Browsing by Author "Narendra Kumar Pandey"

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Concept and role of immunomodulatory medicinal plants used in Ayurvedic health care system
(EnPress Publisher, LLC, 2024) Sachin; Vineet Kumar; Mohit Sharma; Vaishnavi; Priyanka Chaudhary; Saurabh Singh; Kalvatala Sudhakar; Bimlesh Kumar; Narendra Kumar Pandey; Sachin Kumar Singh; Anand Kumar Choudhary; Dileep Singh Baghel
The statement "prevention is better than cure" and its applications is not a new for Ayurvedic health care system. The statement defines the aim and objectives of Ayurvedic health care system in a nutshell "swasthasya swasthya rakshanam aaturasya vikara prashamanam". The immune system is certainly considered one of our most discreet biological systems withinside the body. Immunizations may be obtained by us actively or passively. Active immunization includes stimulating with an antigen to generate immunological defenses against a destiny exposure, rather than passive vaccination, which includes administering antibodies to someone who has already been exposed to an antigen. Both plant and animal sources produce immunomodulatory effects to boost the body’s immunological reactivity against infections by engaging the non-specific immune system. Herbal immunomodulators are substances that either activate or suppress innate and adaptive immune responses in the body. Different ailments including allergies, asthma, rheumatoid arthritis, cancer, and other infectious disorders are caused by immune system failure. Therefore, regulating the many infectious illnesses requires significant immune response modification. Global scientific study is currently focused on how various medicinal plant components might alter the immune system. Numerous Indian and "Rasayana" and medicinal plants may have immunomodulatory characteristics. Some of these plants are Tinospora cordifolia, Morus alba, Acacia catechu, Allium sativum, and Mangifera indica. There are many more that are still undiscovered and offer space for greater study. © 2024 by author(s).
Development of V2O5@GO (1D/2D) nanohybrid based chemiresistor for low-trace of toluene
(Elsevier B.V., 2024) Shivangi Srivastava; Ajeet Singh; Mohammad A. Sahz; Bal Chandra Yadav; Narendra Kumar Pandey
A room temperature operated V2O5 nanorods-decorated graphene oxide (GO) nanosheets-nanocomposite based chemiresistor has been fabricated for detecting low-trace of toluene (5–60 ppm). The V2O5 nanorods were grown on GO nanosheets via hydrothermal method. The surface morphological investigation done by SEM and confirmed the decoration of V2O5 nanorods on GO nanosheets. The Rietveld refinement was performed for structural analysis of V2O5 nanorods confirmed the orthorhombic phase structure. At lowest concentration of 5 ppm, the sensor response of V2O5 @GO nanohybrid was 4.90 which was 2.84 and 3.52 times higher than pure GO and V2O5, respectively. The rapid response and recovery time at 5 ppm were observed to be 4.18 s and 5.86 s, respectively. The decoration of V2O5 nanorods on GO nanosheets increased the activated sites and formed p-n heterojunction, resulting in the enhanced sensing performance. The sensor response for the maximum concentration of 60 ppm was 36.25. Also, the V2O5@GO chemiresistor demonstrated high long-term stability and selectivity towards toluene as compared to other interfering volatile organic compounds such as, methanol, ethanol, aniline, formaldehyde, benzene, and acetone. This work opens a novel window for the development of devices that are room temperature operatable, highly sensitive and selective for rapid detection of toluene gas for its commercialization. © 2023 Elsevier B.V.
Ethnopharmacological, Phytochemical, and Toxicological Characteristics of Dactylorhiza hatagirea: A Synoptic Overview
(CRC Press, 2025) Baburam Pokhrel; Saurabh Singh; Narendra Kumar Pandey; Bimlesh Kumar; Anand Kumar Chaudhary; Saumya Das; Rupa Mazumder; Avijit Mazumder; Shruti Sharma; Kardam Joshi; Dhara Patel; Dileep Singh Baghel
Salampunja; Ayurvedic name: Munjataka (Dactylorhiza hatagirea syn. Orchis hatagirea or Orchis latifolia.; Family: Orchidaceae conventional therapeutic plant, commonly prescribed for the treatment of various pathophysiological conditions in ASU (Ayurveda, Siddha, and Unani) system of medicine in India. Plant parts such as tubers and roots have been reported for their therapeutic potential. It helps to cure Pravahika (dysentery), Atisara (diarrhea), Jwara (fever), kasa (cough), Ajirna (indigestion or upset stomach), Vrana (wounds), Agnidagdha (burns), Khanda Bhagna or Asthi Bhagna (fractures), Medhya (nervine tonic), and Vajikarana or Vrishya chikitsa (aphrodisiac). Moreover, it has also shown remarkable efficacy against Gram-positive and Gram-negative bacteria and their associated illness. The principal phytochemicals in D. hatagirea are alkaloids, glycosides, phenolic compounds, carbohydrates, flavonoids, saponins, starch, gum, and mucilage. However, further clinical studies will still be needed to confirm the plant’s safety and effectiveness in humans. The toxicological results from clinical studies provided assurance of the plant’s safety. The objective of this chapter is to present current knowledge on Dactylorhiza hatagirea, including its ethnomedicinal, phytochemical, pharmacological, and toxicological characteristics. © 2026 selection and editorial matter, Jashanpreet Singh, Hitesh Vasudev, Chander Prakash, and Manpreet Singh individual chapters, the contributors.
