambezia Province, Mozambique, had the highest estimated HIV mortality rate (1163·0 [679·0–1866·8]) deaths per 100 000 people. Further, the rate of reduction in HIV incidence and mortality from 2000 to 2018, as well as the ratio of new infections to the number of people living with HIV was highly variable. Although most second-level administrative units had declines in the number of new cases (3316 [81·1%] of 4087 units) and number of deaths (3325 [81·4%]), nearly all appeared well short of the targeted 75% reduction in new cases and deaths between 2010 and 2020. Interpretation: Our estimates suggest that most second-level administrative units in sub-Saharan Africa are falling short of the targeted 75% reduction in new cases and deaths by 2020, which is further compounded by substantial within-country variability. These estimates will help decision makers and programme implementers expand access to ART and better target health resources to higher burden subnational areas. Funding: Bill & Melinda Gates Foundation. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990–2050
(Elsevier B.V., 2021) Angela E. Micah; Ian E. Cogswell; Brandon Cunningham; Satoshi Ezoe; Anton C. Harle; Emilie R. Maddison; Darrah McCracken; Shuhei Nomura; Kyle E. Simpson; Hayley N. Stutzman; Golsum Tsakalos; Lindsey E. Wallace; Yingxi Zhao; Rahul R. Zende; Cristiana Abbafati; Michael Abdelmasseh; Aidin Abedi; Kedir Hussein Abegaz; E.S. Abhilash; Hassan Abolhassani; Michael R.M. Abrigo; Tara Ballav Adhikari; Saira Afzal; Bright Opoku Ahinkorah; Sepideh Ahmadi; Haroon Ahmed; Muktar Beshir Ahmed; Tarik Ahmed Rashid; Marjan Ajami; Budi Aji; Yonas Akalu; Chisom Joyqueenet Akunna; Hanadi Al Hamad; Khurshid Alam; Fahad Mashhour Alanezi; Turki M. Alanzi; Yosef Alemayehu; Robert Kaba Alhassan; Cyrus Alinia; Syed Mohamed Aljunid; Sami Almustanyir Almustanyir; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Saeed Amini; Mostafa Amini-Rarani; Hubert Amu; Robert Ancuceanu; Catalina Liliana Andrei; Tudorel Andrei; Blake Angell; Mina Anjomshoa; Carl Abelardo T. Antonio; Catherine M. Antony; Muhammad Aqeel; Jalal Arabloo; Morteza Arab-Zozani; Timur Aripov; Alessandro Arrigo; Tahira Ashraf; Desta Debalkie Atnafu; Marcel Ausloos; Leticia Avila-Burgos; Asma Tahir Awan; Getinet Ayano; Martin Amogre Ayanore; Samad Azari; Gulrez Shah Azhar; Tesleem Kayode Babalola; Mohammad Amin Bahrami; Atif Amin Baig; Maciej Banach; Nastaran Barati; Till Winfried Bärnighausen; Amadou Barrow; Sanjay Basu; Bernhard T. Baune; Mohsen Bayati; Habib Benzian; Adam E. Berman; Akshaya Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Sonu Bhaskar; Sadia Bibi; Ali Bijani; Virginia Bodolica; Nicola Luigi Bragazzi; Dejana Braithwaite; Nicholas J.K. Breitborde; Alexey V. Breusov; Nikolay Ivanovich Briko; Reinhard Busse; Lucero Cahuana-Hurtado; Emily Joy Callander; Luis Alberto Cámera; Carlos A. Castañeda-Orjuela; Ferrán Catalá-López; Jaykaran Charan; Souranshu Chatterjee; Soosanna Kumary Chattu; Vijay Kumar Chattu; Simiao Chen; Arrigo Francesco Giuseppe Cicero; Omid Dadras; Saad M.A. Dahlawi; Xiaochen Dai; Koustuv