Browsing by Author "Prabhakar Semwal"

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Emergence of monkeypox: a worldwide public health crisis
(Springer, 2023) J. P. Shabaaz Begum; Leirika Ngangom; Prabhakar Semwal; Sakshi Painuli; Rohit Sharma; Ashim Gupta
The human monkeypox virus (MPV), a zoonotic illness that was hitherto solely prevalent in Central and West Africa, has lately been discovered to infect people all over the world and has become a major threat to global health. Humans unintentionally contract this zoonotic orthopoxvirus, which resembles smallpox, when they come into contact with infected animals. Studies show that the illness can also be transferred through frequent proximity, respiratory droplets, and household linens such as towels and bedding. However, MPV infection does not presently have a specified therapy. Smallpox vaccinations provide cross-protection against MPV because of antigenic similarities. Despite scant knowledge of the genesis, epidemiology, and ecology of the illness, the incidence and geographic distribution of monkeypox outbreaks have grown recently. Polymerase chain reaction technique on lesion specimens can be used to detect MPV. Vaccines like ACAM2000, vaccinia immune globulin intravenous (VIG-IV), and JYNNEOS (brand name: Imvamune or Imvanex) as well as FDA-approved antiviral medications such as brincidofovir (brand name: Tembexa), tecovirimat (brand name: TPOXX or ST-246), and cidofovir (brand name: Vistide) are used as therapeutic medications against MPV. In this overview, we provide an outline of the MPV’s morphology, evolution, mechanism, transmission, diagnosis, preventative measures, and therapeutic approaches. This study offers the fundamental information required to prevent and manage any further spread of this emerging virus. © 2023, The Author(s) under exclusive licence to Japan Human Cell Society.
Exploring nutritional supplement use for countering respiratory tract infections through an X (formerly Twitter)-based survey
(Elsevier B.V., 2025) Rajeev K. Singla; Himel Mondal; Shailja Singla; Ronita De; Sahar Behzad; Mihnea Alexandru Gǎman; Siva Sai Chandragiri; Merisa Ćenanović; Jayanta Kumar Patra; Jennifer R. Depew; Boyina Hemanth Kumar; Abdulkadir Yusif Maigoro; Soojin Lee; Omar Mohammad Atrooz; Gitishree Das; Fabien Schultz; Emad M. Abdallah; Hitesh Chopra; Jamil Ahmad; Rupesh Kumar Gautam; Sourav Sanchit Patnaik; Goh Bey Hing; Smith Borakaeyabe Babiaka; Sharad Vats; Michael P. Okoh; Atallah F. Ahmed; Ankit Kumar Dubey; Ronan Lordan; Parasuraman Aiya Subramani; Amit Kumar Singh; José M. Alvarez-Suarez; Dinesh Kumar Chellappan; Shravan Kumar Paswan; Prabhakar Semwal; Johra Khan; Sadeeq Muhammad Sheshe; Neeraj Kumar Sethiya; Tomasz M. Karpiński; Muhammad Ijaz Riaz; Zahra Emam-Diomeh; Girish Kumar Gupta; Reecha Madaan; Suresh Kumar; Neeraj Choudhary; Salvatore Parisi; Harald Willschke; Vasil Radoslavov Pirgozliev; Rehab A. Rayan; Valentin Ritschl; Shaikat Mondal; Gokhan Zengin; Pritt Verma; Bhupinder Kapoor; Monica Gulati; Gareeballah Osman Adam Balla; Dan Khoa Le; Valeria Pittalà; Amr El-Demerdash; Garba Mohammed Khalid; Jesus Simal-Gandara; Qushmua E. Alzahrani; G. L. RUSSO; Kiran R. Kharat; Anupam Bishayee; Dongdong Wang; I. E. Orhan; Hammad Ullah; Michael M. Heinrich; Bikash Baral; Nikolay T. Tzvetkov; Andy Wai Kan Yeung; João Dias-Ferreira; Scarlett Perez Olea; Yugal Kishore Mohanta; Azazahemad A. Kureshi; Claudiu T. Supuran; Neeraj Rani; Rohit Gundamaraju; Eoghan Joseph Mulholland; Sara Di Lonardo; Albena T. Dinkova-Kostova; Elena Ma González-Burgos; Lucian Hriţcu; Pravin Badhe; Abhilasha Singh; Fuad Al-Rimawi; Antoni Sureda Gomila; Rambod Abiri; Nady Braidy; Lorenz Kapral; A. N. Abdullahi; Christhian Delfino Villanueva Medina; Helen Sheridan; Massimo Lucarini; A. Durazzo; Francesca Giampieri; Davide Barreca; Witkowska Anna Maria; J. C. Andrade; Carmela Fimognari
