Browsing by Author "Neha Mishra"

Now showing 1 - 5 of 5

A Review of Marine Natural Product Resources with Potential Bioactivity Against SARS-COV-2
(Faculty of Pharmacy, University of Benin, 2023) Neha Mishra; Ena Gupta; Angelo Mark P. Walag; Ravindra N. Kharwar; Priyangka Singh; Pragya Mishra
The emergence of new pathogenic viruses and the constant outbreak of viral diseases have created an upsurge in novel antiviral agents. Marine natural products are the most unexplored reservoir of novel, biologically active, chemically diverse compounds. A systematic literature review was conducted using PRISMA guidelines, accessing four major databases; PubMed, Science Direct, Scopus, and Google Scholar. Numerous studies supported the robust antiviral activity of marine resources against drug-resistant viruses such as SARS, Ebola, Influenza, and HIV. However, adequate research on marine resources for developing anti-covid therapy is lacking. The aim of the review was to explore the marine resources and their compounds that could lead to developing an effective antiviral drug. We also highlighted the current status of novel compounds against different species of corona family and discussed the future prospects of marine resources against COVID-19 management. © 2023 the authors.
Chest radiograph findings in children aged 2-59 months hospitalised with community-acquired pneumonia, prior to the introduction of pneumococcal conjugate vaccine in India: a prospective multisite observational study
(NLM (Medline), 2020) Shally Awasthi; Tuhina Rastogi; Neha Mishra; Abhishek Chauhan; Namita Mohindra; Ram Chandra Shukla; Monika Agarwal; Chandra Mani Pandey; Neera Kohli; Cap Study Group
OBJECTIVES: The current study was a hospital-based surveillance of cases hospitalised with WHO-defined community-acquired pneumonia in children aged 2-59 months, to assess the radiological abnormalities in chest X-rays and to identify the demographic and clinical correlates of specific radiological abnormalities, in residents of prespecified districts of Uttar Pradesh and Bihar, India. DESIGN: Prospective, active, hospital-based surveillance. SETTING: Multisite study conducted in a network of 117 secondary/tertiary care hospitals in four districts of Uttar Pradesh and Bihar, India. PARTICIPANTS: Included were children aged 2-59 months, hospitalised with community-acquired pneumonia, residing in the project district, with duration of illness <14 days and who had not been hospitalised elsewhere for this episode nor had been recruited previously. MAIN OUTCOME MEASURE: Concordant radiological abnormalities in the chest X-rays. RESULTS: From January 2015 to April 2017, 3214 cases were recruited and in 99.40% (3195/3214) chest X-rays were available, among which 88.54% (2829/3195) were interpretable. Relevant radiological abnormalities were found in 34.53% (977/2829, 95% CI 32.78 to 36.28). These were primary end point pneumonia alone or with other infiltrates in 22.44% (635/2829, 95% CI 20.90% to 23.98%) and other infiltrates in 12.09% (342/2829; 95% CI 10.88% to 13.29%). There was a statistically significant interdistrict variation in radiological abnormalities. Statistically significantly higher proportion of abnormal chest X-rays were found in girls, those with weight-for-age z-score ≤-3SD, longer duration of fever, pallor and with exposure to biomass fuel. CONCLUSIONS: Among hospitalised cases of community-acquired pneumonia, almost one-third children had abnormal chest radiographs, which were higher in females, malnourished children and those with longer illnesses; and an intra-district variation was observed. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Evidence and Prospects of Lycopene as Powerful Red Superfood: Modern Approach to Food Science
(Bentham Science Publishers, 2024) Ena Gupta; Pragya Mishra; Priyanka Singh; Neha Mishra
Lycopene is a plant-derived important nutrient belonging to a group of pigments identified as carotenoids. Lycopene has distinctive chemical and structural features contributing to defi-nite biological properties. Lycopene is a powerful antioxidant and prevents cells and tissues from damage caused by singlet oxygen or free radicals. Research studies have shown the health-promoting potential of lycopene or its metabolites in the prevention of chronic diseases like diabe-tes, cancer, asthma, metabolic syndrome, arthritis, and cardiovascular diseases. Lycopene is stable for processing like other natural compounds when present in the plant tissue matrix. Over the last few years, the global lycopene market has increased in different sectors like pharmaceuticals, cos-metics, food and dairy products, and other dietary supplements. The most important aspect of lyco-pene as a superfood is its synergistic nature with other nutrients. The main aim of this review article is to study chemistry, biosynthetic pathways, biotransformation, sources, and acceptable daily in-take. Its characterization as a superfood, therapeutic potential, and wide range of applications in the food industry are also studied. © 2024 Bentham Science Publishers.
