Browsing by Author "Priyanka Yadav"

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Ageing and mating status affect food utilization efficiencies and assimilation of macronutrients in adults of Parthenium beetle, Zygogramma bicolorata Pallister
(John Wiley and Sons Inc, 2024) Priyanka Yadav; Priya Patel; Arvind Kumar Patel; Ritabrata Chowdhury; Ankit Upadhyay; Bhupendra Kumar; Dinesh Kumar
Investigations of age-based food conversion and utilization efficiencies in phytophagous insects are very few. Studies examining the effects of age, sex and mating status on biochemical assimilation of macronutrients by phytophagous insects are scarce as well. Hence, we designed the present study to evaluate the combined effect of age, sex and mating status on food consumption and utilization efficiencies, and the assimilation of macronutrients by the Parthenium beetle, Zygogramma bicolorata Pallister (Coleoptera: Chrysomelidae), on the invasive weed, Parthenium hysterophorus Linnaeus (Asterales: Asteraceae). We hypothesized that mated adults would consume and utilize more food than unmated adults, that assimilation of nutrients by old adults would be lower than young adults and that females would consume and utilize food more efficiently than males. However, our results revealed that as adults aged, their food consumption and utilization efficiencies decreased, and they assimilated less proteins and glucose in their body. Despite that, their mean body biomass and assimilation of triglycerides increased. While mated adults had higher food utilization efficiencies and increased assimilation of triglycerides and glucose, unmated adults assimilated more proteins. Females had higher food consumption rates and increased assimilation of nutrients, whereas males had higher food conversion efficiencies and growth rates. Furthermore, middle-aged adults had higher food utilization efficiencies and they assimilated more nutrients than young and old adults. Our results therefore suggest compensatory feeding in adults of Z. bicolorata with ageing. We also recommend the release of more numbers of mated middle-aged females to control P. hysterophorus in agro-ecosystems. © 2024 Royal Entomological Society.
An Experimental and Theoretical Study of the Conformational Stability of Triazinone Fleximers: Quantitative Analysis for Intermolecular Interactions
(John Wiley and Sons Inc, 2023) Akhilesh Kumar; Praveen Singh; Ranjeet Kumar; Priyanka Yadav; Amit Jaiswal; Ashish Kumar Tewari
Synthesis and characterization of triazinone based propylene linked phthalimide and benzimidazole have been carried out for conformational analysis and the study of their quantitative intermolecular interactions. The conformational analyses have been calculated by X-ray crystallography in the solid state and theoretical calculations in the gaseous state. From the crystal structure and theoretical calculations we have found that all compounds are stable in the folded conformation. These stable conformations are stabilized by different intra and intermolecular interactions, such as C−H⋯O, C−H⋯N, C−H⋯π and π⋯π. Quantitative intermolecular interactions and interactions energy calculations of both compounds have been carried out by Hirshfeld surface analysis. © 2023 Wiley-VCH GmbH.
Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017
(BMJ Publishing Group, 2020) Juanita A. Haagsma; Spencer L. James; Chris D. Castle; Zachary V. Dingels; Jack T. Fox; Erin B. Hamilton; Zichen Liu; Lydia R. Lucchesi; Nicholas L.S. Roberts; Dillon O. Sylte; Oladimeji M. Adebayo; Alireza Ahmadi; Muktar Beshir Ahmed; Miloud Taki Eddine Aichour; Fares Alahdab; Suliman A. Alghnam; Syed Mohamed Aljunid; Rajaa M. Al-Raddadi; Ubai Alsharif; Khalid Altirkawi; Mina Anjomshoa; Carl Abelardo T. Antonio; Seth Christopher Yaw Appiah; Olatunde Aremu; Amit Arora; Hamid Asayesh; Reza Assadi; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Shivanthi Balalla; Amrit Banstola; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Shahrzad Bazargan-Hejazi; Neeraj Bedi; Masoud Behzadifar; Meysam Behzadifar; Corina Benjet; Derrick A. Bennett; Isabela M. Bensenor; Soumyadeep Bhaumik; Zulfiqar A. Bhutta; Ali Bijani; Guilherme Borges; Rohan Borschmann; Dipan Bose; Soufiane Boufous; Alexandra Brazinova; Julio Cesar Campuzano Rincon; Rosario Cárdenas; Juan J. Carrero; Félix Carvalho; Carlos A. Castañeda-Orjuela; Ferrán Catalá-López; Jee-Young J. Choi; Devasahayam