Formulation and standardization of fermented biomedicines kutajarishta
(American Institute of Physics, 2025) Rohit Garga; Bimlesh Kumar; Narendra Kumar Pandey; Saurabh Singh; Anand Kumar Chaudhary; Amrik Singh; Rupa Mazumder; Avijit Mazumder; Amit Mittal; Dileep Singh Baghel
Ayurvedic medication has tends to be regained the lost fame due to its preventive, curative nature, less side effects and holistic approach. This is largely because of quality drugs, clinical trials and evidence-based medicine. The large-scale production of medicine is done by Ayurvedic pharmacies. Quality production is the need from these Ayurvedic pharmacies. Standardization of raw drugs, finished drugs and process validation are of prime importance for each dosage form including Sandhan Kalpana. During the pharmaceutical procedure of Madya and Suktat Sandhan the fungal growth during pharmaceutical procedure is considered as major problems. As the Bhaishajya Kalpana, most developed branch of Ayurveda, deals with the preparation of different formulations from the raw material available in the nature. This conversion depends upon many factors like availability of the drug throughout the year, shelf life, good taste, pleasant smell, quick in action even in small doses. A conglomeration of source material by which shelf generated alcohol is prepared by keeping all together to convert it into a medicinal form called as Sandhan. Kutajarishta is a self-generated alcoholic preparation. It contains Holarrhena antidysenterica (Apocynaceae) as a chief ingredient. It is used in the condition like diarrhoea, dysentery disorders due to its antibacterial & antiprotozoal activity. © 2025 Author(s)
In vitro anti-inflammatory and antioxidant activities of Hinguleswara rasa-based herbomineral formulations
(Innovare Academics Sciences Pvt. Ltd, 2018) Abhishek Chatterjee; Dileep Singh Baghel; Amit Mittal; Saurabh Singh; Bimlesh Kumar; Narendra Kumar Pandey; Sachin Kumar Singh; S. Tamilvanan; Shruti Chopra; Amit Bhatia; Anand Kumar Chaudhary
Objective: The aims of the present investigation were to develop the herbal and/or herbomineral formulations of Hinguleswara rasa and to compare their anti-inflammatory and antioxidant activities, in vitro, with that of standard drug samples. Methods: This study was an interventional investigation in three samples: In the first sample, Hinguleswara rasa (HR1) was prepared as per methodology described in Rasatarangini using Shuddha Hingula (10 g), Shuddha Vatsanabha (10 g), and Pippali (10 g). In the second and third sample, respectively, Hinguleswara rasa was prepared by replacing Shuddha Hingula with Kajjali where Kajjali made from Hingulotha parada and Sodhita parada constitutes two varieties of Hinguleswara rasa, i.e. HR2 and HR3. In vitro antioxidant activity was studied using 2,2-diphenyl-1-picrylhydrazyl, and the absorbance was recorded at 517 nm. For evaluating the in vitro anti-inflammatory studies, the inhibition of albumin denaturation technique was performed. Results: The results showed that the formulation of Hinguleswara rasa has shown dose-dependent activity which was observed in 100 µg concentration. HR1, HR2, and HR3 showed 36.11, 17.22, and 16.11% radical scavenging activity. Conclusion: It could be concluded that the changes made in the formulations did not affect the in vitro anti-inflammatory and antioxidant effects of the herbomineral formulations. © 2018, Innovare Academics Sciences Pvt. Ltd. All rights reserved.