Dalal; Lalit Dandona; Rakhi Dandona; Dragos Virgil Davitoiu; Jan-Walter De Neve; Antonio Reis de Sá; Edgar Denova-Gutiérrez; Deepak Dhamnetiya; Samath Dhamminda Dharmaratne; Leila Doshmangir; John Dube; Elham Ehsani-Chimeh; Maysaa El Sayed Zaki; Maha El Tantawi; Sharareh Eskandarieh; Farshad Farzadfar; Tomas Y. Ferede; Florian Fischer; Nataliya A. Foigt; Alberto Freitas; Sara D. Friedman; Takeshi Fukumoto; Nancy Fullman; Peter Andras Gaal; Mohamed M. Gad; M.A. Garcia-Gordillo; Tushar Garg; Mansour Ghafourifard; Ahmad Ghashghaee; Asadollah Gholamian; Ali Gholamrezanezhad; Ghozali Ghozali; Syed Amir Gilani; Ionela-Roxana Glãvan; Ekaterina Vladimirovna Glushkova; Salime Goharinezhad; Mahaveer Golechha; Srinivas Goli; Avirup Guha; Veer Bala Gupta; Vivek Kumar Gupta; Annie Haakenstad; Mohammad Rifat Haider; Alemayehu Hailu; Samer Hamidi; Asif Hanif; Harapan Harapan; Risky Kusuma Hartono; Ahmed I. Hasaballah; Shoaib Hassan; Mohamed H. Hassanein; Khezar Hayat; Mohamed I. Hegazy; Golnaz Heidari; Delia Hendrie; Ileana Heredia-Pi; Claudiu Herteliu; Kamal Hezam; Ramesh Holla; Sheikh Jamal Hossain; Mehdi Hosseinzadeh; Sorin Hostiuc; Tanvir M. Huda; Bing-Fang Hwang; Ivo Iavicoli; Bulat Idrisov; Olayinka Stephen Ilesanmi; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Nahlah Elkudssiah Ismail; Gaetano Isola; Mohammad Ali Jahani; Nader Jahanmehr; Mihajlo Jakovljevic; Manthan Dilipkumar Janodia; Tahereh Javaheri; Sathish Kumar Jayapal; Ranil Jayawardena; Seyed Behzad Jazayeri; Ravi Prakash Jha; Jost B. Jonas; Tamas Joo; Farahnaz Joukar; Mikk Jürisson; Billingsley Kaambwa; Rohollah Kalhor; Tanuj Kanchan; Himal Kandel; Behzad Karami Matin; Salah Eddin Karimi; Getinet Kassahun; Gbenga A. Kayode; Ali Kazemi Karyani; Leila Keikavoosi-Arani; Yousef Saleh Khader; Himanshu Khajuria; Rovshan Khalilov; Mohammad Khammarnia; Junaid Khan; Jagdish Khubchandani; Neda Kianipour; Gyu Ri Kim; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Stefan Kohler; Soewarta Kosen; Rajasekaran Koteeswaran; Sindhura Lakshmi Koulmane Laxminarayana; Ai Koyanagi; Kewal Krishan; G. Anil Kumar; Dian Kusuma; Demetris Lamnisos; Van Charles Lansingh; Anders O. Larsson; Savita Lasrado; Long Khanh Dao Le; Shaun Wen Huey Lee; Yeong Yeh Lee; Stephen S. Lim; Stany W. Lobo; Rafael Lozano; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; Mokhtar Mahdavi Mahdavi; Azeem Majeed; Alaa Makki; Afshin Maleki; Reza Malekzadeh; Ana Laura Manda; Fariborz Mansour-Ghanaei; Mohammad Ali Mansournia; Carlos Alberto Marrugo Arnedo; Adolfo Martinez-Valle; Seyedeh Zahra Masoumi; Richard James Maude; Martin McKee; Carlo Eduardo Medina-Solís; Ritesh G. Menezes; Atte Meretoja; Tuomo J. Meretoja; Mohamed Kamal Mesregah; Tomislav Mestrovic; Neda Milevska Kostova; Ted R. Miller; G.K. Mini; Andreea Mirica; Erkin M. Mirrakhimov; Bahram Mohajer; Teroj Abdulrahman Mohamed; Mokhtar Mohammadi; Abdollah Mohammadian-Hafshejani; Shafiu Mohammed; Modhurima Moitra; Ali H. Mokdad; Mariam Molokhia; Mohammad Ali Moni; Yousef Moradi; Jakub Morze; Seyyed Meysam Mousavi; Christine Mpundu-Kaambwa; Moses K. Muriithi; Saravanan