Browsing by Author "Priyanjalee Banerjee"

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Reactive oxygen species, redox signaling and neuroinflammation in Alzheimer’s disease: The NF-κB connection
(Bentham Science Publishers B.V., 2015) Upinder Kaur; Priyanjalee Banerjee; Aritri Bir; Maitrayee Sinha; Atanu Biswas; Sasanka Chakrabarti
Oxidative stress and inflammatory response are important elements of Alzheimer's disease (AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with inflammatory mediators have not been elucidated in details in this disorder. The review summarizes the facts about redox-signaling cascade in the cells operating through an array of kinases, phosphatases and transcription factors and their downstream components. The biology of NF-κB and its activation by reactive oxygen species (ROS) and proinflammatory cytokines in the pathogenesis of AD have been specially highlighted citing evidence both from post-mortem studies in AD brain and experimental research in animal or cell-based models of AD. The possibility of identifying new disease-modifying drugs for AD targeting NF-κBsignaling cascade has been discussed in the end. © 2015 Bentham Science Publishers.