J. Christopher; Christopher Stephen Crowe; Koustuv Dalal; Ahmad Daryani; Dragos Virgil Davitoiu; Louisa Degenhardt; Diego De Leo; Jan-Walter De Neve; Kebede Deribe; Getenet Ayalew Dessie; Gabrielle Aline deVeber; Samath Dhamminda Dharmaratne; Linh Phuong Doan; Kate A. Dolan; Tim Robert Driscoll; Manisha Dubey; Ziad El-Khatib; Christian Lycke Ellingsen; Maysaa El Sayed Zaki; Aman Yesuf Endries; Sharareh Eskandarieh; Andre Faro; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Irina Filip; Florian Fischer; Richard Charles Franklin; Takeshi Fukumoto; Kebede Embaye Gezae; Tiffany K. Gill; Alessandra C. Goulart; Ayman Grada; Yuming Guo; Rahul Gupta; Hassan Haghparast Bidgoli; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Randah R. Hamadeh; Samer Hamidi; Josep Maria Haro; Hadi Hassankhani; Hamid Yimam Hassen; Rasmus Havmoeller; Delia Hendrie; Andualem Henok; Martha Híjar; Michael K. Hole; Enayatollah Homaie Rad; Naznin Hossain; Sorin Hostiuc; Guoqing Hu; Ehimario U. Igumbor; Olayinka Stephen Ilesanmi; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Rebecca Q. Ivers; Kathryn H. Jacobsen; Nader Jahanmehr; Mihajlo Jakovljevic; Achala Upendra Jayatilleke; Ravi Prakash Jha; Jost B. Jonas; Zahra Jorjoran Shushtari; Jacek Jerzy Jozwiak; Mikk Jürisson; Ali Kabir; Rizwan Kalani; Amir Kasaeian; Abraham Getachew Kelbore; Andre Pascal Kengne; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Nauman Khalid; Ejaz Ahmad Khan; Abdullah T. Khoja; Aliasghar A. Kiadaliri; Young-Eun Kim; Daniel Kim; Adnan Kisa; Ai Koyanagi; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Manasi Kumar; Ratilal Lalloo; Hilton Lam; Faris Hasan Lami; Van C. Lansingh; Janet L. Leasher; Shanshan Li; Shai Linn; Raimundas Lunevicius; Flavia R. Machado; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; Narayan Bahadur Mahotra; Marek Majdan; Azeem Majeed; Reza Malekzadeh; Manzoor Ahmad Malik; Deborah Carvalho Malta; Ana-Laura Manda; Mohammad Ali Mansournia; Benjamin Ballard Massenburg; Pallab K. Maulik; Hailemariam Abiy Alemu Meheretu; Man Mohan Mehndiratta; Addisu Melese; Walter Mendoza; Melkamu Merid Mengesha; Tuomo J. Meretoja; Atte Meretoja; Tomislav Mestrovic; Tomasz Miazgowski; Ted R. Miller; G.K. Mini; Erkin M. Mirrakhimov; Babak Moazen; Naser Mohammad Gholi Mezerji; Roghayeh Mohammadibakhsh; Shafiu Mohammed; Mariam Molokhia; Lorenzo Monasta; Stefania Mondello; Pablo A. Montero-Zamora; Yoshan Moodley; Mahmood Moosazadeh; Ghobad Moradi; Maziar Moradi-Lakeh; Lidia Morawska; Ilais Moreno Velásquez; Shane Douglas Morrison; Marilita M. Moschos; Seyyed Meysam Mousavi; Srinivas Murthy; Kamarul Imran Musa; Gurudatta Naik; Farid Najafi; Vinay Nangia; Bruno Ramos Nascimento; Duduzile Edith Ndwandwe; Ionut Negoi; Trang Huyen Nguyen; Son Hoang Nguyen; Long Hoang Nguyen; Huong Lan Thi Nguyen; Dina Nur Anggraini Ningrum; Yirga Legesse Nirayo; Richard Ofori-Asenso; Felix Akpojene Ogbo; In-Hwan Oh; Olanrewaju Oladimeji; Andrew T. Olagunju; Tinuke O. Olagunju; Pedro R. Olivares; Heather M. Orpana; Stanislav S. Otstavnov; P.A. Mahesh; Smita Pakhale; Eun-Kee Park; George C. Patton; Konrad Pesudovs; Michael R. Phillips; Suzanne Polinder; Swayam Prakash; Amir Radfar; Anwar Rafay; Alireza Rafiei; Siavash Rahimi; Vafa Rahimi-Movaghar; Muhammad Aziz Rahman; Rajesh Kumar Rai; Kiana Ramezanzadeh; Salman Rawaf; David Laith Rawaf; Andre M.N. Renzaho; Serge Resnikoff; Shahab Rezaeian; Leonardo Roever; Luca Ronfani; Gholamreza Roshandel; Yogesh Damodar Sabde; Basema Saddik; Payman Salamati; Yahya Salimi; Inbal Salz; Abdallah M. Samy; Juan Sanabria; Lidia Sanchez Riera; Milena M. Santric Milicevic; Maheswar Satpathy; Monika Sawhney; Susan M. Sawyer; Sonia Saxena; Mete Saylan; Ione J.C. Schneider; David C. Schwebel; Soraya Seedat; Sadaf G. Sepanlou; Masood Ali Shaikh; Mehran Shams-Beyranvand; Morteza Shamsizadeh; Mahdi Sharif-Alhoseini; Aziz Sheikh; Jiabin Shen; Mika Shigematsu; Rahman Shiri; Ivy Shiue; João Pedro Silva; Jasvinder A. Singh; Dhirendra Narain Sinha; Adauto Martins Soares Filho; Joan B. Soriano; Sergey Soshnikov; Ireneous N. Soyiri; Vladimir I. Starodubov; Dan J. Stein; Mark A. Stokes; Mu'awiyyah Babale Sufiyan; Jacob E. Sunshine; Bryan L. Sykes; Rafael Tabarés-Seisdedos; Karen M. Tabb; Arash Tehrani-Banihashemi; Gizachew Assefa Tessema; Jarnail Singh Thakur; Khanh Bao Tran; Bach Xuan Tran; Lorainne Tudor Car; Olalekan A. Uthman; Benjamin S. Chudi Uzochukwu; Pascual R. Valdez; Elena Varavikova; Ana Maria Nogales Vasconcelos; Narayanaswamy Venketasubramanian; Francesco S. Violante; Vasily Vlassov; Yasir Waheed; Yuan-Pang Wang; Tissa Wijeratne; Andrea Sylvia Winkler; Priyanka Yadav; Yuichiro Yano; Muluken Azage Yenesew; Paul Yip; Engida Yisma; Naohiro Yonemoto; Mustafa Z. Younis; Chuanhua Yu; Shamsa Zafar; Zoubida Zaidi; Sojib Bin Zaman; Mohammad Zamani; Yong Zhao; Sanjay Zodpey; Simon I. Hay; Alan D. Lopez; Ali H. Mokdad; Theo Vos
