Browsing by Author "Nidhi Dwivedi"

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A Study on Quality of Life among the Elderly at Urban Health Center in North Delhi
(Wolters Kluwer Medknow Publications, 2023) Gunjan Mahaur; Archana Dwivedi; Deepika Joshi; Nidhi Dwivedi
Background: Elderly population in India is growing around 3% annually and is supposed to triple by 2050 than that at the time of 2011 census, according to a country report published by the UN Population Fund (UNFPA, 2017). A better quality of life (QOL) of the elderly has become a major public health challenges of the 21st century, so timely emphasis on maintenance of physical health and psychological issues is crucial. Therefore, the aim of the present study is to measure QOL among the elderly population and to find out the association with sociodemographic factors. Materials and Methods: This is a cross-sectional study done among the elderly population of an urban health training center. The study includes the World Health Organization Quality of Life Questionnaire‑Brief version and a questionnaire for sociodemographic variables. Univariate and multivariate analyses were used to determine associations and P value. Results: The overall QOL scores ranged between 52 and 110, with a mean score of 78.59 ± 12.6. Good QOL was observed among 64.9%of the elderly, excellent was observed among 19.8%; and the rest 15.3% had fair/average, while none of the elderly had poor QOL. Determinants significantly associated with QOL with P < 0.05 are age, educational status, professional status, marital status, and behavior of children with them and the elderly with comorbidities. Conclusion: This study shows the association of multiple factors with QOL among the elderly. Factors such as age, educational status, professional status, marital status, and behavior of children with them and the elderly with comorbidities significantly affect the QOL of the elderly. Hence, strengthening the health-care system, increase in level of education, encouraging social interaction, social security systems, and better environmental infrastructure could potentially increase QOL of the elderly population. © 2024 Journal of Mid-life Health.
Anion directed structural diversity in zinc complexes with conformationally flexible quinazoline ligand: Structural, spectral and theoretical studies
(Royal Society of Chemistry, 2016) Nidhi Dwivedi; Sumit Kumar Panja; Monika; Satyen Saha; Sailaja S. Sunkari
In this paper, we report the synthesis, structure and photophysical studies of four new complexes of conformationally flexible 6-chloro-4-phenyl-2-(pyridin-2-yl)quinazoline ligand (L) with Zn(ii). The coordinating ability of the ligand and geometrical preferences of the resultant complexes are tuned by varying the anion of the metal salt as confirmed by structural and DFT studies. The choice of the metal salt (especially anion) directs the stabilisation of different conformations of the ligand arising out of twisting of the pyridyl ring with respect to the quinazoline ring, resulting in complexes with different nuclearity (monomer/dimer) as well as different coordination geometries (tetrahedral/trigonal bipyramidal/octahedral). Photophysical properties are also found to be tuned due to conformational changes on complexation. DFT studies on the ligand establish the conformationally stable forms as observed in the reported structures. © The Royal Society of Chemistry 2016.
Association of Catechol-O-Methyltransferase Gene rs4680 Polymorphism and Levodopa Induced Dyskinesia in Parkinson’s Disease: A Meta-Analysis and Systematic Review
(SAGE Publications Inc., 2023) Archana Dwivedi; Nidhi Dwivedi; Anand Kumar; Varun K. Singh; Abhishek Pathak; R.N. Chaurasia; V.N. Mishra; Sujata Mohanty; Deepika Joshi
Introduction: Long-term levodopa therapy for Parkinson’s disease (PD) can cause levodopa induced dyskinesia (LID). Genetic predisposition has a significant role to play in inter-individual heterogeneity in the clinical manifestation of LID. Despite accumulating evidence for the role of COMT gene polymorphism (rs4680) as a genetic basis for LID, to date results have been inconsistent. Early assessment of the Catechol-O-Methyltransferase (COMT) genotype might be helpful to stratify PD patients concerning their individual risk for LID. Method: In this meta-analysis, we have used 9 studies, which were selected through online databases. Statistical analysis was performed using R (v-3.6) software. 5 genetic models have been used in the present study: Allele model (A vs. G), Dominant model (AA+AG vs. GG), Homozygote model (AA vs. GG), Co-dominant/heterozygote model (AG vs. GG), and Recessive model (AA vs. AG + GG). Results: The results indicated a significant association between COMT rs4680 (Val158Met) polymorphism and LID risk. The genotype AA of COMT rs4680 is a risk factor for LID in PD patients under the recessive model (AA vs GG+AG) in the random-effect model. Analysis based on ethnicity showed that COMT rs4680 SNP allele A is a risk factor for LID development in Asian PD patients, while GG genotype is a risk factor for LID development in non-Asian PD patients using different genetic models. Conclusion: The results of the present meta-analysis support that the COMT Val158Met polymorphism is a risk factor for the development of LID in PD patients having ethnic variations. © The Author(s) 2022.
