Browsing by Author "Prateek Gupta"

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Expressional analysis of MSX1 (Human) revealed its role in sagittal jaw relationship
(Journal of Clinical and Diagnostic Research, 2017) Prateek Gupta; Thakur Prasad Chaturvedi; Vipul Sharma
Introduction: Abnormal skeletal jaw relationships is an important factor causing difficulty in speech, mastication, sleep and social interaction, thus affect the overall well being of an individual. Aim: The present study was an attempt to decipher the role of human MSX1 in terms of sagittal jaw relationship by employing Polymerase Chain Reaction (PCR) based analysis. Materials and Methods: Ninety-eight case subjects belonging to North India with skeletal Class II and Class III jaw relationships were selected. Further, thirty-five control subjects of the same region having Class I skeletal and dental relationships (normal Jaw relationships) with good alignment of all teeth were enrolled. MSX1 gene sequencing was performed using the subjects’ blood samples. Multiple sequence alignment was performed to find Single Nucleotide Polymorphisms (SNP’s). Nine SNP’s were obtained of which seven were reported and two novels. Statistical analysis was performed using Chi square test to compare genotype differences between case and control groups. Results: SNP rs186861426 was found to be significantly associated in Class I subjects (p-value=0.02). The sequencing results suggested that individuals having changes from G (guanosine) with A (adenine) genotype had approximately seven times low risk for developing Class II division 1 malocclusion as compared to those alleles having GG genotype and therefore, allele ‘A’ position on chromosome 4 (rs186861426) seems to have a protective role. Conclusion: The study unfolds an important relationship between MSX1 gene and Class II division 1 malocclusion and Class I normal skeletal relationships. The study tried to interpret the role of human MSX1 and extend the gene pool responsible for the skeletal anomalies related to development of abnormal upper and lower jaws. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.
Intersecting Oppressions: The Lived Realities of Dom Women in Banaras, India
(ACCB Publishing, 2025) Anuradha Singh; Rana Abhyendra Singh; Prateek Gupta; Vishal Singh Bhadauriya
This research presents a theory-driven, qualitative account of how caste and gender work together to shape structural oppression in the lives of Dom women in Banaras (Varanasi), India. Based on fifteen in-depth interviews and approximately eighty hours of participant observation in the cremation settlements adjacent to the Manikarnika and Harishchandra Ghats, the research adopts an intersectional lens rooted in feminist standpoint epistemology. Inductive coding of verbatim transcripts identifies three mutually reinforcing mechanisms—affective discipline (gendered coercion through gratitude and fear), spatial stigma (postal-code proxies for ritual pollution), and metabolic inequality (unequal exposure to toxic ash, bleach, and smoke) — that lock Dom women into hazardous, low-wage niches of the informal economy. Compared with both upper-caste women and Dom men, participants experience significantly higher rates of occupational injury, wage theft and everyday humiliation, confirming that caste-gender oppression is not additive but synergistic. The findings refine intersectionality theory by specifying how “purity” logics operate as a caste-gender gearbox in a South-Asian urban context. By foregrounding the voices of one of India’s most marginalised constituencies, the study demonstrates why adequate social protection must address caste and gender simultaneously, rather than in parallel. © 2025 Singh et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.