Browsing by Author "P.R. Sinha"

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Adverse effects of oral amiodarone therapy.
(1992) P.R. Sinha; S. Dube; Sujata; P.R. Gupta; P. Avasthey; P.N. Somani
Oral amiodarone was administered to 38 patients (25 males, 13 females) with mean age of 43.6 years. Ventricular and supraventricular arrhythmias were present in 30 and 8 patients respectively. Amiodarone was given as 400-1200 mg/day for 1-2 weeks as loading dose and then it was maintained as 100-600 mg/day. The mean duration of therapy was 12.4 months. Adverse effects were noted in 21 (55.3%) cases. The commonest adverse effects observed were asymptomatic corneal microdeposits followed by gastrointestinal, cardiac, neurological and cutaneous disturbances. The drug was withdrawn in 2 (5.3%) patients because of nausea and vomiting. One patient died of pulmonary infiltrations. It is concluded that adverse effects are common with amiodarone but are tolerated well, making this drug an excellent choice for treatment of cardiac arrhythmias.
BATAL: The balloon measurement campaigns of the Asian tropopause aerosol layer
(American Meteorological Society, 2018) J.-P. Vernier; T.D. Fairlie; T. Deshler; M. Venkat Ratnam; H. Gadhavi; B.S. Kumar; M. Natarajan; A.K. Pandit; S.T. Akhil Raj; A. Hemanth Kumar; A. Jayaraman; A.K. Singh; N. Rastogi; P.R. Sinha; S. Kumar; S. Tiwari; T. Wegner; N. Baker; D. Vignelles; G. Stenchikov; I. Shevchenko; J. Smith; K. Bedka; A. Kesarkar; V. Singh; J. Bhate; V. Ravikiran; M. Durga Rao; S. Ravindrababu; A. Patel; H. Vernier; F.G. Wienhold; H. Liu; T.N. Knepp; L. Thomason; J. Crawford; L. Ziemba; J. Moore; S. Crumeyrolle; M. Williamson; G. Berthet; F. Jégou; J.-B. Renard
A series of NASA-ISRO-sponsored balloon campaigns in India and Saudi Arabia, called the Asian tropopause aerosol layer (ATAL) was conducted between 2014 and 2017 to study the nature, formation, and transport of polluted aerosols in the upper troposphere and lower stratosphere during the Asian summer monsoon (ASM). The ATAL was confirmed through solar occultation observations by Stratospheric Aerosol and Gas Experiment (SAGE) II after improving the cloud-aerosol separation approach using the ratio between aerosol extinction coefficients retrieved at two wavelengths. Analysis of long-term satellite measurements of upper troposphere and lower stratosphere (UTLS) aerosols suggested that ATAL's aerosol optical depth had increased by 2-3 times since the late 1990s, pointing out its possible connection with Asian pollution growth.
Chronic atrial fibrillation reverting to sinus rhythm following thumpversion in a case of rheumatic heart disease.
(1990) P.R. Gupta; P.R. Sinha; P.N. Somani
[No abstract available]
Cor-triatriatum with atrial septal defect and bicuspid aortic valve diagnosed by cross-sectional echocardiography.
(1990) P.R. Gupta; P.R. Sinha; P. Avasthey
We report a rare case with a combination of cor-triatriatum, large secundum atrial septal defect and bicuspid aortic valve. The diagnosis was made by cross-sectional echocardiography. A defect was present between proximal (accessory) left atrial chamber and right atrium decompressing the accessory left atrial chamber. The large left to right shunt resulted in severe pulmonary arterial hypertension.
Diastolic collapse of both atria in patients of cardiac tamponade: report of two cases.
(1992) P.R. Sinha; P.R. Gupta; P. Avasthey
[No abstract available]
Intracardiac hydatid cyst and sudden death in a child
(1995) P.R. Sinha; N. Jaipuria; P. Avasthey
Left ventricular hydatid cyst was diagnosed in a 4-year-old boy by echocardiography. The patient did not respond to oral mebendazole therapy and had a sudden death, probably due to rupture of the cyst. The occurrence of cardiac hydatid cyst and its life threatening complications are rare and have not been reported in children. © 1995.
