Browsing by Author "P.N. Singla"

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A comparative clinical study of saril and oral streptomycin in the treatment of diarrhoea in children
(1978) P.N. Singla; B.D. Bhatia; C.J. Singh; K.N. Agarwal
[No abstract available]
Acardiac anomaly spectrum
(Wiley-Liss Inc., 2000) C. Mohanty; O.P. Mishra; C.P. Singh; B.K. Das; P.N. Singla
Background: Acardiac anomaly spectrum is a rare congenital malformation found in monozygotic twin pregnancy. Besides the absence of heart, the condition is associated with variable grades of developmental disruption. Thus, no two cases are similar. Methods: This case report is based on physical examination and autopsy findings. Results: The twin had acardia and partial development of head and face. There was complete absence of upper extremities. Conclusions: The twin reversed arterial perfusion (TRAP) theory is the most accepted etiology of the disorder. Normally, the cephalic pole is the most severely affected, being most distal to the retrograde perfusion. In acardia, partial development of head, face, and brain is usually associated with the development of the upper extremities. However, in the present case, there was extensive cephalic development in the absence of upper extremity development. (C) 2000 Wiley-Liss, Inc.
Class I histiocytosis: Response to combination of etoposide and prednisolone
(1999) Vikram Datta; O.P. Mishra; B.K. Das; Mohan Kumar; V. Bhargava; P.N. Singla
[No abstract available]
Cord serum and placental tissue iron status in maternal hypoferremia
(1979) P.N. Singla; S. Chand; K.N. Agarwal
Studies on 85 mothers term infants and 32 mothers with preterm infants revealed that the cord serum and placental tissue iron levels were significantly reduced (P<0.001) in the mothers with hypoferremia (serum iron ≤ 50 μg/100 ml). These levels were found to have linear correlations with the maternal serum iron levels, suggesting that the fetus and the placenta extracted iron in amounts proportional to the levels available in the mother. The high serum iron values in cord blood compared to the maternal blood even in the mothers with hypoferremia suggested that the process of active transfer of iron from mother to the fetus was maintained in maternal iron deficiency.
Endoscopic and histopathological evaluation of preschool children with chronic diarrhoea
(2001) O.P. Mishra; Taru Dhawan; P.N. Singla; V.K. Dixit; N.C. Arya; G. Nath
Fifty-seven children with chronic diarrhoea, aged 1-5 years, were studied. Protein-energy malnutrition was present in 49 (85.9 per cent) children. Anaemia (89.5 per cent), presence of mucus and blood in stool (66.6 per cent), abdominal distension (52.6 per cent), and abdominal pain (28.1 percent) were the common clinical findings at admission. The enteropathogens isolated from the stool of 68.4 per cent of patients were Escherichia coli (19.3 per cent), Candida albicans (12.3 per cent), E. histolytica (8.8 per cent), and Giardia lamblia (7 per cent). Secondary lactose intolerance was present in 21 per cent of children, endoscopic appearance was abnormal in 23.3 per cent of children and the commonest finding was chronic duodenitis (16.7 per cent). Abnormal histopathology was observed in 73.3 per cent of cases and villous atrophy with mononuclear cell infiltration (56.7 percent) was the most common abnormality detected. The mean duration of diarrhoea had no impact on endoscopic appearance but is significantly affected the histopathological changes. However, no correlation was found in endoscopic and histopathological lesions in relation to malnutrition and aetiological agents.
Erythrocytic enzymes and amino acids related to glutamic acid metabolism in childhood hypoproteinemic states
(1981) K.N. Agarwal; B.D. Bhatia; R.K. Batta; P.N. Singla; R. Shankar
[No abstract available]
Etiology of maternal and early childhood deficiency anemia
(Springer India, 1986) D.K. Agarwal; B. Bhardwaj; P.N. Singla; A.M. Tripathi; K.N. Agarwal
One hundred mothers from the urban slum and rural areas of Varanasi and their 109 children between 3 months and 3 years of age were studied. The prevalence of anemia in the mothers (Hb<12·0 g%) and their children (Hb<11·0 g%) was 57·0 and 55·0 and 55·0 per cent respectively. The mean age of anemic children (18·4±9·2 months) was higher than that of nonanemic children (15·1±11·3 months). The prevalence of anemia in the children of anemic mothers was 63·5 per cent as compared to 43·5 per cent in the children of non-anemic mothers (p<0·05). This difference could be due to poor maternal iron stores, prolonged breast feeding and higher prevalence of intestinal parasites in the anemic mothers and children (73·8 and 59·9% respectivelty) compared to (19·4 and 2·6%) in their non-anemic counterparts. © 1986 Dr. K C Chaudhuri Foundation.
Evaluation of frequency and dose of iron and other hematinics - An alternative strategy for anemia prophylaxis in rural preschoolers
(1984) B.K. Das; M.S. Bal; A.M. Tripathi; P.N. Singla; D.K. Agarwal; K.N. Agarwal
[No abstract available]
Fetal growth in maternal anaemia
(Oxford University Press, 1997) P.N. Singla; M. Tyagi; Ashok Kumar; D. Dash; R. Shankar
The effect of maternal iron deficiency anemia on fetal growth was studied in 54 anaemic (haemoglobin < 11.0 g/dl) mothers. Twenty-two mothers served as controls (haemoglobin ≤ 11.0 g/dl). All the women had singleton live births at term gestation. The maternal iron status was assessed by serum ferritin estimation. The birth weight, head circumference, chest circumference, mid-arm circumference, and crown heel length were significantly low in infants born to women with moderate haemoglobin 6.1 ± 8.5 g/dl) and severe anaemia (haemoglobin ≤ 6.0 g/dl), in comparison to infants born to non-anaemic women. Similarly, birth weight, mid-arm circumference, and crown-heel length were significantly low in infants of women with depleted iron stores (serum ferritin < 10 μg/l) than in infants of women with serum ferritin levels of 20 μg/l or more. A indices of fetal growth showed linear relationships with maternal haemoglobin, as well as with serum ferritin. The growth retarding effect of maternal anaemia was more on fetal birth weight and mid-arm circumference than on other anthropometric indices of the newborn.