Pharmaceutical Standardization and Comparative Study of Varunadi Kvatha Churna as Varunadi Ghana Vati/Tablet and Varunadi Pravahi Kvatha
(Informatics Publishing Limited, 2024) Gurmeet Singh; Priyanka Chaudhary; Mohit Sharma; Vaishnavi; Ankit Kumar Yadav; Saurabh Singh; Bimlesh Kumar; Narendra Kumar Pandey; Sachin Kumar Singh; Anand Kumar Choudhary; Dileep Singh Baghel
Background: In Ayurveda, there are many types of potent dosage forms available with their different specifications, anupan, preparation procedure and shelf life. The preparation of medicines of herbal drug origin is generally included in the Bhaishajya Kalpana section. In Bhaishajya Kalpana there are five basic dosage forms necessary to prepare formulations from herbal origin drugs i.e. Swarasa, Kalka, Kvatha, Hima and Phanta. These five basic formulations are potent dosage forms which can moulded into different finished formulations. Aim: The objectives of this study were to prepare and standardise the Varunadi Kvatha Churna as Varunadi Ghana Vati/Tablet and Varunadi Pravahi Kvatha with a comparative study. Methods: Firstly, kvatha churna was prepared as per the master formula. The kvatha churna was then used in two different ways i.e. firstly it was used to prepare Varunadi Ghana Vati (Tablet) without using any additives as it acts as a self-binder. On the other hand, Pravahi kvatha was prepared which is a self-generated alcohol formulation, in which dhataki pushpa, gudda and babool are added as a fermentation initiator and additives. Results: Physicochemical parameters do not show significant variation. According to the TLC profile, the Ghana Vati has six spots i.e. having much more active constituents than the Pravahi kvatha having two spots. Therefore, according to the parameters, it might be stated that the Pravahi kvatha has much more stability than the Ghana Vati. But as far as palatability and activity are concerned Ghana Vati is comparatively better than Pravahi kvatha Conclusion: Converting Varunadi Kvatha Churna into Varunadi Ghana Vati, Varunadi Pravahi Kvatha provides several benefits related to ease of use, dosage precision, and patient preference. Hence based on observation we stated that the Varunadi Ghana Vati has a better choice of dosage form as compared to Varunadi Pravahi Kvatha, although it has better stability. © 2024, Informatics Publishing Limited. All rights reserved.
Pharmacognostical Study and Analytical Standardization of Bhringaraja Taila: An Ayurvedic Oleaginous Medicine
(Informatics Publishing Limited, 2024) Pranav Kumar; Saurabh Singh; Bimlesh Kumar; Kalvatala Sudhakar; Narendra Kumar Pandey; Anand Kumar Choudhary; Rupa Mazumder; Saumya Das; Pramod Pokhrel; Dileep Singh Baghel
Background: Bhringaraja Taila is an Ayurvedic classical formulation. The formulation is indicated as keshaya. The present study is structured around validating the fact of preparing the formulation with and without the addition of mineral (Gairika). Aim: The objectives of this study were to prepare and analyze Bhringaraja Taila. Method: After performing the murchanna samsakara, a specified amount of Drava, Kalka and Sneha dravyas were taken and subjected to moderate heating till the watery portion evaporated Bhringraja Taila prepared with and without Gairika. Results: The refractive index of Bhringraja Taila with and without the addition of Gairika was found to be decreased in both samples. The specific gravity and saponification values of both samples were found to be within the limit but slightly increased in the sample prepared with the addition of Gairika. The iodine value of both samples was found to be less than the limit. A decreased iodine value signifies less tendency toward rancidity. The acid value of both samples was found to be within the limit but more in the sample prepared with the addition of Gairika. The peroxide value of the sample prepared with the addition of Gairika was higher than the sample prepared without Gairika. Higher peroxide value indication of rancidity. The pH of the sample prepared with the addition of Gairika was found to be acidic and the sample prepared without the addition of Gairika was found to be basic. Conclusion: Thus considering the above fact it can be concluded that the formulation was prepared without mineral (Gairika) can be more stable but the therapeutic efficacy between the two formulation cannot be confirmed until and unless there is clinical validation. © 2024, Informatics Publishing Limited. All rights reserved.
Preparation of Apamarg Kshar Tablet and Assessment of In Vitro Potential against Urolithiasis (Mutrakrichra)
(Research Journal of Pharmacy and Technology, 2022) Dileep Singh Baghel; Saurabh Singh; Narendra Kumar Pandey; Bimlesh Kumar; Amit Mittal; Anand Kumar Chaudhary; Anu Mittal; Amrik Singh
Background: Urolithiasis (Mutrakricchra) is an age-old disorder which has multi-factorial etiological as well as associated with re-occurrence. It is standout among the most troubling disorders related to urinary tract. Acharya Sushruta, a pioneer in the art of surgery, described the root causes and management of urolithiasis (Mutrakricchra). In present day restorative practice, a lot of the management/treatment choices are available which begins from the utilization of uresis-elevating specialist to dietary or nourishing enhancement consumption. Amalgamating the Ayurvedic principle/concept with current medicinal practice is a promising methodology used for the management of urolithiasis (Mutrakricchra) now a days. Objective: To prepare apamarg kshar and evaluate its potential against Urolithiasis (Mutrakrichra) by In-vitro technique. Materials and Methods: Apamarg kshar were prepared as per the methodology mentioned in Rasatarangni and the prepared Kshar is compressed in tablet dosage form. Various parameters of apmarg kshar tablets were evaluated. Results: Physicochemical and stability studies have not shown any remarkable variations with prepared tablet dosage form. In-vitro studies shows that 82 % of crystal inhibition at 550 µg/ml. Conclusion: The prepared tablet dosage form of Apamarg Kshar does not have remarkable variation during physicochemical and stability studies. The developed dosage form produces promising result in vitro against Urolithiasis (Mutrakrichra). © RJPT All right reserved.