Browsing by Author "Namrata Dwivedi"

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Bacopa monnieri and neural health: An Indian herb
(Bentham Science Publishers, 2023) Prachi Pattnaik; Chetan Panda; Tarun Minocha; Sanjeev Kumar Yadav; Namrata Dwivedi; Sandeep Kumar Singh
The disorders of the central nervous system are increasingly recognized as one of the most prevalent disorders in the present world. It has been envisaged that neurological disorders will be of great concern in the present and future populations worldwide. The different neurological disorders may be associated with signs, such as loss of memory, impaired brain function, cognitive deficits, etc. The occurrence of such degenerative diseases of the nervous system certainly imposes medical and public health burdens on populations worldwide. The multifactorial nature of such neural disorders entails the use of modern medicine in combination with conventional medicines for treatment. There has been undeniably a revolution in the foundation of existing medical facilities, which have been strengthened by the amalgamation of phytomedicine. In recent times, the use of medicinal herbs to improve mental function has come into the limelight in both developed and developing countries. Increased research is being carried out to discover Ayurvedic medications owing to their biosafety profile and utility in cognitive impairment. The current chapter deals with the depiction of one such plant, that is Bacopa monnieri, which possesses neuroprotective properties, and is considered to be Medhya Rasayana (a nootropic drug). This Indian herb, being a dietary anti-oxidant, has several modes of action to protect the brain against oxidative damage and age-related issues. A majority of the plant compounds, such as polyphenols, alkaloids, and terpenes, present in medicinal plants, have been known to have therapeutic properties against neurodegeneration mainly by virtue of their antioxidant, anti-inflammatory, and anti-amyloidogenic effects. © 2023 Bentham Science Publishers. All rights reserved.
Epigenetic drugs based on antiaging approach: an overview
(Elsevier, 2022) Tarun Minocha; Namrata Dwivedi; Chetan Panda; Anamika Misra; Barsha Baisakhi Nayak; Sanjeev Kumar Yadav; Hareram Birla; Sandeep Kumar Singh
Aging is a natural physiological process that takes place during the course of life in all living beings. It is the main culprit in the growth and development of several chronic diseases because of changes or gradual decline of normal physiological functions. Several reports revealed that the epigenetic changes foisted and established a great impact on the aging process. Indeed, aging associated with epigenetic dysregulations imposes serious health concerns for various human pathologies including metabolic diseases, cardiovascular diseases, cancer, neurological and psychological disorders. During the last few decades, a variety of natural and synthetic drugs are being employed for various therapeutic applications because of antiaging attributes; however, the results are still unsatisfactory. Therefore, nowadays, epigenetic drugs-based therapy has emerged as a possible and crucial approach for the treatment of several diseases associated with aging. In a nutshell, this chapter epitomes the role of epigenetic drugs that not only targets epigenetic pathways involved in a myriad of pathologies but also improves the lifespan of patients. © 2022 Elsevier Inc. All rights reserved.
Fighting tuberculosis: An old disease new challenges
(2005) Rama P. Tripathi; Neetu Tewari; Namrata Dwivedi; Vinod K. Tiwari
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a leading cause of mortality worldwide into 21st century. The mortality and spread of this disease has further been aggravated because of synergy of this disease with HIV. A number of anti-TB drugs are ineffective against this disease because of development of resistance strains. Internationally efforts are being made to develop new anti-tubercular agents. A number of drug targets from cell wall biosynthesis, nucleic acid biosynthesis, and many other biosynthetic pathways are being unraveled throughout the world and are being utilized for drug development. In this review, socioeconomic problems in developing countries, efforts to control this disease in different individuals, the targets (known already and newly discovered), existing anti-tubercular agents including natural products and lead molecules, and the future prospects to develop new anti-TB agents are described. © 2004 Wiley Periodicals, Inc.