Background: Respiratory tract infections are a common health issue, driving interest in preventive strategies like nutritional supplements, while evidence on their usage and effectiveness remains limited. In this context, social media platforms, particularly X (formerly Twitter), provide a unique opportunity to gather large-scale public health-related data. Objectives: In this study, we aimed to survey participants’ uses and opinions on nutritional supplements in prevention or treatment of respiratory tract infections, by using X. Methods: A survey was conducted between 1st and 15th December 2022. A single open-ended question “Which are the best dietary supplements to counteract respiratory infections?“ was asked. One week after the start of the survey, a poll was posted to get more relevant information and boost the survey's reach. Total endorsements were calculated for each tweet posted as the total sum of replies, retweets, and likes. Results: The open-ended question received a total of 118 retweets, 39 quotes, and 371 likes, while the poll received 56 retweets, 13 quotes, and 67 likes. A total of 495 replies, 2,251 retweets, 5,118 likes, and 148 quotes were received for the question and its related tweets. Vitamin D (1,607 endorsements), zinc (1,347 endorsements), vitamin C (803 endorsements), magnesium (694 endorsements), and honey (661 endorsements) were the nutritional supplements that received most endorsements. Conclusion: Various foods, drinks, and natural ingredients have been suggested as potentially helpful for counteracting respiratory infections. Approximately half of respondents indicated using such supplements for themselves. The result of this study supports the idea that the X platform can be used as an effective survey tool to study global health-related behaviours and trends. © 2025 The Authors
Formulation and assessment of penetration potential of Risedronate chitosan nanoparticles loaded transdermal gel in the management of osteoporosis: In vitro and ex vivo screening
(Elsevier Ltd, 2024) Sandhya Pathak; Prashant Sahu; J.P. Shabaaz Begum; Sushil K Kashaw; Archana Pandey; Prabhakar Semwal; Rohit Sharma
Osteoporosis targeting by transdermal distribution has drawn a lot of attention as a cutting-edge, environmentally friendly platform for sustainable pain management. We investigate a novel biocompatible transdermal gel (RCNGL) containing biodegradable chitosan nanoparticles and Risedronate (RS) to treat osteoporosis. The RCNGL was formulated using the Pluronic F 127 co-polymer system and the ionic gelation process. The formulation showed a robust architecture of nanoparticle dispersion with a nano-size range of 201.8 nm when it was thoroughly analysed for Scanning Electron Microscopy, Dynamic electron Microscopy and transmission electron microscopy. At various temperatures, the entrapment efficiency was 67.53±1.05% with steady rheology and respectable porosity, validating FT-IR spectra that showed structural compatibility of RS with other excipients. The drug release test resulted in an 88% RS gel release, supporting sustained release kinetics. The ex vivo Franz diffusion study and in vitro cell uptake and distribution experiments revealed clear cell uptake and distribution with notable skin permeation displaying >70% RS release in mouse epidermal tissue. Overall, our research shows that biodegradable RCNGL may offer a potential osteoporosis and pain control strategy in clinical platforms using passive targeting. © 2024
Literature-based screening and bibliometric analysis of the chemical composition, antioxidant and antimicrobial potential of essential oils isolated from Allium genus: 23 years of investigation
(Elsevier B.V., 2024) Baby Gargi; Pooja Singh; Sakshi Painuli; Nishant Rai; Prabhakar Semwal; Natália Cruz-Martins; Rohit Sharma