Muthupandian; Ahamarshan Jayaraman Nagarajan; Mukhammad David Naimzada; Vinay Nangia; Atta Abbas Naqvi; Aparna Ichalangod Narayana; Bruno Ramos Nascimento; Muhammad Naveed; Biswa Prakash Nayak; Javad Nazari; Rawlance Ndejjo; Ionut Negoi; Sandhya Neupane Kandel; Trang Huyen Nguyen; Justice Nonvignon; Jean Jacques Noubiap; Vincent Ebuka Nwatah; Bogdan Oancea; Foluke Adetola Ogunyemi Ojelabi; Andrew T. Olagunju; Babayemi Oluwaseun Olakunde; Stefano Olgiati; Jacob Olusegun Olusanya; Obinna E. Onwujekwe; Adrian Otoiu; Nikita Otstavnov; Stanislav S. Otstavnov; Mayowa O. Owolabi; Jagadish Rao Padubidri; Raffaele Palladino; Songhomitra Panda-Jonas; Eun-Cheol Park; Fatemeh Pashazadeh Kan; Shrikant Pawar; Hamidreza Pazoki Toroudi; David M. Pereira; Arokiasamy Perianayagam; Konrad Pesudovs; Cristiano Piccinelli; Maarten J. Postma; Sergio I. Prada; Mohammad Rabiee; Navid Rabiee; Fakher Rahim; Vafa Rahimi-Movaghar; Mohammad Hifz Ur Rahman; Mosiur Rahman; Amir Masoud Rahmani; Usha Ram; Chhabi Lal Ranabhat; Priyanga Ranasinghe; Chythra R. Rao; Priya Rathi; David Laith Rawaf; Salman Rawaf; Lal Rawal; Reza Rawassizadeh; Robert C. Reiner; Andre M.N. Renzaho; Bhageerathy Reshmi; Mavra A. Riaz; Rezaul Karim Ripon; Anas M. Saad; Mohammad Ali Sahraian; Maitreyi Sahu; Joseph S. Salama; Sana Salehi; Abdallah M. Samy; Juan Sanabria; Francesco Sanmarchi; Joao Vasco Santos; Milena M. Santric-Milicevic; Brijesh Sathian; Miloje Savic; Deepak Saxena; Mehdi Sayyah; Falk Schwendicke; Subramanian Senthilkumaran; Sadaf G. Sepanlou; Allen Seylani; Saeed Shahabi; Masood Ali Shaikh; Aziz Sheikh; Adithi Shetty; Pavanchand H. Shetty; Kenji Shibuya; Mark G. Shrime; Kanwar Hamza Shuja; Jasvinder A. Singh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Shahin Soltani; Moslem Soofi; Emma Elizabeth Spurlock; Simona Cǎtǎlina Stefan; Viktoria Szerencses; Miklos Szocska; Rafael Tabares-Seisdedos; Biruk Wogayehu Taddele; Yonas Getaye Tefera; Aravind Thavamani; Ruoyan Tobe-Gai; Roman Topor-Madry; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Lorainne Tudor Car; Anayat Ullah; Saif Ullah; Nasir Umar; Eduardo A. Undurraga; Pascual R. Valdez; Tommi Juhani Vasankari; Jorge Hugo Villafane; Francesco S. Violante; Vasily Vlassov; Bay Vo; Sebastian Vollmer; Theo Vos; Giang Thu Vu; Linh Gia Vu; Richard G. Wamai; Andrea Werdecker; Mesfin Agachew Woldekidan; Befikadu Legesse Wubishet; Gelin Xu; Sanni Yaya; Vahid Yazdi-Feyzabadi; Vahit Yiǧit; Paul Yip; Birhanu Wubale Yirdaw; Naohiro Yonemoto; Mustafa Z. Younis; Chuanhua Yu; Ismaeel Yunusa; Telma Zahirian Moghadam; Hamed Zandian; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Zhi-Jiang Zhang; Arash Ziapour; Yves Miel H. Zuniga; Simon I. Hay; Christopher J.L. Murray; Joseph L. Dieleman
