Browsing by Author "Priyanka Mishra"

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Antidiabetic role of Swertia chirayita: Phytochemical and pharmacological perspective of a Himalayan botanical
(Bentham Science Publishers, 2023) Nikhil Pandey; Priyanka Mishra; Yamini B Tripathi
As the Himalayan mountains and valleys keep on the continuous progression of their expansion during evolution, so does their cradle of medicinal plants. Humans started to find answers to various ailments by studying these medicinal plants. One such valuable medicinal plant from the Himalayas is called Swertia chirayita (Chiraito, SC), which shows a variety of therapeutic properties. SC has been shown to be effective in a wide therapeutic spectrum and acts as an anti-oxidant, anti-inflammatory, hypoglycaemic, anti-diabetic, anti-obesity, anti-tumor, anti-microbial, and chemoprotective agent. Due to its numerous medicinal properties, it is one of the main ingredients in a variety of herbal preparations in Ayurveda, Unani, Siddha, Tibetian, and Traditional Chinese medicines. Apart from the traditional medicine systems, it is systematically mentioned under various pharmaceutical codexes like the Indian, UK, and American pharmacopeias. SC is significantly used as an anti-diabetic in various herb-based medicinal practices. Swertia chirayita is one of the very important plants known for its hypoglycaemic potential and hence exhibits a potential for the management of type II diabetes. © 2023 Bentham Science Publishers. All rights reserved.
Decline in seminal quality in Indian men over the last 37 years
(BioMed Central Ltd., 2018) Priyanka Mishra; Mahendra Pal Singh Negi; Mukesh Srivastava; Kiran Singh; Singh Rajender
Background: Since the first report of a decline in semen quality in 1974, there have been several reports of similar declines across populations. Despite some scattered reports of declining semen quality in the Indian sub-continent, comprehensive studies analyzing semen quality over the last few decades have not been undertaken. We undertook the present study to investigate the temporal trend in semen parameters in Indian populations over a period of 37 years (1979-2016). Methods: Publications providing semen analysis details for fertile and infertile men from the Indian sub-continent were collected by a thorough literature search. Semen quality data for 6466 normal fertile or presumptive normal men (from 119 studies/data sets) and 7020 infertile men (from 63 studies/data sets) published between 1979 and 2016 were retrieved. We undertook systematic review and quantitative analysis of mean sperm count, motility, normal morphology and other available parameters. Data were analyzed to estimate semen parameters reference values for Indian men and to assess temporal trends in infertile, fertile and all subjects. Results: Seminal quality shows a decreasing temporal trend and the decrease is higher in infertile than fertile males. In pooled analysis for all individuals, significant (p < 0.05 or < 0.001) declines in sperm concentration and normal morphology are observed; however, isolated analysis for each group shows declines without statistical significance. The mean (± SD) semen volume, sperm concentration, total motility, rapid linear progressive motility, normal sperm morphology and sperm viability for Indian fertile men are 2.88 ± 0.77 ml, 81.08 ± 29.21 million/ml, 66.37 ± 10.95%, 52.64 ± 15.78%, 56.68 ± 20.23% and 72.63 ± 8.31%, respectively, whereas in infertile these are 3.07 ± 1.27 ml, 37.94 ± 26.41 million/ml, 40.22 ± 13.76%, 26.79 ± 15.47%, 36.41 ± 21.66% and 55.25 ± 11.99%, respectively. The mean seminal parameter values were significantly lower (p < 0.001) in infertile as compared to fertile men, except semen volume. Conclusions: Semen parameters in Indian men have declined with time and the deterioration is quantitatively higher in the infertile group. The study also provides reference values for semen parameters in Indian men. © 2018 The Author(s).