Fetal iron status in maternal anemia
(Blackwell Publishing Ltd, 1996) P.N. Singla; M. Tyagi; R. Shankar; D. Dash; A. Kumar
Hemoglobin, serum iron, transferrin saturation and ferritin were measured on paired maternal and cord blood samples in 54 anemic (hemoglobin < 110 g/L) and 22 non-anemic (hemoglobin ≤ 110 g/L) pregnant women at term gestation. The levels of hemoglobin, serum iron, transferrin saturation and ferritin were significantly low in the cord blood of anemic women, suggesting that iron supply to the fetus was reduced in maternal anemia. The linear relationships of these parameters with both maternal hemoglobin and maternal serum ferritin indicated that the fetus extracted iron in amounts proportional to the levels available in the mother. Infants of mothers with moderate and severe anemia had significantly lower cord serum ferritin levels and hence poor iron stores at birth. It is concluded that iron deficiency anemia during pregnancy adversely affects the iron endowment of the infant at birth.
Haemostatic status of children with protein-energy malnutrition [2]
(1998) P.N. Singla; J.S. Kashyap; O.P. Mishra; B. Dube
[No abstract available]
Influence of gestational age on cord blood immunogilobulin and complement levels
(1996) Ashok Kumar; Praveen Jauhari; Usha Singh; P.N. Singla
[No abstract available]
Iniobezoar
(1982) G.D. Singhal; P.N. Singla; B.D. Bhatia
[No abstract available]
Outcome of dialysed patients with acute renal failure
(1996) U.T.N. Acharya; P.N. Singla; R.G. Singh Usha; O.P. Mishra
[No abstract available]
Quantitation of T cells in venous blood of healthy neonates
(Springer India, 1994) Ashok Kumar; Praveen Jauhari; Usha Singh; P.N. Singla
Quantitation of T Cells in blood is the part of the diagnostic workup for cellular immunity. Specimens of venous blood were collected within 24 hours of birth from 51 healthy, appropriate for gestational age infants. T lymphocytes were identified on the basis of their ability to form rosettes with sheep erythrocytes. The lymphocytes were harvested from peripheral venous blood, which is considered to be more representative of the immune status in the newborn than the cord blood. In the newborn infants the proportion in T cells was found to be considerably diminished in comparison to previously reported values for adults. Preterm infants, especially those with gestational age of 34 wk or less had significantly lower percentage of T cells in their blood as compared with term infants. The proportion of T cells was statistically reduced in infants weighing 2000g or less in contrast to those weighing 2500 g or more. © 1994 Dr. K C Chaudhuri Foundation.
Serum magnesium levels in protein-energy malnutrition
(Oxford University Press, 1998) P.N. Singla; Prakash Chand; Ashok Kumar; J.S. Kachhawaha
Serum magnesium levels were measured by atomic absorption spectrophotometry in 46 malnourished and 12 healthy children, aged 3 months to 5 years. The nutritional status of children was classified in relation to weight for age and height for age using the Indian Academy of Pediatrics and the Waterlow classifications, respectively. NCHS data were used for the purposes of comparison. Serum magnesium levels were significantly low in children with moderate (weight for age 61-70 per cent) and severe (weight ≤ 60 per cent) malnutrition, and in children with marked linear growth retardation (height for age < 85 per cent). Nearly half of the marasmic children had serum magnesium levels in the hypomagnesemic range (below 1.56 mg/dl). Serum magnesium levels had significant correlations with height for age and serum albumin.
Serum, zinc and copper levels in children with protein energy malnutrition
(The Indian Journal of Pediatrics, 1996) P.N. Singla; Prakash Chand; Ashok Kumar; J.S. Kachhawaha
Serum zinc and copper were measured by atomic absorption spectrophotometry in 58 children (3 months-5 years); of these, 46 children had protein energy malnutrition (PEM), and 12 children served as controls. The levels of serum zinc and copper were found to be significantly low in children with severe malnutrition (grades III and IV PEM). There was a significant positive correlation between serum zinc and height-for-age (r = 0.8809, p < 0.001). Serum copper was found low only in children exhibiting marked linear growth retardation (height-for-age < 85% of the normal). Hypoalbuminemia (serum albumin < 2.5 g/dl), and anemia (hemoglobin ≤ 8.0 g/dl) in malnourished children were associated with significant decline in serum zinc and copper levels, respectively.
Studies on normal hemoglobin and hematocrit values in healthy children based on hematinic supplementation
(1981) P.N. Singla; K.N. Agarwal
[No abstract available]
Vitamin B12 and folic acid in preschool anemia
(1985) P.N. Singla; B. Bhardwaj; D.K. Agarwal; K.N. Agarwal
[No abstract available]