Browsing by Author "Preeti Srivastava"

Now showing 1 - 12 of 12

2-Acetylfuran-2-furoylhydrazone complexes of some 3d-metal ions
(Kluwer Academic Publishers, 1986) Bachcha Singh; Preeti Srivastava
2-Acetylfuran-2-furoylhydrazone (1), [HL] reacts with metal ions to yield the complexes of two types, compounds [VO(HL)SO4] and M(HL)2Cl2 [M = CoII, NiII or CuII] and compounds M(L)2(H2O)2 [M = CoII, NiII or CuII], depending on the pH of the medium. These complexes have been characterized by elemental analyses, molar conductance, magnetic susceptibility, visible, e.s.r. and i.r. spectral studies. Square pyramidal geometry for [VO(HL)SO4] and octahedral geometry for the remaining complexes are proposed.[Figure not available: see fulltext.] © 1986 VCH Verlagsgesellschaft mbH.
Comparative in vitro regeneration study of mature and juvenile nodal explants and extraction, isolation, characterization of bio-active constituents from leaves of an endangered medicinal plant Desmodium gangeticum (L.) DC
(International Congress of Chemistry and Environment, 2014) Preeti Srivastava; Brahma Deo Singh; Kavindra Nath Tiwari
An efficient and reproducible micropropagation system for Desmodium gangeticum (L.) DC, an endangered medicinal plant through in vitro culture of nodal explants from one year old branches of field grown mature plants and from 4 week old seedlings has been developed. Nodal explants cultured on growth regulator (GR) free MS medium did not show Auxiliary shoot development. BA (6-benzyl aminopurine) at 4.4 μM induced shoot development from the 100% and 88% of the explants from seedling and mature plant branches respectively; it also produced the highest number of shoots per explants (24.1 and 18.7 shoots from seedling and mature shoot -derived nodal explants respectively). Three subcultures of the nodal explants enable mass multiplication of shoots without the evidence of any decline. The shoots were elongated on 0.58 μM GA3. The highest rooting (96%) and the maximum number of roots (9) per shoot were obtained when elongated shoots were dipped in indole-3-butyric acid (IBA) solution (492.12 μM) for 30 minutes and then cultured on half-strength MS medium. Plantlets were successfully acclimatized and transferred to the field with survival rate of 96%. These plants grew normally in the field without any observable morphological variation.
High frequency in vitro multiplication from cotyledonary node explants of an endangered medicinal plant Desmodium gangeticum L. (DC)
(World Research Association, 2013) Preeti Srivastava; Brahma Deo Singh; Kavindra Nath Tiwari
An efficient, rapid and reproducible plant regeneration protocol was developed for Desmodium gangeticum (L.) DC an endangered medicinal plant. Cotyledonary node explants from 10 day-old aseptic seedlings were cultured on full and half-strength Murashige and Skoog (MS) and Gamborg's (B5) media containing the cytokinins 6-benzyl aminopurine (BA), kinetin (KIN) and thiadiazuran (TDZ). BA was found to be the most effective for shoot proliferation. The highest response (98% of explants) and the maximum number of shoots (12.4 per explant) were induced on MS medium supplemented with 4.44 μM BA. Repeated subcultures of cotyledonary nodes for three months on the above medium enabled mass multiplication of shoots without any evidence of decline. The highest rooting (98%) and maximum number of roots (8) per shoot were obtained when shoots were dipped in indol-3-butyric acid (IBA) solution (492.12 μM) for 30 minutes and then cultured on half-strength MS medium. Plantlets were successfully acclimatized in soilrite with survival rate of 96%. Regenerated plants grew normally in the field without showing any morphological variation.