Demand and Supply Gaps: Seeds and Raw Material
(Springer International Publishing, 2022) Priyanka Mishra; Praveen Kumar; Yamini B. Tripathi; Neha Garg
Hemp is one of the oldest known crops with huge industrial and pharmaceutical applications.Most parts of the hemp plant are used in industry: stem for fibre production, leaves for animal bedding and construction, roots in phytoremediation and flowers for essential oils and pharmaceuticals. Seeds of the Hemp plant are a rich source of various nutrients that can be used to produce oil, flour for bread supplementation, as feed for organic farming. Realizing Hemp as a multifaceted and sustainable crop, recently there is a renewed interest in Hemp production. In this chapter, we are discussing Hemp global market, demand and supply and factors affecting industrial hemp production. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
Gut Microbiota and Genetic Polymorphisms Appear to Drive Disease Expression of Nonalcoholic Fatty Liver Disease in Lean Individuals
(Elsevier B.V., 2025) Prajna Anirvan; Zaiba Hasan Khan; Pallavi Bhuyan; Sujata Dixit; Rishikesh Dash; Priyanka Mishra; Giriprasad Venugopal; Gowri Manohari Manohari Balachander; Pankaj Bharali; Mrinal Gogoi; Manoj Kumar Panigrahi; Manoranjan R. Ranjit; Balamurugan Ramadass; Shivaram Prasad Singh
Background/Objectives: There are very few comparative studies worldwide between ‘lean’ and ‘nonlean/obese nonalcoholic fatty liver disease (NAFLD)’ patients analyzing the differences in gut microbiome, genotype, and serum bile acids. Our aim was to compare the genotype, gut microbiome, bile acid profile, and metabolic patterns of lean NAFLD and obese NAFLD patients with special reference to hepatic fibrosis. Methods: Both lean and obese NAFLD patients diagnosed by ultrasonography along with matched controls were included. Genotyping, fecal microbiome analysis and estimation of serum total bile acid levels were done for patients as well as controls. Results: Biochemical and metabolic patterns of lean and obese NAFLD patients were comparable. Lean NAFLD patients had lower fasting plasma glucose (FPG) and homoeostasis model assessment-insulin resistance (HOMA-IR), although the proportions of patients having elevated HOMA-IR and metabolic syndrome (MS) were comparable. Noninvasive scores of liver fibrosis were also comparable. A greater proportion of lean NAFLD patients had the PNPLA3 rs738409 (G/G) genotype. However, there was no association of genetic polymorphisms with steatosis or fibrosis. Nonlean and lean NAFLD patients had comparable serum total bile acid levels. On microbiome analysis, lean NAFLD patients were found to have distinct expression of bacterial species while beta diversity was found to be significantly different across all groups. Conclusion: Lean NAFLD patients were found to have the PNPLA3 rs738409 (G/G) genotype. Lean NAFLD patients were also found to have unique gut microbial signatures, while beta diversity significantly differed across all groups. Differential expression of gut microbiota and genetic polymorphisms could underlie the pathogenesis of lean NAFLD. © 2025 Indian National Association for Study of the Liver
Hypoxia-Responsive Delivery Nanoplatforms in Cancer Theranostics
(CRC Press, 2023) Priyanka Mishra; Yamini B. Tripathi; Namdev L. Dhas; Neha Garg
Hypoxia, a key feature of the majority of widely disseminated solid tumours, is critical for angiogenesis, metastasis, and resistance to conventional cancer therapeutic methods, promoting the development of cancer. However, hypoxic cells’ typical characteristics, such as a highly bio-reductive environment and low oxygen concentration, can provide stimuli-responsive drug release to aid in tumour-specific radio, chemo, sonodynamic, and photodynamic therapies. This strategy, which focuses on the habitats of inadequately oxygenated tumours, offers the potential to get around problems caused by the heterogeneous nature of tumours and may be applied to the construction of diagnostic and therapeutic nanocarriers for many solid cancer types. As a result, research into effective methods to address drug resistance in solid tumours is proceeding quickly in hypoxia-triggered nanoparticle-based drug delivery systems. The development of hypoxia-responsive nanovehicles for drug delivery to heterogeneous cancers has made considerable strides, which are presented in this chapter. The chapter’s opening sections give readers an understanding of how hypoxia develops in cancer cells as they grow and how it affects the course of the disease. Also mentioned are the existing drawbacks and potential future applications of hypoxia-stimulated nanomachines for the treatment of cancer. © 2024 selection and editorial matter, Yashwant V. Pathak, Jayvadan K. Patel, Namdev L. Dhas and Vipul P. Patel; individual chapters, the contributors.