Background The epidemiological transition of non-communicable diseases replacing infectious diseases as the main contributors to disease burden has been well documented in global health literature. Less focus, however, has been given to the relationship between sociodemographic changes and injury. The aim of this study was to examine the association between disability-adjusted life years (DALYs) from injury for 195 countries and territories at different levels along the development spectrum between 1990 and 2017 based on the Global Burden of Disease (GBD) 2017 estimates. Methods Injury mortality was estimated using the GBD mortality database, corrections for garbage coding and CODEm-the cause of death ensemble modelling tool. Morbidity estimation was based on surveys and inpatient and outpatient data sets for 30 cause-of-injury with 47 nature-of-injury categories each. The Socio-demographic Index (SDI) is a composite indicator that includes lagged income per capita, average educational attainment over age 15 years and total fertility rate. results For many causes of injury, age-standardised DALY rates declined with increasing SDI, although road injury, interpersonal violence and self-harm did not follow this pattern. Particularly for self-harm opposing patterns were observed in regions with similar SDI levels. For road injuries, this effect was less pronounced. Conclusions The overall global pattern is that of declining injury burden with increasing SDI. However, not all injuries follow this pattern, which suggests multiple underlying mechanisms influencing injury DALYs. There is a need for a detailed understanding of these patterns to help to inform national and global efforts to address injury-related health outcomes across the development spectrum. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Challenges of Frontline health workers on reduction of anaemia among adolescents: A Qualitative enquiry
(Indian Association of Preventive and Social Medicine, 2024) Priyanka Yadav; Alok Kumar; Sangeeta Kansal
Background: High prevalence of anaemia is a severe public health problem in several low-and middle-income countries like India. In adolescents, anaemia has been linked to impaired physical and mental development and increases reproductive morbidities among adolescent girls during their womanhood. To tackle this high prevalence, number of government programs have been launched in India. However, a slow decline in the prevalence of anaemia has been reported in Indian adolescents over the recent past. Therefore, it is important to unfold the issues in reduction of prevalence of anaemia and the current study was carried out to identify challenges in reducing anaemia among adolescent girls. Methods: 33 Frontline Health Workers (FHW) were recruited from 6 randomly selected villages (out of 6, 2 villages were having population less than 2000, 2 villages were having population 2000 to 5000 and 2 villages were having more than 5000 population) of Kashi Vidyapeeth block, Varanasi. between January 2022 to April 2022. In-depth, face-to-face interviews were carried out in local language using an interview guide. All the interviews were recorded and transcribed verbatim. Transcribed data was analysed manually for theme extraction. This study was granted ethical permission by the Institutional Ethics Committee. Results: Following major themes were extracted during the data analysis: (i) Poor knowledge about adolescent health-related issues; (ii) non-adherence to program guidelines; (iii) Irregularity in the supply chain; (iv) Beneficiary’s lack of interest in only education about anaemia in the community; (v) Excessive administrative burden; (vi) Dissatisfaction in terms of monetary remuneration. Conclusions: The emerging findings throw light on the knowledge & perspective of Frontline health workers about program guidelines and also highlights the different challenges in implementing anaemia prevention strategies faced by them at the grass root level. © The Author(s). 2024.
