Browsing by Author "Priyanka Sharma"

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Atmospheric Fine and Coarse Mode Aerosols at Different Environments of India and the Bay of Bengal During Winter-2014: Implications of a Coordinated Campaign
(Springer India, 2014) A. Sen; Y. Nazeer Ahammed; B.C. Arya; Tirthankar Banerjee; G. Reshma Begam; B.P. Baruah; A. Chatterjee; Anil K. Choudhuri; Amit Dhir; Trupti Das; Pitamber Prasad Dhyani; N.C. Deb; Ranu Gadi; Mangesh Gauns; Sanjay Kumar Ghosh; Abhishek Gupta; K.C. Sharma; A.H. Khan; K. Maharaj Kumari; Manish Kumar; Arun Kumar; Jagdish Chandra Kuniyal; Anita Lakhani; R.K. Meena; P.S. Mahapatra; S.W.A. Naqvi; Dharam Pal Singh; S. Pal; Sipra Panda; Rohtash; J. Saikia; P. Saikia; A. Sharma; Priyanka Sharma; M. Saxena; D.M. Shenoy; C. Viswanatha Vachaspati; S.K. Sharma; T.K. Mandal
In this paper, we present mass concentrations of particulate matter [PM2.5, PM10 size fractions and total suspended particulates (TSP)] measured simultaneously over land stations (Kullu, Patiala, Delhi, Ajmer, Agra, Lucknow, Varanasi, Giridih, Kolkata, Darjeeling, Jorhat, Itanagar, Imphal, Bhubaneswar, and Kadapa), mostly distributed across the Indo-Gangetic plain (IGP) of India as well as in the marine atmosphere over Bay of Bengal (BoB) in the period from 20 January to 3 February, 2014. The main objective of this study was to quantify the continental outflow of particulates (PM2.5, PM10 and TSP) from IGP and associated regions into the BoB along with low level north-east wind flow during winter monsoon period. The present study provides a glimpse of the aerosol loading over the IGP region. During this campaign, the highest average PM2.5 (187.8 ± 36.5 µg m−3, range 125.6–256.2 µg m−3), PM10 (272.6 ± 102.9 µg m−3, range 147.6–520.1 µg m−3) and TSP (325.0 ± 71.5 µg m−3, range 220.4–536.6 µg m−3) mass concentrations were recorded at Varanasi, Kolkata and Lucknow over middle and lower IGP regions. The PM2.5 (average 41.3 ± 11.9 µg m−3; range 15.0–54.4 µg m−3), PM10 (average 53.9 ± 18.9 µg m−3; range 30.1–82.1 µg m−3) and TSP (average 78.8 ± 29.7 µg m−3; range 49.1–184.5 µg m−3) loading over BoB were found to be comparable to land stations and suggests possible continental outflow. Over the continental region, the highest PM2.5/PM10 ratio was recorded at Delhi (0.87). The PM2.5/PM10 ratio over BoB (0.77) was found to be quite high and comparable to Varanasi (0.80) and Agra (0.79). © 2014, Metrology Society of India.
Clinical breast examination: A screening tool for lower- and middle-income countries
(John Wiley and Sons Inc, 2024) Divya Khanna; Priyanka Sharma; Atul Budukh; Ajay Kumar Khanna
Breast cancer (BC) remains a global health challenge, devastatingly impacting women's lives. Low-and-middle-income countries (LMIC), such as India, experience a concerning upward trend in BC incidence, necessitating the implementation of cost-effective screening methods. While mammography, ultrasonography, and magnetic resonance imaging are preferred screening modalities in resource-rich settings, limited resources in LMICs make clinical breast examination (CBE) the method of choice. This review explores the merits of CBE, its coverage, barriers, and facilitators in the Indian context for developing strategies in resource-constrained settings. CBE has shown significant down-staging and cost-effectiveness. Performed by trained health workers in minutes, CBE offers an opportunity for education about BC. Various individual and health system barriers, such as stigma, financial constraints, and the absence of opportunistic screening hinder CBE coverage. Promising facilitators include awareness programs, capacity building, and integrating CBE through universal health care. No healthcare provider must miss any screening opportunity through CBE. © 2024 The Author(s). Asia-Pacific Journal of Clinical Oncology published by John Wiley & Sons Australia, Ltd.
