Browsing by Author "Nargis Khanam"

Now showing 1 - 5 of 5

Effects of SARS-Cov-2 infection and rhino-orbital mucormycosis on concentrations of inflammatory biomarkers in Indian populations
(IP Innovative Publication Pvt. Ltd., 2022) Ajay Kumar Yadav; Shivam Tiwari; Bhupendra Kumar; Abhay Kumar Yadav; Ashish Ashish; Nitish Kumar Singh; Manpreet Kaur; Shivani Mishra; Shani Vishwakarma; Surendra Pratap Mishra; Rajendra Prakash Maurya; Nargis Khanam; Pooja Dubey; Janhavi Yadav; Royana Singh; Sayeed Mehbub Ul Kadir
Rhino-orbital mucormycosis is a rare life threatening invasive fungal infection that has recently shown a very high mortality rate in India during COVID-19 pandemic. We have designed the present study to find out associations between COVID-19 induced rhino-orbital mucormycosis and concentrations of inflammatory markers, i.e. D-dimer, Ferritin, IL-6, CRP and PCT, in blood serum of Indian population. There were four groups in the study, viz. control group with healthy subjects, treatment group-1 with patients suffering from SARS-COV-2 infection, treatment group-2 with patients suffering from both SARS-COV-2 infection and rhino-orbital mucormycosis, and treatment group-3 with patients suffering from rhino-orbital mucormycosis after SARS-COV-2 infection recovery. Inflammatory markers were quantified with standard protocols, and recorded data were subjected to statistical analyses. We found that patients suffering from SARS-COV-2 infection were more susceptible to rhino-orbital mucormycosis, as they had higher concentrations of inflammatory markers in their blood than the other subjects. Diabetes mellitus, hypertension, cardiovascular diseases and renal disorders were the associated comorbidities with the patients. We also found higher concentrations of inflammatory markers in males than the females, indicating towards their higher susceptibility in developing rhino-orbital mucormycosis than females. Present study therefore suggests that the frequent occurrence of rhino-orbital mucormycosis in India during second wave of COVID-19 was possibly due to indiscriminate use of corticosteroids by COVID-19 patients. Subjects with previous history of comorbidities like diabetes mellitus, hypertension, cardiovascular disorders and renal diseases are the most susceptible population groups for developing infection. Moreover, males are at higher risk of developing mucormycosis than the females. © 2022 Innovative Publication, All rights reserved.
Genetic Analysis of Recurrent Pregnancy Loss: Role of Karyotyping in Understanding Pathogenesis and Management
(Jaypee Brothers Medical Publishers (P) Ltd, 2025) Shivani Mishra; Royana Singh; Sangeeta Rai; Ashish Ashish; Nitish Kumar Singh; Manpreet Kaur; Nargis Khanam; Janhavi Yadav; Chetan Sahni
Introduction: Recurrent pregnancy loss (RPL) is defined as two or more spontaneous pregnancy losses within 20–24 weeks of the gestational period, which typically occur in the early stages of pregnancy. Various factors can contribute to RPL, including genetic factors, hormonal imbalances, uterine abnormalities, autoimmune disorders, infections, and lifestyle factors. Materials and methods: This study involved the conventional karyotyping of women facing RPL with the G-banding method and the culture procedure of leukocytes. The statistical analysis was done by IBM SPSS 20 after the biochemical data collection and karyotyping results. Results: The total samples were collected from 160 couples, out of which only 130 were successfully done with conventional karyotyping. It was noted in this study that the genetic rearrangement in female partners was found to be 11.5%, excluding the anatomical, immunogenic, and hormonal factor dysfunctions. The advanced maternal age and primary RPL were found to be more actively causing recurrent miscarriages. Conclusion: These investigations emphasize the importance of genetic analysis in RPL cases, biochemical, and cytogenetic analysis. The karyotyping must be done to rule out any chromosomal rearrangement in male and female partners. The previous family history may indicate the likelihood of carrying chromosomal rearrangements; thus, further study needs to be done in large populations. © (2025), (Jaypee Brothers Medical Publishers (P) Ltd). All rights reserved.