Current imaging techniques for evaluation of fistula in ano: a review
(Springer Science and Business Media Deutschland GmbH, 2020) Ashish Sharma; Priyanka Yadav; Manoranjan Sahu; Ashish Verma
Background: Fistula in ano is one of the common anorectal disorders which have a tendency to recur specially in complex cases usually due to missed or undetected sepsis at the time of examination or surgery. A correct identification of the primary source of crypt infection along with a complete understanding of the anatomical course of primary and secondary tracks and abscesses is a prerequisite for the successful management of fistula. Preoperative evaluation of fistula in ano using radio-imaging techniques provides a handy insight of fistula anatomy and helps in planning the appropriate treatment strategy. The objective of this article is to review the role of different radio-imaging techniques in the diagnosis and evaluation of fistula in ano along with their advantages and disadvantages over one another. Main text: A comprehensive literature review was performed searching through the electronic databases as well as the standard textbooks of colorectal surgery. X-rays (plain radiographs and contrast fistulography), computed tomography (CT) scanning, anal endosonography, and magnetic resonance (MR) imaging are the modalities used for preoperative imaging of fistula in ano. Due to low accuracy, X-ray fistulography is not used now for fistula imaging. CT fistulography can be more accurate in cases associated with acute inflammations and abscesses and the fistulas related with inflammatory bowel disease. Anal endosonography and MRI are two of the mostly used and reliable imaging techniques for fistula in ano. Though the use of a 3D technology has improved the accuracy of anal endosonography, MRI is the preferred choice by many. However, various reports have depicted comparable accuracies for both MRI and anal endosonography showing both to be equally sensitive but MRI to be more specific. 3D endoanal ultrasound, on the other hand, is more rapid and can also be used intraoperatively to provide live imaging during surgical exploration. Conclusion: Complex and recurrent fistula cases should undergo a preoperative imaging to reduce the chances of recurrence. MRI is recommended as the imaging modality of choice for such cases. 3D anal endosonography may however be a good option over MRI owing to its rapidity, availability, and potential of intraoperative assistance during surgery. © 2020, The Author(s).
Designing symmetrically folded scaffolds of pyridazinone and triazinone derivatives linked via N,N-diethyl-4-nitro-benzenesulfonamide to explore luminescent materials
(Royal Society of Chemistry, 2025) Vipin Kumar; Krishanu Bandyopadhyay; Manisha Nidhar; Vishal Prasad Sharma; Priyanka Yadav; Suman Gill; Priyanka K. Sonker; Abhineet Verma; Satyen Saha; Ashish Kumar Tewari
The study investigates π⋯π interaction in an aromatic-heteroaromatic folded scaffold as well as (NO)π⋯π(arene) and O⋯π(arene) of pyridazinone and 1,2,4-triazinone and their implication for the design of luminescent materials. The research is focused on elucidating the materials' emission spectra and specifically emphasizing the donor-accepter stacking phenomena in the synthesized compounds by altering heteroaromatic units. The studies enlightened the effect of the methoxy group on emission spectra obtained by flipping the DPM molecule in the liquid and solid phases. Results highlight the importance of intramolecular and intermolecular interactions in determining the optical and electrical properties of organic materials. The full spectral profile and quantum yield (φ) of all compounds were examined in the liquid state. Crystallographic data for compounds DP, DT, DPM, and DTM are presented, highlighting the distinct conformers and stacking strength and affirming the stability of crystal geometry. Furthermore, theoretical studies established the correlation between molecular structure and the absorption spectra of molecules. © 2025 The Royal Society of Chemistry.
Dispersion and dissipation of shear horizontal wave in magneto-electro-elastic material loaded with complex magnetic viscous fluid
(Institute of Physics, 2025) Ravindra Singh; Ramnarayan; Priyanka Yadav; Surendra Prasad
The present study outlines the theoretical analysis of Shear horizontal (SH) wave propagation on magneto-electro-elastic (MEE) material lying on an elastic half-space and subjected to magnetic fluid loading. Using an exact analytical approach, complex dispersion relations for SH waves are derived under both electric short and electric open boundary conditions. To validate these derived relations, specific cases are considered where the MEE material behaves as piezoelectric and piezomagnetic. The complex dispersion relations are separated into real and imaginary components, revealing nonlinear relationships between phase velocity and attenuation of SH waves in relation to geometric parameters, frequency, and the physical properties of the magnetic fluid. Five different magnetic fluids are examined to illustrate the phase velocity and attenuation characteristics graphically. The effects of geometric and physical parameters of the magnetic fluids, the thickness of the MEE material, and the frequency and density of the elastic half-space on the phase velocity and attenuation of SH waves are discussed. Additionally, the finite element method (FEM) is employed to validate the results, ensuring the accuracy of the analytical findings. The results of this study are fundamental and can be used to design and development of surface acoustic wave (SAW) liquid sensors as well as magnetic field sensors. © 2025 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Efficient: N -formylation of primary aromatic amines using novel solid acid magnetic nanocatalyst
(Royal Society of Chemistry, 2020) Jitendra Kumar Yadav; Priyanka Yadav; Satish K. Awasthi; Alka Agarwal
Sulfonic acid functionalized over biguanidine fabricated silica-coated heterogeneous magnetic nanoparticles (NP@SO3H) have been synthesized, well characterized and explored for the first time, as an efficient and recyclable catalyst for N-formylation of primary amines under mild reaction conditions. Exploiting the magnetic nature of Fe3O4, the prepared catalyst was readily recovered from the reaction mixture via an external magnet. The catalyst can be reused for up to six cycles without any substantial loss of catalytic activity. The cost effectiveness, simple methodology, wide substrate tolerance, excellent yield and easy work-up are the additional advantages of present catalytic system. This journal is © The Royal Society of Chemistry.