Enhancement in phase sensitivity of SU(1,1) interferometer with Kerr state seeding
(Elsevier B.V., 2024) Priyanka Sharma; Aviral Kumar Pandey; Gaurav Shukla; Devendra Kumar Mishra
A coherent seeded SU(1,1) interferometer provides a prominent technique in precision measurement. We theoretically study the phase sensitivity of SU(1,1) interferometer with Kerr state seeding under single intensity and homodyne detection schemes. To find the lower bound in this case we calculate the quantum Cramér–Rao bound using the quantum Fisher information technique. We found that, under some conditions, the Kerr seeding performs better in phase sensitivity compared to the well-known vacuum and coherent seeded case. We expect that the Kerr state might act as an alternative non-classical state in the field of quantum information and sensing technologies. © 2024 Elsevier B.V.
Enhancement of angular displacement measurement sensitivity by modified-SU(2) interferometry
(SPIE, 2023) Karunesh Kumar Mishra; Priyanka Sharma; Devendra Kumar Mishra
In this paper, we analysis the angular displacement measurements using the homodyne detection scheme in a modified-SU(2) Mach-Zehnder interferometer (MZI). Three parametric amplifiers (PAs) are used in order to increase the number of photons and to reduce the shot-noise. We also consider quantum Fisher information (QFI) and derive expressions for single- and two-parameter cases and corresponding quantum Cramér-Rao bounds (QCRB). We find that angular displacement sensitivity exceeds the standard quantum limit (SQL) or shot-noise limit (SNL) and approaches single- and two-parameter QCRB. Finally, we look at the impact of photon losses on the sensitivity of interferometer. © 2023 SPIE.
Identifying the mechanisms of α-synuclein-mediated cytotoxicity in Parkinson's disease: New insights from a bioinformatics-based approach
(Future Medicine Ltd., 2020) Sankha S. Chakrabarti; Venkatadri S. Sunder; Upinder Kaur; Sapna Bala; Priyanka Sharma; Manjari Kiran; Ravindra K. Rawal; Sasanka Chakrabarti
Aim: A large body of evidence has implicated the cytotoxicity of α-synuclein in Parkinson's disease (PD). We planned to use a bioinformatics-based approach to gain further insight into this process. Materials & methods: Using STRING version 10, we identified interacting proteins of α-synuclein. Using α-synuclein and one of these interactors involved in apoptosis as query proteins, we identified other linked proteins. We further analyzed the interactions between some of these proteins by Protein-Protein Docking using ClusPro. Results: We identified BAX as an interacting protein of α-synuclein. Interactions of α-synuclein and BAX as well as BAX and BCL2L1 were determined. Conclusion: The interaction of α-synuclein and BAX could play a crucial role in the cell death process of PD where apoptosis and mitochondrial permeability transition-driven necrosis may coexist. © 2020 Sankha Shubhra Chakrabarti.
Isoprenaline induced hepatic alterations and modulation by hydroalcoholic extract of juglans regia hull in wistar rats
(Informatics Publishing Limited and The Society of Toxicology, 2020) Priyanka Sharma; Pawan Kumar Verma; Rajinder Raina; Shilpa Sood; Shahid Prawez; Lenesha Manhas
The present study aimed at determining isoprenaline (ISO) induced hepatic alterations and effect of hydroalcoholic extract of Juglans regia hull supplementation in modulating those alterations in Wistar rats. Various biochemical, histopathological and antioxidant biomarkers in hepatic tissue viz. transferases (aspartate and alanine aminotransferases), Total Plasma Proteins (TPP), Albumins (ALB), Total Antioxidant Status (TAS), Total Thiols (TTH), Catalase (CAT), Superoxide Dismutase (SOD), Acetylcholinesterase (AChE), Arylesterase (AE), Glutathione Peroxidase (GPX) and Glutathione Reductase (GR), and cellular damage indicators viz. Malondialdehyde (MDA) and Advanced Oxidation Protein Product (AOPP) were assessed. Intra-peritoneal administration of ISO produced significant increase in aspartate aminotransferase, AChE, MDA and AOPP levels and reduced TPP, ALB, TTH, TAS, AE and GPx, activities in hepatic tissue of rats. Histopathologically, the liver sections of ISO treated rats revealed congestion, vacuolar degeneration and necrosis of liver parenchyma, bile duct hyperplasia and edema along with cellular infiltration in portal triad areas. Pretreatment with hull extract restored TAS, AOPP, AChE, CAT, AE activities and significantly reduced severity of histomorphological changes in hepatic tissue of ISO treated rats. The protective effect may be attributed to phytochemical constituents present in hull. Overall, our results show that hydroalcoholic extract of J. regia hull confers partial protection to hepatic tissue against ISO induced oxidative changes in Wistar rats. © 2020 Informatics Publishing Limited and The Society of Toxicology. All rights reserved.