Background: The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods: We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$ per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings: In 2019, health spending globally reached $8·8 trillion (95% uncertainty interval [UI] 8·7–8·8) or $1132 (1119–1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total, $40·4 billion (0·5%, 95% UI 0·5–0·5) was development assistance for health provided to low-income and middle-income countries, which made up 24·6% (UI 24·0–25·1) of total spending in low-income countries. We estimate that $54·8 billion in development assistance for health was disbursed in 2020. Of this, $13·7 billion was targeted toward the COVID-19 health response. $12·3 billion was newly committed and $1·4 billion was repurposed from existing health projects. $3·1 billion (22·4%) of the funds focused on country-level coordination and $2·4 billion (17·9%) was for supply chain and logistics. Only $714·4 million (7·7%) of COVID-19 development assistance for health went to Latin America, despite this region reporting 34·3% of total recorded COVID-19 deaths in low-income or middle-income countries in 2020. Spending on health is expected to rise to $1519 (1448–1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation: Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Funding: Bill & Melinda Gates Foundation. © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Use of multidimensional item response theory methods for dementia prevalence prediction: an example using the Health and Retirement Survey and the Aging, Demographics, and Memory Study
(BioMed Central Ltd, 2021) Emma Nichols; Foad Abd-Allah; Amir Abdoli; Ahmed Abualhasan; Eman Abu-Gharbieh; Ashkan Afshin; Rufus Olusola Akinyemi; Fahad Mashhour Alanezi; Vahid Alipour; Amir Almasi-Hashiani; Jalal Arabloo; Amir Ashraf-Ganjouei; Getinet Ayano; Jose L. Ayuso-Mateos; Atif Amin Baig; Maciej Banach; Miguel A. Barboza; Suzanne Lyn Barker-Collo; Bernhard T. Baune; Akshaya Srikanth Bhagavathula; Krittika Bhattacharyya; Ali Bijani; Atanu Biswas; Archith Boloor; Carol Brayne; Hermann Brenner; Katrin Burkart; Sharath Burugina Nagaraja; Felix Carvalho; Luis F. S. Castro-De-Araujo; Ferrán Catalá-López; Ester Cerin; Nicolas Cherbuin; Dinh-Toi Chu; Xiaochen Dai; Antonio Reis de Sá-Junior; Shirin Djalalinia; Abdel Douiri; David Edvardsson; Shaimaa I. El-Jaafary; Sharareh Eskandarieh; Andre Faro; Farshad Farzadfar; Valery L. Feigin; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Irina Filip; Florian Fischer; Shilpa Gaidhane; Lucia Galluzzo; Gebreamlak Gebremedhn Gebremeskel; Ahmad Ghashghaee; Alessandro Gialluisi; Elena V. Gnedovskaya; Mahaveer Golechha; Rajeev Gupta; Vladimir Hachinski; Mohammad Rifat Haider; Teklehaimanot Gereziher Haile; Mohammad Hamiduzzaman; Graeme J. Hankey; Simon I. Hay; Golnaz Heidari; Reza Heidari-Soureshjani; Hung Chak Ho; Mowafa Househ; Bing-Fang Hwang; Licia Iacoviello; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Seyed Sina Naghibi Irvani; Masao Iwagami; Ihoghosa Osamuyi Iyamu; Ravi Prakash Jha; Rizwan Kalani; André Karch; Ayele Semachew Kasa; Yousef Saleh Khader; Ejaz Ahmad Khan; Mahalaqua Nazli Khatib; Yun Jin Kim; Sezer Kisa; Adnan Kisa; Mika Kivimäki; Ai Koyanagi; Manasi Kumar; Iván Landires; Savita Lasrado; Bingyu Li; Stephen S. Lim; Xuefeng Liu; Shilpashree Madhava Kunjathur; Azeem Majeed; Preeti Malik; Man Mohan Mehndiratta; Ritesh G. Menezes; Yousef Mohammad; Salahuddin