Impact of short- and long-duration thermal stress on antioxidant enzyme activity in Parthenium beetles
(John Wiley and Sons Inc, 2025) Priyanka Yadav; Arvind Kumar Patel; Parinita Singh; Sourabh Verma; Ritabrata Chowdhury; Bhupendra Kumar
Insects encounter variable temperature conditions in their natural habitats. Under non-optimal temperatures, they experience thermal stress and oxidative damage, which are mitigated by antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (LPO). While short-term effects of thermal stress on antioxidant enzyme activities in insects are well understood, the long-term effects are less explored. We investigated both short-term (3 and 6 h) and long-term (24 h) effects of thermal stress on SOD, CAT and LPO activities in the Parthenium beetle, Zygogramma bicolorata Pallister at cold (15°C), control/optimal (25°C) and hot (35°C) temperatures. Although Z. bicolorata is an effective biocontrol agent for noxious Parthenium weed, no prior study assessed the impact of thermal stress on antioxidant enzyme activities in this beetle. Our results revealed that antioxidant enzymes activities increased above control levels in both larvae and adults when exposed to thermal stress for short durations. Under long-term thermal stress, CAT and LPO activities decreased below control levels, while SOD activity increased. Regardless of temperature conditions, early larval instars exhibited higher enzyme activities compared to later instars. In adults, males showed higher SOD and CAT activities, whereas LPO activity did not differ significantly between sexes. Our findings suggest that short-term thermal stress can stimulate protective enzyme activity in these beetles and help them adapt to suboptimal temperatures. However, prolonged exposure may lead to excessive stimulation, potentially inhibiting protective enzyme activity and causing the beetles to activate alternative pathways to manage thermal stress. Moreover, fourth instars and adult females are the most thermal stress-tolerant stages for Parthenium biocontrol. © 2024 Royal Entomological Society.
Impact of short- and long-duration thermal stress on antioxidant enzyme activity in Parthenium beetles
(John Wiley and Sons Inc, 2024) Priyanka Yadav; Arvind Kumar Patel; Parinita Singh; Sourabh Verma; Ritabrata Chowdhury; Bhupendra Kumar
Insects encounter variable temperature conditions in their natural habitats. Under non-optimal temperatures, they experience thermal stress and oxidative damage, which are mitigated by antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (LPO). While short-term effects of thermal stress on antioxidant enzyme activities in insects are well understood, the long-term effects are less explored. We investigated both short-term (3 and 6 h) and long-term (24 h) effects of thermal stress on SOD, CAT and LPO activities in the Parthenium beetle, Zygogramma bicolorata Pallister at cold (15°C), control/optimal (25°C) and hot (35°C) temperatures. Although Z. bicolorata is an effective biocontrol agent for noxious Parthenium weed, no prior study assessed the impact of thermal stress on antioxidant enzyme activities in this beetle. Our results revealed that antioxidant enzymes activities increased above control levels in both larvae and adults when exposed to thermal stress for short durations. Under long-term thermal stress, CAT and LPO activities decreased below control levels, while SOD activity increased. Regardless of temperature conditions, early larval instars exhibited higher enzyme activities compared to later instars. In adults, males showed higher SOD and CAT activities, whereas LPO activity did not differ significantly between sexes. Our findings suggest that short-term thermal stress can stimulate protective enzyme activity in these beetles and help them adapt to suboptimal temperatures. However, prolonged exposure may lead to excessive stimulation, potentially inhibiting protective enzyme activity and causing the beetles to activate alternative pathways to manage thermal stress. Moreover, fourth instars and adult females are the most thermal stress-tolerant stages for Parthenium biocontrol. © 2024 Royal Entomological Society.