Mitigating sloppiness in joint estimation of successive squeezing parameters
(Institute of Physics, 2025) Priyanka Sharma; Stefano Olivares; Devendra Kumar Mishra; Matteo G. A. Paris
When two successive squeezing operations with the same phase are applied to a field mode, reliably estimating the amplitude of each is impossible because the output state depends solely on their sum. In this case, the quantum statistical model becomes sloppy, and the quantum Fisher information matrix turns singular. However, estimation of both parameters becomes feasible if the quantum state is subjected to an appropriate scrambling operation between the two squeezing operations. In this work, we analyze in detail the effects of a phase-shift scrambling transformation, optimized to reduce sloppiness and maximize the overall estimation precision using only classical probes. We also compare the optimized precision bounds of joint estimation with those of stepwise estimation methods, finding that joint estimation retains an advantage despite the quantum noise induced by the residual parameter incompatibility. Finally, we analyze the precision achievable by general-dyne detection and find that it approaches the optimal precision when one of the two squeezing amplitudes is large enough. © 2025 The Author(s). Published by IOP Publishing Ltd on behalf of the Institute of Physics and Deutsche Physikalische Gesellschaft.
Optimization of a process for microgreen and fruit-based functional beverage
(Academia Brasileira de Ciencias, 2020) Priyanka Sharma; Anjali Sharma; Prasad Rasane; Anirban Dey; Asish Choudhury; Jyoti Singh; Sawinder Kaur; Kajal Dhawan; Damanpreet Kaur
Microgreen based functional juice blends containing fenugreek (Trigonella foenum-graecum), kinnow mandarin (Citrus reticulate) and aloe vera (Aloe brobadensis) in different ratios were blended with sorbitol and stevia. The different ratios of juice blends were analyzed for total soluble solids, sedimentation, viscosity and titrable acidity. They were also screened for total phenolic content, total carotenoid content and antioxidant properties such as DPPH, reducing power and metal chelating activity. The formulation with highest TPC, TCC and antioxidant property was selected to optimize a microgreen based functional juice. The optimized microgreen blend formulation had 20 ml 100-1 ml microgreen juice, 40 ml 100-1 ml kinnow juice, 8.5 ml 100-1 ml sorbitol, 1.78 g 100-1 ml stevia and 29.72 ml 100-1 ml aloe vera juice. It had high protein, minerals (sodium and potassium) and vitamin (vitamin C) content as well as good source beta-carotene, phenols and antioxidants. Antioxidant helps in reducing diabetic complications by reducing the oxidative stress and because of their protective action against reactive oxygen species. © 2020, Academia Brasileira de Ciencias. All rights reserved.
