Browsing by Author "Parameswarappa S. Byadgi"

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An approach to the understanding of the clinical-etiopathological aspect of COVID-19 (SARS-CoV-2)
(J. K. Welfare and Pharmascope Foundation, 2020) Meena Kumari; Monika Agrawal; Rakesh Kumar Singh; Parameswarappa S. Byadgi
Currently, the world is facing a health and socioeconomic crisis caused by the novel coronavirus disease COVID-19. On 11 March 2020, the World Health Organization (WHO) has declared this disease as a pandemic. The condition (COVID-19) is an infectious disorder triggered by a newly discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2. Most of the COVID-19 infected patients will experience mild to moderate respiratory symptoms and recover without any unique therapy. Assessment of the clinical and epidemio-logical characteristics of SARS-CoV-2 cases suggests the infected patients will not be contagious until the onset of severe symptoms and affects the other organs. Well-differentiated cells of apical airway epithelia communicating with ACE2 were promptly infected to SARS-CoV-2 virus. But the expression of ACE 2 in poorly differentiated epithelia facilitated SARS spike (S) protein-pseudo typed virus entry and it is replicated in polarized epithelia and espe-cially exited via the apical surface. Limiting the transmission of COVID-19 infection & its prevention can be regarded as a hierarchy of controls. In this article, we briefly discuss the most recent advances in respect to aetiology, pathogenesis and clinical progression of the disease COVID-19. © 2020, J. K. Welfare and Pharmascope Foundation. All rights reserved.
Clinical efficacy of Gojihvadi Kwath, Shirishadi Kwath, Sanjeevani Vati, Panchagavya Ghrita Granules & Shunthi Churna for COVID-19 management, a randomized controlled trial
(National Institute of Science Communication and Policy Research, 2024) Parameswarappa S. Byadgi; Meena Kumari; Vishwambhar Singh; Arun Kumar Dwivedi; Sunil Kumar Mishra; Sushil Kumar Dubey; Ashvanee Kumar Chaudhary; R.N. Chaurasia; Namrata Joshi; Hitesh Jani; Rajeev Kumar Mishra; T.B. Singh; P.S. Arunima; Remya Jayakumar
The obscure disease pattern of COVID-19 have to be evaluated with Ayurvedic interventions and the present clinical trial was a randomized open label parallel three-arm control trial on the major and minor symptomatic patients with the recent pandemic. The patients were recruited from the Super specialty building of Sir Sunderlal hospital, COVID-19 ward and home isolated ones. The Ayurvedic intervention includes the 15 days oral administration (Group A) –Gojihvadi Kwath, Sanjeevani Vati; Panchagavya Ghrit Granules; Shunthi (Dry ginger powder) plus conventional treatment, in (Group B) – Shirishadi Kwath, Sanjeevani Vati; Panchagavya Ghrit Granules; Shunthi (Dry ginger powder) plus conventional treatment and in Group C (control group) only the conventional medicines. Assessment was done based on the RT-PCR reports, signs and symptoms. The results point out the efficacy of trial medicine (that is group A and B) to discharge the patients earlier than those from the control group. The early reduction in the signs and symptoms noted were also observed. Group B showed a faster recovery from dry cough and shortness of breath and improvement in appetite. Home-isolation patients showed faster recovery of clinical symptoms than the hospitalized patients. Ayurvedic interventions can accelerate viral load clearance associated with quicker recovery and concurrently decrease the risk of viral dissemination. Additionally, there were no adverse reactions observed with these trial medicines. © 2024, National Institute of Science Communication and Policy Research. All rights reserved.
Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host
(Elsevier Ltd, 2022) Shivangi Agrawal; Ekta Pathak; Rajeev Mishra; Vibha Mishra; Afifa Parveen; Sunil Kumar Mishra; Parameswarappa S. Byadgi; Sushil Kumar Dubey; Ashvanee Kumar Chaudhary; Vishwambhar Singh; Rameshwar Nath Chaurasia; Neelam Atri
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections generate approximately one million virions per day, and the majority of available antivirals are ineffective against it due to the virus's inherent genetic mutability. This necessitates the investigation of concurrent inhibition of multiple SARS-CoV-2 targets. We show that fortunellin (acacetin 7-O-neohesperidoside), a phytochemical, is a promising candidate for preventing and treating coronavirus disease (COVID-19) by targeting multiple key viral target proteins. Fortunellin supports protective immunity while inhibiting pro-inflammatory cytokines and apoptosis pathways and protecting against tissue damage. Fortunellin is a phytochemical found in Gojihwadi kwath, an Indian traditional Ayurvedic formulation with an antiviral activity that is effective in COVID-19 patients. The mechanistic action of its antiviral activity, however, is unknown. The current study comprehensively evaluates the potential therapeutic mechanisms of fortunellin in preventing and treating COVID-19. We have used molecular docking, molecular dynamics simulations, free-energy calculations, host target mining of fortunellin, gene ontology enrichment, pathway analyses, and protein-protein interaction analysis. We discovered that fortunellin reliably binds to key targets that are necessary for viral replication, growth, invasion, and infectivity including Nucleocapsid (N-CTD) (−54.62 kcal/mol), Replicase-monomer at NSP-8 binding site (−34.48 kcal/mol), Replicase-dimer interface (−31.29 kcal/mol), Helicase (−30.02 kcal/mol), Papain-like-protease (−28.12 kcal/mol), 2′-O-methyltransferase (−23.17 kcal/mol), Main-protease (−21.63 kcal/mol), Replicase-monomer at dimer interface (−22.04 kcal/mol), RNA-dependent-RNA-polymerase (−19.98 kcal/mol), Nucleocapsid-NTD (−16.92 kcal/mol), and Endoribonuclease (−16.81 kcal/mol). Furthermore, we identify and evaluate the potential human targets of fortunellin and its effect on the SARS-CoV-2 infected tissues, including normal-human-bronchial-epithelium (NHBE) and lung cells and organoids such as pancreatic, colon, liver, and cornea using a network pharmacology approach. Thus, our findings indicate that fortunellin has a dual role; multi-target antiviral activities against SARS-CoV-2 and immunomodulatory capabilities against the host. © 2022 Elsevier Ltd
Proper digestion as a regulator of female reproductive physiology-an ayurvedic perspective
(J. K. Welfare and Pharmascope Foundation, 2019) Mishra Sarita; Parameswarappa S. Byadgi
Neuro-hormonal regulation of female reproductive system is a well-established theory till today which believes that Gonadotropin-Releasing Hormone(GnRH) is the primary signal that control the activity of Anterior Pituitary Gonadotrops which regulates secretion of Follicular Stimulating Hormone (FSH) and Luteinzing Hormone (LH). Further FSH and LH regulate growth of ovarian follicle and their proper balance results in ovulation. There is consensus among experts about hypothalamus that secret GnRH is the primary site that regulates female reproductive physiology. Now researchers are focused on the factors regulating HPO axis. Since last one decade role of GIT in regulation of HPO axis became the area of interest for researchers. Various studies have been done showing relationship between GIT and HPO axis. In Ayurvedic samhitas artava dhatu and artava-vaha strotasas are considered as the factors regulating reproductive physiology. In present study literature review of Charak Samhita, Sushruta Samhita and Ashtanga Hridaya was done to understand concept of artava dhatu and its regulatory factors. It was found that artava dhatu is formed only after proper digestion. Various factors e.g. type of diet, life style and Agni (status of digestive capacity) having their role on digestion that indirectly influencing artava and artava-vaha strotas. It can be concludes that Ayurvedic concept of ahar, agni and digestion have their regulatory role on female reproductive physiology by regulating formation of artava dhatu. © 2019 and International Journal of Research in Pharmaceutical Sciences.
Stress and fertility-past conviction, present cognizance and future orchestrations
(J. K. Welfare and Pharmascope Foundation, 2019) Mishra Sarita; Parameswarappa S. Byadgi; S.P. Mishra
Different studies have been done to study the effect of stress on reproductive physiology and fertility. Pathogenesis of stress-induced infertility/decrease fecundity is explained by various neuro-hormonal axis and theory of oxidative stress, but proper management of stress and regulation of these neurohormonal axis along with oxidative stress is lacking in modern medical science. A better understanding of stress and its relation with body physiology, especially fertility, is attempted in light of Ayurveda to get knowledge about the etiopathogenesis of stress-induced infertility and its holistic management. In Ayurveda concept of stress is not only confined to psychological factors, but it is the state of disturb body homeostasis, i.e. the state where doshas, dhatus, malas &agni are not in their proper functioning. Diet and lifestyle have their role in maintaining body homeostasis. Along with diet and lifestyle various drugs, therapeutic procedure (panchakarma) & non-materialistic treatment (achar rasayan-rules and beliefs to be followed in life) have been described in Ayurveda to manage disturbed body homeostasis, and thus it helps in the management of stress in a holistic way. Concept of stress management by Ayurvedic concepts like diet, lifestyle, Agni, body puriication methods along with rasayan and ojo-vardhak objects (diet, lifestyle, and drugs) will open a vast area of research about the applicability of these concepts in stress management by the holistic way. It will help to serve society by providing not only cure of stress-related infertility but also give a healthy reproductive life. © 2019, J. K. Welfare and Pharmascope Foundation. All rights reserved.