Co-occurrence of Parkinson's disease and Retinitis Pigmentosa: A genetic and in silico analysis
(Elsevier Ltd, 2025) Archana Dwivedi; Anand Kumar; Mohammad D. Faruq; Varun Kumar Singh; Nidhi Dwivedi; Kamaljeet Singh; Ibrahim Hussain; Swati Parida; Gaurab Kumar Jha; N. Suresh Kumar; Deepika Srivastava Joshi
Introduction: Parkinson's disease (PD) is primarily driven by the protein Alpha Synuclein (A-Syn) accumulation. Synphilin-1 protein, encoded by the SNCAIP gene, which co-localizes with A-Syn is a known risk factor for PD. Retinitis pigmentosa (RP), is a cluster of retinal degenerative disorders, and Cyclic Nucleotide Gated channel subunit Alpha 1 (CNGA1) is one of the initial genes associated with RP. Patients with PD can have various kinds of visual dysfunction as a non-motor manifestation, but to date, CNGA1 mutation and RP as a PD associated visual symptom has not been reported. We report a mutation in the SNCAIP gene in a PD patient, not reported earlier, and its co-occurrence with RP-associated CNGA1 gene mutation. Method: Whole exome sequencing (WES) of the patient DNA sample and in-silico protein–protein interaction (PPI) analysis performed to find out proteins interacting with SNCAIP relevant concerning reported mutation of SNCAIP and further, CNGA1 interaction with SNCAIP. Result: We are reporting, a missense mutation (p.Thr64Ser) at the SNCAIP gene, co-occurring with a missense variation (p.Gly509Arg) in the CNGA1 gene. In silico PPI analysis suggests SIAH1 as an important protein affected by SNCAIP mutation. LGALS4 and SNCA (gene encoding A-Syn) are common interactors between SNCAIP and CNGA1. Conclusion: The current study has determined the co-occurrence of RP and PD, whole exome sequencing ascertains the mutations in SNCAIP and CNGA1 genes, which could be the cause of PD and RP co-occurrence. © 2024 International Brain Research Organization (IBRO)
First report of the application of simple molecular complexes as organo-catalysts for Knoevenagel condensation
(Royal Society of Chemistry, 2015) Sumit Kumar Panja; Nidhi Dwivedi; Satyen Saha
A series of molecular complexes have been designed, synthesized and used as organo-catalysts for the first time for very efficient Knoevenagel condensation. Molecular complexes are thermally stable, easily recyclable, and have a low cost of preparation. The role of acidic protons in molecular complexes in Knoevenagel condensations has been identified as the key factor and helps us to provide useful information about the reaction pathway. The acidic proton of a catalyst enhances the electrophilicity of an aldehyde and accelerates the dehydration process of the reaction at room temperature (RT). An eco-friendly, green synthetic protocol for the Knoevenagel condensation is used to synthesize a series of important cyano group containing synthetic precursors for synthesis of biologically active molecules at RT using a minimum amount of catalyst (∼5 mol%) without the need for chromatographic separation techniques. Detailed mechanistic studies and substituent effects of aromatic aldehydes on the reaction have been investigated. In addition, biologically active 2-amino-4H-chromene derivatives have also been synthesized by the Knoevenagel condensation of salicylic aldehydes with active methylene compounds, followed by intramolecular cyclization (via Michael addition) delivering higher yields within shorter reaction times at RT without any need for chromatographic separation. © The Royal Society of Chemistry 2015.
