Browsing by Author "Nidhi Chandra"

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Oxidative stress and aging
(Elsevier, 2025) Vineeta Singh; Anamika; Nidhi Chandra; Vartika Gupta; Priyanka Gautam; Shivani Rath; Arshdeep Kaur Sethi; Rameshwar Nath Chaurasi; Vijay Nath Mishra
Oxidative stress results from an imbalance between reactive oxygen species and reactive nitrogen species production and the body’s antioxidant defense mechanisms. Excessive accumulation of these reactive molecules damages lipids, proteins, and DNA, contributing to cellular dysfunction and aging. The Free Radical Theory of Aging, proposed by Denham Harman, suggests that oxidative stress accelerates molecular deterioration, leading to age-related functional decline. However, modern research highlights a nuanced perspective where oxidative stress plays both detrimental and adaptive roles, influencing cellular signaling and stress responses. Emerging evidence underscores the interplay of genetic and environmental factors in oxidative homeostasis, offering insights into potential therapeutic interventions for aging-related disorders. Understanding oxidative stress as a dynamic and regulated process rather than a purely degenerative force opens avenues for targeted strategies to modulate aging and extend healthspan. © 2026 Elsevier Inc. All rights reserved..
Protein misfolding and aggregation and its role in dementia with Lewy bodies
(Elsevier, 2025) Vineeta Singh; Anamika; Nidhi Chandra; Vartika Gupta; Priyanka Gautam; Bhargawi Mishra; Arshdeep Kaur Sethi; Shivani Rath; Vijay Nath Mishra
Dementia with Lewy bodies (DLB) is a progressive neurodegenerative disorder characterized by the accumulation of misfolded α-synuclein within Lewy bodies, leading to widespread neuronal dysfunction. Protein misfolding and aggregation serve as key pathological mechanisms, influenced by genetic mutations, as well as environmental triggers like toxins and infections. The interplay between α-synuclein and other neurodegenerative pathways, particularly tau and amyloid-β, exacerbates disease progression. Advances in biomarker research, including neuroimaging and fluid-based assays, are enhancing early detection, while emerging therapeutic strategies focus on molecular chaperones, autophagy enhancement, and gene-editing approaches. Understanding the mechanisms of protein misfolding in DLB not only improves diagnostic accuracy but also provides potential avenues for disease-modifying therapies. Ongoing research offers promising prospects for targeted interventions, bridging the gap between pathophysiological insights and clinical applications in neurodegenerative disorders. © 2026 Elsevier Inc. All rights reserved..