Introduction: Various medicinal and aromatic plants possess bioactive components that exhibit therapeutic, cosmetic and pharmaceutical properties. Allium species comprise a subgroup of these medicinal plants which offers these potential advantages. The natural volatile oils derived from these plants have a broad range of functions owing to their richness in bioactive components. Therefore, the interest of presents study is to provide an updated and quantified information regarding the therapeutical commercial products, chemical composition, and biological applications, such as antioxidant and antimicrobial activity of Allium genus essential oils. Methods: This work is designed using a mixed methodology; an extensive data search was conducted for the period from 2000 to 2023 (July). The keywords “Essential oil”, “Allium genus”, “Bioactive components”, “Antimicrobial activity”, and “Antioxidant potential”, were utilised to extract the data. The information for the literature review was obtained from the PubMed database, while the SCOPUS online database was used for bibliometric analysis. Results: A total of 294 entries were found in PubMed, out of which only 42 studies were selected for comprehensive review based on their experimental approach, including in vivo (1) and in vitro (41) studies. Apart from this, 244 articles were selected and subjected to bibliometric analysis using the VOSviewer and Bibliometrix software. The Allium genus is one of the most representative genera from Amaryllidaceae family, whose therapeutic benefits are properly consolidated in a wide variety of ailments. Traditionally, the Allium species have been consumed in China as spices and vegetables. Although, modern Chinese medicine system have conducted several studies over the years to address the chemical composition, biological applications and commercially available products containing the essential oils of genus Allium. Conclusion: In this sense, this concise review provides an overview of the composition and biological potential (antioxidant and antimicrobial) of the Allium species-derived essential oils. The results from published works also illustrate that these volatile oils are effective in several microbial species and can be exploited as a multi-potent drug against various ailments with advanced safety and efficacy. Although, the integration of past knowledge with current research underscores the enduring significance of Allium essential oils. Furthermore, it highlights the research patterns and future trends in this research domain, providing valuable insights for future researchers to explore this domain further. © 2024 The Author(s)
Mechanistic inhibition of gastric cancer-associated bacteria Helicobacter pylori by selected phytocompounds: A new cutting-edge computational approach
(Elsevier Ltd, 2023) Shopnil Akash; Imren Bayıl; Sajjat Mahmood; Nobendu Mukerjee; Tamanna Akter Mili; Kuldeep Dhama; Md Anisur Rahman; Swastika Maitra; Mohamed Mohany; Salim S. Al-Rejaie; Nemat Ali; Prabhakar Semwal; Rohit Sharma
Background: Helicobacter pylori (H. pylori) is a persistent bacterial inhabitant in the stomachs of approximately half the global populace. This bacterium is directly linked to chronic gastritis, leading to a heightened risk of duodenal and gastric ulcer diseases, and is the predominant risk factor for gastric cancer - the second most common cause of cancer-related deaths globally. The increasing prevalence of antibiotic resistance necessitates the exploration of innovative treatment alternatives to mitigate the H. pylori menace. Methods: Initiating our study, we curated a list of thirty phytochemicals based on previous literature and subjected them to molecular docking studies. Subsequently, eight phytocompounds—Glabridin, Isoliquiritin, Sanguinarine, Liquiritin, Glycyrrhetic acid, Beta-carotin, Diosgenin, and Sarsasapogenin—were meticulously chosen based on superior binding scores. These were further subjected to an extensive computational analysis encompassing ADMET profiling, drug-likeness evaluation, principal component analysis (PCA), and molecular dynamic simulations (MDs) in comparison with the conventional drug, Mitomycin. Results: The natural compounds investigated demonstrated superior docking affinities to H. pylori targets compared to the