Highly stable naphthalene core based novel cleft-shaped strain molecule: Influence of intermolecular H-bonding architectures
(Royal Society of Chemistry, 2016) Sumit Kumar Panja; Nidhi Dwivedi; Satyen Saha
The significance of intermolecular classical and non-classical H-bonding interactions in the stabilization of a naphthalene core based conformationally rigid cleft-shaped 1,5-dioxocin (BNAP) is presented here. The importance of H-bonding interactions to account for the unusual stability of a catalytically important novel molecule is reported for the first time. In addition to strong CH⋯π interactions, the formation of the unique intermolecular seven-membered H-bonded ring in the crystalline state through classical and non-classical H-bonding interaction was found to provide the unusual stability. This supramolecular structure was also found to impart stability in the presence of a strong acid as evident from the detailed UV-Visible spectroscopic studies. In addition to DFT calculations, the Hirshfeld surfaces, mapped with dnorm, and 2D fingerprint plots, support the existence of these classical and non-classical H-bonding and CH⋯π interactions. Furthermore, BNAP shows its remarkable catalytic activity for the Knoevenagel condensation reaction. © 2016 The Royal Society of Chemistry.
I2-Catalyzed three-component protocol for the synthesis of quinazolines
(Elsevier Ltd, 2012) Sumit Kumar Panja; Nidhi Dwivedi; Satyen Saha
An efficient and one-pot three-component strategy for synthesizing highly functionalized quinazoline derivatives is presented. A mixture of 2-aminobenzophenone, aromatic aldehyde and ammonium acetate in the presence of I2-catalyst provides desired products in excellent yields even at moderate temperature (40 °C) without the involvement of any chromatographic purification. Oxidizing and Lewis acidic properties of molecular I2 have been utilized here. Detailed mechanism has been established based on an isolated intermediate and its single crystal X-ray crystallographic structure. © 2012 Elsevier Ltd. All rights reserved.
Manipulating the proton transfer process in molecular complexes: Synthesis and spectroscopic studies
(Royal Society of Chemistry, 2016) Sumit Kumar Panja; Nidhi Dwivedi; Satyen Saha
The proton transfer process in carefully designed molecular complexes has been investigated directly in the solid and solution phase. SCXRD studies have been employed to investigate the N-H-O bonding interaction sites of the molecular complexes, with additional experimental support from FTIR and Raman spectroscopic studies, to gain information on the relative position of hydrogen in between the N and O centers. Further, the proton transfer process in solution is studied using UV-Visible spectroscopy through monitoring the intramolecular charge transfer (ICT) process in these molecular complexes, which is primarily governed by the number of electron withdrawing groups (nitro groups) on proton donor moieties (NP, DNP and TNP). It is found that the magnitude of the ICT process depends on the extent of proton transfer, which on the other hand depends on the relative stabilities of the constituent species (phenolate species). A correlation is observed between an increase in the number of nitro groups and an increase in the melting point of the molecular complexes, indicating the enhancement of ionic character due to the proton transfer process. The aliphatic H-bonding is identified and monitored using 1H-NMR spectroscopy, which reveals that the identity of molecular complexes in solution interestingly depends on the extent of proton transfer, in addition to the nature of the solvents. The aliphatic C-H-O H-bonding interaction between the oxygen atom of the nitro group and the alkyl hydrogen in piperidinium was also found to play a significant role in strengthening the primary interaction involving a hydrogen transfer process. The conductivity of the molecular complexes increases with an increase in the number of nitro groups, indicating the enhancement in ionic character of the molecular complexes. © 2016 the Owner Societies.