Mohammed; Ali H. Mokdad; Mohammad Ali Moni; Gabriele Nagel; Muhammad Naveed; Vinod C. Nayak; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Virginia Nunez-Samudio; Andrew T. Olagunju; Samuel M. Ostroff; Nikita Otstavnov; Mayowa O. Owolabi; Fatemeh Pashazadeh Kan; Urvish K. Patel; Michael R. Phillips; Michael A. Piradov; Constance Dimity Pond; Faheem Hyder Pottoo; Sergio I. Prada; Amir Radfar; Fakher Rahim; Juwel Rana; Vahid Rashedi; Salman Rawaf; David Laith Rawaf; Nickolas Reinig; Andre M N. Renzaho; Nima Rezaei; Aziz Rezapour; Michele Romoli; Gholamreza Roshandel; Perminder S. Sachdev; Amirhossein Sahebkar; Mohammad Ali Sahraian; Mehrnoosh Samaei; Mete Saylan; Feng Sha; Masood Ali Shaikh; Kenji Shibuya; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Diego Augusto Santos Silva; Jasvinder A. Singh; Deepika Singhal; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Amin Soheili; Houman Sotoudeh; Emma Elizabeth Spurlock; Cassandra E I. Szoeke; Rafael Tabarés-Seisdedos; Biruk Wogayehu Taddele; Marcos Roberto Tovani-Palone; Gebiyaw Wudie Tsegaye; Marco Vacante; Narayanaswamy Venketasubramanian; Simone Vidale; Vasily Vlassov; Giang Thu Vu; Yuan-Pang Wang; Jordan Weiss; Abrha Hailay Weldemariam; Ronny Westerman; Anders Wimo; Andrea Sylvia Winkler; Chenkai Wu; Ali Yadollahpour; Metin Yesiltepe; Naohiro Yonemoto; Chuanhua Yu; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Zhi-Jiang Zhang; Christopher J. L. Murray; Theo Vos
Background: Data sparsity is a major limitation to estimating national and global dementia burden. Surveys with full diagnostic evaluations of dementia prevalence are prohibitively resource-intensive in many settings. However, validation samples from nationally representative surveys allow for the development of algorithms for the prediction of dementia prevalence nationally. Methods: Using cognitive testing data and data on functional limitations from Wave A (2001–2003) of the ADAMS study (n = 744) and the 2000 wave of the HRS study (n = 6358) we estimated a two-dimensional item response theory model to calculate cognition and function scores for all individuals over 70. Based on diagnostic information from the formal clinical adjudication in ADAMS, we fit a logistic regression model for the classification of dementia status using cognition and function scores and applied this algorithm to the full HRS sample to calculate dementia prevalence by age and sex. Results: Our algorithm had a cross-validated predictive accuracy of 88% (86–90), and an area under the curve of 0.97 (0.97–0.98) in ADAMS. Prevalence was higher in females than males and increased over age, with a prevalence of 4% (3–4) in individuals 70–79, 11% (9–12) in individuals 80–89 years old, and 28% (22–35) in those 90 and older. Conclusions: Our model had similar or better accuracy as compared to previously reviewed algorithms for the prediction of dementia prevalence in HRS, while utilizing more flexible methods. These methods could be more easily generalized and utilized to estimate dementia prevalence in other national surveys. © 2021, The Author(s).