Insight into the interaction of benzothiazole tethered triazole analogues with human serum albumin: Spectroscopy and molecular docking approaches
(John Wiley and Sons Ltd, 2019) Priyanka Yadav; Jitendra Kumar Yadav; Arvind Kumar Dixit; Alka Agarwal; Satish Kumar Awasthi
The interaction of four benzothiazole tethered triazole analogues (MS43, MS70, MS71, and MS78) with human serum albumin (HSA) was investigated using various spectroscopic techniques (ultraviolet–visible (UV–vis) light absorption, fluorescence, circular dichroism (CD), molecular docking and density functional theory (DFT) studies). Fluorescence quenching constants (~1012) revealed a static mode of quenching and binding constants (Kb ~104) indicating the strong affinity of these analogues for HSA. Further alteration in the secondary structure of HSA in the presence of these analogues was also confirmed by far UV–CD spectroscopy. The intensity loss in CD studied at 222 nm indicated an increase in random coil/β-sheet conformations in the protein. Binding energy values (MS71 (−9.3 kcal mol−1), MS78 (−8.02 kcal mol−1), MS70 (−7.16 kcal mol−1) and MS43 (−6.81 kcal mol−1)) obtained from molecular docking revealed binding of these analogues with HSA. Molecular docking and DFT studies validated the experimental results, as these four analogues bind with HSA at site II through hydrogen bonding and hydrophobic interactions. © 2019 John Wiley & Sons, Ltd.
Insights into the interaction of potent antimicrobial chalcone triazole analogs with human serum albumin: Spectroscopy and molecular docking approaches
(Royal Society of Chemistry, 2019) Priyanka Yadav; Jitendra Kumar Yadav; Alka Agarwal; Satish K. Awasthi
Mechanistic insights into the interaction of five previously chemically synthesized triazole-linked chalcone analogs (CTs) with human serum albumin (HSA) were sought using various spectroscopic techniques (UV-visible absorption, fluorescence, and circular dichroism) and molecular docking. The fluorescence quenching experiments performed at three different temperatures (288, 298 and 308 K) revealed the static mode of quenching and the binding constants (Kb ∼ 106-9) obtained indicated the strong affinity of these analogs for HSA. Furthermore, significant changes in the secondary structure of HSA in the presence of these analogs were also confirmed by far UV-CD spectroscopy. The thermodynamic properties such as the enthalpy change (ΔH°), Gibbs free energy change (ΔG°) and entropy change (ΔS°) revealed that the binding process was spontaneous and exothermic. Theoretical studies, viz., DFT and molecular docking corroborated the experimental results as these five analogs could bind with HSA through hydrogen bonding and hydrophobic interactions. The present study provides useful information regarding the interaction mechanism of these analogs with HSA, which can provide a new avenue to design more potent chalcone triazole analogs for use in the biomedical field. © The Royal Society of Chemistry 2019.
Lead modification via computational studies: Synthesis of pyrazole-containing β-amino carbonyls for the treatment of type 2 diabetes
(John Wiley and Sons Inc, 2023) Manisha Nidhar; Vipin Kumar; Archisman Mahapatra; Priya Gupta; Priyanka Yadav; Priyanka Sonker; Akhilesh Kumar; Shweta Mishra; Rahul Kumar Singh; Ashish Kumar Tewari
This article describes studies on the design, synthesis, and biological evaluation of pyrazole-containing β-amino carbonyl compounds (5a–5q) as DPP-4 inhibitors and anti-diabetic agents. In contrast, mannich reactions went smoothly with bismuth nitrate (Bi (NO3)3) catalyst in the presence of ethanol and produced pyrazole-containing β-amino carbonyl compounds in good yield. Molecular docking studies of designed derivatives with DPP-4 enzyme (PDB: 2OLE), compounds 5d, 5h, 5j, and 5k showed excellent interaction. 3D QSAR and pharmacophoric model studies were also carried out. ADMET parameters, pharmacokinetic properties, and in vivo toxicity studies further confirmed that all the designed compounds were found to have good bioavailability and were less toxic. Further, these compounds were evaluated as enzyme-based in vitro DPP-4 inhibitory activity, and 5d, 5h, 5i, 5j, and 5k exhibited IC50 toward DPP-4 enzyme of 10.52, 10.41, 5.55, 4.16, and 7.5 nM, respectively. The most potent compound, 5j, was further selected for in vivo anti-diabetic activity using an STZ-induced diabetic mice model, and 5j showed a significant diabetic control effect. © 2022 John Wiley & Sons Ltd.
