Browsing by Author "Priyanka Bangar"

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Direct transport theory: From the nose to the brain
(Elsevier, 2021) Namdev Dhas; Dattatray Yadav; Ashutosh Singh; Atul Garkal; Ritu Kudarha; Priyanka Bangar; Jignasa Savjani; Chandrakantsing V. Pardeshi; Neha Garg; Tejal Mehta
The delivery of drugs to CNS has been constrained due to the presence of blood-brain barrier (BBB). The intranasal route involving several pathways (viz., olfactory, trigeminal, and rostral migratory stream-based pathway) has emerged as potential route to bypass the BBB and transport drug directly to the brain. In another terms, intranasal route involves two distinct mechanistic transportation pathways, viz., extracellular and intracellular. Extracellular pathway is responsible for the transportation of drug directly to cerebrospinal fluid (CSF) by passing through paracellular space across the nasal epithelium, then through the perineuronal space to the subarachnoid space of the brain. However, intracellular pathways start with olfactory sensory cell-based endocytosis, followed by axonal transportation to their synaptic clefts in the olfactory bulb where the therapeutic moiety is exocytosed. This chapter inculcates various pathways and transport mechanisms involved in the direct transportation of drugs to the brain. The several case studies involving pharmacokinetics of nanoparticle-based delivery systems when administered intranasally have also been explained in this chapter. © 2021 Elsevier Inc.
Molybdenum-based hetero-nanocomposites for cancer therapy, diagnosis and biosensing application: Current advancement and future breakthroughs
(Elsevier B.V., 2021) Namdev Dhas; Ritu Kudarha; Atul Garkal; Vivek Ghate; Shilpa Sharma; Prabhakar Panzade; Shubham Khot; Pinal Chaudhari; Ashutosh Singh; Mitali Paryani; Shaila Lewis; Neha Garg; Narinder Singh; Priyanka Bangar; Tejal Mehta
In recent years, there have been significant advancements in the nanotechnology for cancer therapy. Even though molybdenum disulphide (MoS2)-based nanocomposites demonstrated extensive applications in biosensing, bioimaging, phototherapy, the review article focusing on MoS2 nanocomposite platform has not been accounted for yet. The review summarizes recent strategies on design and fabrication of MoS2-based nanocomposites and their modulated properties in cancer treatment. The review also discussed several therapeutic strategies (photothermal, photodynamic, immunotherapy, gene therapy and chemotherapy) and their combinations for efficient cancer therapy along with certain case studies. The review also inculcates various diagnostic techniques viz. magnetic resonance imaging, computed tomography, photoacoustic imaging and fluorescence imaging for diagnosis of cancer. © 2020 Elsevier B.V.
Stimuli responsive and receptor targeted iron oxide based nanoplatforms for multimodal therapy and imaging of cancer: Conjugation chemistry and alternative therapeutic strategies
(Elsevier B.V., 2021) Namdev Dhas; Ritu Kudarha; Abhijeet Pandey; Ajinkya N. Nikam; Shilpa Sharma; Ashutosh Singh; Atul Garkal; Kartik Hariharan; Amanpreet Singh; Priyanka Bangar; Dattatray Yadhav; Dhaivat Parikh; Krutika Sawant; Srinivas Mutalik; Neha Garg; Tejal Mehta
Cancer being one of the most precarious and second most fatal diseases evokes opportunities for multimodal delivery platforms which will act synergistically for efficient cancer treatment. Multifunctional iron oxide magnetic nanoparticles (IONPs) are being studied for few decades and still attracting increasing attention for several biomedical applications owing to their multifunctional design and intrinsic magnetic properties that provide a multimodal theranostic platform for cancer therapy, monitoring and diagnosis. The review article aims to provide brief information on various surface chemistries involved in modulating IONPs properties to exhibit potential therapy in cancer treatment. The review addresses structural, magnetic, thermal and optical properties of IONPs which aids in the fabrication of efficient multimodal nanoplatform in cancer therapy. The review discussed the pharmacokinetics of IONPs and attributes influencing them. This review inculcates recent advancements in therapies, focused on tumor-microenvironment-responsive and targeted therapy along with their eminent role in cancer diagnosis. The concept of stimuli-responsive including endogenous, exogenous and dual/multi stimuli-based delivery platform demonstrated significantly enhanced anticancer therapy. Several therapeutic approaches viz. chemotherapy, radiotherapy, immunotherapy, hyperthermia, gene therapy, sonodynamic therapy, photothermal, photodynamic-based therapy along with biosensing and several toxicity aspects of IONPs have been addressed in this review for effective cancer treatment. © 2021