Genetic Association of ACE2 rs2285666 Polymorphism With COVID-19 Spatial Distribution in India
(Frontiers Media S.A., 2020) Anshika Srivastava; Audditiya Bandopadhyay; Debashurti Das; Rudra Kumar Pandey; Vanya Singh; Nargis Khanam; Nikhil Srivastava; Prajjval Pratap Singh; Pavan Kumar Dubey; Abhishek Pathak; Pranav Gupta; Niraj Rai; Gazi Nurun Nahar Sultana; Gyaneshwer Chaubey
Studies on host-pathogen interaction have identified human ACE2 as a host cell receptor responsible for mediating infection by coronavirus (COVID-19). Subsequent studies have shown striking difference of allele frequency among Europeans and Asians for a polymorphism rs2285666, present in ACE2. It has been revealed that the alternate allele (TT-plus strand or AA-minus strand) of rs2285666 elevate the expression level of this gene upto 50%, hence may play a significant role in SARS-CoV-2 susceptibility. Therefore, we have first looked the phylogenetic structure of rs2285666 derived haplotypes in worldwide populations and compared the spatial frequency of this particular allele with respect to the COVID-19 infection as well as case-fatality rate in India. For the first time, we ascertained a significant positive correlation for alternate allele (T or A) of rs2285666, with the lower infection as well as case-fatality rate among Indian populations. We trust that this information will be useful to understand the role of ACE2 in COVID-19 susceptibility. © Copyright © 2020 Srivastava, Bandopadhyay, Das, Pandey, Singh, Khanam, Srivastava, Singh, Dubey, Pathak, Gupta, Rai, Sultana and Chaubey.
Publisher Correction: The major genetic risk factor for severe COVID‑19 does not show any association among South Asian populations (Scientific Reports, (2021), 11, 1, (12346), 10.1038/s41598-021-91711-4)
(Nature Research, 2021) Prajjval Pratap Singh; Anshika Srivastava; Gazi Nurun Nahar Sultana; Nargis Khanam; Abhishek Pathak; Prashanth Suravajhala; Royana Singh; Pankaj Shrivastava; George van Driem; Kumarasamy Thangaraj; Gyaneshwer Chaubey
In the original version of this Article, Kumarasamy Thangaraj was omitted as a corresponding author. Correspondence and request for materials should also be addressed to thangs@ccmb.res.in. In addition, the email address of the co-corresponding author Gyaneshwer Chaubey was incorrectly given as thangs@ccmb.res.in. Correspondence and request for materials should also be addressed to gyaneshwer.chaubey@bhu.ac.in. The original Article has been corrected. © 2021, The Author(s).
The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations
(Nature Research, 2021) Prajjval Pratap Singh; Anshika Srivastava; Gazi Nurun Nahar Sultana; Nargis Khanam; Abhishek Pathak; Prashanth Suravajhala; Royana Singh; Pankaj Shrivastava; George van Driem; Kumarasamy Thangaraj; Gyaneshwer Chaubey
With the growing evidence on the variable human susceptibility against COVID-19, it is evident that some genetic loci modulate the severity of the infection. Recent studies have identified several loci associated with greater severity. More recently, a study has identified a 50 kb genomic segment introgressed from Neanderthal adding a risk for COVID-19, and this genomic segment is present among 16% and 50% people of European and South Asian descent, respectively. Our studies on ACE2 identified a haplotype present among 20% and 60% of European and South Asian populations, respectively, which appears to be responsible for the low case fatality rate among South Asian populations. This result was also consistent with the real-time infection rate and case fatality rate among various states of India. We readdressed this issue using both of the contrasting datasets and compared them with the real-time infection rates and case fatality rate in India. We found that the polymorphism present in the 50 kb introgressed genomic segment (rs10490770) did not show any significant correlation with the infection and case fatality rate in India. © 2021, The Author(s).