Screening and identification of salicin compound from Desmodium gangeticum and its in vivo anticancer activity and docking studies with cyclooxygenase (COX) proteins from mus musculus
(2013) Preeti Srivastava; Vinay K. Singh; Brahma Deo Singh; Gaurava Srivastava; Bhuwan B. Misra; Vyasji Tripathi
Cancer continues to be a worldwide killer, despite the enormous amount of research and rapid developments seen during the past decade. It has been suggested that by 2020 more than 15 million new cases of cancer will be diagnosed. Since it is commonly believed that many are preventable, there is urgent need to identify/develop natural medicines as effective chemopreventive agents. The purpose of this current study was to assess the effect of isolated and characterized salicin on cyclooxygenase (COX) proteins by molecular docking studies and by assessments of the effects of drug-ligand interaction. Salicin isolated from Desmodium gangeticum, a medicinal legume, is a COX inhibitor. The present study report the extraction, isolation and identification of salicin and its interaction with COX-1 and COX-2 derivatives, which may be useful for drug-designing for anti-cancer activities. Molecular modeling and docking studies revealed the binding orientations of salicin into the active sites of COX-1 and COX-2 enzymes. Extraction, isolation and characterization of the compound 2-(hydroxymethyl) phenyl hexopyranoside, also known as 'salicin', from the leaves of D. gangeticum first time. Anticancer evaluation of salicin in in vivo mice model. © 2013 Srivastava P, et al.
Spinal muscular dystrophy–a revisit of the diagnosis and treatment modalities
(Taylor and Francis Ltd, 2019) Gaurava Srivastava; Preeti Srivastava
Spinal Muscular Atrophy (SMA) is a pan-ethnic disorder and generally characterized as prevalent lethal genetic disease of infants. It is an autosomal recessive neuromuscular disease caused by degeneration of alpha motor neurons in the spinal cord, resulting in progressive proximal muscle weakness and paralysis. Due to the high carrier frequency (1:50), the burden of this genetic disorder is very heavy in developing countries. Till date no absolute cure or effective treatment of the disease is available in clinical practice, whereas minor enhancement of SMN protein levels can be beneficial. It can be achieved by augmenting SMN2 transcription, stimulating exon 7 splicing and protein stabilization. Due to its low prevalence among population, costly screening and diagnosis, the disease is still lacking proper management. SMN is expressed almost in all tissues of body, still the reason why only lower motor neurons are affected in SMA is unknown. Research is still going on and with advancement of innovative therapies and gene modification, improved outcome may come in near future. Presently, supportive care including respiratory, nutritional, psychiatric and orthopaedic management can ameliorate clinical symptoms and improve survival rates if SMA is diagnosed early in life. Routine prenatal and new-born screening can help with potential benefits and timely management. In this review, the concept of newer methodological system and recent advances for molecular diagnosis of SMA with the variability in the clinical features is stressed. The public health community should remain alert to the rapidly changing developments in early detection and treatment of SMA. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Studies on 2,6-diacetylpyridine bis(2-furoylhydrazone) complexes of bivalent 3d-metal ions
(Kluwer Academic Publishers, 1987) Bachcha Singh; Preeti Srivastava
The chelating behaviour of neutral and deprotonated 2,6-diacetyl-pyridine bis(2-furoylhydrazone), H2dapf, has been investigated in some new complexes of oxovanadium(IV), manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II). The hydrazone reacts with the metal salts to yield complexes of two types; the addition compounds [VO(H2dapf)]SO4, [M(H2dapf)Cl]Cl and the deprotonated complexes [M(dapf)H2O] [M=manganese(II), cobalt(II), nickel(II), copper(II) or zinc(II)] in neutral and alkaline media, respectively. The complexes have been characterized by elemental analyses, molar conductance, magnetic susceptibility, electronic, i.r. and e.s.r. studies and their stereochemistries are discussed. © 1987 Chapman and Hall Ltd.
Studies on 2-acetylpyridine-2-furgylhydrazone complexes of some bivalent transition metal ions
(1986) B. Singh; Preeti Srivastava
Metal(II) complexes of the compositions M(HL)Cl2 [M = Mn, Co, Zn, Cd, Hg], Ni(HL)2Cl2·4H2O, Cu(HL)Cl2·3H2O, M(L)2·nH2O [M = Mn, Co, Ni, Cu, Zn] and the oxovanadium(IV) complex, VO(L)2, LHL = 2-acetylpyridine-2-furoylhydrazone] have been prepared and characterized. Molar conductivities indicate non-electroytic behaviour of the complexes. Magnetic and spectral data such as infrared, electronic and ESR of the complexes are used to establish the stereochemistry and mode of bonding in these complexes. © 1986, Taylor & Francis Group, LLC. All rights reserved.
