Browsing by Author "Po-Ru Loh"

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Genetic evidence for recent population mixture in India
(2013) Priya Moorjani; Kumarasamy Thangaraj; Nick Patterson; Mark Lipson; Po-Ru Loh; Periyasamy Govindaraj; Bonnie Berger; David Reich; Lalji Singh
Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) not closely related to groups outside the subcontinent. The date of mixture is unknown but has implications for understanding Indian history. We report genome-wide data from 73 groups from the Indian subcontinent and analyze linkage disequilibrium to estimate ANI-ASI mixture dates ranging from about 1,900 to 4,200 years ago. In a subset of groups, 100% of the mixture is consistent with having occurred during this period. These results show that India experienced a demographic transformation several thousand years ago, from a region in which major population mixture was common to one in which mixture even between closely related groups became rare because of a shift to endogamy. © 2013 The American Society of Human Genetics.