Intrapericardial echogenic images and development of constrictive pericarditis in patients with pericardial effusion
(Mosby Inc., 1996) P.R. Sinha; B.P. Singh; N. Jaipuria; K.D. Rao; G.G. Shetty; P. Avasthey
[No abstract available]
Neuropsychiatric presentations in a case of infective endocarditis.
(1994) P.R. Sinha; S.R. Saxena; P.K. Srivastava
[No abstract available]
Patterns and determinants of dyslipidaemia in 'Young' versus 'Not so Young' patients of coronary artery disease: A multicentric, randomised observational study in northern India
(Elsevier B.V., 2012) Nakul Sinha; Sudeep Kumar; Himanshu Rai; Neha Singh; Aditya Kapoor; Satyendra Tewari; R.K. Saran; V.S. Narain; R.P.S. Bharadwaj; R.K. Bansal; P.C. Saxena; P.R. Sinha; P.R. Gupta; Mukul Mishra; Praveen Jain; C.M. Pandey; Uttam Singh; S.S. Agarwal
Aims: The aims of the study were to ascertain difference in lipid levels of 'Young' onset of coronary artery disease (CAD) (≤ 45 years) vs. 'Not so Young' onset of CAD (≥ 55 years) among north Indians and also to investigate determinants of 'dyslipidaemia' in CAD patients. Methods: This was a prospective, multicentric, randomised, observational study carried in eight cen- tres of UP, India. All blood investigations were performed employing a central laboratory. Results: Out of a total 435 patients studied, 218 were in the 'young group' (YG) and 235 were in the 'Not so Young Group' (NSYG). Dyslipidaemia was more common in YG as evident by significantly higher levels of total cholesterol, triglycerides, low- and very low-density lipoprotein cholesterol as compared to NSYG. Diabetes, hypertension, urban lifestyle, and family history of CAD were found to be important determinants of dyslipidaemia in YG. Conclusion: We conclude that lipid levels among north Indians are significantly higher in younger patients with CAD when compared with elderly. © 2012, Cardiological Society of India. All rights reserved.
Some unusual and severe forms of adverse drug reactions : A call for setting adverse drug reaction monitoring centres
(1998) S.K. Bhattacharya; N.K. Singh; R.C. Prasad; P.R. Sinha
Thirty four patients aged 14 to 65 years (18 males and 16 females) admitted to the University Hospital with various unusual and severe forms of adverse drug reactions were studied. It comprised of toxic epidermal necrolysis in 8 patients, systemic vasculitis in 7 of which 3 patients had gangrene of fingers and/or toes, severe erosive gastritis in 9 patients, Stevens-Johnson syndrome in 7 patients, thrombocytopenic purpura in 2 patients and generalised convulsions in 1 patient Various drugs responsible for causing these adverse drug reactions included antibacterial, antimalarials, anticonvulsants, antituberculars and nonsteroidal anti-inflammatory drugs. Most of the patients recovered. However, 5 of the 8 patients having toxic epidermal necrolysis died of which 2 patients had developed tetanus as a preterminal event. In view of ongoing addition of newer drugs to the therapeutic armamentarium and an increasing incidence of various unusual and severe forms of adverse drug reactions, it is our contention that a separate adverse drug reaction monitoring cell should be established in every hospital setting.
Two-dimensional echocardiographic detection of biventricular thrombi in a case of idiopathic dilated cardiomyopathy
(1993) P.R. Sinha; S.S. Agrawal; P.R. Gupta
A man aged 50 years presented with a 6-month history of exertional dyspnea and palpitation with features of congestive heart failure. Echocardiography demonstrated biventricular apical thrombi. There was no episode of thromboembolism. The patient was treated with warfarin and was doing well at the time of this study.