standard Mitomycin. Notably, the phytocompounds Diosgenin and Sarsasapogenin stood out due to their exceptional binding affinities and pharmacokinetic properties, including favorable ADMET profiles. Conclusion: Our comprehensive and technologically-advanced approach showcases the potential of identified phytocompounds as pioneering therapeutic agents against H. pylori-induced gastric malignancies. In light of our promising in silico results, we recommend these natural compounds as potential candidates for advancing H. pylori-targeted drug development. Given their potential, we strongly advocate for subsequent in vitro and in vivo studies to validate their therapeutic efficacy against this formidable gastrointestinal bacterium. © 2023
Nanoparticles in clinical trials of COVID-19: An update
(Elsevier Ltd, 2022) Abdur Rauf; Tareq Abu-Izneid; Anees Ahmed Khalil; Nabia Hafeez; Ahmed Olatunde; Mominur Rahman; Prabhakar Semwal; Yahya Saleh Al-Awthan; Omar Salem Bahattab; Ishaq N. Khan; Muhammad Arslan Khan; Rohit Sharma
Once the World Health Organization (WHO) declared the COVID-19 (Coronavirus Infectious Disease-19) outbreak to be pandemic, massive efforts have been launched by researchers around the globe to combat this emerging infectious disease. Strategies that must be investigated such as expanding testing capabilities, developing effective medicines, as well as developing safe and effective vaccines for COVID-19 disease that produce long-lasting immunity to human system. Now-a-days, bio-sensing, medication delivery, imaging, and antimicrobial treatment are just a few of the medical applications for nanoparticles (NPs). Since the early 1990s, nanoparticle drug delivery methods have been employed in clinical trials. Since then, the discipline of nanomedicine has evolved in tandem with expanding technological demands to better medicinal delivery. Newer generations of NPs have emerged in recent decades that are capable of performing additional delivery tasks, allowing for therapy via novel therapeutic modalities. Many of these next generation NPs and associated products have entered clinical trials and have been approved for diverse indications in the present clinical environment. For systemic applications, NPs or nanomedicine-based drug delivery systems have substantial benefits over their non-formulated and free drug counterparts. Nanoparticle systems, for example, are capable of delivering medicines and treating parts of the body that are inaccessible to existing delivery systems. As a result, NPs medication delivery is one of the most studied preclinical and clinical systems. NPs-based vaccines delivering SARS-CoV-2 antigens will play an increasingly important role in prolonging or improving COVID-19 vaccination outcomes. This review provides insights about employing NPs-based drug delivery systems for the treatment of COVID-19 to increase the bioavailability of current drugs, reducing their toxicity, and to increase their efficiency. This article also exhibits their capability and efficacy, and highlighting the future aspects and challenges on nanoparticle products in clinical trials of COVID-19. © 2022 IJS Publishing Group Ltd
Superbugs or multidrug resistant microbes: A new threat to the society
(John Wiley and Sons Inc, 2023) Sakshi Painuli; Prabhakar Semwal; Rohit Sharma; Shopnil Akash
[No abstract available]
The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis
(Elsevier GmbH, 2023) Rajeev K. Singla; Ronita De; Thomas Efferth; Bruno Mezzetti; Md. Sahab Uddin; Sanusi; Fidele Ntie-Kang; Dongdong Wang; Fabien Schultz; Kiran R. Kharat; Hari Prasad Devkota; Maurizio Battino; Daniel Sur; Ronan Lordan; Sourav S Patnaik; Christos Tsagkaris; Chandragiri Siva Sai; Surya Kant Tripathi; Mihnea-Alexandru Găman; Mosa E.O. Ahmed; Elena González-Burgos; Smith B. Babiaka; Shravan Kumar Paswan; Joy Ifunanya Odimegwu; Faizan Akram; Jesus Simal-Gandara; Mágali S. Urquiza; Aleksei Tikhonov; Himel Mondal; Shailja Singla; Sara Di Lonardo; Eoghan J Mulholland; Merisa Cenanovic; Abdulkadir Yusif Maigoro; Francesca Giampieri; Soojin Lee; Nikolay T. Tzvetkov; Anna Maria Louka; Pritt Verma; Hitesh Chopra; Scarlett Perez Olea; Johra Khan; José M. Alvarez Suarez; Xiaonan Zheng; Michał Tomczyk; Manoj Kumar Sabnani; Christhian Delfino Villanueva Medina; Garba M. Khalid; Hemanth Kumar Boyina; Milen I. Georgiev; Claudiu T. Supuran; Eduardo Sobarzo-Sánchez; Tai-Ping Fan; Valeria Pittala; Antoni Sureda; Nady Braidy; Gian Luigi Russo; Rosa Anna Vacca; Maciej Banach; Gérard Lizard; Amira Zarrouk; Sonia Hammami; Ilkay Erdogan Orhan; Bharat B. Aggarwal; George Perry; Mark JS Miller; Michael Heinrich; Anupam Bishayee; Anake Kijjoa; Nicolas Arkells; David Bredt; Michael Wink; Bernd l. Fiebich; Gangarapu Kiran; Andy Wai Kan Yeung; Girish Kumar Gupta; Antonello Santini; Massimo Lucarini; Alessandra Durazzo; Amr El-Demerdash; Albena T. Dinkova-Kostova; Alejandro Cifuentes; Eliana B. Souto; Muhammad Asim Masoom Zubair; Pravin Badhe; Javier Echeverría; Jarosław Olav Horbańczuk; Olaf K. Horbanczuk; Helen Sheridan; Sadeeq Muhammad Sheshe; Anna Maria Witkowska; Ibrahim M. Abu-Reidah; Muhammad Riaz; Hammad Ullah; Akolade R. Oladipupo; Víctor Lopez; Neeraj Kumar Sethiya; Bhupal Govinda Shrestha; Palaniyandi Ravanan; Subash Chandra Gupta; Qushmua E. Alzahrani; Preethidan Dama Sreedhar; Jianbo Xiao; Mohammad Amin Moosavi; Parasuraman Aiya Subramani; Amit Kumar Singh; Ananda Kumar Chettupalli; Jayanta Kumar Patra; Gopal Singh; Tomasz M. Karpiński; Fuad Al-Rimawi; Rambod Abiri; Atallah F. Ahmed; Davide Barreca; Sharad Vats; Said Amrani; Carmela Fimognari; Andrei Mocan; Lucian Hritcu; Prabhakar Semwal; Md. Shiblur Rahaman; Mila Emerald; Akinleye Stephen Akinrinde; Abhilasha Singh; Ashima Joshi; Tanuj Joshi; Shafaat Yar Khan; Gareeballah Osman Adam Balla; Aiping Lu; Sandeep Ramchandra Pai; Imen Ghzaiel; Niyazi Acar; Nour Eddine Es-Safi; Gokhan Zengin; Azazahemad A. Kureshi; Arvind Kumar Sharma; Bikash Baral; Neeraj Rani; Philippe Jeandet; Monica Gulati; Bhupinder Kapoor; Yugal Kishore Mohanta; Zahra Emam-Djomeh; Raphael Onuku; Jennifer R. Depew; Omar M. Atrooz; Bey Hing Goh; Jose Carlos Andrade; Bikramjit Konwar; V.J. Shine; João Miguel Lousa Dias Ferreira; Jamil Ahmad; Vivek K. Chaturvedi; Krystyna Skalicka-Woźniak; Rohit Sharma; Rupesh K. Gautam; Sebastian Granica; Salvatore Parisi; Rishabh Kumar; Atanas G. Atanasov; Bairong Shen
Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week “2021 INPST Twitter Networking Event” (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events. © 2022 The Author(s)
The Neuroprotective Potential of Endophytic Fungi and Proposed Molecular Mechanism: A Current Update
(Hindawi Limited, 2022) Prabhakar Semwal; Sakshi Painuli; Jigisha Anand; Natália Cruz Martins; Marisa Machado; Rohit Sharma; Gaber El-Saber Batiha; Clement Amen Yaro; Jose M. Lorenzo; Md. Mominur Rahman
Millions of people are affected by neuronal disorders that are emerging as a principal cause of death after cancer. Alzheimer's disease, ataxia, Parkinson's disease, multiple system atrophy, and autism comprise the most common ones, being accompanied by loss of cognitive power, impaired balance, and movement. In past decades, natural polyphenols obtained from different sources including bacteria, fungi, and plants have been utilized in the traditional system of medicine for the treatment of several ailments. Endophytes are one such natural producer of secondary metabolites, namely, polyphenols, which exhibit strong abilities to assist in the management of such affections, through modifying multiple therapeutic targets and weaken their complex physiology. Limited research has been conducted in detail on bioactive compounds present in the endophytic fungi and their neuroprotective effects. Therefore, this review aims to provide an update on scientific evidences related to the pharmacological and clinical potential along with proposed molecular mechanism of action of endophytes for neuronal protection. © 2022 Prabhakar Semwal et al.