Browsing by Author "R. Dixit"

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EPIDEMIOLOGICAL STUDY OF BREAST CANCER PATIENTS AND THEIR ASSOCIATION WITH ABO BLOOD GROUP
(Verduci International, 2020) R. Dixit; S.K. Bhartiya; K.K. Singh; V.K. Shukla
Objective: ABO Blood groups play an important biological role in the immunological system. Studies have reported a strong relationship between ABO and Rhesus (Rh) blood types with various cancers; however, results are contrasting. This study encompasses epidemiology of breast cancer patients in north-eastern Uttar Pradesh region and also investigates the distribution of ABO and Rh blood antigens among breast cancer patients. Patients and Methods: A total of 187 breast cancer patients and 209 controls were enrolled in the study. Blood group, Rh factor, histological type, and different clinicopathological parameters were recorded. The frequencies of the ABO blood group among both the groups were evaluated and compared with different clinical parameters. Results: Frequency of blood group B (40.6%) was comparatively higher in breast cancer patients than other groups (A – 22.5%, AB – 6.4%, O – 30.5%), and the distribution of blood group among cases and controls did not differ significantly. Blood group B (n=53; 69.7%) has been found to be higher in grade II differentiation of breast cancer, but the difference was not significant. Moreover, we did not find any association of blood group with any of the receptor status. Conclusions: Results suggested that blood group B was found to be higher in breast cancer patients, but it did not show any significant role. In addition, we did not find any association between Rh factor and breast cancer. Study findings have shown that breast cancer type, grade, stage, age of menarche (AOM), and hormonal status showed no significant associations with ABO blood group. However, further studies with larger number of patients are needed to clearly establish the role of ABO/Rh blood groups as a prognostic factor in breast cancer patients. © 2020, Verduci International. All rights reserved.
Study of AP endonuclease (APEX1/REF1), a DNA repair enzyme, in gallbladder carcinoma
(2012) V.K. Shukla; P.C. Das; R. Dixit; S.K. Bhartiya; S. Basu; M.J. Raman
Aim: This study investigated the levels of Apurinic/Apyrimidinic Endonuclease (APEX1) in gallbladder carcinoma (CaGB) tissue and co-related these levels with various clinicopathological parameters. Patients and Methods: Twenty cases of CaGB and cholelithiasis were included in the study. Western blot analysis of APEX1 protein was performed using actin as the reference point. Densitometric analysis and the integrated density value (IDV) of APEX1 protein samples were determined. The ratio of IDV of APEX1/actin was determined. Results: The mean IDV ratio of APEX1 in CaGB was 0.63±0.33 and 0.45±0.19 in cholelithiasis. The mean IDV ratio of a variant of APEX1 (ΔAPEX1) in CaGB was 0.50±0.09, whereas it was 0.40±0.16 in cholelithiasis. Calculating the mean IDV ratio of total APEX (APEX1+ΔAPEX1) in CaGB was 1.13±0.31 whereas in cholelithiasis, 0.85±0.23. The differences were statistically significant (p<0.05). Conclusion: A significant correlation was found between the relative expressions of APEX1 in cancer as compared to that in cholelithiasis patients. There was significant association between APEX1 expression and perineural invasion. A variant of APEX1 correlated with tumor infiltration. Hence APEX1 may be of use as a prognostic marker in patients with CaGB.