Studies on 2-acetylthiophene-2-furoylhydrazone complexes of 3d-bivalent metal ions
(Kluwer Academic Publishers, 1987) Bachcha Singh; Preeti Srivastava
Metal(II) complexes of 2-acetylthiophene-2-furoylhydrazone (HL) of the types [VO(HL)SO4], [Cu(HL)2Cl2(H2O)], [M(HL)2Cl2] [M=CoII, NiII, or ZnII] and [ML2(H2O)2] [M=CoII, NiII, CuII or ZnII] have been prepared and characterized on the basis of elemental analyses, molar conductance, magnetic susceptibility, visible, e.s.r. and i.r. spectral studies. The bonding and stereochemistry of the complexes are discussed. © 1987 Chapman and Hall Ltd.
Studies on 2-aminobenzophenone-2-thenolhydrazone complexes of some bivalent transition metal ions
(Kluwer Academic Publishers, 1988) Bachcha Singh; Ashutosh K. Srivastav; Preeti Srivastava
Complexes having the chemical compositions [VO(Habth)2SO4], [M(Habth)2Cl2] [M=CoII, NiII, CuII or ZnII) and [M(abth)2] [M=VIVO, CoII, NiII, CuII or ZnII) and Habth=2-aminobenzophenone-2-thenoylhydrazone] have been prepared and characterized. The complexes are non-electrolytes. Magnetic moments and electronic, photoacoustic, e.s.r. and i.r. spectra of the complexes are used to establish the stereochemistry and mode of bonding of the hydrazone. © 1988 Chapman and Hall Ltd.
Studies on acetylacetonebis-(2-fuboylhydrazone) complexes of some 3d-metal ions
(1988) B. Singh; Preeti Srivastava
A number of new complexes of the compositions VO(H2aafh)SO4, M(H2aafh)Cl2 and M(aafh)(H20)2[m =Mn(II), Co(II), Ni(II), Cu(II) or Zn(II); H2aafh = acetylacetonebis-(2-furoylhydrazone)] have been synthesized and characterized. Molar conductance values indicate the 1:1 electrolytic nature of the vanadyl complex, the 1:2 ionic behaviour of the Cu(H2aafh)Cl2 complex and the non-el ectrolytic nature of the remaining complexes in DMF solution. Magnetic susceptibility and spectral studies such as infrared, electronic and electron spin resonance are used to elucidate the structure of the complexes and the mode of bonding of the ligand. © 1988, Taylor & Francis Group, LLC. All rights reserved.
Studies on o-hydroxyacetophenone-2-furoylhydrazone complexes of some 3d-bivalent metal ions
(Kluwer Academic Publishers, 1986) Bachcha Singh; Preeti Srivastava
Complexes of o-hydroxyacetophenone-2-furoylhydrazone, H2L, of the types M(H2L)C12 · nH2O [Mn = CoII, n=0; NiII, n=2]; Cu(HL)Cl, M(HL)2 [M = VIVO, CoII, NiII or CuII] and M(L)(H2O)n [M = CoII or NiII, n=2; M = CuII, n=0] have been prepared and characterized by elemental analyses, molar conductance, magnetic susceptibility, visible, e.s.r. and i.r. spectral studies. The different modes of ligand chelation and the stereochemistry around the metal ions are discussed. © 1986 VCH Verlagsgesellschaft mbH.
Synthesis and characterization of pyrrole-2-thiqcarboxamide complexes with some bivalent metal ions
(1992) B. Singh; Preeti Srivastava; A.K. Srivastav
Pyrrole-2-thiocarboxamide, HNC4H3C(S)NH2 (ptca), complexes having 1:2 metal-ligand stoichiometry have been prepared and cnaracterized by elemental analyses, molar conductance, magnetic 1 13 susceptibility, electronic, esr, ir and nmr ( H and C) spectral studies. Tetrahedral stereochemistry around Co(II), Ni(ll), Zn(ll), Cd(II) andHg(H) and five coordinate geometry around Cu(ll) have been proposed on the basis of magnetic and spectral studies. © 1992, Taylor & Francis Group, LLC. All rights reserved.