Browsing by Author "Priyadarshini Dorairaj"

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Infectious etiology of intussusception in Indian children less than 2 years old: a matched case-control analysis
(BioMed Central Ltd, 2024) Ira Praharaj; Samarasimha Nusi Reddy; Nayana Prabhakaran Nair; Jacqueline Elizabeth Tate; Sidhartha Giri; Varunkumar Thiyagarajan; Venkata Raghava Mohan; Rajendiran Revathi; Kalaivanan Maheshwari; Priya Hemavathy; Nirmal Kumar; Mohan Digambar Gupte; Rashmi Arora; Sowmiya Senthamizh; Suhasini Mekala; Krishna Babu Goru; Padmalatha Pamu; Manohar Badur; Subal Pradhan; Mrutunjay Dash; Nirmal Kumar Mohakud; Rajib Kumar Ray; Geetha Gathwala; Madhu Gupta; Ravi Kanojia; Rajkumar Gupta; Suresh Goyal; Pramod Sharma; Mannancheril Abraham Mathew; Tarun John Kochukaleekal Jacob; Balasubramanian Sundaram; Chethrapilly Purusothaman Girish Kumar; Priyadarshini Dorairaj; Ramasubramaniam Pitchumani; Raghul Maniam; Sambandan Kumaravel; Hemant Jain; Jayanta Kumar Goswami; Ashish Wakhlu; Vineeta Gupta; Jie Liu; Eric R. Houpt; Umesh D. Parashar; Gagandeep Kang
Background: Enteric infections are hypothesized to be associated with intussusception in children. A small increase in intussusception following rotavirus vaccination has been seen in some settings. We conducted post-marketing surveillance for intussusception following rotavirus vaccine, Rotavac introduction in India and evaluated association of intussusception with enteric pathogens. Methods: In a case-control study nested within a large sentinel hospital-based surveillance program in India, stool samples from 272 children aged less than 2 years admitted for intussusception and 272 age-, gender- and location-matched controls were evaluated with Taqman array card based molecular assays to detect enteric viruses, bacterial enteropathogens and parasites. Matched case-control analysis with conditional logistic regression evaluated association of enteropathogens with intussusception. Population attributable fractions (PAF) were calculated for enteropathogens significantly associated with intussusception. Results: The most prevalent enteropathogens in cases and controls were enteroaggregative Escherichia coli, adenovirus 40/41, adenovirus C serotypes and enteroviruses. Children with intussusception were more likely to harbor adenovirus C serotypes (adjusted odds-ratio (aOR) = 1.74; 95% confidence interval (CI) 1.06–2.87) and enteroviruses (aOR = 1.77; 95% CI 1.05–2.97) than controls. Rotavirus was not associated with increased intussusception risk. Adenovirus C (PAF = 16.9%; 95% CI 4.7% − 27.6%) and enteroviruses (PAF = 14.7%; 95% CI 4.2% − 24.1%) had the highest population attributable fraction for intussusception. Conclusion: Adenovirus C serotypes and enteroviruses were significantly associated with intussusception in Indian children. Rotavirus was not associated with risk of intussusception. © The Author(s) 2024.