Impact of Nano Preparation of Phytoconstituents in Medulloblastoma
(Humana Press Inc., 2022) Priyanka Mishra; Y.B. Tripathi
The conventional cancer treatment strategies from chemotherapy to surgery often lead to inadequate results which in some cases lead to relapsing of the tumor being treated. Medulloblastoma witness 30% relapse rate which is universally fatal among children. Although the treatment of primary medulloblastoma is well established including surgical excision, postsurgical irradiation, and, more recently, chemotherapy, there is no established treatment for its recurrence. Despite efforts to improve its therapy, frequent long-haul survivors have been recorded in the world’s medical literature. In this book chapter, we have attempted to focus light on the nano preparation of phytoconstituents as an alternative approach as it has advantage of providing better bioavailability of the compound in terms of crossing the blood–brain barrier and an additional benefit in terms of limited adverse effects of the natural product over the traditional chemotherapeutic approaches. In recent times, biological methods or green approaches in the case of plants have received immense attention due to its safety and lack of contamination in the process. In this chapter, we will explore some plant products that have been incorporated into nanocarriers to improve their bioavailability in this tumor treatment. © 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
In silico screening of Pueraria tuberosa (PTY-2) for targeting COVID-19 by countering dual targets Mpro and TMPRSS2
(Taylor and Francis Ltd., 2022) Priya Shree; Priyanka Mishra; Prateek Kumar; Harsh Pandey; Rajanish Giri; Radha Chaube; Neha Garg; Yamini Bhusan Tripathi
COVID-19 pandemic was started in Wuhan city of China in December 2019; immensely affected global population. Herein, an effort was made to identify potential inhibitors from active phytochemicals of Pueraria tuberosa (PTY-2) via molecular docking study. Our study showed five potential inhibitors (Robinin, Genistin, Daidzin, Hydroxytuberosone, Tuberostan) against Mpro and five inhibitors (Robinin, Anhydrotuberosin, Daidzin, Hydroxytuberosone, Stigmasterol) against TMPRSS2. Out of these, Robinin, Daidzin and Hydroxytuberosone were common inhibitors for Mpro and TMPRSS2. Among these, Robinin showed the highest binding affinity, therefore, tested for MD simulation runs and found stable. ADMET analysis revealed the best-docked compounds are safe and follow the Lipinski Rule of Five. Thus, it could be suggested that phytochemicals of PTY-2 could serve as potential inhibitors for COVID-19 targets. Communicated by Ramaswamy H. Sarma. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
Medicinal plants from the himalayas acting on inflammatory and oxidative stress pathways
(Bentham Science Publishers, 2023) Priyanka Mishra; Nikhil Pandey; Yamini B Tripathi
Located between the Indian subcontinent and the Tibetan plateau, the Himalayas are home to a rich repertoire of medicinal resources. A wide range of communities from Asia and Africa prefer natural remedies, including medicinal plants, over prescription drugs. Since so many people use medicinal plants as their only source of healing, the plants are also an important source of income for the locals.. The plants found in the entire region of this snowy mountain range provide remedies ranging from bronchitis to cancer. We attempted to summarise the important medicinal plants of this region in this book chapter, specifically those that act and modulate the inflammatory and oxidative stress pathways, as these are the primary culprits behind many diseases and disorders. The current chapter will list the ethnobotanicals used, their active ingredients, and reported pharmacological properties, as well as potential mechanisms of action. © 2023 Bentham Science Publishers. All rights reserved.
