Browsing by Author "Prashant Kumar Gupta"

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A Highly Sensitive Ag/MG-CQDs/ZnO NP Ultraviolet Photodetector
(Institute of Electrical and Electronics Engineers Inc., 2022) Anil Kumar; Prashant Kumar Gupta; Monika Srivastava; Amritanshu Pandey; Amit Srivastava; S.K. Srivastava
This article reports the fabrication of marigold flower-derived carbon quantum dots (MG-CQDs) and ZnO nanoparticle (NP)-layered thin-film-based ultraviolet (UV) photodetector (PD) on Si/SiO2 substrates. The MG-CQDs have been green synthesized from natural biomass marigold (MG) flowers by a facile, low-cost hydrothermal synthesis method. The ZnO NPs have been prepared through a rapid sol-gel process. The Ag/MG-CQDs/ZnO NP-layered thin-film-based fabricated UV PDs have good responsivity ({R} ), external quantum efficiency (EQE), and detectivity ({D}{ast } ) values 42.78 A/W, 14535.54%, and {1.99}times {10}{{13}} jones, respectively, under UV radiation (365 nm). The response time of Ag/MG-CQDs/ZnO NP-fabricated UV PD shows adequate rise time (0.213 s) and fall time (0.085 s). © 2001-2012 IEEE.
Characterization of Swarna Bhasma and Swarnaprash and Determination of Antimicrobial Properties Against Gut-Pathobiont and Symbiont
(Springer, 2025) Kavita Singh; Prashant Kumar Gupta; Awanish Kiran Kumar; Brij Mohan Singh
Ayurveda has a long-standing tradition of healthcare in Southeast Asia. Swarnaprash, a classical Ayurveda preparation, is commonly given as the pre-lacteal feed to neonates to prevent labor-related complications and infections. It comprises incinerated gold particles (InAuP/Swarna Bhasma), honey (Madhu), and clarified butter oil (CBO/Cow Ghrita). This in vitro study aimed to evaluate the therapeutic potential of the individual ingredients and combinations of Swarnaprash against selected neonatal gut pathobionts and symbionts. The study employed sophisticated instruments, including SEM with EDAX and X-ray diffraction analysis, to investigate the shape and structural disparities in the ingredients of Swarnaprash. The reported size of gold particles in Swarnaprash ranges from 0.6 to 9.5 µm. These particles are relatively smaller than those in Swarna Bhasma but larger than synthetic gold particles. Swarnaprash demonstrated both bactericidal and bacteriostatic activity against selected neonatal gut pathobionts, with the largest inhibition zones observed for P. aeruginosa and S. Typhi. It surpassed the individual efficacy of its components—Prash, InAuPs, honey, or CBO alone. Notably, Swarnaprash did not affect the selected beneficial gut bacteria. The results warrant further in vivo and clinical studies to explore the effects of Swarnaprash on neonatal gut flora, which would provide vital information for research in neonatal healthcare. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Characterization of Swarna Bhasma and Swarnaprash and Determination of Antimicrobial Properties Against Gut-Pathobiont and Symbiont
(Springer, 2024) Kavita Singh; Prashant Kumar Gupta; Awanish Kumar; Brij Mohan Singh
Ayurveda has a long-standing tradition of healthcare in Southeast Asia. Swarnaprash, a classical Ayurveda preparation, is commonly given as the pre-lacteal feed to neonates to prevent labor-related complications and infections. It comprises incinerated gold particles (InAuP/Swarna Bhasma), honey (Madhu), and clarified butter oil (CBO/Cow Ghrita). This in vitro study aimed to evaluate the therapeutic potential of the individual ingredients and combinations of Swarnaprash against selected neonatal gut pathobionts and symbionts. The study employed sophisticated instruments, including SEM with EDAX and X-ray diffraction analysis, to investigate the shape and structural disparities in the ingredients of Swarnaprash. The reported size of gold particles in Swarnaprash ranges from 0.6 to 9.5 µm. These particles are relatively smaller than those in Swarna Bhasma but larger than synthetic gold particles. Swarnaprash demonstrated both bactericidal and bacteriostatic activity against selected neonatal gut pathobionts, with the largest inhibition zones observed for P. aeruginosa and S. Typhi. It surpassed the individual efficacy of its components—Prash, InAuPs, honey, or CBO alone. Notably, Swarnaprash did not affect the selected beneficial gut bacteria. The results warrant further in vivo and clinical studies to explore the effects of Swarnaprash on neonatal gut flora, which would provide vital information for research in neonatal healthcare. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
CuO NPs Blended WS2-QDs/Si (0D/3D) Vertical Heterojunction for Uniform and Spectrally Enhanced Broadband Photodetection
(American Chemical Society, 2025) Yashwant Puri Goswami; Prashant Kumar Gupta; Amritanshu Pandey
Broadband photodetectors (i.e., sensing units) within the sensor node are a crucial component that plays a critical role in efficiently embedding cutting-edge technologies like the Internet of Things. Compared to other fabrication techniques, 2D layered material’s hybrid structure-based broadband photodetectors (PDs) may be more helpful in effectively deploying these technologies, as they can eliminate fabrication challenges such as complex device fabrication, low operating temperature requirements, and the toxic fabrication environment. Despite the above fabrication eases, the issue of nonuniform spectral response across the operating wavelength, adversely impacting PD efficacy, still needs to be addressed. The present work demonstrates a cost-effective and facile approach for achieving a substantially uniform spectral response across the broadband. The comparative investigation of WS2-QDs-based PD fabricated with and without CuO NPs blending revealed that by blending WS2-QDs with CuO NPs, the spectral response’s uniformity has been improved in addition to the quantitative improvement in the responsivity. The blended heterojunction PD structure demonstrated a broadband response between 365 and 950 nm at a low operating voltage of −1.5 V, with a peak responsivity of 111.84 A/W, EQE of 37993.74%, and detectivity of 2.13 × 1014 Jones. The PD’s temporal response was similarly found to be sufficiently fast, with rise and fall times of 40.83 and 39.76 ms, respectively. © 2025 American Chemical Society.