Optimizing phase sensitivity of Mach-Zehnder interferometer having superposition of coherent state with single-photon-added coherent state
(Elsevier B.V., 2025) Priyanka Sharma; Anand Kumar; Gaurav Shukla; Devendra Kumar Mishra
Precision measurement of an unknown parameter using a Mach-Zehnder interferometer (MZI) plays an important role in quantum metrology. We use hybrid coherent states (HCS), consisting of a superposition of coherent state (CS) and single-photon-added coherent state (SPACS), as well as solely CS, as inputs of the MZI. We computed the phase sensitivity of the MZI for three detection schemes: single intensity detection (SID), intensity difference detection (IDD), and optimal detection (OD). We find that HCS offers improved phase sensitivity under certain conditions, compared to CS combined with SPACS or double CS inputs and CS combined with the squeezed vacuum state as the input of MZI, under lossless and lossy scenarios. Also, we found that SID outperforms the IDD and OD schemes approximately in all cases. Furthermore, we explore the lower bound in phase sensitivity using quantum Fisher information (QFI) and the corresponding quantum Cramér–Rao bound (QCRB). We found that HCS with CS approaches the QCRB for SID and OD cases. Our results suggest that HCS could serve as a promising nonclassical resource for enhancing phase super-sensitivity in MZI, especially in realistic operational environments. © 2025 Elsevier B.V.
Oxidative Stress, Neuroinflammation, and NADPH Oxidase: Implications in the Pathogenesis and Treatment of Alzheimer's Disease
(Hindawi Limited, 2021) Upasana Ganguly; Upinder Kaur; Sankha Shubhra Chakrabarti; Priyanka Sharma; Bimal Kumar Agrawal; Luciano Saso; Sasanka Chakrabarti
NADPH oxidase as an important source of intracellular reactive oxygen species (ROS) has gained enormous importance over the years, and the detailed structures of all the isoenzymes of the NADPH oxidase family and their regulation have been well explored. The enzyme has been implicated in a variety of diseases including neurodegenerative diseases. The present brief review examines the body of evidence that links NADPH oxidase with the genesis and progression of Alzheimer's disease (AD). In short, evidence suggests that microglial activation and inflammatory response in the AD brain is associated with increased production of ROS by microglial NADPH oxidase. Along with other inflammatory mediators, ROS take part in neuronal degeneration and enhance the microglial activation process. The review also evaluates the current state of NADPH oxidase inhibitors as potential disease-modifying agents for AD. © 2021 Upasana Ganguly et al.
Prevalence and associated factors of mammography uptake among the women aged 45 years and above: policy implications from the longitudinal ageing study in India wave I survey
(BioMed Central Ltd, 2025) Priyanka Sharma; Dipak Das; Divya Khanna; Atul Madhukar Budukh; Anita K. Khokhar; Satyajit Pradhan; Ajay Kumar Khanna; Pankaj P. Chaturvedi; Rajendra Achyut Badwe
Background: Breast cancer emerged as number one cancer among women worldwide in terms of incidence and mortality. Majority of breast cancers diagnosed in India are among women aged 45 years and above. A low proportion of Indian female population in reproductive age group (30–49 years) underwent breast cancer screening. The national operational framework includes mammography as one of the investigation modalities under the algorithm for early detection and management of breast cancer. This study describes prevalence and associated factors of mammography uptake in women aged 45 years and above. Methods: We utilized data from 35,083 women aged ≥ 45 years in the Longitudinal Aging Study of India, a nationwide representative survey of the Indian population. The outcome variable was self-reported history of undergoing mammography in past two years before the survey as a representation of early detection of breast cancer. Demographic, behavioural, and clinical characteristics were taken as independent variables. Univariable and multivariable models were applied for the following age groups: 45–59 years and ≥ 60 years, and unadjusted and adjusted odds ratios were calculated. Results: The prevalence of mammography was 1.3% among Indian women aged 45 years and above, 1.7% among 45–59 years and 0.9% among women ≥ 60 years. The highest prevalence was reported in Kerala and the lowest was in Nagaland. Among women in 45–59 years age group, secondary or higher education, being currently in union, having diabetes, neurological illness, hearing problems, and reproductive health problems, better cognition level, and self-history of cancer were found to be associated with increased mammography uptake. Urban residence, being currently in union, having bone/joint disease, hearing problem, and one or multi-morbidity, better cognition level and self and family history of cancer were associated with higher mammography uptake among elderly women. Conclusions: Low rates of mammography among women across the country, along with inter-state disparities, highlight inadequate coverage of early detection of breast cancer under National program. Increasing burden of breast cancer in all states underscores need to implement early detection program proactively. Disparities in mammography uptake by age, residence and co-morbidities reflect the need for special focus and context-specific research for pragmatic interventions. © The Author(s) 2025.