On the Applications of Nonsmooth Vector Optimization Problems to Solve Generalized Vector Variational Inequalities Using Convexificators
(Springer Verlag, 2020) Balendu Bhooshan Upadhyay; Priyanka Mishra; Ram N. Mohapatra; Shashi Kant Mishra
In this paper, we employ the characterization for an approximate convex function in terms of its convexificator to establish the relationships between the solutions of Stampacchia type vector variational inequality problems in terms of convexificator and quasi efficient solution of a nonsmooth vector optimization problems involving locally Lipschitz functions. We identify the vector critical points, the weak quasi efficient points and the solutions of the weak vector variational inequality problem under generalized approximate convexity assumptions. The results of the paper extend, unify and sharpen corresponding results in the literature. In particular, this work extends and generalizes earlier works by Giannessi [11], Upadhyay et al. [31], Osuna-Gomez et al. [30], to a wider class of functions, namely the nonsmooth approximate convex functions and its generalizations. Moreover, this work sharpens earlier work by Daniilidis and Georgiev [5] and Mishra and Upadhyay [23], to a more general class of subdifferentials known as convexificators. © 2020, Springer Nature Switzerland AG.
Prevention of mortality in acute lung injury induced by oleic acid: Application of polyherbal decoction (bronco T)
(Frontiers Media S.A., 2022) Priyanka Mishra; Ratna Pandey; Nikhil Pandey; Suyash Tripathi; Yamini Bhusan Tripathi
Acute lung injury (ALI) is a lethal respiratory disorder; directed uncontrolled inflammation, sloughing of the alveolar cells and their diffusion, and altered cardiorespiratory parameters with a global mortality rate of 40%. This study was designed to assess the preventive effect of a polyherbal decoction (Bronco T, 1.5 g/kg b. w.) on cardiorespiratory variables in oleic acid-induced ALI in rats. Oleic acid increases the level of neutrophil infiltration leading to pulmonary edema and alters the cardiorespiratory dynamics. The adult male rats were surgically cannulated and treated with intravenous oleic acid (0.38 ml/kg b. w.) to establish the ALI model. Bronco T was pre-administered orally 3 hours before oleic acid. The biophysical, histological, biochemical, and molecular effects were compared with dexamethasone (5 mg/kg b. w. i. p.). The animals were randomly divided into control, lethal, standard, and treatment groups. Respiratory frequency (RF), heart rate (HR), and mean arterial pressure (MAP) were recorded on a computerized chart recorder; arterial blood sample was collected to determine PaO2/FiO2, TNF-α, and MPO. Lipid peroxidation, superoxide dismutase, and catalase activity were evaluated to measure oxidative stress in bronchoalveolar lavage. Additionally, the pulmonary water content, COX-2 expression and histological examination were determined in the lung. A molecular docking study of the active phytoconstituent of BT obtained from HR-LCMS analysis against reported targets (IL-6, COX-2, TNFα, MPO and ENaC) of ALI was carried out. The B.T. pretreatment prevents mortality in comparison to the oleic acid group. It protects the lungs and heart from the detrimental effect of oleic acid, on par with dexamethasone. COX-2 mRNA expression was significantly down-regulated in the treatment group. The reduced level of TNF-α, MPO, SOD and catalase supported the protective effect of B.T. The in silico study revealed strong binding interaction between the phytoconstituent (Galangin 3- [galactosyl-(1–4)-rhamnoside and Beta solamarine] of BT and the reported target. The B.T. pre-administration attenuates the oleic acid-induced mortality and cardiorespiratory toxicity. Copyright © 2022 Mishra, Pandey, Pandey, Tripathi and Tripathi.
Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants–Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi)–a molecular docking study
(Taylor and Francis Ltd., 2022) Priya Shree; Priyanka Mishra; Chandrabose Selvaraj; Sanjeev Kumar Singh; Radha Chaube; Neha Garg; Yamini Bhusan Tripathi
COVID-19 (Coronavirus disease 2019) is a transmissible disease initiated and propagated through a new virus strain SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) since 31st December 2019 in Wuhan city of China and the infection has outspread globally influencing millions of people. Here, an attempt was made to recognize natural phytochemicals from medicinal plants, in order to reutilize them against COVID-19 by the virtue of molecular docking and molecular dynamics (MD) simulation study. Molecular docking study showed six probable inhibitors against SARS-CoV-2 Mpro (Main protease), two from Withania somnifera (Ashwagandha) (Withanoside V [10.32 kcal/mol] and Somniferine [9.62 kcal/mol]), one from Tinospora cordifolia (Giloy) (Tinocordiside [8.10 kcal/mol]) and three from Ocimum sanctum (Tulsi) (Vicenin [8.97 kcal/mol], Isorientin 4′-O-glucoside 2″-O-p-hydroxybenzoagte [8.55 kcal/mol] and Ursolic acid [8.52 kcal/mol]). ADMET profile prediction showed that the best docked phytochemicals from present work were safe and possesses drug-like properties. Further MD simulation study was performed to assess the constancy of docked complexes and found stable. Hence from present study it could be suggested that active phytochemicals from medicinal plants could potentially inhibit Mpro of SARS-CoV-2 and further equip the management strategy against COVID-19-a global contagion. Highlights Holistic approach of Ayurvedic medicinal plants to avenge against COVID-19 pandemic. Active phytoconstituents of Ayurvedic medicinal plants Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi) predicted to significantly hinder main protease (Mpro or 3Clpro) of SARS-CoV-2. Through molecular docking and molecular dynamic simulation study, Withanoside V, Somniferine, Tinocordiside, Vicenin, Ursolic acid and Isorientin 4′-O-glucoside 2″-O-p-hydroxybenzoagte were anticipated to impede the activity of SARS-CoV-2 Mpro. Drug-likeness and ADMET profile prediction of best docked compounds from present study were predicted to be safe, drug-like compounds with no toxicity. Communicated by Ramaswamy H. Sarma. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Uranium enrichment in altered metasedimentary rocks of Jahaz uranium deposit, North Delhi fold belt, Rajasthan, India: Inferences from whole-rock geochemical studies
(Elsevier Ltd, 2025) Priyanka Mishra; Rajagopal Krishnamurthi; Ajit Kumar Sahoo; Shailendra Kumar Sharma
Jahaz deposit is one of the promising Na-metasomatic uranium deposits along the “albitite line” and is hosted in the Meso-Proterozoic metamorphic rocks of the North Delhi Fold Belt, Rajasthan, India. This article presents whole-rock geochemical analyses of major, trace, and rare-earth elements of less to moderately altered and albitized rocks, which are used to quantify the exchange of chemical components during fluid-rock interaction. The alteration box plot indicates the intensity of alterations (albitization, chloritization, calcitization, sericitization, pyritization), and it is inferred that Na-Ca-Mg-K metasomatism was responsible for the formation of albite, chlorite, calcite, and sericite in the altered rocks. Isocon diagrams have been constructed using major and selected trace element concentrations of less to moderately altered and albitized garnetiferous quartz biotite schist/amphibolite to determine the net loss and gain of elements during rock-fluid interaction. The correlation coefficients indicated that elements such as Zr, Nb, Hf, and Ti were less mobile during fluid-rock interaction. Isocon analyses show that the albitized garnetiferous quartz biotite schist is significantly enriched in U, Na, Mg, Fe, Ca, Mo, Cu, Rb, and depleted in K, Pb, Ba, Ni, Zn. Albitized amphibolites are enriched in Na, Cu, Mg, Cu, Y, Cr, Se, Ni, K, LOI and depleted in Ba, Co, Pb, Zn, Ca, P, Mn, Fe. The low Th/U ratio of albitized garnetiferous quartz biotite schist indicates that the albitized rocks are significantly enriched in uranium. Hence, uranium enrichment is positively correlated with Na, Mo, Cu, Th, Zr, LOI, and light rare-earth elements of albitized garnetiferous quartz biotite schist/amphibolite in the Jahaz uranium deposit. These results are similar to Kirovograd and Novoukrainka (Ukraine), Lagoa Real (Brazil), Valhalla (Australia), Longshoushan (China), Aricheng (Guyana) and Coles Hill (USA) Na-metasomatic uranium-deposits. © 2025 Elsevier Ltd