Browsing by Author "Palak Thakur"

Now showing 1 - 4 of 4

Alleviation of salt stress using PGPR
(Nova Science Publishers, Inc., 2023) Palak Thakur; Damini; Kushal Thakur; Kirti Raina; Ruchika Kumari; Rohit Sharma; Randeep Singh; Amandeep Singh; Ashun Chaudhary
Nowadays, increased salt content in agricultural fields has become an acritical environmental concern, posing a threat to the human population worldwide regarding food security. Salinity can occur for several reasons, both natural and man-made. Natural soil salinization is caused by the weathering of high-salt-content rock minerals and sediments, fossil salt deposits, coastal land salinization, and salt transport in rivers. Anthropogenic activities result in salinization via improper irrigation, excessive groundwater extraction, land clearing for agriculture, the utilization of waste effluents, and excessive usage of chemical fertilizers. The freshwater supply is gradually dwindling and there is an urgent need for elucidation of the threat caused by salinity. Cultivating salt tolerance through classical breeding programmes is a much-preferred scientific purpose, but with modest success. Starting to introduce salt-tolerant microorganisms that increase crop development is another method for boosting crop salt tolerance. The salt-impacted region around the vicinity of plant roots provides a source of PGPR that can aid plants in adjusting to and growing in high-salinity conditions. Eco-friendly and plant growth is influenced by PGPR in direct and indirect ways with no detrimental effects on the environment. Direct mechanisms include phytohormone biosynthesis, siderophore, increased nitrogen fixation, and increased phosphate solubilization. Indirect mechanisms include phytopathogen inhibition, synthesis of antibiotics, siderophores, and ACC deaminase. By influencing elemental cycling as well as nutrient management, effective PGPR can help to manage salt stress, accelerate the production of crops, and diminish the use of fertilizers. © 2024 Nova Science Publishers, Inc. All rights reserved.
Mechanistic role and potential of Ayurvedic herbs as anti-aging therapies
(Walter de Gruyter GmbH, 2023) Kirti Raina; Ruchika Kumari; Palak Thakur; Rohit Sharma; Randeep Singh; Abhinay Thakur; Vikas Anand; Ashun Chaudhary
Introduction: Medicinal plants and herbs are the most important part of the Ayurveda. The term Rasayana in Charaka Samhita confers long life, youthfulness, strong body, freedom from diseases and the plants mentioned in Rsayana possess antiaging property. Aging is the collective term used for the complex detrimental physiological changes that reduce the functional ability of the cell. Oxidative stress, telomeres shortening, inflammation, and mitochondrial dysfunction are the main factors that regulate the aging process. Chronological aging is an irreversible process but the factors causing biological aging can be controlled. Ayurvedic herbs are better for the management of age-related problems. There are several natural bioactive agents present in plants that can delay the aging process in humans. They trigger actions like enhancing gene longevity and telomerase activity, ROS scavenging furthermore regeneration of tissues. Content: The plants mentioned in the Rasayana of Ayurveda have antiaging potential and can be used to solve modern problems related to aging. Some Ayurvedic plants and their antiaging potential has explained in this review. The main causes of aging, medicinal plants and their use as potential antiaging mediator are covered in this study. Summary: The process of aging is still an enigma. It is a complex, irretrievable, dynamic process that involves a number of factors and is subject to a number of environmental and genetic influences. Rasayana aspect has not been much investigated in clinical trials. Aging is considered to result from free radical damage. According to Charaka, Rasayana drugs open the partially or fully blocked channels. Many Rasayanas show free radical scavenging activity and has the potential to mitigate the effects of aging. It gives an overview of the significance of Ayurvedic medicinal plants as a source of inspiration and the use of these plants as remedies for antiaging. Outlook: This study briefly outlooks the causes of aging and how medicinal plants can be used to reverse the aging process. In this study, we discussed the antiaging potential and mechanistic roles of Ayurvedic herbs. These herbs have the properties to slow down the natural process of aging and can successfully manage common age-related problems. © 2023 Walter de Gruyter GmbH, Berlin/Boston.