Exploring the role of pomalidomide in androgen-dependent prostate cancer: a computational analysis
(Springer Nature, 2025) Shivani Pathak; Vipendra Kumar Singh; Prashant Kumar Gupta; Arun Kumar Mahapatra; Rajanish Giri; Rashmi Sahu; Rohit Sharma; Neha Garg
Prostate cancer (PC) is among the most prevalent cancers in males. It is the leading cause of death in men, in around 48 out of 185 countries. Increased androgen receptor (AR) activity is the key factor contributing to the development or progression of newly diagnosed cases of prostate cancer. Over time, numerous compounds targeting AR have been identified, presenting encouraging avenues for suppressing its hyperactivity. In our investigation, we used the GEPIA tool to study the importance of AR in the context of prostate cancer. This tool integrates the data from TCGA and GTEx in the gene expression pattern analysis and their clinical relevance. This analysis evaluates overall survival, disease-free survival, and transcripts per million (TPM) analysis of AR in PC. We performed docking and simulation for FDA-approved anticancer drugs to assess their potential interactions with the AR. We also conducted a comprehensive analysis of drugs using a quantum calculation (DFT) which provides electronic properties, chemical reactivity, and stability using the HOMO–LUMO energy gap. This study suggests that repurposed synthetic anticancer drugs could be better options for treating prostate cancer by inhibiting AR. In this work, we have shown the potential of pomalidomide, a synthetic anticancer drug, as a potential candidate for androgen-dependent PC treatment. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.
Exploring the role of pomalidomide in androgen-dependent prostate cancer: a computational analysis
(Springer Nature, 2024) Shivani Pathak; Vipendra Kumar Singh; Prashant Kumar Gupta; Arun Kumar Mahapatra; Rajanish Giri; Rashmi Sahu; Rohit Sharma; Neha Garg
Prostate cancer (PC) is among the most prevalent cancers in males. It is the leading cause of death in men, in around 48 out of 185 countries. Increased androgen receptor (AR) activity is the key factor contributing to the development or progression of newly diagnosed cases of prostate cancer. Over time, numerous compounds targeting AR have been identified, presenting encouraging avenues for suppressing its hyperactivity. In our investigation, we used the GEPIA tool to study the importance of AR in the context of prostate cancer. This tool integrates the data from TCGA and GTEx in the gene expression pattern analysis and their clinical relevance. This analysis evaluates overall survival, disease-free survival, and transcripts per million (TPM) analysis of AR in PC. We performed docking and simulation for FDA-approved anticancer drugs to assess their potential interactions with the AR. We also conducted a comprehensive analysis of drugs using a quantum calculation (DFT) which provides electronic properties, chemical reactivity, and stability using the HOMO–LUMO energy gap. This study suggests that repurposed synthetic anticancer drugs could be better options for treating prostate cancer by inhibiting AR. In this work, we have shown the potential of pomalidomide, a synthetic anticancer drug, as a potential candidate for androgen-dependent PC treatment. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.
In vitro analysis of synergistic effect of honey against chemically induced hepatic insult in Balb/c mice
(Research Journal of Pharmacy and Technology, 2021) Prashant Kumar Gupta; Chandradeo Narayan; Kamal Shah; Arvind Kumar; Brij Mohan Singh
Human being knows honey since thousands of years for its nutritional and medicinal values. Traditional medicine systems like Ayurveda have elaborated honey as boon for health and patient care. Synergistic effect of honey was research but to a limited extend. Honey is advised with Picrorhiza kurroa for hepatic disorders or hepato-protection in Ayurveda. Here we have examined in vitro synergistic effect of honey when given with Picrorhiza kurroa in acetaminophen-induced hepatotoxicity in Balb/c mice model. We obtained Serum and liver lysate to check levels of hepatic markers, Alkaline phosphatase and Glutathione. The level of alkaline phosphatase raised while glutathione level is reduced during hepatic offence. We observed a compensation of above markers when P. Kurrua, honey and its combination were used in acetaminophen induced hepatic toxicity. We observed a better mice weight gain in combination group (Group IV) compared to control group. This study can pave a way for future research on honey as a better adjuvant for hepatotoxic drugs and other herb-drug interactions researches. © RJPT All right reserved.
Nanopetal-Assembled SnS Flower-Based Vis-NIR Photodetector
(American Chemical Society, 2024) Prashant Kumar Gupta; Yashwant Puri Goswami; Amritanshu Pandey
This paper reports a simple, low-cost, and high-performance two-dimensional (2D) nanopetal-assembled three-dimensional (3D) SnS flowers/Si heterojunction-based visible-near-infrared (vis-NIR) photodetector (PD). A modified chemical bath deposition (CBD) method was used to grow a uniform and closely spaced array of SnS flowers on a Si substrate. This type of nanostructure offers a large photoactive area, thus generating a large number of carriers. The high-performance parameters of the fabricated PD (responsivity, 68.21 A/W; external quantum efficiency (EQE), 1.32 × 104%; detectivity, 6.87 × 1013 Jones; rise time, 193.91 ms; and fall time, 94.19 ms at 635 nm) are attributed to the heterojunction characteristics resulting from closely spaced nanopetal-assembled SnS flowers on silicon. © 2024 American Chemical Society.