Browsing by Author "Namra Aziz"

Now showing 1 - 3 of 3

Comprehensive Review on Cervical Cancer: Global Health Burden
(Bentham Science Publishers, 2025) Namra Aziz; Vikrant Abbot; Aishwarya Bajpai; Wal Pranay; Ankita Wal; Rakesh Verma; Mukesh Chandra Sharma
Cervical cancer is one of the four most common cancers that affect women worldwide, along with breast, colorectal, lung, and cervical cancer. It is a major public health concern that mostly affects women. Virtually all cases of cervical cancer are linked to human papillomavirus (HPV) infections. Patients must be screened and immunized to prevent this disease, although developed and developing nations have different rates of cervical cancer incidence. Palliative chemotherapy continues to be the go-to therapy for patients who are not candidates for radiation therapy or curative surgery. To counteract chemotherapy's low effectiveness, other treatment approaches are being developed. The main goals of this review study are to advance knowledge of cervical cancer, promote awareness and educated decision-making, and investigate cutting-edge approaches to the disease's treatment. A literature review was done from databases like Google Scholar, PUBMED-MEDLINE, and Scopus using standard keywords “Cancer,” “Cervical Cancer,” “Human papillomavirus,” “Chemotherapy,” and “Treatment Therapies” from 2010-2023. The Government of India intends to initiate a three-phase vaccination drive against Human Papillomavirus (HPV) for girls aged 9-14, aiming to mitigate the risk of cervical cancer. The vaccine also offers protection against the HPV strains that cause cancer of the anus, vagina, and oropharynx. Although cervical cancer is still a tough foe, we are getting closer to a time when it may be prevented and treated, even in the most underprivileged areas, due to continuous advancements and steadfast dedication. © 2025 Bentham Science Publishers.
Mechanistic Approach to Ferroptosis in Cancer and Neurological Diseases
(Bentham Science Publishers, 2025) Wal Pranay; Abhijeet Singh Jadaun; Rakesh Chandra Verma; Renuka Jyothi-S; Sunil Kumar Dwivedi; Kunal Sharad Surwade; Namra Aziz
Ferroptosis is a form of oxidative, iron-dependent, non-apoptotic cell death characterized by the accumulation of lipid peroxides and the depletion of glutathione. Ferroptosis plays a significant role in human cancer and is essential in neurological disorders, including neurodegeneration, stroke, and neurotrauma. One of the key challenges in cancer research is how to effectively kill cancer cells while leaving healthy cells intact. Cancer cells often have defects in cell death executioner mechanisms, which is one of the main reasons for therapy resistance. To enable growth, cancer cells exhibit an increased iron demand compared with normal, non-cancer cells. This iron dependency can make cancer cells more vulnerable to iron-catalyzed necrosis, referred to as ferroptosis. It is a newly identified regulated form of cell death, which is thought to play a major role in neurodegenerative diseases. The mechanisms of ferroptosis in several neurological disorders are discussed in detail in this article. It also provides an overview of emerging medications that target ferroptosis in the treatment of neurological disorders. It also highlights the variations and connections between the different cell death pathways implicated in neurological disorders. Clarifying the function of ferroptosis in the brain will help us better understand the mechanisms behind neurological disorders and offer possible strategies for both acute and long-term neurological illness prevention and therapy. Consequently, we provide an overview and brief description of the main pathways involved in ferroptosis in this review, focusing on its regulation and its dual roles as a tumor suppressor and an oncogenic process in various human malignancies. The identification of FDA-approved drugs as ferroptosis inducers has raised high expectations for ferroptosis as a promising new approach to killing therapy-resistant cancers. 2025, Bentham Science Publishers
Pharmacological Evaluation of the Combination Therapy of Novel Herbal Mixture in Polycystic Ovary Syndrome
(Bentham Science Publishers, 2025) Chandana Pyne; Chandra Sekhar Barik; Rakesh Chandra Verma; Rajendra Dnyandeo Dighe; Namra Aziz; Mohd Imran Ansari; Wal Pranay; Amin Gasmi
Introduction: An endocrine condition known as Poly-Cystic Ovarian Syndrome (PCOS) makes females of reproductive age more susceptible to insulin resistance, excessive levels of male hormones, and delayed ovulation. It is the main reason that stimulates infertility in females during their reproductive years. Thus, the objective of the present research is to determine whether oleo-gum resins derived from Boswellia serrata and Commiphora myrrh could be beneficial in the treatment of PCOS using a female animal model (Wistar rats) that were administered 1 mg/ kg of letrozole for induction of the disease. Methods: A combination therapy of Boswellia serrata and Commiphora myrrh was used to study its effect on rat models administered letrozole (1 mg/kg), employed to induce PCOS. OECD Guidelines 407 and 423 were followed for toxicity studies. Results: It was revealed that the polyherbal mixture is nontoxic and safe to use, according to the results. Furthermore, studies have investigated the potential of a combination of oleo-gum resins in the treatment of letrozole-induced PCOS using animal models. According to the information gathered, it was found that the prepared herbal mixture significantly affected the letrozole-induced PCOS rat models. Additionally, it seems to have potential benefits for PCOS-related hormonal and reproductive disorders. Conclusion: The polyherbal mixture was considered safe for consumption at a dose concentration of under 2000 mg/ kg and can be used for an extended period. Additionally, the polyherbal mixture improved the outcome of the therapy of PCOS in rat models administered with letrozole (1 mg/ kg) employed to induce PCOS. Bentham Science Publishers