SYNERGISTIC EFFECTS OF NITROGEN DEPRIVATION AND HIGH IRRADIANCE TO ENHANCE BIOMASS AND LIPID PRODUCTION IN NANNOCHLOROPSIS
(Slovak University of Agriculture, 2023) Neha Mishra; Pragya Mishra; Ena Gupta; Priyanka Singh
Nannochloropsis, due to its high lipid content, small size and growth rate, can be exploited for the production of biofuel and other value-added products. This study analyzed synergistic responses of high irradiance and nitrogen deprivation on Nannochloropsis cells to enhance biomass and lipid production. The growth of Nannochloropsis was first optimized under different irradiance 50, 100, 150, 200 and 250 μmol photons m-2 s-1. The maximum specific growth rate (0.25 day-1) and dry weight (0.67 g L-1) were obtained (p<0.05) at photosynthetically active radiation (PAR) of 200 μmol photons m-2 s-1, further increase in light intensity decreased the growth rate and dry weight up to 0.2 day-1 and 0.41g L-1, respectively. The stress of high light for a short period increased the lipid content by 51.1% and decreased the protein content by 35.2% over the control values. In the second phase of the study, the combined stress of high light intensity of 200 μmol photons m-2 s-1 PAR and nitrate depletion (50%, 75%, 100% N-) were studied and observed significant (p<0.05) increase in lipid content from 21.3±1.4% to 43.2±1.56% DCW and decrease in protein from 30.7±1.3% to 16.3±1.2% DCW, respectively. The highest lipid productivity (140 mg L-1 d-1) had been observed in a culture grown at 75% N-starved cells (p<0.05). However, the further increase of nitrate deprivation to 100% decreased the lipid productivity to 107 mg L-1 d-1. Maximum accumulations of TG (19.6% DCW) were observed on 6 days (early stationary phase) in a 100% nitrogen deprived medium, although significant accumulation was observed on 4 days and 6 days of nitrate reduction. © 2023, Journal of Microbiology, Biotechnology and Food Sciences. All Rights Reserved.
Topic: Utilization of fruit peel for the development of functional fruit peel bar
(Elsevier Ltd, 2023) Ena Gupta; Pragya Mishra; Neha Mishra; Priyanka Singh; Abeer Sheikh
Due to increased consumer interest in healthy products, this study aims to formulate fruit peel bar as health-promoting functional products and minimize environmental impacts through agricultural waste utilization. The bar was formulated by optimizing the ingredient through Response Surface Methodology (RSM) and Textural profile analysis (TPA). The three critical ingredients A = FPB (i.e., sweet-lime peel and apple peel blend in the ratio of 2:5), B = Jaggery and C = germinated pearl millet mixed with other ingredients like almonds (5 g), corn flakes (10 g), flax seeds (2.5 g), dates (2.5 g), peanuts (2.5 g) and guar gum (2.5 g) to make a balanced and wholesome bar. The ANOVA results (desirability test) revealed that the optimized ratio of critical independent parameters (A = 16.95 g, B = 88.45 g and C = 13.31 g) against the critical responses (energy= 395.34 kcal, protein = 11.81 g and overall acceptability = 8.30) was obtained in the formulated fruit peel bar with an excellent textural profile [hardness = 5483.83 (g force), cohesiveness=0.02 (dimension less), springiness = 2.07 (mm), chewiness = 284.45 (N/mm), gumminess =5483.83(N)]. Fruit peel products potentially increase the functionality and nutrition of such snack products, ultimately fulfilling the energy requirement and the prevalence of cravings among kids. © 2023 The Author(s)