Browsing by Author "Narendra Kumar Bagri"

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Chédiak-higashi syndrome: A case report
(2013) Shashikant C. U. Patne; Sandip Kumar; Narendra Kumar Bagri; Ashok Kumar; Jyoti Shukla
Chédiak-Higashi syndrome (CHS) is an extremely rare autosomal recessive immunodeficiency disorder. Approximately 200 cases have been reported worldwide. To the best of our knowledge, not more than 10 cases have been reported from India. Herein we are reporting a case of CHS in one-and-half-year-old boy who presented to us in the accelerated phase of disease. Other syndromes presenting with similar clinical features have also been discussed. © 2012 Indian Society of Haematology & Transfusion Medicine.
Neonatal endogenous endophthalmitis: A report of six cases
(2013) Sriparna Basu; Ashok Kumar; Kanika Kapoor; Narendra Kumar Bagri; Abhishek Chandra
Endogenous endophthalmitis is a rare but potentially blinding complication of neonatal sepsis. Early diagnosis and aggressive treatment are essential to avoid vision loss. Therapeutic options include systemic and intravitreal antibiotics, as well as vitrectomy in selected cases. We report a series of 6 premature very low birth weight neonates who developed endogenous endophthalmitis in our NICU over the past 3 years. Endophthalmitis was part of early-onset sepsis in 2 newborns, both of whom died, and late-onset sepsis in 4 newborns, of which 1 infant died. None of the neonates had any history of previous trauma or intervention to the eye. Maternal screening for congenital infections, including HIV, was negative in all. Causative organisms included Klebsiella pneumoniae (2 cases), Pseudomonas aeruginosa (2 cases), Methicillin-resistant Staphylococcus aureus (1 case), and Candida albicans (1 case). All bacterial isolates showed resistance to first-line antibiotics. Of the 3 survivors, 2 infants had normal vision in the affected eye, and 1 developed phthisis bulbi after corneal perforation and required enucleation. This report draws attention to the emergence of endophthalmitis as a complication of neonatal sepsis in places where, although survival of very low birth weight newborns has increased significantly due to improved care, the burden of infection continues to be high. We emphasize the importance of daily examination of eyes as a part of routine clinical care in septic new-borns for early diagnosis of endophthalmitis and prompt intervention in consultation with an ophthalmologist to optimize the outcome. Copyright © 2013 by the American Academy of Pediatrics.
Palatal perforation due to late congenital syphilis
(Springer India, 2014) Narendra Kumar Bagri; Vineeta Gupta
[No abstract available]
Tubercular abscess of pons in a child with quadriparesis
(BMJ Publishing Group, 2010) Rajniti Prasad; Narendra Kumar Bagri; Neha Bagri; Utpal Kant Singh; Om Prakash Mishra
Tuberculous brain abscess is a rare manifestation of tuberculosis of the central nervous system. We report a case of a 6-year-old girl with a pontine tuberculous abscess, who presented with fever and quadriparesis and recovered completely after stereotactic aspiration and antituberculous treatment with four drugs (isoniazid, rifampicin, pyrazinamide, and ethambutol). Tuberculous abscess was confirmed based on findings of magnetic resonance imaging, a positive tuberculin test, and the presence of acid fast bacilli in smear and culture of abscess aspirate.
Zinc supplementation for neonatal hyperbilirubinemia: A randomized controlled trial
(Springer India, 2014) Ashok Kumar; Narendra Kumar Bagri; Sriparna Basu; Ravi Kumar Asthana
Objectives: To determine the efficacy of oral zinc for treatment of idiopathic neonatal hyperbilirubinemia in near-term and term (35-41 weeks) neonates. Design: Randomized placebo-controlled trial. Setting: Tertiary-care teaching hospital Participants: Eighty newborns with idiopathic neonatal hyperbilirubinemia. Intervention: Neonates were randomized to receive either oral zinc sulfate (10 mg/d) or placebo for 7 days. Main outcome measures: Primary: total serum bilirubin levels at 48 (±12) h, 96 (±12) h and 144 (±12) h after intervention. Secondary: duration of phototherapy, and serum zinc and copper levels. Results: Baseline mean (SD) total serum bilirubin levels were 14.8 (3.8) and 14.4 (3.5) mg/dL in zinc and placebo groups, respectively. No significant differences were observed in total bilirubin levels between the two groups after the intervention. Mean (SD) total serum bilirubin levels in zinc and placebo groups were 13.9 (2.5) vs. 13.4 (1.9) mg/dL (mean difference 0.566; 95% CI -0.535, 1.668, P=0.038) at 48 h, 13.1 (2.7) vs. 12.8 (2.3) mg/dL (mean difference 0.234; 95% CI -1.011, 1.479, P =0.708) at 96 h and 8.0 (2.0) vs. 8.6 (1.2) mg/dL (mean difference -0.569, 95% CI -1.382, 0.242, P=0.166) at 144 h. Although the mean duration of phototherapy in the zinc group was less by 21.3 h (95% CI 11.6, 30.9, P=0.052), the difference was not significant. Postintervention, serum zinc levels were significantly higher in the zinc-supplemented group while serum copper levels were comparable between the two groups. Conclusions: Oral zinc sulfate, in a dose of 10 mg/day, is not effective in the management of idiopathic neonatal hyperbilirubinemia. © 2014 Indian Academy of Pediatrics.