Modelling and optimization of TiO2based two- dimensional photonic crystal for salinity detection in water
(Elsevier GmbH, 2025) Priyanka Yadav; Ravindra Singh; Ram Narayan; Surendra Prasad
In this article, we have presented a computational analysis of two-dimensional photonic crystals (2D- PCs) having circular and elliptical waveguide structures inside aTiO2 host material for the salinity detection in the water. The band structure of the proposed 2D- PCs has been optimized for better salinity detection based on the number of circular and elliptical waveguiding pores taken in the PCs structure and changes in the radius of circular pores and for different major-minor axis of elliptical pores. The electric field profiles corresponding to these structures have also been plotted. The salinity detection sensitivity is calculated by computing the change in transmittance (∆Tn1.333−n1.35) corresponding to changes in refractive indices due to salinity in water. It is observed that maximum sensitivity is obtained corresponding to refractive indices, n1.333,n1.35 which is equal to 0.9198 in the circular pore in the 2D-PCs structure. For the elliptical pore, the sensitivity is 0.8679. © 2024 Elsevier GmbH
Modulation of hybrid plasmon phonon polaritons mode in circular cylindrical three-layer graphene waveguide
(Elsevier GmbH, 2024) Ramnarayan; Ravindra Singh; Priyanka Yadav; Yogesh Sharma; Surendra Prasad
In this present research article, we have investigated analytically the characteristics of the fundamental mode of hybrid surface plasmon phonon polariton (HSPPhPs) mode in a circular cylindrical three-layer graphene (CTLG) waveguide structure. The dispersion equation of HSPPhPs is derived by using Maxwell's equations and continuity conditions of tangential components of electric and magnetic fields in cylindrical geometry. The dispersion curve has been illustrated and thoroughly examined in relation to the effects of temperature and chemical potential (μc) of graphene, as well as variations in the thickness of silicon dioxide (SiO2) and hexagonal boron nitride (hBN) layers, and found that in the presence of hBN, the effective mode index exhibits hyperbolic behavior with wave number. Up to the first Reststrahlen band (∼830.57 cm⁻¹), it varies slightly with graphene temperature; increasing graphene's (μc) lowers the index, while a thicker hBN layer reduces it, whereas the index increases with SiO₂ layer thickness. Also, we looked at how the CTLG waveguide structure is affected by the electric field distribution, phase speed, and propagation length. © 2024 Elsevier GmbH
Molecular docking and density functional theory studies of potent 1,3-disubstituted-9H-pyrido[3,4-b]indoles antifilarial compounds
(Springer, 2021) Jitendra Kumar Yadav; Priyanka Yadav; Vinay Kumar Singh; Alka Agarwal
The interaction of three potent antifilarial compounds (4C, 4F, and 3F) with filarial proteins thioredoxin, glutathione s-transferase and cyclophilin were investigated using molecular docking and density functional theory (DFT) studies. Molecular docking was performed using YASARA tool, Hex 8.0.0 Cuda tool and PatchDock server and docked complex were visualized by Discovery Studio 3.0. The predicted binding energy of antifilarial compounds 4C (−247.6, −243.8, −256.8 kcal mol−1), 4F (−242.6, −246.4, −232.4 kcal mol−1) and 3F (−272.4, −248.5, −277.7 kcal mol−1) with filarial protein 4FYU, 5D73, and 1A33, respectively. Docking results were strongly supported by molecular dynamics data and molecular mechanics-generalized born surface area (MM-GBSA) calculations. The optimized geometries of all three compounds were used for calculating the energies of the frontier molecular orbitals highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO). The lowest HOMO–LUMO energy gap in compound 3F suggested that it is the most bioactive molecule among all these three compounds, which is in accordance with the docking results of these compounds. The interaction energies between ligand and protein are mainly due to hydrogen bonds, hydrophobic interactions, and van der Waals interactions which give the stability to the complex. The structural information and docking studies of different filarial proteins with antifilarials obtained from this study could aid in screening and designing new antifilarial or selective inhibitors for chemotherapy against filariasis. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Morphology of Mouthparts and Distribution of Sensilla in Immature Stages and Adults of Parthenium Beetles
(Oxford University Press, 2025) Priyanka Yadav; Arvind Kumar Patel; Desh Deepak Chaudhary; Bhupendra Kumar
The Parthenium beetle, Zygogramma bicolorata Pallister (Coleoptera: Chrysomelidae) is a notable biocontrol agent against invasive Parthenium weed in Australia, South Africa, and the Indian subcontinent. While larvae consume both inflorescences and leaves, and adults feed exclusively on leaves, no prior study has compared the mouthparts of Z. bicolorata larvae and adults. Present study utilized scanning electron microscopy to investigate the morphology and distribution of sensilla on mouthparts of fourth-instar larvae, pupae, and adults. Our results revealed that fourth-instar larvae had 9-different sensillum types: sensilla chaetica (Sch I-III), sensilla basiconica (Sb I-V), and sensilla digitiformia (Ds) on their mouthparts, whereas pupal sensilla were fewer and less distinct. In adults, 13-different sensillum types were present: sensilla chaetica (Sch I-III) on labrum, labium, mandibles, and maxillae; sensilla basiconica (Sb I-VI) on labium, epipharyx, lacinia, maxillary palps, and labial palps; sensilla digitiformia (Ds) on maxillary palps; and sensilla campaniformia (Sca), and sensilla coeloconica (Sco I-II) on epipharyx. These sensilla likely play vital roles in feeding behavior, sensory perception, and host plant detection. Our findings provide a microscopic morphological foundation for further research on food recognition mechanisms and local adaptations in specialist phytophagous insects. © The Author(s) 2025. Published by Oxford University Press on behalf of the Microscopy Society of America. All rights reserved.