Molecular Packing Dependent Solid State Fluorescence Response of Supramolecular Metal-Organic Frameworks: Phenoxo-Bridged Trinuclear Zn(II) Centered Schiff Base Complexes with Halides and Pseudohalides
(American Chemical Society, 2018) Nidhi Dwivedi; Sailaja S. Sunkari; Abhineet Verma; Satyen Saha
Molecular packing plays a key role in determining the photophysical properties in the aggregated state, but fine controlling of molecular packing is a great challenge. Here we report a series of new phenoxo-bridged homometallic trinuclear Zn (II) metal complexes (BN3, BNCS, BN(CN)2, BCl, BBr, and BI [complexes 1-6] having different anions with an aim to vary the photophysical properties of the complexes, where B stands for the ligand, N,N′-bis(3-ethoxysalicylidenimino)-1,4-diaminobutane. All the complexes are structurally characterized by single crystal X-ray diffraction technique. The crystallographic investigation indicates that the complexes contain two types of Zn (II) centers: distorted square pyramidal and octahedral. The crystal structures are stabilized by intermolecular hydrogen bonding and C-H - -π interactions leading to distinct supramolecular frameworks. The ground state and excited state electronic properties of these metal complexes have been investigated. In solution state, all the metal complexes are found to be moderately fluorescent and emit at similar wavelengths with no significant effect of anions on fluorescence emission. However, interestingly, solid state emission properties have been found to be significantly dependent on molecular assembly. In this series, dicyanamide [2] and thiocyanate [3] complexes exhibit significantly red-shifted high fluorescence response in the solid state which is attributed to their distinct packing in comparison to others. To the best of our knowledge, these complexes are the first example of Schiff base complexes demonstrating intriguing molecular packing dependent fluorescence emission. Copyright © 2018 American Chemical Society.
NIR luminescent heterodinuclear [ZnII LnIII] complexes: Synthesis, crystal structures and photophysical properties
(Elsevier B.V., 2017) Nidhi Dwivedi; Sumit K. Panja; Abhineet Verma; Tomohisa Takaya; Koichi Iwata; Sailaja S. Sunkari; Satyen Saha
Two series of new 3d-4f heterodinuclear [ZnIILnIII] Schiff base complexes of general formula [Zn(µ-L1)(µ-CH3COO)Ln(NO3)2(S)] [Ln = Pr (1), Nd (2), Sm (3), Gd (4); S = MeOH; H2L1= N,N-bis(3-methoxysalicylidene)-1,4-diaminobutane] and [Zn(µ-L2)(µ-CH3COO)Ln(NO3)2(S)] [Ln= Pr (5), Nd (6), Sm (7), Gd (8), S= MeOH; H2L2= N,N-bis(3-ethoxysalicylidene)-1,4-diaminobutane] are synthesized and fully characterized. Complexes 1, 2, 3, 4, 5 & 7 are structurally characterized by single crystal X-ray crystallography. The crystallographic investigation indicates that the complexes contain 9 and 10-coordinated LnIII ions, while the ZnII ions always display a distorted square-pyramidal geometry. The crystal structure of the complexes are stabilized by inter molecular extended hydrogen bonding and C-H····π interactions resulting in supramolecular frameworks. Luminescence studies for the heterodinuclear compounds containing NdIII & SmIII reveal that the Zn-complex moiety acts as antenna for the emission from LnIII ions. In addition to the ligand-centered emission in the UV–Vis region, complex 2 (having NdIII) exhibits emission in NIR region also, thus resulting a new NIR emitting material. © 2017
Significance of weak interactions in imidazolium picrate ionic liquids: Spectroscopic and theoretical studies for molecular level understanding
(Royal Society of Chemistry, 2015) Sumit Kumar Panja; Nidhi Dwivedi; Hemanth Noothalapati; Shinsuke Shigeto; A.K. Sikder; Abhijit Saha; Sailaja S. Sunkari; Satyen Saha
The effects of interionic hydrogen bonding and π-π stacking interactions on the physical properties of a new series of picrate anion based ionic liquids (ILs) have been investigated experimentally and theoretically. The existence of aromatic (C2-H⋯O) and aliphatic (C7-H⋯O-N22 and C6-H⋯O-N20) hydrogen bonding and π-π stacking interactions in these ILs has been observed using various spectroscopic techniques. The aromatic and aliphatic C-H⋯O hydrogen bonding interactions are found to have a crucial role in binding the imidazolium cation and picrate anion together. However, the π-π stacking interactions between two successive layers are found to play a decisive role in tight packing in ILs leading to differences in physical properties. The drastic difference in the melting points of the methyl and propyl derivatives (mmimPic and pmimPic respectively) have been found to be primarily due to the difference in the strength and varieties of π-π stacking interactions. While in mmimPic, several different types of π-π stacking interactions between the aromatic rings (such as picrate-picrate, picrate-imidazole and imidazolium-imidazolium cation rings) are observed, only one type of π-π stacking interaction (picrate-picrate rings) is found to exist in the pmimPic IL. NMR spectroscopic studies reveal that the interaction of these ILs with solvent molecules is different and depends on the dielectric constant of the solvent. While an ion solvation model explains the solvation in high dielectric solvents, an ion-pair solvation model is found to be more appropriate for low dielectric constant solvents. The enhanced stability of these investigated picrate ILs compared with that of inorganic picrate salts under high doses of γ radiation clearly indicates the importance of weak interionic interactions in ILs, and also opens up the possibility of the application of picrate ILs as prospective diluents in nuclear separation for advanced fuel cycling process. © the Owner Societies 2015.