Pyrus pashia fruit extract and its major phytometabolite chrysin prevent hippocampal apoptosis and memory impairment in PTZ-kindled mice
(Taylor and Francis Ltd., 2024) Priyanka Sharma; Amita Kumari; Padmanabh Singh; Sweta Srivas; Mahendra K. Thakur; Siva Hemalatha
Objectives: Epilepsy is a chronic neurological condition with recurrent seizures. One-third of epilepsy patients experience unacceptable side effects from antiepileptic drugs. Pyrus pashia is a deciduous tree from southern Asia. Ethnomedicinally, Malakand tribes use its fruits for epilepsy treatment. Our prior research demonstrated the anticonvulsive properties of ethanolic extract of Pyrus pashia (EPP) and its bioactive compound chrysin in acute seizure tests. This study aims to investigate the impact of EPP and chrysin on cognitive impairment in a PTZ-induced kindling mice model of epilepsy. Methods: Swiss albino male mice were equally divided into four groups. The first group received 0.5% carboxy methyl cellulose dissolved in normal saline while the other three groups were pre-treated with Diazepam (DZP) (1 mg/kg, i.p.), EPP (200 mg/kg, p.o.) and chrysin (5 mg/kg, p.o.). After 30 min, all groups were administered PTZ (35 mg/kg, i.p.) and evaluated for seizure severity, cognitive function, and neuronal apoptosis. Western blot analysis was conducted to analyze the expressions of apoptosis biomarkers and memory-related genes, including cAMP response element-binding protein (CREB) and Brain Derived Neurotrophic Factor (BDNF). Results: The therapeutic effects of EPP and Chrysin were comparable to DZP in terms of reducing seizure severity, but unlike DZP, they prevented PTZ-induced memory impairment in experimental animals. Additionally, they increased the levels of BDNF and CREB while reducing apoptotic biomarkers in the hippocampus of experimental animals. Conclusions: Based on the leads offered by this study EPP and its major bioactive constituent, could be developed as the treatment option for epilepsy. © 2023 Informa UK Limited, trading as Taylor & Francis Group.
Quantum sub-phase sensitivity of a Mach–Zehnder interferometer with the superposition of Schrödinger's cat-like state with vacuum state as an input under product detection scheme
(Elsevier B.V., 2024) Gaurav Shukla; Dhiraj Yadav; Priyanka Sharma; Anand Kumar; Devendra Kumar Mishra
We study the phase sensitivity of a Mach–Zehnder interferometer (MZI) with product detection (PD) scheme by using the superposition of Schrödinger's cat-like state with the vacuum state (SCVS) and the coherent state as the inputs. We compare the results derived from PD with the parity detection scheme's results. We found that PD performs better than parity detection and approaches the single parameter quantum Cramér-Rao bound in some cases. Therefore, we expect that SCVS may play as an alternative quantum resource with PD for the improvement in the phase sensitivity of an MZI having potential application in quantum metrology and quantum sensing. © 2023
Super-resolution and super-sensitivity of quantum LiDAR with a multi-photonic state and binary outcome photon counting measurement
(Optica Publishing Group (formerly OSA), 2024) Priyanka Sharma; Manoj K. Mishra; Devendra Kumar Mishra
Here, we are investigating the enhancement in resolution and phase sensitivity of a Mach-Zehnder interferometer (MZI) based quantum LiDAR. We are using a multi-photonic state (MPS), superposition of four coherent states [Int. J. Quantum Inf. 19, 2150013 (2021)], as the input state and binary outcome parity photon counting measurement and binary outcome zero non-zero photon counting measurement as the measurement schemes. We have thoroughly investigated the results in lossless as well as lossy cases. We found enhancement in resolution and phase sensitivity in comparison to the coherent state and even coherent superposition state (ECSS) based quantum LiDAR. Our analysis shows that MPS may be an alternative nonclassical resource in the field of quantum imaging and quantum sensing technologies, like in quantum LiDAR. © 2024 Optica Publishing Group