Morphometric analysis of Parthenium beetle, Zygogramma bicolorata (Pallister) under thermal-stress conditions
(Springer Nature, 2025) Arvind Kumar Patel; Priyanka Yadav; Bhupendra Kumar
This study highlights the effects of thermal stress on the morphology of the Parthenium beetle, Zygogramma bicolorata Pallister. Our findings indicate that temperature significantly influences the body biomass of adults, with optimal (25 ± 2 °C) conditions resulting in the highest biomass. Body size and antennal length were reduced under both cold (15 ± 2 °C) and hot (35 ± 2 °C) conditions, with greater variability recorded at cold temperatures. Moreover, cold stress increased melanization and induced developmental abnormalities, such as fused flagellomeres in the antennae. The abundance of sensilla varied significantly across temperature treatments, except for sensilla chaetica types I and II. Antennal segments also exhibited temperature-dependent variations in length. Eight types of sensilla were identified, with sensilla trichodea I and sensilla coeloconica being more abundant under thermal extremes, potentially influencing host and mate detection. Sensilla chaetica were the most widespread and robust, displaying variability in both length and abundance. Structural differences were observed between sensilla trichodea and sensilla basiconica, particularly in terms of curvature and socket embedding. Overall, the results suggest that thermal stress affects both morphological and sensory traits in Z. bicolorata, which may in turn, impact their survival and reproductive success. © African Association of Insect Scientists 2025.
NaHS alters synaptic plasticity proteins and enhances dendritic arborization to improve cognitive and motor deficits after traumatic brain injury in mice
(John Wiley and Sons Inc, 2025) Farheen Nasir; Priyanka Yadav; Thamil Mani Sivanandam
Background and Purpose: Traumatic brain injury (TBI) is a complex medical condition affecting people globally. Hydrogen sulfide (H2S) is a recently discovered gaseous mediator and is dysregulated in the brain after TBI. Sodium hydrogen sulfide (NaHS), a known donor of H2S, is beneficial in various biological processes involving aging and diseases, including injury. It is neuroprotective against oxidative stress, neuroinflammation, and other secondary injury processes. However, the NaHS-H2S system has not been investigated as a regulator of injury-mediated synaptic plasticity proteins and the underlying mechanisms after TBI. Experimental approach: We developed a model of TBI in Swiss albino mice to study the effects of exogenous H2S, administered as NaHS. We assessed cognitive function (Barnes maze and novel object recognition) and motor function (rotarod). Brain tissue was analysed with ELISA, qRT-PCR, immunoblotting, Golgi-cox staining, and immunofluorescence. Key results: NaHS administration restored the injury-caused decline in H2S levels. Injury-mediated oxidative stress parameters were improved following NaHS. It down-regulated TBI biomarkers, ameliorated the synaptic marker proteins, and improved cognitive and motor deficits. These changes were accompanied by enhanced dendritic arborization and spine number. Restoration of N-methyl D-aspartate receptor subunits and diminished glutamate and calcium levels, along with marked changes in microtubule-associated protein 2 A and calcium/calmodulin-dependent protein kinase II, formed the basis of the underlying mechanism(s). Conclusion and Implications: Our findings suggest that NaHS could have therapeutic activity against TBI, as it ameliorated cognitive and motor deficits caused by changes in synaptic plasticity proteins and dendritic arborisation, in our model. © 2024 British Pharmacological Society.
Neuroprotective effect of vitamin B12 supplementation on cognitive functions and neuronal morphology at different time intervals after traumatic brain injury in male Swiss albino mice
(Elsevier Ltd, 2024) Priyanka Yadav; Farheen Nasir; Thamil Mani Sivanandam
Traumatic brain injury is a highly irreversible process that consists of primary as well as secondary injury which develops and progresses over months to years, leading to cognitive dysfunctions. Vitamin B12 received considerable interest due to its potential therapeutic properties. The pathways of vitamin B12 are closely related to neuronal survival but its effects on the pathophysiology of injury with respect to cognition is a relatively unexplored area of research. In this study, we investigated, the effect of vitamin B12 and its involvement in neuroprotection on TBI-induced pathophysiology in male Swiss albino mice. Our findings suggested that vitamin B12 supplementation improves TBI-mediated neurological impairments, spatial and recognition memory, and anxiety-like behavior. Furthermore, the oxidative stress was reduced by declined homocysteine level with vitamin B12 supplementation validating declined expression of astrocytes and TBI biomarkers. The studies on neuronal morphology revealed that vitamin B12 supplementation increases the dendritic arborization and density of mushroom and filopodia-shaped spines and further increases the expression of synaptic plasticity-related genes and proteins. Taken together, our findings reveal that, supplementation of vitamin B12 restored the TBI-induced downregulation of dendritic arborization, and spine density which ultimately increases synaptic plasticity, cell survival, and recovery of cognitive dysfunctions. © 2024 Elsevier Ltd