Tetranuclear Copper(II) Complexes with Simultaneous Phenoxo and Azido Bridges - Synthesis, Structural and Magnetic Studies
(Wiley-Blackwell, 2018) Priyanka Pandey; Nidhi Dwivedi; Goulven Cosquer; Masahiro Yamashita; Sailaja Sunkari
Tetradentate Schiff base ligands with multiple coordinaton sites are one of the best choice for the construction of multinuclear metal complexes. Coupled with auxiliary ligands under self assembling conditions, the scope for generating new structures increases manifold due to various structure directing factors in operation. Though, phenoxo or azido bridged copper(II) systems have been investigated thoroughly from structural and magnetic aspects, the literature is scanty with combined phenoxo and azido bridged systems. In a study on the effect of synthetic conditions on the structures generated and associated magnetic properties, two new tetranuclear copper complexes, viz., [Cu4(L1)2(μ-N3)2(N3)2] (1) and [Cu4(L2)2(μ-N3)2(N3)2] (2) where L1=N,N′-Bis(salicylidene)diaminopropane (salpn) and L2=N,N′-Bis(salicylidene)diaminobenzene (salophen) with both phenoxo and azido bridges are reported. The tetranuclear cluster is made of two inversion related dimers built of phenoxo bridged Cu1 and Cu2 with distorted square planar and square pyramidal geometries respectively. These dimers are bridged by symmetrically bridging azides leading to a tetranuclear core. The contrasting magnetic behavior inspite of same coordination environments, antiferromagnetic in 1 (J1=−2.17 cm−1; J2=−28.15 cm−1) and ferromagnetic in 2 (J1=−74.7 cm−1; J2=146.5 cm−1), is understood in terms of lower bridge angles and closer separation between copper centers in 2 than in 1. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Tuning the intramolecular charge transfer (ICT) process in push-pull systems: Effect of nitro groups
(Royal Society of Chemistry, 2016) Sumit Kumar Panja; Nidhi Dwivedi; Satyen Saha
The intramolecular charge transfer (ICT) process in donor-acceptor systems has tremendous importance in various physical and biological systems. Three nitrophenolate salts were synthesized and studied here. The ICT and π → π∗ transition processes were identified in these derivatives using UV-Vis spectroscopy and theoretical calculations. It was observed that by simple substitution with nitro groups, one can generate and control the ICT process by regulating the charge distribution over the molecule. While for a monosubstitute nitro derivative, only one ICT band was observed, additional ICT processes can be generated at will by introducing a second nitro group. The intensity of this second ICT channel can be regulated with introduction of a third nitro group. Further, the association constants and solvation processes for these potassium nitrophenolate derivatives were found to be drastically dependent on the number of ICT channels present in the molecule. Theoretical studies (MEP analysis) support the experimental observations presented here. The results show that by simply introducing additional acceptor groups to the system, one can tune the ICT band efficiently in a conjugate system. © 2016 The Royal Society of Chemistry.