Mechanistic role and potential of Ayurvedic herbs as anti-aging therapies
(De Gruyter Open Ltd, 2023) Kirti Raina; Ruchika Kumari; Palak Thakur; Rohit Sharma; Randeep Singh; Abhinay Thakur; Vikas Anand; Ashun Chaudhary
Medicinal plants and herbs are the most important part of the Ayurveda. The term Rasayana in Charaka Samhita confers long life, youthfulness, strong body, freedom from diseases and the plants mentioned in Rsayana possess antiaging property. Aging is the collective term used for the complex detrimental physiological changes that reduce the functional ability of the cell. Oxidative stress, telomeres shortening, inflammation, and mitochondrial dysfunction are the main factors that regulate the aging process. Chronological aging is an irreversible process but the factors causing biological aging can be controlled. Ayurvedic herbs are better for the management of age-related problems. There are several natural bioactive agents present in plants that can delay the aging process in humans. They trigger actions like enhancing gene longevity and telomerase activity, ROS scavenging furthermore regeneration of tissues. The plants mentioned in the Rasayana of Ayurveda have antiaging potential and can be used to solve modern problems related to aging. Some Ayurvedic plants and their antiaging potential has explained in this review. The main causes of aging, medicinal plants and their use as potential antiaging mediator are covered in this study. The process of aging is still an enigma. It is a complex, irretrievable, dynamic process that involves a number of factors and is subject to a number of environmental and genetic influences. Rasayana aspect has not been much investigated in clinical trials. Aging is considered to result from free radical damage. According to Charaka, Rasayana drugs open the partially or fully blocked channels. Many Rasayanas show free radical scavenging activity and has the potential to mitigate the effects of aging. It gives an overview of the significance of Ayurvedic medicinal plants as a source of inspiration and the use of these plants as remedies for antiaging. This study briefly outlooks the causes of aging and how medicinal plants can be used to reverse the aging process. In this study, we discussed the antiaging potential and mechanistic roles of Ayurvedic herbs. These herbs have the properties to slow down the natural process of aging and can successfully manage common age-related problems. © 2023 Walter de Gruyter GmbH, Berlin/Boston.
Network pharmacology on mechanistic role of Thymus linearis Benth. against gastrointestinal and neurological diseases
(Elsevier GmbH, 2023) Palak Thakur; Rakesh Kumar; Neha Choudhary; Rohit Sharma; Ashun Chaudhary
Background: Thymus linearis Benth. (TL) is native to the Himalayas and has been used traditionally to cure various diseases. Thymus is a well-known aromatic perennial herb commonly known as Van ajwain or Himalayan Thyme. The main components of the TL essential oil are thymol, terpinene, and p-cymene. There are many biological properties that TL has been reported to exhibit, including antioxidant, analgesic, anti-inflammatory, antipyretic, antibacterial, anticancerogenic, and neuroprotective effects. Purpose: In this study, the network pharmacology and molecular docking were used to explore the potential compounds of TL and their interaction mechanism toward gastrointestinal complications and neurological diseases. Methods: Network pharmacology was used to analyze the active compounds and protein targets of TL on gastrointestinal and neurological related diseases. Protein-protein interaction and Kyoto Encyclopaedia of Genes and Genomes analysis were used to enrich and evaluate key pathways of target proteins. To ensure the reliability of the network pharmacology prediction estimates, molecular docking was used to confirm the relationships between the core components and targets of TL. Result: 77 physiologically active compounds and their 717 predicted protein targets with high association to the neuroactive ligand-receptor interaction pathway were derived from TL. Beta-citronellol, piperitol, p-cymen-8-ol, and alpha-humulene were found to have a role in gastrointestinal diseases associated with neurological diseases. These compounds showed significant levels of multitargeting cluster regulatory activity. The molecular docking results showed regulatory activity of highlighted multi-targeting compounds and the highest docking energy was reported in piperitol. Conclusion: The study shows that Thymus linearis Benth., a medicinal plant with traditional use, possesses valuable biologically active compounds. It emphasizes the potential of Thymus in treating gastrointestinal and neurological diseases by regulating oxidative stress pathways. This research opens up possibilities for discovering antioxidant molecules for future drug development. It is an interesting study with promising implications for further research. © 2023 Elsevier GmbH